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'''Transcription elongation regulator 1''', also known as '''TCERG1''', is a [[protein]] which in humans is encoded by the ''TCERG1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TCERG1 transcription elongation regulator 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10915| accessdate = }}</ref><ref name="pmid9315662">{{cite journal |vauthors=Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA | title = CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription | journal = Molecular and Cellular Biology | volume = 17 | issue = 10 | pages = 6029–39 |date=October 1997 | pmid = 9315662 | pmc = 232452 | doi = | url = http://mcb.asm.org/cgi/content/abstract/17/10/6029 | issn = }}</ref><ref name="pmid11003711">{{cite journal |vauthors=Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA | title = Expression analysis and mapping of the mouse and human transcriptional regulator CA150 | journal = Mammalian Genome | volume = 11 | issue = 10 | pages = 930–3 |date=October 2000 | pmid = 11003711 | doi = 10.1007/s003350010162 | url = | issn = }}</ref> | |||
== Function == | |||
This gene encodes a nuclear protein that regulates [[Transcription (genetics)#Elongation|transcriptional elongation]] and pre-[[mRNA splicing]]. The encoded protein interacts with the hyperphosphorylated [[C-terminus|C-terminal]] [[protein domain|domain]] of [[RNA polymerase II]] via multiple FF domains, and with the pre-mRNA splicing factor [[SF1 (gene)|SF1]] via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.<ref name="entrez" /> | |||
==Interactions== | |||
Transcription elongation regulator 1 has been shown to [[Protein-protein interaction|interact]] with [[SF1 (gene)|SF1]]<ref name=pmid11604498>{{cite journal |last=Goldstrohm |first=A C |authorlink= |author2=Albrecht T R |author3=Suñé C |author4=Bedford M T |author5=Garcia-Blanco M A |date=November 2001 |title=The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1 |journal=Mol. Cell. Biol. |volume=21 |issue=22 |pages=7617–28 |publisher= |location = United States| issn = 0270-7306| pmid = 11604498 |doi = 10.1128/MCB.21.22.7617-7628.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=99933 }}</ref> and [[POLR2A]].<ref name=pmid10908677>{{cite journal |last=Carty |first=S M |authorlink= |author2=Goldstrohm A C |author3=Suñé C |author4=Garcia-Blanco M A |author5=Greenleaf A L |date=August 2000 |title=Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=16 |pages=9015–20 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10908677 |doi = 10.1073/pnas.160266597 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16813 }}</ref> | |||
== References == | |||
{{Reflist}} | |||
== Further reading == | |||
{{Refbegin | 2}} | |||
{{PBB_Further_reading | |||
| citations = | |||
*{{cite journal |vauthors=Suñé C, Hayashi T, Liu Y, etal |title=CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 6029–39 |year= 1997 |pmid= 9315662 |doi= | pmc=232452 }} | |||
*{{cite journal |vauthors=Neubauer G, King A, Rappsilber J, etal |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }} | |||
*{{cite journal |vauthors=Suñé C, Garcia-Blanco MA |title=Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4719–28 |year= 1999 |pmid= 10373521 |doi= | pmc=84270 }} | |||
*{{cite journal |vauthors=Carty SM, Goldstrohm AC, Suñé C, etal |title=Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 9015–20 |year= 2000 |pmid= 10908677 |doi= 10.1073/pnas.160266597 | pmc=16813 }} | |||
*{{cite journal |vauthors=Bohne J, Cole SE, Suñe C, etal |title=Expression analysis and mapping of the mouse and human transcriptional regulator CA150 |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 930–3 |year= 2000 |pmid= 11003711 |doi=10.1007/s003350010162 }} | |||
*{{cite journal |vauthors=Holbert S, Denghien I, Kiechle T, etal |title=The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1811–6 |year= 2001 |pmid= 11172033 |doi= 10.1073/pnas.041566798 | pmc=29339 }} | |||
*{{cite journal |vauthors=Goldstrohm AC, Albrecht TR, Suñé C, etal |title=The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1 |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7617–28 |year= 2001 |pmid= 11604498 |doi= 10.1128/MCB.21.22.7617-7628.2001 | pmc=99933 }} | |||
*{{cite journal |vauthors=Zhou Z, Licklider LJ, Gygi SP, Reed R |title=Comprehensive proteomic analysis of the human spliceosome |journal=Nature |volume=419 |issue= 6903 |pages= 182–5 |year= 2002 |pmid= 12226669 |doi= 10.1038/nature01031 }} | |||
*{{cite journal |vauthors=Carty SM, Greenleaf AL |title=Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing |journal=Mol. Cell. Proteomics |volume=1 |issue= 8 |pages= 598–610 |year= 2003 |pmid= 12376575 |doi= 10.1074/mcp.M200029-MCP200}} | |||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | |||
*{{cite journal |vauthors=Chattopadhyay B, Ghosh S, Gangopadhyay PK, etal |title=Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India |journal=Neurosci. Lett. |volume=345 |issue= 2 |pages= 93–6 |year= 2003 |pmid= 12821179 |doi=10.1016/S0304-3940(03)00436-1 }} | |||
*{{cite journal |vauthors=Reuter TY, Medhurst AL, Waisfisz Q, etal |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211–21 |year= 2003 |pmid= 14499622 |doi=10.1016/S0014-4827(03)00261-1 }} | |||
*{{cite journal |vauthors=Palancade B, Marshall NF, Tremeau-Bravard A, etal |title=Dephosphorylation of RNA polymerase II by CTD-phosphatase FCP1 is inhibited by phospho-CTD associating proteins |journal=J. Mol. Biol. |volume=335 |issue= 2 |pages= 415–24 |year= 2004 |pmid= 14672652 |doi=10.1016/j.jmb.2003.10.036 }} | |||
*{{cite journal |vauthors=Nagel JE, Smith RJ, Shaw L, etal |title=Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10 |journal=BMC Immunol. |volume=5|pages= 17 |year= 2005 |pmid= 15296517 |doi= 10.1186/1471-2172-5-17 | pmc=514893 }} | |||
*{{cite journal |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }} | |||
*{{cite journal |vauthors=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004 | pmc=517884 }} | |||
*{{cite journal |vauthors=Smith MJ, Kulkarni S, Pawson T |title=FF domains of CA150 bind transcription and splicing factors through multiple weak interactions |journal=Mol. Cell. Biol. |volume=24 |issue= 21 |pages= 9274–85 |year= 2004 |pmid= 15485897 |doi= 10.1128/MCB.24.21.9274-9285.2004 | pmc=522232 }} | |||
*{{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }} | |||
*{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} | |||
*{{cite journal |vauthors=McFie PJ, Wang GL, Timchenko NA, etal |title=Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha |journal=J. Biol. Chem. |volume=281 |issue= 26 |pages= 18069–80 |year= 2006 |pmid= 16644732 |doi= 10.1074/jbc.M512734200 }} | |||
}} | |||
{{Refend}} | |||
{{PDB Gallery|geneid=10915}} | |||
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Revision as of 05:23, 16 October 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
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Wikidata | |||||||
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Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.[1][2][3]
Function
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.[1]
Interactions
Transcription elongation regulator 1 has been shown to interact with SF1[4] and POLR2A.[5]
References
- ↑ 1.0 1.1 "Entrez Gene: TCERG1 transcription elongation regulator 1".
- ↑ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology. 17 (10): 6029–39. PMC 232452. PMID 9315662.
- ↑ Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome. 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711.
- ↑ Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. United States. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498.
- ↑ Carty, S M; Goldstrohm A C; Suñé C; Garcia-Blanco M A; Greenleaf A L (August 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (16): 9015–20. doi:10.1073/pnas.160266597. ISSN 0027-8424. PMC 16813. PMID 10908677.
Further reading
- Suñé C, Hayashi T, Liu Y, et al. (1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. PMC 232452. PMID 9315662.
- Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
- Suñé C, Garcia-Blanco MA (1999). "Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner". Mol. Cell. Biol. 19 (7): 4719–28. PMC 84270. PMID 10373521.
- Carty SM, Goldstrohm AC, Suñé C, et al. (2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9015–20. doi:10.1073/pnas.160266597. PMC 16813. PMID 10908677.
- Bohne J, Cole SE, Suñe C, et al. (2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mamm. Genome. 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711.
- Holbert S, Denghien I, Kiechle T, et al. (2001). "The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1811–6. doi:10.1073/pnas.041566798. PMC 29339. PMID 11172033.
- Goldstrohm AC, Albrecht TR, Suñé C, et al. (2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMC 99933. PMID 11604498.
- Zhou Z, Licklider LJ, Gygi SP, Reed R (2002). "Comprehensive proteomic analysis of the human spliceosome". Nature. 419 (6903): 182–5. doi:10.1038/nature01031. PMID 12226669.
- Carty SM, Greenleaf AL (2003). "Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing". Mol. Cell. Proteomics. 1 (8): 598–610. doi:10.1074/mcp.M200029-MCP200. PMID 12376575.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chattopadhyay B, Ghosh S, Gangopadhyay PK, et al. (2003). "Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India". Neurosci. Lett. 345 (2): 93–6. doi:10.1016/S0304-3940(03)00436-1. PMID 12821179.
- Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
- Palancade B, Marshall NF, Tremeau-Bravard A, et al. (2004). "Dephosphorylation of RNA polymerase II by CTD-phosphatase FCP1 is inhibited by phospho-CTD associating proteins". J. Mol. Biol. 335 (2): 415–24. doi:10.1016/j.jmb.2003.10.036. PMID 14672652.
- Nagel JE, Smith RJ, Shaw L, et al. (2005). "Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10". BMC Immunol. 5: 17. doi:10.1186/1471-2172-5-17. PMC 514893. PMID 15296517.
- Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
- Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888.
- Smith MJ, Kulkarni S, Pawson T (2004). "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions". Mol. Cell. Biol. 24 (21): 9274–85. doi:10.1128/MCB.24.21.9274-9285.2004. PMC 522232. PMID 15485897.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- McFie PJ, Wang GL, Timchenko NA, et al. (2006). "Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha". J. Biol. Chem. 281 (26): 18069–80. doi:10.1074/jbc.M512734200. PMID 16644732.
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