MCC (gene): Difference between revisions

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{{Infobox_gene}}
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'''Colorectal mutant cancer protein''' is a [[protein]] that in humans is encoded by the ''MCC'' [[gene]].<ref name="pmid1848370">{{cite journal |vauthors=Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A | title = Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers | journal = Science | volume = 251 | issue = 4999 | pages = 1366–70 |date=Apr 1991 | pmid = 1848370 | pmc = | doi =10.1126/science.1848370  |display-authors=etal}}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Mutated in colorectal cancers
| HGNCid = 6935
| Symbol = MCC
| AltSymbols =; FLJ38893; FLJ46755; MCC1
| OMIM = 159350
| ECnumber = 
| Homologene = 20539
| MGIid = 
| GeneAtlas_image1 = PBB_GE_MCC_206132_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4163
    | Hs_Ensembl = ENSG00000171444
    | Hs_RefseqProtein = NP_002378
    | Hs_RefseqmRNA = NM_002387
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 112385695
    | Hs_GenLoc_end = 112852426
    | Hs_Uniprot = P23508
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Mutated in colorectal cancers''', also known as '''MCC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MCC mutated in colorectal cancers| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4163| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MCC mutated in colorectal cancers| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4163| accessdate = }}</ref>
| summary_text = This gene is a candidate colorectal [[tumor suppressor gene]] that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a [[phosphoprotein]] associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into [[S phase]]. Multiple transcript variants encoding different [[Gene isoform | isoforms]] have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MCC mutated in colorectal cancers| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4163| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Lindgren V, Bryke CR, Ozcelik T, ''et al.'' |title=Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis. |journal=Am. J. Hum. Genet. |volume=50 |issue= 5 |pages= 988-97 |year= 1992 |pmid= 1315124 |doi=  }}
*{{cite journal   |vauthors=Lindgren V, Bryke CR, Ozcelik T, etal |title=Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis |journal=Am. J. Hum. Genet. |volume=50 |issue= 5 |pages= 988–97 |year= 1992 |pmid= 1315124 |doi= | pmc=1682619 }}
*{{cite journal | author=Nishisho I, Nakamura Y, Miyoshi Y, ''et al.'' |title=Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. |journal=Science |volume=253 |issue= 5020 |pages= 665-9 |year= 1991 |pmid= 1651563 |doi=  }}
*{{cite journal   |vauthors=Nishisho I, Nakamura Y, Miyoshi Y, etal |title=Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients |journal=Science |volume=253 |issue= 5020 |pages= 665–9 |year= 1991 |pmid= 1651563 |doi=10.1126/science.1651563 }}
*{{cite journal  | author=Hoshino Y, Horikawa I, Oshimura M, Yuasa Y |title=Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity. |journal=Biochem. Biophys. Res. Commun. |volume=174 |issue= 1 |pages= 298-304 |year= 1991 |pmid= 1846539 |doi= }}
*{{cite journal  |vauthors=Hoshino Y, Horikawa I, Oshimura M, Yuasa Y |title=Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity |journal=Biochem. Biophys. Res. Commun. |volume=174 |issue= 1 |pages= 298–304 |year= 1991 |pmid= 1846539 |doi=10.1016/0006-291X(91)90520-H }}
*{{cite journal  | author=Kinzler KW, Nilbert MC, Vogelstein B, ''et al.'' |title=Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. |journal=Science |volume=251 |issue= 4999 |pages= 1366-70 |year= 1991 |pmid= 1848370 |doi= }}
*{{cite journal   |vauthors=Curtis LJ, Bubb VJ, Gledhill S, etal |title=Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer |journal=Hum. Mol. Genet. |volume=3 |issue= 3 |pages= 443–6 |year= 1994 |pmid= 8012355 |doi=10.1093/hmg/3.3.443 }}
*{{cite journal | author=Curtis LJ, Bubb VJ, Gledhill S, ''et al.'' |title=Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer. |journal=Hum. Mol. Genet. |volume=3 |issue= 3 |pages= 443-6 |year= 1994 |pmid= 8012355 |doi=  }}
*{{cite journal   |vauthors=Matsumine A, Senda T, Baeg GH, etal |title=MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10341–6 |year= 1996 |pmid= 8626604 |doi=10.1074/jbc.271.17.10341 }}
*{{cite journal | author=Matsumine A, Senda T, Baeg GH, ''et al.'' |title=MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10341-6 |year= 1996 |pmid= 8626604 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 19:06, 16 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.[1][2]

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. ↑ Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, et al. (Apr 1991). "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers". Science. 251 (4999): 1366–70. doi:10.1126/science.1848370. PMID 1848370.
  2. ↑ 2.0 2.1 "Entrez Gene: MCC mutated in colorectal cancers".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=MCC_(gene)&oldid=1420446"