EIF4ENIF1: Difference between revisions

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{{Infobox_gene}}
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'''Eukaryotic translation initiation factor 4E transporter''' is a [[protein]] that in humans is encoded by the ''EIF4ENIF1'' [[gene]].<ref name="pmid10856257">{{cite journal | vauthors = Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N | title = A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E | journal = EMBO J | volume = 19 | issue = 12 | pages = 3142–56 |date=Aug 2000 | pmid = 10856257 | pmc = 203362 | doi = 10.1093/emboj/19.12.3142 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56478| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Eukaryotic translation initiation factor 4E nuclear import factor 1
| HGNCid = 16687
| Symbol = EIF4ENIF1
| AltSymbols =; 4E-T; Clast4; FLJ21601; FLJ26551
| OMIM = 607445
| ECnumber = 
| Homologene = 10522
| MGIid = 1921453
| GeneAtlas_image1 = PBB_GE_EIF4ENIF1_218626_at_tn.png
| Function = {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008565 |text = protein transporter activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0015031 |text = protein transport}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 56478
    | Hs_Ensembl = ENSG00000184708
    | Hs_RefseqProtein = NP_062817
    | Hs_RefseqmRNA = NM_019843
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 30165355
    | Hs_GenLoc_end = 30215704
    | Hs_Uniprot = Q9NRA8
    | Mm_EntrezGene = 74203
    | Mm_Ensembl = ENSMUSG00000020454
    | Mm_RefseqmRNA = NM_023743
    | Mm_RefseqProtein = NP_076232
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 3102395
    | Mm_GenLoc_end = 3144588
    | Mm_Uniprot = Q5NBZ7
  }}
}}
'''Eukaryotic translation initiation factor 4E nuclear import factor 1''', also known as '''EIF4ENIF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56478| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.<ref name="entrez">{{cite web | title = Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56478| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.<ref name="entrez">{{cite web | title = Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56478| accessdate = }}</ref>
}}
}}
==Interactions==
EIF4ENIF1 has been shown to [[Protein-protein interaction|interact]] with [[EIF4E]].<ref name=pmid10856257 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Dostie J, Ferraiuolo M, Pause A, ''et al.'' |title=A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. |journal=EMBO J. |volume=19 |issue= 12 |pages= 3142-56 |year= 2000 |pmid= 10856257 |doi= 10.1093/emboj/19.12.3142 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Warner DR, Roberts EA, Greene RM, Pisano MM |title=Identification of novel Smad binding proteins. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 4 |pages= 1185–90 |year= 2004 |pmid= 14651998 |doi=10.1016/j.bbrc.2003.11.049 }}
*{{cite journal  | author=Warner DR, Roberts EA, Greene RM, Pisano MM |title=Identification of novel Smad binding proteins. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 4 |pages= 1185-90 |year= 2004 |pmid= 14651998 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal}}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  | vauthors=Collins JE, Wright CL, Edwards CA |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |display-authors=etal}}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Andrei MA, Ingelfinger D, Heintzmann R |title=A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies. |journal=RNA |volume=11 |issue= 5 |pages= 717–27 |year= 2005 |pmid= 15840819 |doi= 10.1261/rna.2340405 | pmc=1370757 |display-authors=etal}}
*{{cite journal  | author=Andrei MA, Ingelfinger D, Heintzmann R, ''et al.'' |title=A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies. |journal=RNA |volume=11 |issue= 5 |pages= 717-27 |year= 2005 |pmid= 15840819 |doi= 10.1261/rna.2340405 }}
*{{cite journal  | vauthors=Ferraiuolo MA, Basak S, Dostie J |title=A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. |journal=J. Cell Biol. |volume=170 |issue= 6 |pages= 913–24 |year= 2005 |pmid= 16157702 |doi= 10.1083/jcb.200504039 | pmc=2171455 |display-authors=etal}}
*{{cite journal  | author=Ferraiuolo MA, Basak S, Dostie J, ''et al.'' |title=A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. |journal=J. Cell Biol. |volume=170 |issue= 6 |pages= 913-24 |year= 2005 |pmid= 16157702 |doi= 10.1083/jcb.200504039 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Wichroski MJ, Robb GB, Rana TM |title=Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. |journal=PLoS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041 | pmc=1458959 }}
*{{cite journal  | author=Wichroski MJ, Robb GB, Rana TM |title=Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. |journal=PLoS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041 }}
*{{cite journal  | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | vauthors=Denoeud F, Kapranov P, Ucla C |title=Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. |journal=Genome Res. |volume=17 |issue= 6 |pages= 746–59 |year= 2007 |pmid= 17567994 |doi= 10.1101/gr.5660607 | pmc=1891335 |display-authors=etal}}
*{{cite journal  | author=Denoeud F, Kapranov P, Ucla C, ''et al.'' |title=Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. |journal=Genome Res. |volume=17 |issue= 6 |pages= 746-59 |year= 2007 |pmid= 17567994 |doi= 10.1101/gr.5660607 }}
}}
}}
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Latest revision as of 00:25, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene.[1][2]

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.[2]

Interactions

EIF4ENIF1 has been shown to interact with EIF4E.[1]

References

  1. ↑ 1.0 1.1 Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N (Aug 2000). "A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E". EMBO J. 19 (12): 3142–56. doi:10.1093/emboj/19.12.3142. PMC 203362. PMID 10856257.
  2. ↑ 2.0 2.1 "Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1".

Further reading



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