G3BP1: Difference between revisions

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Revision as of 08:34, 31 August 2017

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.^[1]^[2]^[3]

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged.^[4] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[3]

Interactions

G3BP1 has been shown to interact with USP10.^[5] It also interacts with SND1[5].

References

↑ Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B (Jul 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561–9. PMC 231246. PMID 8649363.
↑ Costa M, Ochem A, Staub A, Falaschi A (Mar 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Res. 27 (3): 817–21. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.
↑ ^3.0 ^3.1 "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".
↑ Annibaldi, A; Dousse, A; Martin, S; Tazi, J; Widmann, C (2011). "Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1". PLoS ONE. 6 (12): e29024. doi:10.1371/journal.pone.0029024. PMC 3242762. PMID 22205990.
↑ Soncini, C; Berdo I; Draetta G (Jun 2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. England. 20 (29): 3869–79. doi:10.1038/sj.onc.1204553. ISSN 0950-9232. PMID 11439350.

[5]Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J., Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions.FEBS Letters, Volume 584, Issue 16, Pages 3525-3532.

Irvine K, Stirling R, Hume D, Kennedy D (2005). "Rasputin, more promiscuous than ever: a review of G3BP". Int. J. Dev. Biol. 48 (10): 1065–77. doi:10.1387/ijdb.041893ki. PMID 15602692.
Onno M, Nakamura T, Hillova J, Hill M (1993). "Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes". Oncogene. 7 (12): 2519–23. PMID 1461655.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Gallouzi IE, Parker F, Chebli K, et al. (1998). "A Novel Phosphorylation-Dependent RNase Activity of GAP-SH3 Binding Protein: a Potential Link between Signal Transduction and RNA Stability". Mol. Cell. Biol. 18 (7): 3956–65. PMC 108980. PMID 9632780.
Kociok N, Esser P, Unfried K, et al. (1999). "Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells". J. Cell. Biochem. 74 (2): 194–201. doi:10.1002/(SICI)1097-4644(19990801)74:2<194::AID-JCB5>3.0.CO;2-M. PMID 10404389.
Soncini C, Berdo I, Draetta G (2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. 20 (29): 3869–79. doi:10.1038/sj.onc.1204553. PMID 11439350.
Tourrière H, Gallouzi IE, Chebli K, et al. (2001). "RasGAP-Associated Endoribonuclease G3BP: Selective RNA Degradation and Phosphorylation-Dependent Localization". Mol. Cell. Biol. 21 (22): 7747–60. doi:10.1128/MCB.21.22.7747-7760.2001. PMC 99945. PMID 11604510.
Barnes CJ, Li F, Mandal M, et al. (2002). "Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors". Cancer Res. 62 (5): 1251–5. PMID 11888885.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tourrière H, Chebli K, Zekri L, et al. (2003). "The RasGAP-associated endoribonuclease G3BP assembles stress granules". J. Cell Biol. 160 (6): 823–31. doi:10.1083/jcb.200212128. PMC 2173781. PMID 12642610.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Katsafanas GC, Moss B (2005). "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer". J. Biol. Chem. 279 (50): 52210–7. doi:10.1074/jbc.M411033200. PMID 15471883.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nat. Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174.

External links

G3BP1 human gene location in the UCSC Genome Browser.
G3BP1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[pmid8649363-1] Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B (Jul 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561–9. PMC 231246. PMID 8649363.

[pmid9889278-2] Costa M, Ochem A, Staub A, Falaschi A (Mar 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Res. 27 (3): 817–21. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.

[entrez-3] 3.0 ^3.1 "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".

[4] Annibaldi, A; Dousse, A; Martin, S; Tazi, J; Widmann, C (2011). "Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1". PLoS ONE. 6 (12): e29024. doi:10.1371/journal.pone.0029024. PMC 3242762. PMID 22205990.

[pmid11439350-5] Soncini, C; Berdo I; Draetta G (Jun 2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. England. 20 (29): 3869–79. doi:10.1038/sj.onc.1204553. ISSN 0950-9232. PMID 11439350.

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Ras GTPase-activating protein-binding protein 1''' is an [[enzyme]] that in humans is encoded by the ''G3BP1'' [[gene]].<ref name="pmid8649363">{{cite journal |vauthors=Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B | title = A Ras-GTPase-activating protein SH3-domain-binding protein | journal = Mol Cell Biol | volume = 16 | issue = 6 | pages = 2561–9 |date=Jul 1996 | pmid = 8649363 | pmc = 231246 | doi =  }}</ref><ref name="pmid9889278">{{cite journal |vauthors=Costa M, Ochem A, Staub A, Falaschi A | title = Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway | journal = Nucleic Acids Res | volume = 27 | issue = 3 | pages = 817–21 |date=Mar 1999 | pmid = 9889278 | pmc = 148252 | doi =10.1093/nar/27.3.817  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10146| accessdate = }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = GTPase activating protein (SH3 domain) binding protein 1
- | HGNCid = 30292
- | Symbol = G3BP1
- | AltSymbols =; G3BP; HDH-VIII; MGC111040
- | OMIM = 608431
- | ECnumber =
- | Homologene = 38096
- | MGIid = 1351465
- | GeneAtlas_image1 = PBB_GE_G3BP1_201503_at_tn.png
- | GeneAtlas_image2 = PBB_GE_G3BP1_201514_s_at_tn.png
-  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004003 |text = ATP-dependent DNA helicase activity}} {{GNF_GO|id=GO:0004004 |text = ATP-dependent RNA helicase activity}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10146
-    | Hs_Ensembl = ENSG00000145907
-    | Hs_RefseqProtein = NP_005745
-    | Hs_RefseqmRNA = NM_005754
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 5
-    | Hs_GenLoc_start = 151131664
-    | Hs_GenLoc_end = 151165106
-    | Hs_Uniprot = Q13283
-    | Mm_EntrezGene = 27041
-    | Mm_Ensembl = ENSMUSG00000018583
-    | Mm_RefseqmRNA = XM_985138
-    | Mm_RefseqProtein = XP_990232
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 11
-    | Mm_GenLoc_start = 55313121
-    | Mm_GenLoc_end = 55344310
-    | Mm_Uniprot = Q571F9
-  }}
-}}
-'''GTPase activating protein (SH3 domain) binding protein 1''', also known as '''G3BP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10146| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10146| accessdate = }}</ref>
+| summary_text = This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged.<ref>{{Cite journal
+ | pmid = 22205990
+| pmc = 3242762
+| year = 2011
+| author1 = Annibaldi
+| first1 = A
+| title = Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1
+| journal = PLoS ONE
+| volume = 6
+| issue = 12
+| pages = e29024
+| last2 = Dousse
+| first2 = A
+| last3 = Martin
+| first3 = S
+| last4 = Tazi
+| first4 = J
+| last5 = Widmann
+| first5 = C
+| doi = 10.1371/journal.pone.0029024
+}}</ref> Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez"/>
 }}
+==Interactions==
+G3BP1 has been shown to [[Protein-protein interaction|interact]] with [[USP10]].<ref name=pmid11439350>{{cite journal |last=Soncini |first=C |authorlink= |author2=Berdo I|author3=Draetta G |date=Jun 2001 |title=Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease |journal=Oncogene |volume=20 |issue=29 |pages=3869–79 |publisher= |location = England| issn = 0950-9232| pmid = 11439350 |doi = 10.1038/sj.onc.1204553 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
+It also interacts with SND1[5].
 ==References==
-{{reflist|2}}
+{{reflist}}
+[5]Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J., Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions.FEBS Letters, Volume 584, Issue 16, Pages 3525-3532.
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Irvine K, Stirling R, Hume D, Kennedy D |title=Rasputin, more promiscuous than ever: a review of G3BP. |journal=Int. J. Dev. Biol. |volume=48 |issue= 10 |pages= 1065-77 |year= 2005 |pmid= 15602692 |doi= 10.1387/ijdb.041893ki }}
+*{{cite journal  |vauthors=Irvine K, Stirling R, Hume D, Kennedy D |title=Rasputin, more promiscuous than ever: a review of G3BP |journal=Int. J. Dev. Biol. |volume=48 |issue= 10 |pages= 1065–77 |year= 2005 |pmid= 15602692 |doi= 10.1387/ijdb.041893ki }}
-*{{cite journal  | author=Onno M, Nakamura T, Hillova J, Hill M |title=Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes. |journal=Oncogene |volume=7 |issue= 12 |pages= 2519-23 |year= 1993 |pmid= 1461655 |doi=  }}
+*{{cite journal  |vauthors=Onno M, Nakamura T, Hillova J, Hill M |title=Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes |journal=Oncogene |volume=7 |issue= 12 |pages= 2519–23 |year= 1993 |pmid= 1461655 |doi=  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Parker F, Maurier F, Delumeau I, ''et al.'' |title=A Ras-GTPase-activating protein SH3-domain-binding protein. |journal=Mol. Cell. Biol. |volume=16 |issue= 6 |pages= 2561-9 |year= 1996 |pmid= 8649363 |doi=  }}
+*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal  |vauthors=Gallouzi IE, Parker F, Chebli K |title=A Novel Phosphorylation-Dependent RNase Activity of GAP-SH3 Binding Protein: a Potential Link between Signal Transduction and RNA Stability |journal=Mol. Cell. Biol. |volume=18 |issue= 7 |pages= 3956–65 |year= 1998 |pmid= 9632780 |doi=  | pmc=108980  |display-authors=etal}}
-*{{cite journal  | author=Gallouzi IE, Parker F, Chebli K, ''et al.'' |title=A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability. |journal=Mol. Cell. Biol. |volume=18 |issue= 7 |pages= 3956-65 |year= 1998 |pmid= 9632780 |doi=  }}
+*{{cite journal  |vauthors=Kociok N, Esser P, Unfried K |title=Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells |journal=J. Cell. Biochem. |volume=74 |issue= 2 |pages= 194–201 |year= 1999 |pmid= 10404389 |doi=10.1002/(SICI)1097-4644(19990801)74:2<194::AID-JCB5>3.0.CO;2-M  |display-authors=etal}}
-*{{cite journal  | author=Costa M, Ochem A, Staub A, Falaschi A |title=Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. |journal=Nucleic Acids Res. |volume=27 |issue= 3 |pages= 817-21 |year= 1999 |pmid= 9889278 |doi=  }}
+*{{cite journal  |vauthors=Soncini C, Berdo I, Draetta G |title=Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease |journal=Oncogene |volume=20 |issue= 29 |pages= 3869–79 |year= 2001 |pmid= 11439350 |doi= 10.1038/sj.onc.1204553 }}
-*{{cite journal  | author=Kociok N, Esser P, Unfried K, ''et al.'' |title=Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells. |journal=J. Cell. Biochem. |volume=74 |issue= 2 |pages= 194-201 |year= 1999 |pmid= 10404389 |doi=  }}
+*{{cite journal  |vauthors=Tourrière H, Gallouzi IE, Chebli K |title=RasGAP-Associated Endoribonuclease G3BP: Selective RNA Degradation and Phosphorylation-Dependent Localization |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7747–60 |year= 2001 |pmid= 11604510 |doi= 10.1128/MCB.21.22.7747-7760.2001  | pmc=99945 |display-authors=etal}}
-*{{cite journal  | author=Soncini C, Berdo I, Draetta G |title=Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. |journal=Oncogene |volume=20 |issue= 29 |pages= 3869-79 |year= 2001 |pmid= 11439350 |doi= 10.1038/sj.onc.1204553 }}
+*{{cite journal  |vauthors=Barnes CJ, Li F, Mandal M |title=Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors |journal=Cancer Res. |volume=62 |issue= 5 |pages= 1251–5 |year= 2002 |pmid= 11888885 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Tourrière H, Gallouzi IE, Chebli K, ''et al.'' |title=RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7747-60 |year= 2001 |pmid= 11604510 |doi= 10.1128/MCB.21.22.7747-7760.2001 }}
+*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Barnes CJ, Li F, Mandal M, ''et al.'' |title=Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors. |journal=Cancer Res. |volume=62 |issue= 5 |pages= 1251-5 |year= 2002 |pmid= 11888885 |doi=  }}
+*{{cite journal  |vauthors=Tourrière H, Chebli K, Zekri L |title=The RasGAP-associated endoribonuclease G3BP assembles stress granules |journal=J. Cell Biol. |volume=160 |issue= 6 |pages= 823–31 |year= 2003 |pmid= 12642610 |doi= 10.1083/jcb.200212128  | pmc=2173781 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Tourrière H, Chebli K, Zekri L, ''et al.'' |title=The RasGAP-associated endoribonuclease G3BP assembles stress granules. |journal=J. Cell Biol. |volume=160 |issue= 6 |pages= 823-31 |year= 2003 |pmid= 12642610 |doi= 10.1083/jcb.200212128 }}
+*{{cite journal  |vauthors=Brill LM, Salomon AR, Ficarro SB |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |display-authors=etal}}
-*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
+*{{cite journal  |vauthors=Katsafanas GC, Moss B |title=Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52210–7 |year= 2005 |pmid= 15471883 |doi= 10.1074/jbc.M411033200 }}
-*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
+*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Katsafanas GC, Moss B |title=Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer. |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52210-7 |year= 2005 |pmid= 15471883 |doi= 10.1074/jbc.M411033200 }}
+*{{cite journal  |vauthors=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119–26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119-26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
 }}
 {{refend}}
-{{protein-stub}}
+==External links==
-{{WikiDoc Sources}}
+* {{UCSC genome browser|G3BP1}}
+* {{UCSC gene details|G3BP1}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{gene-5-stub}}

G3BP1: Difference between revisions

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