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{{Infobox_gene}}
{{PBB_Controls
'''TNFAIP3-interacting protein 1''' is a [[protein]] that in humans is encoded by the ''TNIP1'' [[gene]].<ref name="pmid9923610">{{cite journal | vauthors = Fukushi M, Dixon J, Kimura T, Tsurutani N, Dixon MJ, Yamamoto N | title = Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression | journal = FEBS Letters | volume = 442 | issue = 1 | pages = 83–8 | date = Jan 1999 | pmid = 9923610 | pmc =  | doi = 10.1016/S0014-5793(98)01631-7 }}</ref><ref name="pmid11090181">{{cite journal | vauthors = Gupta K, Ott D, Hope TJ, Siliciano RF, Boeke JD | title = A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions | journal = Journal of Virology | volume = 74 | issue = 24 | pages = 11811–24 | date = Dec 2000 | pmid = 11090181 | pmc = 112464 | doi = 10.1128/JVI.74.24.11811-11824.2000 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TNIP1 TNFAIP3 interacting protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10318| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Association with autoimmune diseases ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = TNFAIP3 interacting protein 1
| HGNCid = 16903
| Symbol = TNIP1
| AltSymbols =; ABIN-1; KIAA0113; NAF1; VAN
| OMIM = 607714
| ECnumber = 
| Homologene = 31355
| MGIid = 1926194
| GeneAtlas_image1 = PBB_GE_TNIP1_207196_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0009101 |text = glycoprotein biosynthetic process}} {{GNF_GO|id=GO:0009405 |text = pathogenesis}} {{GNF_GO|id=GO:0045071 |text = negative regulation of viral genome replication}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10318
    | Hs_Ensembl = ENSG00000145901
    | Hs_RefseqProtein = NP_006049
    | Hs_RefseqmRNA = NM_006058
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 150389733
    | Hs_GenLoc_end = 150440762
    | Hs_Uniprot = Q15025
    | Mm_EntrezGene = 57783
    | Mm_Ensembl = ENSMUSG00000020400
    | Mm_RefseqmRNA = NM_021327
    | Mm_RefseqProtein = NP_067302
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 54743753
    | Mm_GenLoc_end = 54868999
    | Mm_Uniprot = Q9WUU8
  }}
}}
'''TNFAIP3 interacting protein 1''', also known as '''TNIP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TNIP1 TNFAIP3 interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10318| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
[[Human genetic variation|Genetic variations]] within the region of the ''TNIP1'' gene have been shown to have [[Genetic association|association]] with several [[autoimmune disease]]s:
{{PBB_Summary
*[[Systemic sclerosis|Systemic Sclerosis]];<ref name="pmid21750679">{{cite journal | vauthors = Allanore Y, Saad M, Dieudé P, Avouac J, Distler JH, Amouyel P, Matucci-Cerinic M, Riemekasten G, Airo P, Melchers I, Hachulla E, Cusi D, Wichmann HE, Wipff J, Lambert JC, Hunzelmann N, Tiev K, Caramaschi P, Diot E, Kowal-Bielecka O, Valentini G, Mouthon L, Czirják L, Damjanov N, Salvi E, Conti C, Müller M, Müller-Ladner U, Riccieri V, Ruiz B, Cracowski JL, Letenneur L, Dupuy AM, Meyer O, Kahan A, Munnich A, Boileau C, Martinez M | display-authors = 6 | title = Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis | journal = PLoS Genetics | volume = 7 | issue = 7 | pages = e1002091 | date = Jul 2011 | pmid = 21750679 | pmc = 3131285 | doi = 10.1371/journal.pgen.1002091 }}</ref>
| section_title =  
*[[Psoriasis]];<ref name="pmid19169254">{{cite journal | vauthors = Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR | display-authors = 6 | title = Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways | journal = Nature Genetics | volume = 41 | issue = 2 | pages = 199–204 | date = Feb 2009 | pmid = 19169254 | pmc = 2745122 | doi = 10.1038/ng.311 }}</ref>
| summary_text =  
*[[Psoriatic arthritis]];<ref name="pmid21623003">{{cite journal | vauthors = Bowes J, Orozco G, Flynn E, Ho P, Brier R, Marzo-Ortega H, Coates L, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, FitzGerald O, Packham J, Morgan AW, Bruce IN, Barton A | display-authors = 6 | title = Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis | journal = Annals of the Rheumatic Diseases | volume = 70 | issue = 9 | pages = 1641–4 | date = Sep 2011 | pmid = 21623003 | pmc = 3147229 | doi = 10.1136/ard.2011.150102 }}</ref>
}}
*[[Lupus erythematosus|Systemic Lupus Erythematosus]]<ref name="pmid19838195">{{cite journal | vauthors = Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, Ortmann W, Kosoy R, Ferreira RC, Nordmark G, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson AA, Rantapää-Dahlqvist S, Baechler EC, Brown EE, Alarcón GS, Edberg JC, Ramsey-Goldman R, McGwin G, Reveille JD, Vilá LM, Kimberly RP, Manzi S, Petri MA, Lee A, Gregersen PK, Seldin MF, Rönnblom L, Criswell LA, Syvänen AC, Behrens TW, Graham RR | display-authors = 6 | title = A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus | journal = Nature Genetics | volume = 41 | issue = 11 | pages = 1228–33 | date = Nov 2009 | pmid = 19838195 | pmc = 2925843 | doi = 10.1038/ng.468 }}</ref><ref name="pmid19838193">{{cite journal | vauthors = Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, Xu JH, Cai ZM, Huang W, Zhao GP, Xie HF, Fang H, Lu QJ, Xu JH, Li XP, Pan YF, Deng DQ, Zeng FQ, Ye ZZ, Zhang XY, Wang QW, Hao F, Ma L, Zuo XB, Zhou FS, Du WH, Cheng YL, Yang JQ, Shen SK, Li J, Sheng YJ, Zuo XX, Zhu WF, Gao F, Zhang PL, Guo Q, Li B, Gao M, Xiao FL, Quan C, Zhang C, Zhang Z, Zhu KJ, Li Y, Hu DY, Lu WS, Huang JL, Liu SX, Li H, Ren YQ, Wang ZX, Yang CJ, Wang PG, Zhou WM, Lv YM, Zhang AP, Zhang SQ, Lin D, Li Y, Low HQ, Shen M, Zhai ZF, Wang Y, Zhang FY, Yang S, Liu JJ, Zhang XJ | display-authors = 6 | title = Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus | journal = Nature Genetics | volume = 41 | issue = 11 | pages = 1234–7 | date = Nov 2009 | pmid = 19838193 | doi = 10.1038/ng.472 }}</ref>


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TNIP1 has been shown to [[Protein-protein interaction|interact]] with [[TNFAIP3]]<ref name="pmid10385526">{{cite journal | vauthors = Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R | title = The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN | journal = The Journal of Cell Biology | volume = 145 | issue = 7 | pages = 1471–82 | date = Jun 1999 | pmid = 10385526 | pmc = 2133159 | doi = 10.1083/jcb.145.7.1471 }}</ref> and [[MAPK1]].<ref name="pmid12220502">{{cite journal | vauthors = Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, Nakajima T, Amagasa T, Enomoto S, Koike K, Miura O, Yamamoto N, Tsuchida N | title = A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling | journal = Biochemical and Biophysical Research Communications | volume = 297 | issue = 1 | pages = 17–23 | date = Sep 2002 | pmid = 12220502 | doi = 10.1016/S0006-291X(02)02086-7 }}</ref>
{{refbegin | 2}}
{{clear}}
{{PBB_Further_reading
== References ==
| citations =
{{reflist|33em}}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
 
*{{cite journal | author=Nagase T, Miyajima N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 1 |pages= 37-43 |year= 1995 |pmid= 7788527 |doi= }}
== Further reading ==
*{{cite journal | author=Loftus SK, Dixon J, Koprivnikar K, ''et al.'' |title=Transcriptional map of the Treacher Collins candidate gene region. |journal=Genome Res. |volume=6 |issue= 1 |pages= 26-34 |year= 1996 |pmid= 8681136 |doi= }}
{{refbegin|33em}}
*{{cite journal | author=Jäkel S, Görlich D |title=Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. |journal=EMBO J. |volume=17 |issue= 15 |pages= 4491-502 |year= 1998 |pmid= 9687515 |doi= 10.1093/emboj/17.15.4491 }}
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = Jun 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
*{{cite journal | author=Fukushi M, Dixon J, Kimura T, ''et al.'' |title=Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression. |journal=FEBS Lett. |volume=442 |issue= 1 |pages= 83-8 |year= 1999 |pmid= 9923610 |doi=  }}
* {{cite journal | vauthors = Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H | title = Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 1 | pages = 37–43 | year = 1995 | pmid = 7788527 | doi = 10.1093/dnares/2.1.37 }}
*{{cite journal  | author=Heyninck K, De Valck D, Vanden Berghe W, ''et al.'' |title=The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. |journal=J. Cell Biol. |volume=145 |issue= 7 |pages= 1471-82 |year= 1999 |pmid= 10385526 |doi= }}
* {{cite journal | vauthors = Loftus SK, Dixon J, Koprivnikar K, Dixon MJ, Wasmuth JJ | title = Transcriptional map of the Treacher Collins candidate gene region | journal = Genome Research | volume = 6 | issue = 1 | pages = 26–34 | date = Jan 1996 | pmid = 8681136 | doi = 10.1101/gr.6.1.26 }}
*{{cite journal  | author=Gupta K, Ott D, Hope TJ, ''et al.'' |title=A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions. |journal=J. Virol. |volume=74 |issue= 24 |pages= 11811-24 |year= 2001 |pmid= 11090181 |doi=  }}
* {{cite journal | vauthors = Jäkel S, Görlich D | title = Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells | journal = The EMBO Journal | volume = 17 | issue = 15 | pages = 4491–502 | date = Aug 1998 | pmid = 9687515 | pmc = 1170780 | doi = 10.1093/emboj/17.15.4491 }}
*{{cite journal | author=Zhang S, Fukushi M, Hashimoto S, ''et al.'' |title=A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 1 |pages= 17-23 |year= 2002 |pmid= 12220502 |doi= }}
* {{cite journal | vauthors = Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R | title = The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN | journal = The Journal of Cell Biology | volume = 145 | issue = 7 | pages = 1471–82 | date = Jun 1999 | pmid = 10385526 | pmc = 2133159 | doi = 10.1083/jcb.145.7.1471 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, Nakajima T, Amagasa T, Enomoto S, Koike K, Miura O, Yamamoto N, Tsuchida N | title = A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling | journal = Biochemical and Biophysical Research Communications | volume = 297 | issue = 1 | pages = 17–23 | date = Sep 2002 | pmid = 12220502 | doi = 10.1016/S0006-291X(02)02086-7 }}
*{{cite journal | author=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793-801 |year= 2003 |pmid= 12927788 |doi= }}
* {{cite journal | vauthors = Leonard D, Ajuh P, Lamond AI, Legerski RJ | title = hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing | journal = Biochemical and Biophysical Research Communications | volume = 308 | issue = 4 | pages = 793–801 | date = Sep 2003 | pmid = 12927788 | doi = 10.1016/S0006-291X(03)01486-4 }}
*{{cite journal | author=Gallagher J, Howlin J, McCarthy C, ''et al.'' |title=Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays. |journal=FEBS Lett. |volume=551 |issue= 1-3 |pages= 8-12 |year= 2003 |pmid= 12965196 |doi= }}
* {{cite journal | vauthors = Gallagher J, Howlin J, McCarthy C, Murphy EP, Bresnihan B, FitzGerald O, Godson C, Brady HR, Martin F | title = Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays | journal = FEBS Letters | volume = 551 | issue = 1-3 | pages = 8–12 | date = Sep 2003 | pmid = 12965196 | doi = 10.1016/S0014-5793(03)00823-8 }}
*{{cite journal | author=Favre M, Butticaz C, Stevenson B, ''et al.'' |title=High frequency of alternative splicing of human genes participating in the HIV-1 life cycle: a model using TSG101, betaTrCP, PPIA, INI1, NAF1, and PML. |journal=J. Acquir. Immune Defic. Syndr. |volume=34 |issue= 2 |pages= 127-33 |year= 2003 |pmid= 14526201 |doi= }}
* {{cite journal | vauthors = Favre M, Butticaz C, Stevenson B, Jongeneel CV, Telenti A | title = High frequency of alternative splicing of human genes participating in the HIV-1 life cycle: a model using TSG101, betaTrCP, PPIA, INI1, NAF1, and PML | journal = Journal of Acquired Immune Deficiency Syndromes | volume = 34 | issue = 2 | pages = 127–33 | date = Oct 2003 | pmid = 14526201 | doi = 10.1097/00126334-200310010-00002 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = Feb 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Hoareau-Aveilla C, Bonoli M, Caizergues-Ferrer M, Henry Y | title = hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase | journal = RNA | volume = 12 | issue = 5 | pages = 832–40 | date = May 2006 | pmid = 16601202 | pmc = 1440901 | doi = 10.1261/rna.2344106 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Hoareau-Aveilla C, Bonoli M, Caizergues-Ferrer M, Henry Y |title=hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase. |journal=RNA |volume=12 |issue= 5 |pages= 832-40 |year= 2006 |pmid= 16601202 |doi= 10.1261/rna.2344106 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|TNIP1}}
* {{UCSC gene details|TNIP1}}

Latest revision as of 12:05, 15 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TNFAIP3-interacting protein 1 is a protein that in humans is encoded by the TNIP1 gene.[1][2][3]

Association with autoimmune diseases

Genetic variations within the region of the TNIP1 gene have been shown to have association with several autoimmune diseases:

Interactions

TNIP1 has been shown to interact with TNFAIP3[9] and MAPK1.[10]

References

  1. Fukushi M, Dixon J, Kimura T, Tsurutani N, Dixon MJ, Yamamoto N (Jan 1999). "Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression". FEBS Letters. 442 (1): 83–8. doi:10.1016/S0014-5793(98)01631-7. PMID 9923610.
  2. Gupta K, Ott D, Hope TJ, Siliciano RF, Boeke JD (Dec 2000). "A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions". Journal of Virology. 74 (24): 11811–24. doi:10.1128/JVI.74.24.11811-11824.2000. PMC 112464. PMID 11090181.
  3. "Entrez Gene: TNIP1 TNFAIP3 interacting protein 1".
  4. Allanore Y, Saad M, Dieudé P, Avouac J, Distler JH, Amouyel P, et al. (Jul 2011). "Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis". PLoS Genetics. 7 (7): e1002091. doi:10.1371/journal.pgen.1002091. PMC 3131285. PMID 21750679.
  5. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, et al. (Feb 2009). "Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways". Nature Genetics. 41 (2): 199–204. doi:10.1038/ng.311. PMC 2745122. PMID 19169254.
  6. Bowes J, Orozco G, Flynn E, Ho P, Brier R, Marzo-Ortega H, et al. (Sep 2011). "Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis". Annals of the Rheumatic Diseases. 70 (9): 1641–4. doi:10.1136/ard.2011.150102. PMC 3147229. PMID 21623003.
  7. Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, et al. (Nov 2009). "A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus". Nature Genetics. 41 (11): 1228–33. doi:10.1038/ng.468. PMC 2925843. PMID 19838195.
  8. Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, et al. (Nov 2009). "Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus". Nature Genetics. 41 (11): 1234–7. doi:10.1038/ng.472. PMID 19838193.
  9. Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R (Jun 1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". The Journal of Cell Biology. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526.
  10. Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, Nakajima T, Amagasa T, Enomoto S, Koike K, Miura O, Yamamoto N, Tsuchida N (Sep 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochemical and Biophysical Research Communications. 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. PMID 12220502.

Further reading

External links