RANGAP1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
{{details|topic=RanGAP proteins in non-human species|RanGAP}}
| update_page = yes
'''Ran GTPase-activating protein 1''' is an [[enzyme]] that in humans is encoded by the ''RANGAP1'' [[gene]].<ref name="pmid7878053">{{cite journal | vauthors = Bischoff FR, Krebber H, Kempf T, Hermes I, Ponstingl H | title = Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport | journal = Proc Natl Acad Sci U S A | volume = 92 | issue = 5 | pages = 1749–53 | date = Apr 1995 | pmid = 7878053 | pmc = 42597 | doi = 10.1073/pnas.92.5.1749 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RANGAP1 Ran GTPase activating protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5905| accessdate = }}</ref>
| require_manual_inspection = no
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}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RANGAP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1z5s.
| PDB = {{PDB2|1z5s}}, {{PDB2|2grn}}, {{PDB2|2gro}}, {{PDB2|2grp}}, {{PDB2|2grq}}, {{PDB2|2grr}}, {{PDB2|2io2}}, {{PDB2|2io3}}, {{PDB2|2iy0}}
| Name = Ran GTPase activating protein 1
| HGNCid = 9854
| Symbol = RANGAP1
| AltSymbols =; Fug1; KIAA1835; MGC20266; SD
| OMIM = 602362
| ECnumber = 
| Homologene = 55700
| MGIid = 103071
| GeneAtlas_image1 = PBB_GE_RANGAP1_212125_at_tn.png
| GeneAtlas_image2 = PBB_GE_RANGAP1_212127_at_tn.png
| Function = {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005098 |text = Ran GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5905
    | Hs_Ensembl = ENSG00000100401
    | Hs_RefseqProtein = NP_002874
    | Hs_RefseqmRNA = NM_002883
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 39971562
    | Hs_GenLoc_end = 40028909
    | Hs_Uniprot = P46060
    | Mm_EntrezGene = 19387
    | Mm_Ensembl = ENSMUSG00000022391
    | Mm_RefseqmRNA = NM_011241
    | Mm_RefseqProtein = NP_035371
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 81531509
    | Mm_GenLoc_end = 81557138
    | Mm_Uniprot = Q3UZD8
  }}
}}
'''Ran GTPase activating protein 1''', also known as '''RANGAP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RANGAP1 Ran GTPase activating protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5905| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.<ref name="entrez">{{cite web | title = Entrez Gene: RANGAP1 Ran GTPase activating protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5905| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
RanGAP1 is a trafficking protein which helps transport other proteins from the cytoplasm to the nucleus. Small ubiqutin-related modifier needs to be associated with it before it can be localized at the nuclear pore.<ref name="pmid10939967">{{cite journal | vauthors = Hochstrasser M | title = Biochemistry. All in the ubiquitin family | journal = Science | volume = 289 | issue = 5479 | pages = 563–4 | year = 2000 | pmid = 10939967 | doi =  10.1126/science.289.5479.563}}</ref>
 
RANGAP1 has been shown to [[Protein-protein interaction|interact]] with:
* [[Ran (gene)|Ran]],<ref name = pmid10394366>{{cite journal | vauthors = Hillig RC, Renault L, Vetter IR, Drell T, Wittinghofer A, Becker J | title = The crystal structure of rna1p: a new fold for a GTPase-activating protein | journal = Mol. Cell | volume = 3 | issue = 6 | pages = 781–91 | date = Jun 1999 | pmid = 10394366 | doi =  10.1016/S1097-2765(01)80010-1}}</ref><ref name = pmid7744835>{{cite journal | vauthors = Becker J, Melchior F, Gerke V, Bischoff FR, Ponstingl H, Wittinghofer A | title = RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae | journal = J. Biol. Chem. | volume = 270 | issue = 20 | pages = 11860–5 | date = May 1995 | pmid = 7744835 | doi =  10.1074/jbc.270.20.11860}}</ref><ref name = pmid8146159>{{cite journal | vauthors = Bischoff FR, Klebe C, Kretschmer J, Wittinghofer A, Ponstingl H | title = RanGAP1 induces GTPase activity of nuclear Ras-related Ran | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 7 | pages = 2587–91 | date = Mar 1994 | pmid = 8146159 | pmc = 43414 | doi =  10.1073/pnas.91.7.2587}}</ref>  and
* [[UBE2I]].<ref name = pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue =  | pages = 89 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name = pmid12924945>{{cite journal | vauthors = Tatham MH, Kim S, Yu B, Jaffray E, Song J, Zheng J, Rodriguez MS, Hay RT, Chen Y | title = Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation | journal = Biochemistry | volume = 42 | issue = 33 | pages = 9959–69 | date = Aug 2003 | pmid = 12924945 | doi = 10.1021/bi0345283 }}</ref><ref name = pmid18691969>{{cite journal | vauthors = Knipscheer P, Flotho A, Klug H, Olsen JV, van Dijk WJ, Fish A, Johnson ES, Mann M, Sixma TK, Pichler A | title = Ubc9 sumoylation regulates SUMO target discrimination | journal = Mol. Cell | volume = 31 | issue = 3 | pages = 371–82 | date = Aug 2008 | pmid = 18691969 | doi = 10.1016/j.molcel.2008.05.022 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Becker J, Melchior F, Gerke V, Bischoff FR, Ponstingl H, Wittinghofer A | title = RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae | journal = J. Biol. Chem. | volume = 270 | issue = 20 | pages = 11860–5 | year = 1995 | pmid = 7744835 | doi = 10.1074/jbc.270.20.11860 }}
| citations =
* {{cite journal | vauthors = Bischoff FR, Klebe C, Kretschmer J, Wittinghofer A, Ponstingl H | title = RanGAP1 induces GTPase activity of nuclear Ras-related Ran | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 7 | pages = 2587–91 | year = 1994 | pmid = 8146159 | pmc = 43414 | doi = 10.1073/pnas.91.7.2587 }}
*{{cite journal | author=Becker J, Melchior F, Gerke V, ''et al.'' |title=RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae. |journal=J. Biol. Chem. |volume=270 |issue= 20 |pages= 11860-5 |year= 1995 |pmid= 7744835 |doi= }}
* {{cite journal | vauthors = Krebber H, Ponstingl H | title = Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1 | journal = Gene | volume = 180 | issue = 1–2 | pages = 7–11 | year = 1997 | pmid = 8973340 | doi = 10.1016/S0378-1119(96)00389-7 }}
*{{cite journal | author=Bischoff FR, Krebber H, Kempf T, ''et al.'' |title=Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1749-53 |year= 1995 |pmid= 7878053 |doi= }}
* {{cite journal | vauthors = Matunis MJ, Coutavas E, Blobel G | title = A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex | journal = J. Cell Biol. | volume = 135 | issue = 6 Pt 1 | pages = 1457–70 | year = 1997 | pmid = 8978815 | pmc = 2133973 | doi = 10.1083/jcb.135.6.1457 }}
*{{cite journal | author=Bischoff FR, Klebe C, Kretschmer J, ''et al.'' |title=RanGAP1 induces GTPase activity of nuclear Ras-related Ran. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 7 |pages= 2587-91 |year= 1994 |pmid= 8146159 |doi= }}
* {{cite journal | vauthors = Mahajan R, Delphin C, Guan T, Gerace L, Melchior F | title = A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2 | journal = Cell | volume = 88 | issue = 1 | pages = 97–107 | year = 1997 | pmid = 9019411 | doi = 10.1016/S0092-8674(00)81862-0 }}
*{{cite journal | author=Krebber H, Ponstingl H |title=Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. |journal=Gene |volume=180 |issue= 1-2 |pages= 7-11 |year= 1997 |pmid= 8973340 |doi= }}
* {{cite journal | vauthors = Görlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E | title = A Novel Class of RanGTP Binding Proteins | journal = J. Cell Biol. | volume = 138 | issue = 1 | pages = 65–80 | year = 1997 | pmid = 9214382 | pmc = 2139951 | doi = 10.1083/jcb.138.1.65 }}
*{{cite journal  | author=Matunis MJ, Coutavas E, Blobel G |title=A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. |journal=J. Cell Biol. |volume=135 |issue= 6 Pt 1 |pages= 1457-70 |year= 1997 |pmid= 8978815 |doi= }}
* {{cite journal | vauthors = Scheffzek K, Ahmadian MR, Kabsch W, Wiesmüller L, Lautwein A, Schmitz F, Wittinghofer A | title = The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants | journal = Science | volume = 277 | issue = 5324 | pages = 333–8 | year = 1998 | pmid = 9219684 | doi = 10.1126/science.277.5324.333 }}
*{{cite journal | author=Mahajan R, Delphin C, Guan T, ''et al.'' |title=A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. |journal=Cell |volume=88 |issue= 1 |pages= 97-107 |year= 1997 |pmid= 9019411 |doi= }}
* {{cite journal | vauthors = Mahajan R, Gerace L, Melchior F | title = Molecular Characterization of the SUMO-1 Modification of RanGAP1 and Its Role in Nuclear Envelope Association | journal = J. Cell Biol. | volume = 140 | issue = 2 | pages = 259–70 | year = 1998 | pmid = 9442102 | pmc = 2132567 | doi = 10.1083/jcb.140.2.259 }}
*{{cite journal | author=Görlich D, Dabrowski M, Bischoff FR, ''et al.'' |title=A novel class of RanGTP binding proteins. |journal=J. Cell Biol. |volume=138 |issue= 1 |pages= 65-80 |year= 1997 |pmid= 9214382 |doi= }}
* {{cite journal | vauthors = Kamitani T, Kito K, Nguyen HP, Fukuda-Kamitani T, Yeh ET | title = Characterization of a second member of the sentrin family of ubiquitin-like proteins | journal = J. Biol. Chem. | volume = 273 | issue = 18 | pages = 11349–53 | year = 1998 | pmid = 9556629 | doi = 10.1074/jbc.273.18.11349 }}
*{{cite journal | author=Scheffzek K, Ahmadian MR, Kabsch W, ''et al.'' |title=The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. |journal=Science |volume=277 |issue= 5324 |pages= 333-8 |year= 1998 |pmid= 9219684 |doi= }}
* {{cite journal | vauthors = Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H | title = In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2 | journal = Biochem. Biophys. Res. Commun. | volume = 254 | issue = 3 | pages = 693–8 | year = 1999 | pmid = 9920803 | doi = 10.1006/bbrc.1998.9995 }}
*{{cite journal | author=Mahajan R, Gerace L, Melchior F |title=Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association. |journal=J. Cell Biol. |volume=140 |issue= 2 |pages= 259-70 |year= 1998 |pmid= 9442102 |doi= }}
* {{cite journal | vauthors = Hillig RC, Renault L, Vetter IR, Drell T, Wittinghofer A, Becker J | title = The crystal structure of rna1p: a new fold for a GTPase-activating protein | journal = Mol. Cell | volume = 3 | issue = 6 | pages = 781–91 | year = 1999 | pmid = 10394366 | doi = 10.1016/S1097-2765(01)80010-1 }}
*{{cite journal | author=Kamitani T, Kito K, Nguyen HP, ''et al.'' |title=Characterization of a second member of the sentrin family of ubiquitin-like proteins. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11349-53 |year= 1998 |pmid= 9556629 |doi= }}
* {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | year = 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
*{{cite journal | author=Okuma T, Honda R, Ichikawa G, ''et al.'' |title=In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 3 |pages= 693-8 |year= 1999 |pmid= 9920803 |doi= 10.1006/bbrc.1998.9995 }}
* {{cite journal | vauthors = Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 8 | issue = 2 | pages = 85–95 | year = 2001 | pmid = 11347906 | doi = 10.1093/dnares/8.2.85 }}
*{{cite journal | author=Hillig RC, Renault L, Vetter IR, ''et al.'' |title=The crystal structure of rna1p: a new fold for a GTPase-activating protein. |journal=Mol. Cell |volume=3 |issue= 6 |pages= 781-91 |year= 1999 |pmid= 10394366 |doi= }}
* {{cite journal | vauthors = Bernier-Villamor V, Sampson DA, Matunis MJ, Lima CD | title = Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1 | journal = Cell | volume = 108 | issue = 3 | pages = 345–56 | year = 2002 | pmid = 11853669 | doi = 10.1016/S0092-8674(02)00630-X }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Joseph J, Tan SH, Karpova TS, McNally JG, Dasso M | title = SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles | journal = J. Cell Biol. | volume = 156 | issue = 4 | pages = 595–602 | year = 2002 | pmid = 11854305 | pmc = 2174074 | doi = 10.1083/jcb.200110109 }}
*{{cite journal | author=Nagase T, Nakayama M, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85-95 |year= 2001 |pmid= 11347906 |doi= }}
* {{cite journal | vauthors = Zhang H, Saitoh H, Matunis MJ | title = Enzymes of the SUMO Modification Pathway Localize to Filaments of the Nuclear Pore Complex | journal = Mol. Cell. Biol. | volume = 22 | issue = 18 | pages = 6498–508 | year = 2002 | pmid = 12192048 | pmc = 135644 | doi = 10.1128/MCB.22.18.6498-6508.2002 }}
*{{cite journal | author=Bernier-Villamor V, Sampson DA, Matunis MJ, Lima CD |title=Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. |journal=Cell |volume=108 |issue= 3 |pages= 345-56 |year= 2002 |pmid= 11853669 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Joseph J, Tan SH, Karpova TS, ''et al.'' |title=SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. |journal=J. Cell Biol. |volume=156 |issue= 4 |pages= 595-602 |year= 2002 |pmid= 11854305 |doi= 10.1083/jcb.200110109 }}
* {{cite journal | vauthors = Macauley MS, Errington WJ, Okon M, Schärpf M, Mackereth CD, Schulman BA, McIntosh LP | title = Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1 | journal = J. Biol. Chem. | volume = 279 | issue = 47 | pages = 49131–7 | year = 2005 | pmid = 15355965 | doi = 10.1074/jbc.M408705200 }}
*{{cite journal | author=Zhang H, Saitoh H, Matunis MJ |title=Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6498-508 |year= 2002 |pmid= 12192048 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Macauley MS, Errington WJ, Okon M, ''et al.'' |title=Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1. |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 49131-7 |year= 2005 |pmid= 15355965 |doi= 10.1074/jbc.M408705200 }}
}}
{{refend}}
{{refend}}


{{gene-22-stub}}
{{PDB Gallery|geneid=5905}}
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Revision as of 08:53, 10 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human
Further information on RanGAP proteins in non-human species: RanGAP

Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.[1][2]

Function

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.[2]

Interactions

RanGAP1 is a trafficking protein which helps transport other proteins from the cytoplasm to the nucleus. Small ubiqutin-related modifier needs to be associated with it before it can be localized at the nuclear pore.[3]

RANGAP1 has been shown to interact with:

References

  1. ↑ Bischoff FR, Krebber H, Kempf T, Hermes I, Ponstingl H (Apr 1995). "Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport". Proc Natl Acad Sci U S A. 92 (5): 1749–53. doi:10.1073/pnas.92.5.1749. PMC 42597. PMID 7878053.
  2. ↑ 2.0 2.1 "Entrez Gene: RANGAP1 Ran GTPase activating protein 1".
  3. ↑ Hochstrasser M (2000). "Biochemistry. All in the ubiquitin family". Science. 289 (5479): 563–4. doi:10.1126/science.289.5479.563. PMID 10939967.
  4. ↑ Hillig RC, Renault L, Vetter IR, Drell T, Wittinghofer A, Becker J (Jun 1999). "The crystal structure of rna1p: a new fold for a GTPase-activating protein". Mol. Cell. 3 (6): 781–91. doi:10.1016/S1097-2765(01)80010-1. PMID 10394366.
  5. ↑ Becker J, Melchior F, Gerke V, Bischoff FR, Ponstingl H, Wittinghofer A (May 1995). "RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae". J. Biol. Chem. 270 (20): 11860–5. doi:10.1074/jbc.270.20.11860. PMID 7744835.
  6. ↑ Bischoff FR, Klebe C, Kretschmer J, Wittinghofer A, Ponstingl H (Mar 1994). "RanGAP1 induces GTPase activity of nuclear Ras-related Ran". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2587–91. doi:10.1073/pnas.91.7.2587. PMC 43414. PMID 8146159.
  7. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  8. ↑ Tatham MH, Kim S, Yu B, Jaffray E, Song J, Zheng J, Rodriguez MS, Hay RT, Chen Y (Aug 2003). "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation". Biochemistry. 42 (33): 9959–69. doi:10.1021/bi0345283. PMID 12924945.
  9. ↑ Knipscheer P, Flotho A, Klug H, Olsen JV, van Dijk WJ, Fish A, Johnson ES, Mann M, Sixma TK, Pichler A (Aug 2008). "Ubc9 sumoylation regulates SUMO target discrimination". Mol. Cell. 31 (3): 371–82. doi:10.1016/j.molcel.2008.05.022. PMID 18691969.

Further reading

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