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{{Infobox_gene}}
{{GNF_Protein_box
'''DNA topoisomerase 3-beta-1''' is an [[enzyme]] that in humans is encoded by the ''TOP3B'' [[gene]].<ref name="pmid9786842">{{cite journal | vauthors = Tang D, Kidd VJ | title = Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis | journal = J Biol Chem | volume = 273 | issue = 44 | pages = 28549–52 |date=Dec 1998 | pmid = 9786842 | pmc =  | doi =10.1074/jbc.273.44.28549 }}</ref><ref name="pmid9074928">{{cite journal | vauthors = Kawasaki K, Minoshima S, Nakato E, Shibuya K, Shintani A, Schmeits JL, Wang J, Shimizu N | title = One-megabase sequence analysis of the human immunoglobulin lambda gene locus | journal = Genome Res | volume = 7 | issue = 3 | pages = 250–61 |date=May 1997 | pmid = 9074928 | pmc =  | doi =10.1101/gr.7.3.250 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TOP3B topoisomerase (DNA) III beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8940| accessdate = }}</ref>
| image =
| image_source =
| PDB =  
| Name = Topoisomerase (DNA) III beta
| HGNCid = 11993
| Symbol = TOP3B
| AltSymbols =; FLJ39376
| OMIM = 603582
| ECnumber =
  | Homologene = 2923
  | MGIid = 1333803
| Function = {{GNF_GO|id=GO:0003917 |text = DNA topoisomerase type I activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000793 |text = condensed chromosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006265 |text = DNA topological change}} {{GNF_GO|id=GO:0006268 |text = DNA unwinding during replication}} {{GNF_GO|id=GO:0006304 |text = DNA modification}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8940
    | Hs_Ensembl =   
    | Hs_RefseqProtein = NP_003926
    | Hs_RefseqmRNA = NM_003935
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 21976
    | Mm_Ensembl = ENSMUSG00000022779
    | Mm_RefseqmRNA = NM_011624
    | Mm_RefseqProtein = NP_035754
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 16784454
    | Mm_GenLoc_end = 16806555
    | Mm_Uniprot = Q3UJF5
  }}
}}
'''Topoisomerase (DNA) III beta''', also known as '''TOP3B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TOP3B topoisomerase (DNA) III beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8940| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.<ref name="entrez">{{cite web | title = Entrez Gene: TOP3B topoisomerase (DNA) III beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8940| accessdate = }}</ref>
| summary_text = This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Kawasaki K, Minoshima S, Nakato E, ''et al.'' |title=One-megabase sequence analysis of the human immunoglobulin lambda gene locus. |journal=Genome Res. |volume=7 |issue= 3 |pages= 250-61 |year= 1997 |pmid= 9074928 |doi=  }}
*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal   |vauthors=Seki T, Seki M, Onodera R, etal |title=Cloning of cDNA encoding a novel mouse DNA topoisomerase III (Topo IIIbeta) possessing negatively supercoiled DNA relaxing activity, whose message is highly expressed in the testis |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 28553–6 |year= 1998 |pmid= 9786843 |doi=10.1074/jbc.273.44.28553 }}
*{{cite journal  | author=Tang D, Kidd VJ |title=Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis. |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 28549-52 |year= 1998 |pmid= 9786842 |doi=  }}
*{{cite journal   |vauthors=Ng SW, Liu Y, Hasselblatt KT, etal |title=A new human topoisomerase III that interacts with SGS1 protein |journal=Nucleic Acids Res. |volume=27 |issue= 4 |pages= 993–1000 |year= 1999 |pmid= 9927731 |doi=10.1093/nar/27.4.993  | pmc=148278 }}
*{{cite journal | author=Seki T, Seki M, Onodera R, ''et al.'' |title=Cloning of cDNA encoding a novel mouse DNA topoisomerase III (Topo IIIbeta) possessing negatively supercoiled DNA relaxing activity, whose message is highly expressed in the testis. |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 28553-6 |year= 1998 |pmid= 9786843 |doi=  }}
*{{cite journal  | vauthors=Shimamoto A, Nishikawa K, Kitao S, Furuichi Y |title=Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta |journal=Nucleic Acids Res. |volume=28 |issue= 7 |pages= 1647–55 |year= 2000 |pmid= 10710432 |doi=10.1093/nar/28.7.1647  | pmc=102787 }}
*{{cite journal | author=Ng SW, Liu Y, Hasselblatt KT, ''et al.'' |title=A new human topoisomerase III that interacts with SGS1 protein. |journal=Nucleic Acids Res. |volume=27 |issue= 4 |pages= 993-1000 |year= 1999 |pmid= 9927731 |doi=  }}
*{{cite journal  | vauthors=Kobayashi M, Hanai R |title=M phase-specific association of human topoisomerase IIIbeta with chromosomes |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 1 |pages= 282–7 |year= 2001 |pmid= 11549288 |doi= 10.1006/bbrc.2001.5580 }}
*{{cite journal  | author=Shimamoto A, Nishikawa K, Kitao S, Furuichi Y |title=Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. |journal=Nucleic Acids Res. |volume=28 |issue= 7 |pages= 1647-55 |year= 2000 |pmid= 10710432 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Kobayashi M, Hanai R |title=M phase-specific association of human topoisomerase IIIbeta with chromosomes. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 1 |pages= 282-7 |year= 2001 |pmid= 11549288 |doi= 10.1006/bbrc.2001.5580 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Cho YH, Park JY, Han SY, Chung IK |title=Identification of the functional elements in the promoter region of human DNA topoisomerase IIIbeta gene |journal=Biochim. Biophys. Acta |volume=1679 |issue= 3 |pages= 272–8 |year= 2004 |pmid= 15358519 |doi= 10.1016/j.bbaexp.2004.08.001 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal  | author=Cho YH, Park JY, Han SY, Chung IK |title=Identification of the functional elements in the promoter region of human DNA topoisomerase IIIbeta gene. |journal=Biochim. Biophys. Acta |volume=1679 |issue= 3 |pages= 272-8 |year= 2004 |pmid= 15358519 |doi= 10.1016/j.bbaexp.2004.08.001 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
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Revision as of 12:09, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA topoisomerase 3-beta-1 is an enzyme that in humans is encoded by the TOP3B gene.[1][2][3]

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.[3]

References

  1. ↑ Tang D, Kidd VJ (Dec 1998). "Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis". J Biol Chem. 273 (44): 28549–52. doi:10.1074/jbc.273.44.28549. PMID 9786842.
  2. ↑ Kawasaki K, Minoshima S, Nakato E, Shibuya K, Shintani A, Schmeits JL, Wang J, Shimizu N (May 1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus". Genome Res. 7 (3): 250–61. doi:10.1101/gr.7.3.250. PMID 9074928.
  3. ↑ 3.0 3.1 "Entrez Gene: TOP3B topoisomerase (DNA) III beta".

Further reading



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