FBXO4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''F-box only protein 4''' is a [[protein]] that in humans is encoded by the ''FBXO4'' [[gene]].<ref name="pmid10531035">{{cite journal | vauthors = Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M | title = Identification of a family of human F-box proteins | journal = Curr Biol | volume = 9 | issue = 20 | pages = 1177–9 | date = Dec 1999 | pmid = 10531035 | pmc =  | doi = 10.1016/S0960-9822(00)80020-2 }}</ref><ref name="pmid10531037">{{cite journal | vauthors = Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW | title = A family of mammalian F-box proteins | journal = Curr Biol | volume = 9 | issue = 20 | pages = 1180–2 | date = Dec 1999 | pmid = 10531037 | pmc =  | doi = 10.1016/S0960-9822(00)80021-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FBXO4 F-box protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26272| accessdate = }}</ref>
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| update_protein_box = yes
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== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = F-box protein 4
| HGNCid = 13583
| Symbol = FBXO4
| AltSymbols =; DKFZp547N213; FBX4; FLJ10141
| OMIM = 609090
| ECnumber = 
| Homologene = 8134
| MGIid = 2146220
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}}
| Process = {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26272
    | Hs_Ensembl = ENSG00000151876
    | Hs_RefseqProtein = NP_036308
    | Hs_RefseqmRNA = NM_012176
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 41961113
    | Hs_GenLoc_end = 41977602
    | Hs_Uniprot = Q9UKT5
    | Mm_EntrezGene = 106052
    | Mm_Ensembl = ENSMUSG00000022184
    | Mm_RefseqmRNA = NM_134099
    | Mm_RefseqProtein = NP_598860
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 3915461
    | Mm_GenLoc_end = 3929573
    | Mm_Uniprot = Q8CHQ0
  }}
}}
'''F-box protein 4''', also known as '''FBXO4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FBXO4 F-box protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26272| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the [[ubiquitin ligase]] complex called SCFs (SKP1-cullin-F-box), which function in [[phosphorylation]]-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing [[WD-40 domain]]s, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: FBXO4 F-box protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26272| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
FBXO4 has been shown to [[Protein-protein interaction|interact]] with:
* [[CUL1]],<ref name = pmid10531035/><ref name = pmid17353931/> and
* [[SKP1A]].<ref name = pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue =  | pages = 89 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name = autogenerated1>{{cite journal | vauthors = Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M | title = Identification of a family of human F-box proteins | journal = Curr. Biol. | volume = 9 | issue = 20 | pages = 1177–9 | date = Oct 1999 | pmid = 10531035 | doi = 10.1016/S0960-9822(00)80020-2 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M | title = Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors | journal = Cytogenet. Cell Genet. | volume = 88 | issue = 3–4 | pages = 255–8 | year = 2000 | pmid = 10828603 | doi = 10.1159/000015532 }}
| citations =
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, ''et al.'' |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177-9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2 }}
* {{cite journal | vauthors = Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW | title = Systematic analysis and nomenclature of mammalian F-box proteins | journal = Genes Dev. | volume = 18 | issue = 21 | pages = 2573–80 | year = 2005 | pmid = 15520277 | pmc = 525538 | doi = 10.1101/gad.1255304 }}
*{{cite journal  | author=Winston JT, Koepp DM, Zhu C, ''et al.'' |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180-2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4 }}
* {{cite journal | vauthors = Lee TH, Perrem K, Harper JW, Lu KP, Zhou XZ | title = The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance | journal = J. Biol. Chem. | volume = 281 | issue = 2 | pages = 759–68 | year = 2006 | pmid = 16275645 | doi = 10.1074/jbc.M509855200 }}
*{{cite journal  | author=Chiaur DS, Murthy S, Cenciarelli C, ''et al.'' |title=Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 255-8 |year= 2000 |pmid= 10828603 |doi=  }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A, Nimer SD | title = The ETS Protein MEF Is Regulated by Phosphorylation-Dependent Proteolysis via the Protein-Ubiquitin Ligase SCFSkp2 | journal = Mol. Cell. Biol. | volume = 26 | issue = 8 | pages = 3114–23 | year = 2006 | pmid = 16581786 | pmc = 1446966 | doi = 10.1128/MCB.26.8.3114-3123.2006 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJ, Rustgi A, Fuchs SY, Diehl JA | title = Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-αBcrystallin complex | journal = Mol. Cell | volume = 24 | issue = 3 | pages = 355–66 | year = 2006 | pmid = 17081987 | pmc = 1702390 | doi = 10.1016/j.molcel.2006.09.007 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein–protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Jin J, Cardozo T, Lovering RC, ''et al.'' |title=Systematic analysis and nomenclature of mammalian F-box proteins. |journal=Genes Dev. |volume=18 |issue= 21 |pages= 2573-80 |year= 2005 |pmid= 15520277 |doi= 10.1101/gad.1255304 }}
*{{cite journal | author=Lee TH, Perrem K, Harper JW, ''et al.'' |title=The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. |journal=J. Biol. Chem. |volume=281 |issue= 2 |pages= 759-68 |year= 2006 |pmid= 16275645 |doi= 10.1074/jbc.M509855200 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Liu Y, Hedvat CV, Mao S, ''et al.'' |title=The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. |journal=Mol. Cell. Biol. |volume=26 |issue= 8 |pages= 3114-23 |year= 2006 |pmid= 16581786 |doi= 10.1128/MCB.26.8.3114-3123.2006 }}
*{{cite journal | author=Lin DI, Barbash O, Kumar KG, ''et al.'' |title=Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. |journal=Mol. Cell |volume=24 |issue= 3 |pages= 355-66 |year= 2006 |pmid= 17081987 |doi= 10.1016/j.molcel.2006.09.007 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 04:41, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

F-box only protein 4 is a protein that in humans is encoded by the FBXO4 gene.[1][2][3]

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.[3]

Interactions

FBXO4 has been shown to interact with:

References

  1. ↑ 1.0 1.1 Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
  2. ↑ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
  3. ↑ 3.0 3.1 "Entrez Gene: FBXO4 F-box protein 4".
  4. ↑ 4.0 4.1 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  5. ↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

Further reading


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