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{{Infobox_gene}}
{{PBB_Controls
'''Tubulin polymerization-promoting protein''' is a [[protein]] that in humans is encoded by the ''TPPP'' [[gene]].<ref name="pmid10083737">{{cite journal | vauthors = Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T | title = A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3 | journal = J Hum Genet | volume = 44 | issue = 2 | pages = 121–2 |date=Apr 1999 | pmid = 10083737 | pmc =  | doi = 10.1007/s100380050122 }}</ref><ref name="pmid12093283">{{cite journal | vauthors = Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J | title = Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations | journal = Biochemistry | volume = 41 | issue = 27 | pages = 8657–64 |date=Jul 2002 | pmid = 12093283 | pmc =  | doi =10.1021/bi020140g  }}</ref><ref name="pmid15590652">{{cite journal | vauthors = Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH | title = p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies | journal = J Biol Chem | volume = 280 | issue = 7 | pages = 5703–15 |date=Feb 2005 | pmid = 15590652 | pmc =  | doi = 10.1074/jbc.M410409200 }}</ref><ref name="pmid17105200">{{cite journal | vauthors = Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J | title = Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions | journal = Biochemistry | volume = 45 | issue = 46 | pages = 13818–26 |date=Nov 2006 | pmid = 17105200 | pmc = | doi = 10.1021/bi061305e }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TPPP brain-specific protein p25 alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11076| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This protein has been linked to [[multiple sclerosis]] myelin lesions and [[cerebrospinal fluid|CSF]] abnormalities in [[multiple sclerosis]] patients.<ref name="pmid21565174">{{cite journal | vauthors = Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J | title = A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis | journal = Biochem. Biophys. Res. Commun. | volume = 409 | issue = 1 | pages = 137–41 |date=May 2011 | pmid = 21565174 | doi = 10.1016/j.bbrc.2011.04.130 }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Brain-specific protein p25 alpha
| HGNCid = 
| Symbol = TPPP
| AltSymbols =; p25; p24
| OMIM = 608773
| ECnumber = 
| Homologene = 21389
| MGIid = 1920198
| Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11076
    | Hs_Ensembl = ENSG00000171368
    | Hs_RefseqProtein = NP_008961
    | Hs_RefseqmRNA = NM_007030
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 712978
    | Hs_GenLoc_end = 746466
    | Hs_Uniprot = O94811
    | Mm_EntrezGene = 72948
    | Mm_Ensembl = ENSMUSG00000021573
    | Mm_RefseqmRNA = NM_182839
    | Mm_RefseqProtein = NP_878259
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 74475480
    | Mm_GenLoc_end = 74501755
    | Mm_Uniprot = Q3URG1
  }}
}}
'''Brain-specific protein p25 alpha''', also known as '''TPPP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TPPP brain-specific protein p25 alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11076| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
This has also been linked to Parkinson's and Alzheimer's Disease<ref>{{Cite journal|last=Kovács|first=Gábor G.|last2=László|first2=Lajos|last3=Kovács|first3=János|last4=Jensen|first4=Poul Henning|last5=Lindersson|first5=Evo|last6=Botond|first6=Gergő|last7=Molnár|first7=Tamás|last8=Perczel|first8=András|last9=Hudecz|first9=Ferenc|date=2004-11-01|title=Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies|url=http://www.sciencedirect.com/science/article/pii/S0969996104001366|journal=Neurobiology of Disease|volume=17|issue=2|pages=155–162|doi=10.1016/j.nbd.2004.06.006|pmid=|access-date=|via=}}</ref><ref>{{Cite journal|last=Kovács|first=Gábor G.|last2=Gelpi|first2=Ellen|last3=Lehotzky|first3=Attila|last4=Höftberger|first4=Romana|last5=Erdei|first5=Anna|last6=Budka|first6=Herbert|last7=Ovádi|first7=Judit|date=2006-11-23|title=The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases|url=https://link.springer.com/article/10.1007/s00401-006-0167-4|journal=Acta Neuropathologica|language=en|volume=113|issue=2|pages=153–161|doi=10.1007/s00401-006-0167-4|issn=0001-6322|pmid=17123092}}</ref>
{{PBB_Summary
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| summary_text =  
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
| citations =
*{{cite journal  | vauthors=Martín CP, Vázquez J, Avila J, Moreno FJ |title=P24, a glycogen synthase kinase 3 (GSK 3) inhibitor. |journal=Biochim. Biophys. Acta |volume=1586 |issue= 1 |pages= 113–22 |year= 2002 |pmid= 11781156 |doi= 10.1016/s0925-4439(01)00092-8 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Seki N, Hattori A, Sugano S, ''et al.'' |title=A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3. |journal=J. Hum. Genet. |volume=44 |issue= 2 |pages= 121-2 |year= 1999 |pmid= 10083737 |doi= }}
*{{cite journal   |vauthors=Tirián L, Hlavanda E, Oláh J, etal |title=TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 24 |pages= 13976–81 |year= 2004 |pmid= 14623963 |doi= 10.1073/pnas.2436331100 | pmc=283531 }}
*{{cite journal  | author=Martín CP, Vázquez J, Avila J, Moreno FJ |title=P24, a glycogen synthase kinase 3 (GSK 3) inhibitor. |journal=Biochim. Biophys. Acta |volume=1586 |issue= 1 |pages= 113-22 |year= 2002 |pmid= 11781156 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Hlavanda E, Kovács J, Oláh J, ''et al.'' |title=Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations. |journal=Biochemistry |volume=41 |issue= 27 |pages= 8657-64 |year= 2002 |pmid= 12093283 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Lehotzky A, Tirián L, Tökési N, etal |title=Dynamic targeting of microtubules by TPPP/p25 affects cell survival. |journal=J. Cell Sci. |volume=117 |issue= Pt 25 |pages= 6249–59 |year= 2005 |pmid= 15564385 |doi= 10.1242/jcs.01550 }}
*{{cite journal | author=Tirián L, Hlavanda E, Oláh J, ''et al.'' |title=TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 24 |pages= 13976-81 |year= 2004 |pmid= 14623963 |doi= 10.1073/pnas.2436331100 }}
*{{cite journal   |vauthors=DeGiorgis JA, Jaffe H, Moreira JE, etal |title=Phosphoproteomic analysis of synaptosomes from human cerebral cortex. |journal=J. Proteome Res. |volume=4 |issue= 2 |pages= 306–15 |year= 2005 |pmid= 15822905 |doi= 10.1021/pr0498436 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Jämsä A, Bäckström A, Gustafsson E, etal |title=Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells. |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 1 |pages= 324–31 |year= 2006 |pmid= 16678793 |doi= 10.1016/j.bbrc.2006.04.032 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Skjoerringe T, Lundvig DM, Jensen PH, Moos T |title=P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain. |journal=J. Neurochem. |volume=99 |issue= 1 |pages= 333–42 |year= 2006 |pmid= 16879710 |doi= 10.1111/j.1471-4159.2006.04073.x }}
*{{cite journal | author=Lehotzky A, Tirián L, Tökési N, ''et al.'' |title=Dynamic targeting of microtubules by TPPP/p25 affects cell survival. |journal=J. Cell. Sci. |volume=117 |issue= Pt 25 |pages= 6249-59 |year= 2005 |pmid= 15564385 |doi= 10.1242/jcs.01550 }}
*{{cite journal   |vauthors=Oláh J, Tokési N, Vincze O, etal |title=Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. |journal=FEBS Lett. |volume=580 |issue= 25 |pages= 5807–14 |year= 2006 |pmid= 17027006 |doi= 10.1016/j.febslet.2006.09.037 }}
*{{cite journal | author=Lindersson E, Lundvig D, Petersen C, ''et al.'' |title=p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5703-15 |year= 2005 |pmid= 15590652 |doi= 10.1074/jbc.M410409200 }}
*{{cite journal   |vauthors=Hlavanda E, Klement E, Kókai E, etal |title=Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases. |journal=J. Biol. Chem. |volume=282 |issue= 40 |pages= 29531–9 |year= 2007 |pmid= 17693641 |doi= 10.1074/jbc.M703466200 }}
*{{cite journal  | author=DeGiorgis JA, Jaffe H, Moreira JE, ''et al.'' |title=Phosphoproteomic analysis of synaptosomes from human cerebral cortex. |journal=J. Proteome Res. |volume=4 |issue= 2 |pages= 306-15 |year= 2005 |pmid= 15822905 |doi= 10.1021/pr0498436 }}
*{{cite journal   |vauthors=Song YJ, Lundvig DM, Huang Y, etal |title=p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy. |journal=Am. J. Pathol. |volume=171 |issue= 4 |pages= 1291–303 |year= 2007 |pmid= 17823288 |doi= 10.2353/ajpath.2007.070201 | pmc=1988878 }}
*{{cite journal | author=Jämsä A, Bäckström A, Gustafsson E, ''et al.'' |title=Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells. |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 1 |pages= 324-31 |year= 2006 |pmid= 16678793 |doi= 10.1016/j.bbrc.2006.04.032 }}
*{{cite journal  | author=Skjoerringe T, Lundvig DM, Jensen PH, Moos T |title=P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain. |journal=J. Neurochem. |volume=99 |issue= 1 |pages= 333-42 |year= 2006 |pmid= 16879710 |doi= 10.1111/j.1471-4159.2006.04073.x }}
*{{cite journal | author=Oláh J, Tokési N, Vincze O, ''et al.'' |title=Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. |journal=FEBS Lett. |volume=580 |issue= 25 |pages= 5807-14 |year= 2006 |pmid= 17027006 |doi= 10.1016/j.febslet.2006.09.037 }}
*{{cite journal | author=Vincze O, Tökési N, Oláh J, ''et al.'' |title=Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. |journal=Biochemistry |volume=45 |issue= 46 |pages= 13818-26 |year= 2007 |pmid= 17105200 |doi= 10.1021/bi061305e }}
*{{cite journal  | author=Hlavanda E, Klement E, Kókai E, ''et al.'' |title=Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases. |journal=J. Biol. Chem. |volume=282 |issue= 40 |pages= 29531-9 |year= 2007 |pmid= 17693641 |doi= 10.1074/jbc.M703466200 }}
*{{cite journal | author=Song YJ, Lundvig DM, Huang Y, ''et al.'' |title=p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy. |journal=Am. J. Pathol. |volume=171 |issue= 4 |pages= 1291-303 |year= 2007 |pmid= 17823288 |doi= 10.2353/ajpath.2007.070201 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
{{gene-5-stub}}

Latest revision as of 21:01, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene.[1][2][3][4][5]

This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients.[6]

This has also been linked to Parkinson's and Alzheimer's Disease[7][8]

References

  1. ↑ Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T (Apr 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". J Hum Genet. 44 (2): 121–2. doi:10.1007/s100380050122. PMID 10083737.
  2. ↑ Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (Jul 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. 41 (27): 8657–64. doi:10.1021/bi020140g. PMID 12093283.
  3. ↑ Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem. 280 (7): 5703–15. doi:10.1074/jbc.M410409200. PMID 15590652.
  4. ↑ Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J (Nov 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. 45 (46): 13818–26. doi:10.1021/bi061305e. PMID 17105200.
  5. ↑ "Entrez Gene: TPPP brain-specific protein p25 alpha".
  6. ↑ Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochem. Biophys. Res. Commun. 409 (1): 137–41. doi:10.1016/j.bbrc.2011.04.130. PMID 21565174.
  7. ↑ Kovács, Gábor G.; László, Lajos; Kovács, János; Jensen, Poul Henning; Lindersson, Evo; Botond, Gergő; Molnár, Tamás; Perczel, András; Hudecz, Ferenc (2004-11-01). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. 17 (2): 155–162. doi:10.1016/j.nbd.2004.06.006.
  8. ↑ Kovács, Gábor G.; Gelpi, Ellen; Lehotzky, Attila; Höftberger, Romana; Erdei, Anna; Budka, Herbert; Ovádi, Judit (2006-11-23). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica. 113 (2): 153–161. doi:10.1007/s00401-006-0167-4. ISSN 0001-6322. PMID 17123092.

Further reading


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