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{{Infobox_gene}}
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'''Thyrotroph embryonic factor''' is a [[protein]] that in humans is encoded by the ''TEF'' [[gene]].<ref name="pmid7835883">{{cite journal | vauthors = Khatib ZA, Inaba T, Valentine M, Look AT | title = Chromosomal localization and cDNA cloning of the human DBP and TEF genes | journal = Genomics | volume = 23 | issue = 2 | pages = 344–51 |date=Feb 1995 | pmid = 7835883 | pmc =  | doi = 10.1006/geno.1994.1510 }}</ref><ref name="pmid15665112">{{cite journal | vauthors = Inukai T, Inaba T, Dang J, Kuribara R, Ozawa K, Miyajima A, Wu W, Look AT, Arinobu Y, Iwasaki H, Akashi K, Kagami K, Goi K, Sugita K, Nakazawa S | title = TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors | journal = Blood | volume = 105 | issue = 11 | pages = 4437–44 |date=May 2005 | pmid = 15665112 | pmc =  | doi = 10.1182/blood-2004-08-2976 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TEF thyrotrophic embryonic factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7008| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Thyrotrophic embryonic factor
| HGNCid = 11722
| Symbol = TEF
| AltSymbols =;
| OMIM = 188595
| ECnumber =
  | Homologene = 31140
| MGIid = 98663
| GeneAtlas_image1 = PBB_GE_TEF_gnf1h02557_at_tn.png
| Function = {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048511 |text = rhythmic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7008
    | Hs_Ensembl = ENSG00000167074
    | Hs_RefseqProtein = NP_003207
    | Hs_RefseqmRNA = NM_003216
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 40107909
    | Hs_GenLoc_end = 40125272
    | Hs_Uniprot = Q10587
    | Mm_EntrezGene = 21685
    | Mm_Ensembl = ENSMUSG00000022389
    | Mm_RefseqmRNA = NM_017376
    | Mm_RefseqProtein = NP_059072
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 81630072
    | Mm_GenLoc_end = 81654118
    | Mm_Uniprot = Q9JLC6
  }}
}}
'''Thyrotrophic embryonic factor''', also known as '''TEF''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TEF thyrotrophic embryonic factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7008| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors.  It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB).  Indeed, TEF can bind to, and transactivate the TSHB promoter.  It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF.  Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties.<ref name="entrez">{{cite web | title = Entrez Gene: TEF thyrotrophic embryonic factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7008| accessdate = }}</ref>
| summary_text = Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors.  It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB).  Indeed, TEF can bind to, and transactivate the TSHB promoter.  It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF.  Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Drolet DW, Scully KM, Simmons DM, ''et al.'' |title=TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. |journal=Genes Dev. |volume=5 |issue= 10 |pages= 1739-53 |year= 1991 |pmid= 1916262 |doi=  }}
*{{cite journal   |vauthors=Drolet DW, Scully KM, Simmons DM, etal |title=TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins |journal=Genes Dev. |volume=5 |issue= 10 |pages= 1739–53 |year= 1991 |pmid= 1916262 |doi=10.1101/gad.5.10.1739  }}
*{{cite journal  | author=Khatib ZA, Inaba T, Valentine M, Look AT |title=Chromosomal localization and cDNA cloning of the human DBP and TEF genes. |journal=Genomics |volume=23 |issue= 2 |pages= 344-51 |year= 1995 |pmid= 7835883 |doi= 10.1006/geno.1994.1510 }}
*{{cite journal   |vauthors=Hunger SP, Li S, Fall MZ, etal |title=The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties |journal=Blood |volume=87 |issue= 11 |pages= 4607–17 |year= 1996 |pmid= 8639829 |doi=  }}
*{{cite journal | author=Hunger SP, Li S, Fall MZ, ''et al.'' |title=The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. |journal=Blood |volume=87 |issue= 11 |pages= 4607-17 |year= 1996 |pmid= 8639829 |doi=  }}
*{{cite journal  | vauthors=Ossipow V, Fonjallaz P, Schibler U |title=An RNA Polymerase II Complex Containing All Essential Initiation Factors Binds to the Activation Domain of PAR Leucine Zipper Transcription Factor Thyroid Embryonic Factor |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1242–50 |year= 1999 |pmid= 9891058 |doi= | pmc=116053 }}
*{{cite journal  | author=Ossipow V, Fonjallaz P, Schibler U |title=An RNA polymerase II complex containing all essential initiation factors binds to the activation domain of PAR leucine zipper transcription factor thyroid embryonic factor. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1242-50 |year= 1999 |pmid= 9891058 |doi=  }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | vauthors=Krueger DA, Warner EA, Dowd DR |title=Involvement of thyrotroph embryonic factor in calcium-mediated regulation of gene expression |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14524–31 |year= 2000 |pmid= 10799536 |doi=10.1074/jbc.275.19.14524 }}
*{{cite journal  | author=Krueger DA, Warner EA, Dowd DR |title=Involvement of thyrotroph embryonic factor in calcium-mediated regulation of gene expression. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14524-31 |year= 2000 |pmid= 10799536 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Newman JR, Keating AE |title=Comprehensive identification of human bZIP interactions with coiled-coil arrays |journal=Science |volume=300 |issue= 5628 |pages= 2097–101 |year= 2003 |pmid= 12805554 |doi= 10.1126/science.1084648 }}
*{{cite journal  | author=Newman JR, Keating AE |title=Comprehensive identification of human bZIP interactions with coiled-coil arrays. |journal=Science |volume=300 |issue= 5628 |pages= 2097-101 |year= 2003 |pmid= 12805554 |doi= 10.1126/science.1084648 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Inukai T, Inaba T, Dang J, ''et al.'' |title=TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors. |journal=Blood |volume=105 |issue= 11 |pages= 4437-44 |year= 2005 |pmid= 15665112 |doi= 10.1182/blood-2004-08-2976 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 11:45, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Thyrotroph embryonic factor is a protein that in humans is encoded by the TEF gene.[1][2][3]

Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties.[3]

References

  1. ↑ Khatib ZA, Inaba T, Valentine M, Look AT (Feb 1995). "Chromosomal localization and cDNA cloning of the human DBP and TEF genes". Genomics. 23 (2): 344–51. doi:10.1006/geno.1994.1510. PMID 7835883.
  2. ↑ Inukai T, Inaba T, Dang J, Kuribara R, Ozawa K, Miyajima A, Wu W, Look AT, Arinobu Y, Iwasaki H, Akashi K, Kagami K, Goi K, Sugita K, Nakazawa S (May 2005). "TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors". Blood. 105 (11): 4437–44. doi:10.1182/blood-2004-08-2976. PMID 15665112.
  3. ↑ 3.0 3.1 "Entrez Gene: TEF thyrotrophic embryonic factor".

Further reading



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