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{{Infobox_gene}}
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'''Sulfotransferase 4A1''' is an [[enzyme]] that in humans is encoded by the ''SULT4A1'' [[gene]].<ref name="pmid10698717">{{cite journal | vauthors = Falany CN, Xie X, Wang J, Ferrer J, Falany JL | title = Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain | series = 346 | journal = Biochem J | volume = Pt 3 | issue =  | pages = 857–64 |date=May 2000 | pmid = 10698717 | pmc = 1220923 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25830| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SULT4A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1zd1.
| PDB = {{PDB2|1zd1}}
| Name = Sulfotransferase family 4A, member 1
| HGNCid = 14903
| Symbol = SULT4A1
| AltSymbols =; BR-STL-1; BRSTL1; DJ388M5.3; MGC40032; NST; SULTX3; hBR-STL-1
| OMIM = 608359
| ECnumber = 
| Homologene = 49378
| MGIid = 1888971
| GeneAtlas_image1 = PBB_GE_SULT4A1_219425_at_tn.png
  | Function = {{GNF_GO|id=GO:0008146 |text = sulfotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
  | Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}  
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006790 |text = sulfur metabolic process}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25830
    | Hs_Ensembl = ENSG00000130540
    | Hs_RefseqProtein = NP_055166
    | Hs_RefseqmRNA = NM_014351
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 42551722
    | Hs_GenLoc_end = 42589731
    | Hs_Uniprot = Q9BR01
    | Mm_EntrezGene = 29859
    | Mm_Ensembl = ENSMUSG00000018865
    | Mm_RefseqmRNA = XM_001002084
    | Mm_RefseqProtein = XP_001002084
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 83903863
    | Mm_GenLoc_end = 83933520
    | Mm_Uniprot = Q8BQV8
  }}
}}
'''Sulfotransferase family 4A, member 1''', also known as '''SULT4A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25830| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to [[schizophrenia]].<ref name="entrez">{{cite web | title = Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25830| accessdate = }}</ref>
| summary_text = This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to [[schizophrenia]].<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Weinshilboum RM, Otterness DM, Aksoy IA, ''et al.'' |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3-14 |year= 1997 |pmid= 9034160 |doi=  }}
*{{cite journal   |vauthors=Weinshilboum RM, Otterness DM, Aksoy IA, etal |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3–14 |year= 1997 |pmid= 9034160 |doi=  }}
*{{cite journal | author=Glatt H, Engelke CE, Pabel U, ''et al.'' |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue=  |pages= 341-8 |year= 2000 |pmid= 10720750 |doi=  }}
*{{cite journal   |vauthors=Glatt H, Engelke CE, Pabel U, etal |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue=  1-3|pages= 341–8 |year= 2000 |pmid= 10720750 |doi=10.1016/S0378-4274(99)00214-3 }}
*{{cite journal  | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1-2 |pages= 141-70 |year= 2001 |pmid= 11154739 |doi=  }}
*{{cite journal  | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1-2 |pages= 141–70 |year= 2001 |pmid= 11154739 |doi=10.1016/S0009-2797(00)00202-7 }}
*{{cite journal | author=Glatt H, Boeing H, Engelke CE, ''et al.'' |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1-2 |pages= 27-40 |year= 2001 |pmid= 11535246 |doi=  }}
*{{cite journal   |vauthors=Glatt H, Boeing H, Engelke CE, etal |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1-2 |pages= 27–40 |year= 2001 |pmid= 11535246 |doi=10.1016/S0027-5107(01)00207-X }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Falany CN, Xie X, Wang J, ''et al.'' |title=Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain. |journal=Biochem. J. |volume=346 Pt 3 |issue=  |pages= 857-64 |year= 2000 |pmid= 10698717 |doi=  }}
*{{cite journal   |vauthors=Sakakibara Y, Suiko M, Pai TG, etal |title=Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization. |journal=Gene |volume=285 |issue= 1-2 |pages= 39–47 |year= 2002 |pmid= 12039030 |doi=10.1016/S0378-1119(02)00431-6 }}
*{{cite journal  | author=Sakakibara Y, Suiko M, Pai TG, ''et al.'' |title=Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization. |journal=Gene |volume=285 |issue= 1-2 |pages= 39-47 |year= 2002 |pmid= 12039030 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Collins JE, Goward ME, Cole CG, etal |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27–36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703 | pmc=430954 }}
*{{cite journal | author=Collins JE, Goward ME, Cole CG, ''et al.'' |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27-36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703 }}
*{{cite journal   |vauthors=Liyou NE, Buller KM, Tresillian MJ, etal |title=Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study. |journal=J. Histochem. Cytochem. |volume=51 |issue= 12 |pages= 1655–64 |year= 2004 |pmid= 14623933 |doi=  10.1177/002215540305101209}}
*{{cite journal | author=Liyou NE, Buller KM, Tresillian MJ, ''et al.'' |title=Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study. |journal=J. Histochem. Cytochem. |volume=51 |issue= 12 |pages= 1655-64 |year= 2004 |pmid= 14623933 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Brennan MD, Condra J |title=Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=139 |issue= 1 |pages= 69–72 |year= 2006 |pmid= 16152568 |doi= 10.1002/ajmg.b.30222 }}
*{{cite journal  | author=Brennan MD, Condra J |title=Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=139 |issue= 1 |pages= 69-72 |year= 2006 |pmid= 16152568 |doi= 10.1002/ajmg.b.30222 }}
*{{cite journal   |vauthors=Allali-Hassani A, Pan PW, Dombrovski L, etal |title=Structural and chemical profiling of the human cytosolic sulfotransferases. |journal=PLoS Biol. |volume=5 |issue= 5 |pages= e97 |year= 2007 |pmid= 17425406 |doi= 10.1371/journal.pbio.0050097 | pmc=1847840 }}
*{{cite journal | author=Allali-Hassani A, Pan PW, Dombrovski L, ''et al.'' |title=Structural and chemical profiling of the human cytosolic sulfotransferases. |journal=PLoS Biol. |volume=5 |issue= 5 |pages= e97 |year= 2007 |pmid= 17425406 |doi= 10.1371/journal.pbio.0050097 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=25830}}
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Latest revision as of 07:17, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene.[1][2]

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia.[2]

References

  1. ↑ Falany CN, Xie X, Wang J, Ferrer J, Falany JL (May 2000). "Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain". Biochem J. 346. Pt 3: 857–64. PMC 1220923. PMID 10698717.
  2. ↑ 2.0 2.1 "Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1".

Further reading



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