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{{Infobox_gene}}
'''Transforming growth factor, beta-induced, 68kDa''', also known as '''TGFBI''' (initially called BIGH3, BIG-H3), is a [[protein]] which in humans is encoded by the ''TGFBI'' [[gene]], locus 5q31.<ref name="entrez">{{cite web | title = Entrez Gene: TGFBI transforming growth factor, beta-induced, 68kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7045| accessdate = }}</ref><ref name="pmid9054935">{{cite journal | vauthors = Munier FL, Korvatska E, Djemaï A, Le Paslier D, Zografos L, Pescia G, Schorderet DF | title = Kerato-epithelin mutations in four 5q31-linked corneal dystrophies | journal = Nat. Genet. | volume = 15 | issue = 3 | pages = 247–51 |date=March 1997 | pmid = 9054935 | doi = 10.1038/ng0397-247 | url = | issn = }}</ref>
== Function ==
This gene encodes an [[arginylglycylaspartic acid|RGD]]-containing protein that binds to type I, II and IV [[collagen]]s. The RGD motif is found in many [[extracellular matrix]] proteins modulating [[cell adhesion]] and serves as a ligand recognition sequence for several [[integrin]]s. This protein plays a role in cell-collagen interactions and may be involved in [[endochondral ossification|endochondrial bone]] formation in cartilage. The protein is induced by [[transforming growth factor-beta]] and acts to inhibit cell adhesion.<ref name="entrez"/>
== Clinical significance ==
Mutations of the gene cause several forms of [[corneal dystrophy (human)|corneal dystrophies]].<ref name="pmid9463327">{{cite journal | vauthors = Korvatska E, Munier FL, Djemaï A, Wang MX, Frueh B, Chiou AG, Uffer S, Ballestrazzi E, Braunstein RE, Forster RK, Culbertson WW, Boman H, Zografos L, Schorderet DF | title = Mutation hot spots in 5q31-linked corneal dystrophies | journal = Am. J. Hum. Genet. | volume = 62 | issue = 2 | pages = 320–4 |date=February 1998 | pmid = 9463327 | pmc = 1376896 | doi = 10.1086/301720 | url = | issn = }}</ref><ref name="pmid19236704">{{cite journal | author = Klintworth GK | title = Corneal dystrophies | journal = Orphanet J Rare Dis | volume = 4 | issue = 1| pages = 7 | year = 2009 | pmid = 19236704 | pmc = 2695576 | doi = 10.1186/1750-1172-4-7 | url = | issn = }}</ref>
[[File:Mutated transforming growth factor beta induced protein in the superficial corneal stroma.jpg|thumb|left|[[Corneal dystrophy of Bowman layer, type I|Reis-Bücklers corneal dystrophy]]. Light microscopy of cornea showing characteristic red stained deposits of mutated TGFBI protein in the superficial [[corneal stroma]]. [[Masson's trichrome stain]].]]
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | vauthors=Fujiki K, Nakayasu K, Kanai A |title=Corneal dystrophies in Japan. |journal=J. Hum. Genet. |volume=46 |issue= 8 |pages= 431–5 |year= 2001 |pmid= 11501939 |doi=10.1007/s100380170041  }}
*{{cite journal  | vauthors=Schmitt-Bernard CF, Pouliquen Y, Argilès A |title=[BIG-H3 protein: mutation of codon 124 and corneal amyloidosis] |journal=Journal français d'ophtalmologie |volume=27 |issue= 5 |pages= 510–22 |year= 2004 |pmid= 15179309 |doi=10.1016/S0181-5512(04)96173-6  }}
*{{cite journal  | vauthors=Pieramici SF, Afshari NA |title=Genetics of corneal dystrophies: the evolving landscape. |journal=Current Opinion in Ophthalmology |volume=17 |issue= 4 |pages= 361–6 |year= 2006 |pmid= 16900028 |doi= 10.1097/01.icu.0000233955.94347.84 }}
*{{cite journal  |vauthors=Skonier J, Neubauer M, Madisen L, etal |title=cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. |journal=DNA Cell Biol. |volume=11 |issue= 7 |pages= 511–22 |year= 1992 |pmid= 1388724 |doi=10.1089/dna.1992.11.511  }}
*{{cite journal  |vauthors=LeBaron RG, Bezverkov KI, Zimber MP, etal |title=Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitro. |journal=J. Invest. Dermatol. |volume=104 |issue= 5 |pages= 844–9 |year= 1995 |pmid= 7738366 |doi=10.1111/1523-1747.ep12607024  }}
*{{cite journal  |vauthors=Skonier J, Bennett K, Rothwell V, etal |title=beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice. |journal=DNA Cell Biol. |volume=13 |issue= 6 |pages= 571–84 |year= 1994 |pmid= 8024701 |doi=10.1089/dna.1994.13.571  }}
*{{cite journal  |vauthors=Escribano J, Hernando N, Ghosh S, etal |title=cDNA from human ocular ciliary epithelium homologous to beta ig-h3 is preferentially expressed as an extracellular protein in the corneal epithelium. |journal=J. Cell. Physiol. |volume=160 |issue= 3 |pages= 511–21 |year= 1994 |pmid= 8077289 |doi= 10.1002/jcp.1041600314 }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  |vauthors=Stone EM, Mathers WD, Rosenwasser GO, etal |title=Three autosomal dominant corneal dystrophies map to chromosome 5q. |journal=Nat. Genet. |volume=6 |issue= 1 |pages= 47–51 |year= 1994 |pmid= 8136834 |doi= 10.1038/ng0194-47 }}
*{{cite journal  |vauthors=Munier FL, Korvatska E, Djemaï A, etal |title=Kerato-epithelin mutations in four 5q31-linked corneal dystrophies. |journal=Nat. Genet. |volume=15 |issue= 3 |pages= 247–51 |year= 1997 |pmid= 9054935 |doi= 10.1038/ng0397-247 }}
*{{cite journal  |vauthors=Hashimoto K, Noshiro M, Ohno S, etal |title=Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagen. |journal=Biochim. Biophys. Acta |volume=1355 |issue= 3 |pages= 303–14 |year= 1997 |pmid= 9061001 |doi=10.1016/S0167-4889(96)00147-4  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  |vauthors=Korvatska E, Munier FL, Djemaï A, etal |title=Mutation hot spots in 5q31-linked corneal dystrophies. |journal=Am. J. Hum. Genet. |volume=62 |issue= 2 |pages= 320–4 |year= 1998 |pmid= 9463327 |doi=10.1086/301720  | pmc=1376896  }}
*{{cite journal  |vauthors=Yamamoto S, Okada M, Tsujikawa M, etal |title=A kerato-epithelin (betaig-h3) mutation in lattice corneal dystrophy type IIIA. |journal=Am. J. Hum. Genet. |volume=62 |issue= 3 |pages= 719–22 |year= 1998 |pmid= 9497262 |doi=10.1086/301765  | pmc=1376959  }}
*{{cite journal  |vauthors=Okada M, Yamamoto S, Watanabe H, etal |title=Granular corneal dystrophy with homozygous mutations in the kerato-epithelin gene. |journal=Am. J. Ophthalmol. |volume=126 |issue= 2 |pages= 169–76 |year= 1998 |pmid= 9727509 |doi=10.1016/S0002-9394(98)00075-0  }}
*{{cite journal  |vauthors=Okada M, Yamamoto S, Tsujikawa M, etal |title=Two distinct kerato-epithelin mutations in Reis-Bücklers corneal dystrophy. |journal=Am. J. Ophthalmol. |volume=126 |issue= 4 |pages= 535–42 |year= 1998 |pmid= 9780098 |doi=10.1016/S0002-9394(98)00135-4  }}
*{{cite journal  |vauthors=Fujiki K, Hotta Y, Nakayasu K, etal |title=A new L527R mutation of the betaIGH3 gene in patients with lattice corneal dystrophy with deep stromal opacities. |journal=Hum. Genet. |volume=103 |issue= 3 |pages= 286–9 |year= 1998 |pmid= 9799082 |doi=10.1007/s004390050818  }}
*{{cite journal  |vauthors=Stewart H, Black GC, Donnai D, etal |title=A mutation within exon 14 of the TGFBI (BIGH3) gene on chromosome 5q31 causes an asymmetric, late-onset form of lattice corneal dystrophy. |journal=Ophthalmology |volume=106 |issue= 5 |pages= 964–70 |year= 1999 |pmid= 10328397 |doi= 10.1016/S0161-6420(99)00539-4 }}
*{{cite journal  |vauthors=Stewart HS, Ridgway AE, Dixon MJ, etal |title=Heterogeneity in granular corneal dystrophy: identification of three causative mutations in the TGFBI (BIGH3) gene-lessons for corneal amyloidogenesis. |journal=Hum. Mutat. |volume=14 |issue= 2 |pages= 126–32 |year= 1999 |pmid= 10425035 |doi= 10.1002/(SICI)1098-1004(1999)14:2<126::AID-HUMU4>3.0.CO;2-W }}
*{{cite journal  |vauthors=Rozzo C, Fossarello M, Galleri G, etal |title=A common beta ig-h3 gene mutation (delta f540) in a large cohort of Sardinian Reis Bücklers corneal dystrophy patients. Mutations in brief no. 180. Online. |journal=Hum. Mutat. |volume=12 |issue= 3 |pages= 215–6 |year= 2000 |pmid= 10660331 |doi=  }}
*{{cite journal  | vauthors=Page L, Polok B, Bustamante M, Schorderet DF |title=Bigh3 is upregulated in regenerating zebrafish fin |journal=Zebrafish |volume=10 |issue= 3 |pages= 36–42 |year= 2013 |doi=10.1089/zeb.2012.0759  }}}}
{{refend}}
{{PDB Gallery|geneid=7045}}
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{{GNF_Protein_box
| image = PBB_Protein_TGFBI_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x3b.
| PDB = {{PDB2|1x3b}}
| Name = Transforming growth factor, beta-induced, 68kDa
| HGNCid = 11771
| Symbol = TGFBI
| AltSymbols =; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; LCD1
| OMIM = 601692
| ECnumber = 
| Homologene = 37294
| MGIid = 99959
| GeneAtlas_image1 = PBB_GE_TGFBI_201506_at_tn.png
| Function = {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007162 |text = negative regulation of cell adhesion}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7045
    | Hs_Ensembl = ENSG00000120708
    | Hs_RefseqProtein = NP_000349
    | Hs_RefseqmRNA = NM_000358
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 135392644
    | Hs_GenLoc_end = 135427253
    | Hs_Uniprot = Q15582
    | Mm_EntrezGene = 21810
    | Mm_Ensembl = ENSMUSG00000035493
    | Mm_RefseqmRNA = NM_009369
    | Mm_RefseqProtein = NP_033395
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 56619208
    | Mm_GenLoc_end = 56648972
    | Mm_Uniprot = Q19PV3
  }}
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'''Transforming growth factor, beta-induced, 68kDa''', also known as '''TGFBI''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TGFBI transforming growth factor, beta-induced, 68kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7045| accessdate = }}</ref>


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[[Category:Extracellular matrix proteins]]
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Fujiki K, Nakayasu K, Kanai A |title=Corneal dystrophies in Japan. |journal=J. Hum. Genet. |volume=46 |issue= 8 |pages= 431-5 |year= 2001 |pmid= 11501939 |doi=  }}
*{{cite journal  | author=Schmitt-Bernard CF, Pouliquen Y, Argilès A |title=[BIG-H3 protein: mutation of codon 124 and corneal amyloidosis] |journal=Journal français d'ophtalmologie |volume=27 |issue= 5 |pages= 510-22 |year= 2004 |pmid= 15179309 |doi=  }}
*{{cite journal  | author=Pieramici SF, Afshari NA |title=Genetics of corneal dystrophies: the evolving landscape. |journal=Current opinion in ophthalmology |volume=17 |issue= 4 |pages= 361-6 |year= 2006 |pmid= 16900028 |doi= 10.1097/01.icu.0000233955.94347.84 }}
*{{cite journal  | author=Skonier J, Neubauer M, Madisen L, ''et al.'' |title=cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. |journal=DNA Cell Biol. |volume=11 |issue= 7 |pages= 511-22 |year= 1992 |pmid= 1388724 |doi=  }}
*{{cite journal  | author=LeBaron RG, Bezverkov KI, Zimber MP, ''et al.'' |title=Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitro. |journal=J. Invest. Dermatol. |volume=104 |issue= 5 |pages= 844-9 |year= 1995 |pmid= 7738366 |doi=  }}
*{{cite journal  | author=Skonier J, Bennett K, Rothwell V, ''et al.'' |title=beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice. |journal=DNA Cell Biol. |volume=13 |issue= 6 |pages= 571-84 |year= 1994 |pmid= 8024701 |doi=  }}
*{{cite journal  | author=Escribano J, Hernando N, Ghosh S, ''et al.'' |title=cDNA from human ocular ciliary epithelium homologous to beta ig-h3 is preferentially expressed as an extracellular protein in the corneal epithelium. |journal=J. Cell. Physiol. |volume=160 |issue= 3 |pages= 511-21 |year= 1994 |pmid= 8077289 |doi= 10.1002/jcp.1041600314 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Stone EM, Mathers WD, Rosenwasser GO, ''et al.'' |title=Three autosomal dominant corneal dystrophies map to chromosome 5q. |journal=Nat. Genet. |volume=6 |issue= 1 |pages= 47-51 |year= 1994 |pmid= 8136834 |doi= 10.1038/ng0194-47 }}
*{{cite journal  | author=Munier FL, Korvatska E, Djemaï A, ''et al.'' |title=Kerato-epithelin mutations in four 5q31-linked corneal dystrophies. |journal=Nat. Genet. |volume=15 |issue= 3 |pages= 247-51 |year= 1997 |pmid= 9054935 |doi= 10.1038/ng0397-247 }}
*{{cite journal  | author=Hashimoto K, Noshiro M, Ohno S, ''et al.'' |title=Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagen. |journal=Biochim. Biophys. Acta |volume=1355 |issue= 3 |pages= 303-14 |year= 1997 |pmid= 9061001 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Korvatska E, Munier FL, Djemaï A, ''et al.'' |title=Mutation hot spots in 5q31-linked corneal dystrophies. |journal=Am. J. Hum. Genet. |volume=62 |issue= 2 |pages= 320-4 |year= 1998 |pmid= 9463327 |doi=  }}
*{{cite journal  | author=Yamamoto S, Okada M, Tsujikawa M, ''et al.'' |title=A kerato-epithelin (betaig-h3) mutation in lattice corneal dystrophy type IIIA. |journal=Am. J. Hum. Genet. |volume=62 |issue= 3 |pages= 719-22 |year= 1998 |pmid= 9497262 |doi=  }}
*{{cite journal  | author=Okada M, Yamamoto S, Watanabe H, ''et al.'' |title=Granular corneal dystrophy with homozygous mutations in the kerato-epithelin gene. |journal=Am. J. Ophthalmol. |volume=126 |issue= 2 |pages= 169-76 |year= 1998 |pmid= 9727509 |doi=  }}
*{{cite journal  | author=Okada M, Yamamoto S, Tsujikawa M, ''et al.'' |title=Two distinct kerato-epithelin mutations in Reis-Bücklers corneal dystrophy. |journal=Am. J. Ophthalmol. |volume=126 |issue= 4 |pages= 535-42 |year= 1998 |pmid= 9780098 |doi=  }}
*{{cite journal  | author=Fujiki K, Hotta Y, Nakayasu K, ''et al.'' |title=A new L527R mutation of the betaIGH3 gene in patients with lattice corneal dystrophy with deep stromal opacities. |journal=Hum. Genet. |volume=103 |issue= 3 |pages= 286-9 |year= 1998 |pmid= 9799082 |doi=  }}
*{{cite journal  | author=Stewart H, Black GC, Donnai D, ''et al.'' |title=A mutation within exon 14 of the TGFBI (BIGH3) gene on chromosome 5q31 causes an asymmetric, late-onset form of lattice corneal dystrophy. |journal=Ophthalmology |volume=106 |issue= 5 |pages= 964-70 |year= 1999 |pmid= 10328397 |doi= 10.1016/S0161-6420(99)00539-4 }}
*{{cite journal  | author=Stewart HS, Ridgway AE, Dixon MJ, ''et al.'' |title=Heterogeneity in granular corneal dystrophy: identification of three causative mutations in the TGFBI (BIGH3) gene-lessons for corneal amyloidogenesis. |journal=Hum. Mutat. |volume=14 |issue= 2 |pages= 126-32 |year= 1999 |pmid= 10425035 |doi= 10.1002/(SICI)1098-1004(1999)14:2<126::AID-HUMU4>3.0.CO;2-W }}
*{{cite journal  | author=Rozzo C, Fossarello M, Galleri G, ''et al.'' |title=A common beta ig-h3 gene mutation (delta f540) in a large cohort of Sardinian Reis Bücklers corneal dystrophy patients. Mutations in brief no. 180. Online. |journal=Hum. Mutat. |volume=12 |issue= 3 |pages= 215-6 |year= 2000 |pmid= 10660331 |doi=  }}
}}
{{refend}}


{{protein-stub}}
{{gene-5-stub}}
{{WikiDoc Sources}}

Latest revision as of 11:48, 15 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in humans is encoded by the TGFBI gene, locus 5q31.[1][2]

Function

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion.[1]

Clinical significance

Mutations of the gene cause several forms of corneal dystrophies.[3][4]

File:Mutated transforming growth factor beta induced protein in the superficial corneal stroma.jpg
Reis-Bücklers corneal dystrophy. Light microscopy of cornea showing characteristic red stained deposits of mutated TGFBI protein in the superficial corneal stroma. Masson's trichrome stain.

References

  1. ↑ 1.0 1.1 "Entrez Gene: TGFBI transforming growth factor, beta-induced, 68kDa".
  2. ↑ Munier FL, Korvatska E, Djemaï A, Le Paslier D, Zografos L, Pescia G, Schorderet DF (March 1997). "Kerato-epithelin mutations in four 5q31-linked corneal dystrophies". Nat. Genet. 15 (3): 247–51. doi:10.1038/ng0397-247. PMID 9054935.
  3. ↑ Korvatska E, Munier FL, Djemaï A, Wang MX, Frueh B, Chiou AG, Uffer S, Ballestrazzi E, Braunstein RE, Forster RK, Culbertson WW, Boman H, Zografos L, Schorderet DF (February 1998). "Mutation hot spots in 5q31-linked corneal dystrophies". Am. J. Hum. Genet. 62 (2): 320–4. doi:10.1086/301720. PMC 1376896. PMID 9463327.
  4. ↑ Klintworth GK (2009). "Corneal dystrophies". Orphanet J Rare Dis. 4 (1): 7. doi:10.1186/1750-1172-4-7. PMC 2695576. PMID 19236704.

Further reading

  • Fujiki K, Nakayasu K, Kanai A (2001). "Corneal dystrophies in Japan". J. Hum. Genet. 46 (8): 431–5. doi:10.1007/s100380170041. PMID 11501939.
  • Schmitt-Bernard CF, Pouliquen Y, Argilès A (2004). "[BIG-H3 protein: mutation of codon 124 and corneal amyloidosis]". Journal français d'ophtalmologie. 27 (5): 510–22. doi:10.1016/S0181-5512(04)96173-6. PMID 15179309.
  • Pieramici SF, Afshari NA (2006). "Genetics of corneal dystrophies: the evolving landscape". Current Opinion in Ophthalmology. 17 (4): 361–6. doi:10.1097/01.icu.0000233955.94347.84. PMID 16900028.
  • Skonier J, Neubauer M, Madisen L, et al. (1992). "cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta". DNA Cell Biol. 11 (7): 511–22. doi:10.1089/dna.1992.11.511. PMID 1388724.
  • LeBaron RG, Bezverkov KI, Zimber MP, et al. (1995). "Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitro". J. Invest. Dermatol. 104 (5): 844–9. doi:10.1111/1523-1747.ep12607024. PMID 7738366.
  • Skonier J, Bennett K, Rothwell V, et al. (1994). "beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice". DNA Cell Biol. 13 (6): 571–84. doi:10.1089/dna.1994.13.571. PMID 8024701.
  • Escribano J, Hernando N, Ghosh S, et al. (1994). "cDNA from human ocular ciliary epithelium homologous to beta ig-h3 is preferentially expressed as an extracellular protein in the corneal epithelium". J. Cell. Physiol. 160 (3): 511–21. doi:10.1002/jcp.1041600314. PMID 8077289.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Stone EM, Mathers WD, Rosenwasser GO, et al. (1994). "Three autosomal dominant corneal dystrophies map to chromosome 5q". Nat. Genet. 6 (1): 47–51. doi:10.1038/ng0194-47. PMID 8136834.
  • Munier FL, Korvatska E, Djemaï A, et al. (1997). "Kerato-epithelin mutations in four 5q31-linked corneal dystrophies". Nat. Genet. 15 (3): 247–51. doi:10.1038/ng0397-247. PMID 9054935.
  • Hashimoto K, Noshiro M, Ohno S, et al. (1997). "Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagen". Biochim. Biophys. Acta. 1355 (3): 303–14. doi:10.1016/S0167-4889(96)00147-4. PMID 9061001.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Korvatska E, Munier FL, Djemaï A, et al. (1998). "Mutation hot spots in 5q31-linked corneal dystrophies". Am. J. Hum. Genet. 62 (2): 320–4. doi:10.1086/301720. PMC 1376896. PMID 9463327.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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