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{{Infobox_gene}}
{{PBB_Controls
'''Microtubule-associated protein 1B''' is a [[protein]] that in humans is encoded by the ''MAP1B'' [[gene]].<ref name="pmid1881920">{{cite journal | vauthors = Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM | title = Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 88 | issue = 17 | pages = 7873–6  | date = Oct 1991 | pmid = 1881920 | pmc = 52406 | doi = 10.1073/pnas.88.17.7873 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP1B microtubule-associated protein 1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4131| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Microtubule-associated protein 1B
| HGNCid = 6836
| Symbol = MAP1B
| AltSymbols =; DKFZp686E1099; DKFZp686F1345; FLJ38954; FUTSCH; MAP5
| OMIM = 157129
| ECnumber = 
| Homologene = 38111
| MGIid = 1306778
| GeneAtlas_image1 = PBB_GE_MAP1B_214577_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}}
| Process = {{GNF_GO|id=GO:0001578 |text = microtubule bundle formation}} {{GNF_GO|id=GO:0016358 |text = dendrite development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4131
    | Hs_Ensembl = ENSG00000131711
    | Hs_RefseqProtein = NP_005900
    | Hs_RefseqmRNA = NM_005909
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 71438874
    | Hs_GenLoc_end = 71538609
    | Hs_Uniprot = P46821
    | Mm_EntrezGene = 17755
    | Mm_Ensembl = ENSMUSG00000052727
    | Mm_RefseqmRNA = NM_008634
    | Mm_RefseqProtein = NP_032660
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 100524598
    | Mm_GenLoc_end = 100616697
    | Mm_Uniprot = A0PJ96
  }}
}}
'''Microtubule-associated protein 1B''', also known as '''MAP1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP1B microtubule-associated protein 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4131| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.<ref name="entrez">{{cite web | title = Entrez Gene: MAP1B microtubule-associated protein 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4131| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MAP1B has been shown to [[Protein-protein interaction|interact]] with [[Acidic leucine-rich nuclear phosphoprotein 32 family member A]]<ref name=pmid12807913>{{cite journal | vauthors = Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY|authorlink6=Huda Zoghbi | title = Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis | journal = J. Biol. Chem. | volume = 278 | issue = 36 | pages = 34691–9  | date = Sep 2003 | pmid = 12807913 | doi = 10.1074/jbc.M302785200 }}</ref> and [[RASSF1]].<ref name=pmid15205320>{{cite journal | vauthors = Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F | title = RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics | journal = Cancer Res. | volume = 64 | issue = 12 | pages = 4112–6  | date = Jun 2004 | pmid = 15205320 | doi = 10.1158/0008-5472.CAN-04-0267 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hammarback JA, Obar RA, Hughes SM, Vallee RB | title = MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain | journal = Neuron | volume = 7 | issue = 1 | pages = 129–39 | year = 1991 | pmid = 1712602 | doi = 10.1016/0896-6273(91)90081-A }}
| citations =
* {{cite journal | vauthors = Schoenfeld TA, McKerracher L, Obar R, Vallee RB | title = MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS | journal = J. Neurosci. | volume = 9 | issue = 5 | pages = 1712–30 | year = 1989 | pmid = 2470876 | doi =  }}
*{{cite journal | author=Hammarback JA, Obar RA, Hughes SM, Vallee RB |title=MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain. |journal=Neuron |volume=7 |issue= 1 |pages= 129-39 |year= 1991 |pmid= 1712602 |doi= }}
* {{cite journal | vauthors = Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J | title = Role of phosphorylated MAPlB in neuritogenesis | journal = Cell Biol. Int. | volume = 18 | issue = 5 | pages = 309–14 | year = 1994 | pmid = 7519512 | doi = 10.1006/cbir.1994.1079 }}
*{{cite journal | author=Lien LL, Boyce FM, Kleyn P, ''et al.'' |title=Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7873-6 |year= 1991 |pmid= 1881920 |doi=  }}
* {{cite journal | vauthors = Lien LL, Feener CA, Fischbach N, Kunkel LM | title = Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15 | journal = Genomics | volume = 22 | issue = 2 | pages = 273–80 | year = 1994 | pmid = 7806212 | doi = 10.1006/geno.1994.1384 }}
*{{cite journal | author=Schoenfeld TA, McKerracher L, Obar R, Vallee RB |title=MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS. |journal=J. Neurosci. |volume=9 |issue= 5 |pages= 1712-30 |year= 1989 |pmid= 2470876 |doi= }}
* {{cite journal | vauthors = Ohyu J, Takashima S | title = Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions | journal = Brain Dev. | volume = 20 | issue = 1 | pages = 22–6 | year = 1998 | pmid = 9533556 | doi = 10.1016/S0387-7604(97)00088-0 }}
*{{cite journal | author=Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J |title=Role of phosphorylated MAPlB in neuritogenesis. |journal=Cell Biol. Int. |volume=18 |issue= 5 |pages= 309-14 |year= 1994 |pmid= 7519512 |doi= }}
* {{cite journal | vauthors = Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC | title = Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium | journal = J. Cell Sci. | volume = 111 ( Pt 10) | issue = 10 | pages = 1351–61 | year = 1998 | pmid = 9570753 | doi =  }}
*{{cite journal | author=Lien LL, Feener CA, Fischbach N, Kunkel LM |title=Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. |journal=Genomics |volume=22 |issue= 2 |pages= 273-80 |year= 1995 |pmid= 7806212 |doi= 10.1006/geno.1994.1384 }}
* {{cite journal | vauthors = Tögel M, Wiche G, Propst F | title = Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain | journal = J. Cell Biol. | volume = 143 | issue = 3 | pages = 695–707 | year = 1998 | pmid = 9813091 | pmc = 2148156 | doi = 10.1083/jcb.143.3.695 }}
*{{cite journal | author=Ohyu J, Takashima S |title=Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions. |journal=Brain Dev. |volume=20 |issue= 1 |pages= 22-6 |year= 1998 |pmid= 9533556 |doi=  }}
* {{cite journal | vauthors = Hanley JG, Koulen P, Bedford F, Gordon-Weeks PR, Moss SJ | title = The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses | journal = Nature | volume = 397 | issue = 6714 | pages = 66–9 | year = 1999 | pmid = 9892354 | doi = 10.1038/16258 }}
*{{cite journal | author=Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC |title=Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium. |journal=J. Cell. Sci. |volume=111 ( Pt 10) |issue= |pages= 1351-61 |year= 1998 |pmid= 9570753 |doi= }}
* {{cite journal | vauthors = Jensen PH, Islam K, Kenney J, Nielsen MS, Power J, Gai WP | title = Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments | journal = J. Biol. Chem. | volume = 275 | issue = 28 | pages = 21500–7 | year = 2000 | pmid = 10764738 | doi = 10.1074/jbc.M000099200 }}
*{{cite journal | author=Tögel M, Wiche G, Propst F |title=Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain. |journal=J. Cell Biol. |volume=143 |issue= 3 |pages= 695-707 |year= 1998 |pmid= 9813091 |doi= }}
* {{cite journal | vauthors = Tanner SL, Franzen R, Jaffe H, Quarles RH | title = Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein | journal = J. Neurochem. | volume = 75 | issue = 2 | pages = 553–62 | year = 2000 | pmid = 10899930 | doi = 10.1046/j.1471-4159.2000.0750553.x }}
*{{cite journal | author=Hanley JG, Koulen P, Bedford F, ''et al.'' |title=The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses. |journal=Nature |volume=397 |issue= 6714 |pages= 66-9 |year= 1999 |pmid= 9892354 |doi= 10.1038/16258 }}
* {{cite journal | vauthors = Mei X, Sweatt AJ, Hammarback JA | title = Regulation of microtubule-associated protein 1B (MAP1B) subunit composition | journal = J. Neurosci. Res. | volume = 62 | issue = 1 | pages = 56–64 | year = 2000 | pmid = 11002287 | doi = 10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-# }}
*{{cite journal | author=Jensen PH, Islam K, Kenney J, ''et al.'' |title=Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21500-7 |year= 2000 |pmid= 10764738 |doi= 10.1074/jbc.M000099200 }}
* {{cite journal | vauthors = Billups D, Hanley JG, Orme M, Attwell D, Moss SJ | title = GABAC receptor sensitivity is modulated by interaction with MAP1B | journal = J. Neurosci. | volume = 20 | issue = 23 | pages = 8643–50 | year = 2000 | pmid = 11102469 | doi =  }}
*{{cite journal | author=Tanner SL, Franzen R, Jaffe H, Quarles RH |title=Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein. |journal=J. Neurochem. |volume=75 |issue= 2 |pages= 553-62 |year= 2000 |pmid= 10899930 |doi= }}
* {{cite journal | vauthors = Franzen R, Tanner SL, Dashiell SM, Rottkamp CA, Hammer JA, Quarles RH | title = Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein | journal = J. Cell Biol. | volume = 155 | issue = 6 | pages = 893–8 | year = 2001 | pmid = 11733546 | pmc = 2150906 | doi = 10.1083/jcb.200108137 }}
*{{cite journal | author=Mei X, Sweatt AJ, Hammarback JA |title=Regulation of microtubule-associated protein 1B (MAP1B) subunit composition. |journal=J. Neurosci. Res. |volume=62 |issue= 1 |pages= 56-64 |year= 2000 |pmid= 11002287 |doi=  }}
* {{cite journal | vauthors = Ding J, Liu JJ, Kowal AS, Nardine T, Bhattacharya P, Lee A, Yang Y | title = Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin | journal = J. Cell Biol. | volume = 158 | issue = 3 | pages = 427–33 | year = 2002 | pmid = 12147674 | pmc = 2173828 | doi = 10.1083/jcb.200202055 }}
*{{cite journal | author=Billups D, Hanley JG, Orme M, ''et al.'' |title=GABAC receptor sensitivity is modulated by interaction with MAP1B. |journal=J. Neurosci. |volume=20 |issue= 23 |pages= 8643-50 |year= 2001 |pmid= 11102469 |doi= }}
* {{cite journal | vauthors = Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA | title = Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region | journal = Biomol. Eng. | volume = 20 | issue = 3 | pages = 91–6 | year = 2003 | pmid = 12684070 | doi = 10.1016/S1389-0344(03)00003-0 }}
*{{cite journal | author=Franzen R, Tanner SL, Dashiell SM, ''et al.'' |title=Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein. |journal=J. Cell Biol. |volume=155 |issue= 6 |pages= 893-8 |year= 2002 |pmid= 11733546 |doi= 10.1083/jcb.200108137 }}
* {{cite journal | vauthors = Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M | title = JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins | journal = Dev. Cell | volume = 4 | issue = 4 | pages = 521–33 | year = 2003 | pmid = 12689591 | doi = 10.1016/S1534-5807(03)00094-7 }}
*{{cite journal | author=Ding J, Liu JJ, Kowal AS, ''et al.'' |title=Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin. |journal=J. Cell Biol. |volume=158 |issue= 3 |pages= 427-33 |year= 2002 |pmid= 12147674 |doi= 10.1083/jcb.200202055 }}
* {{cite journal | vauthors = Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY | title = Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis | journal = J. Biol. Chem. | volume = 278 | issue = 36 | pages = 34691–9 | year = 2003 | pmid = 12807913 | doi = 10.1074/jbc.M302785200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA |title=Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region. |journal=Biomol. Eng. |volume=20 |issue= 3 |pages= 91-6 |year= 2004 |pmid= 12684070 |doi= }}
*{{cite journal  | author=Chang L, Jones Y, Ellisman MH, ''et al.'' |title=JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. |journal=Dev. Cell |volume=4 |issue= 4 |pages= 521-33 |year= 2003 |pmid= 12689591 |doi=  }}
*{{cite journal  | author=Opal P, Garcia JJ, Propst F, ''et al.'' |title=Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34691-9 |year= 2003 |pmid= 12807913 |doi= 10.1074/jbc.M302785200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 20:16, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.[1][2]

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.[2]

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[3] and RASSF1.[4]

References

  1. ↑ Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM (Oct 1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873–6. doi:10.1073/pnas.88.17.7873. PMC 52406. PMID 1881920.
  2. ↑ 2.0 2.1 "Entrez Gene: MAP1B microtubule-associated protein 1B".
  3. ↑ Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (Sep 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913.
  4. ↑ Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.

Further reading


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