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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''DNA polymerase kappa''' is an [[DNA polymerase]] that in humans is encoded by the ''POLK'' [[gene]]. It is involved in [[translesion synthesis]].<ref name="pmid10887153">{{cite journal | vauthors = Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H | title = Error-prone bypass of certain DNA lesions by the human DNA polymerase κ | journal = Genes Dev | volume = 14 | issue = 13 | pages = 1589–94 |date=Aug 2000 | pmid = 10887153 | pmc = 316741 | doi = 10.1101/gad.14.13.1589 }}</ref><ref name="pmid10518552">{{cite journal | vauthors = Gerlach VL, Aravind L, Gotway G, Schultz RA, Koonin EV, Friedberg EC | title = Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 21 | pages = 11922–7 |date=Nov 1999 | pmid = 10518552 | pmc = 18388 | doi =10.1073/pnas.96.21.11922 }}</ref><ref>{{cite web | title = Entrez Gene: POLK Polymerase (DNA directed) kappa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51426| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_POLK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1t94.
| PDB = {{PDB2|1t94}}, {{PDB2|2oh2}}
| Name = Polymerase (DNA directed) kappa
| HGNCid = 9183
| Symbol = POLK
| AltSymbols =; POLQ; DINB1; DINP
| OMIM = 605650
| ECnumber = 
| Homologene = 32140
| MGIid = 1349767
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003887 |text = DNA-directed DNA polymerase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006280 |text = mutagenesis}} {{GNF_GO|id=GO:0006281 |text = DNA repair}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51426
    | Hs_Ensembl = ENSG00000122008
    | Hs_RefseqProtein = NP_057302
    | Hs_RefseqmRNA = NM_016218
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 74843337
    | Hs_GenLoc_end = 74932725
    | Hs_Uniprot = Q9UBT6
    | Mm_EntrezGene = 27015
    | Mm_Ensembl = ENSMUSG00000021668
    | Mm_RefseqmRNA = NM_012048
    | Mm_RefseqProtein = NP_036178
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 97581386
    | Mm_GenLoc_end = 97643184
    | Mm_Uniprot = Q5Q9H2
  }}
}}
'''Polymerase (DNA directed) kappa''', also known as '''POLK''', is a human [[gene]].<ref>{{cite web | title = Entrez Gene: POLK Polymerase (DNA directed) kappa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51426| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bavoux C, Hoffmann JS, Cazaux C |title=Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa. |journal=Biochimie |volume=87 |issue= 7 |pages= 637-46 |year= 2005 |pmid= 15989980 |doi= 10.1016/j.biochi.2005.02.007 }}
*{{cite journal  | vauthors=Bavoux C, Hoffmann JS, Cazaux C |title=Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa |journal=Biochimie |volume=87 |issue= 7 |pages= 637–46 |year= 2005 |pmid= 15989980 |doi= 10.1016/j.biochi.2005.02.007 }}
*{{cite journal  | author=Gerlach VL, Aravind L, Gotway G, ''et al.'' |title=Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 21 |pages= 11922-7 |year= 1999 |pmid= 10518552 |doi= }}
*{{cite journal  | vauthors=Ogi T, Kato T, Kato T, Ohmori H |title=Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB |journal=Genes Cells |volume=4 |issue= 11 |pages= 607–18 |year= 2000 |pmid= 10620008 |doi=10.1046/j.1365-2443.1999.00289.x  }}
*{{cite journal  | author=Ogi T, Kato T, Kato T, Ohmori H |title=Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB. |journal=Genes Cells |volume=4 |issue= 11 |pages= 607-18 |year= 2000 |pmid= 10620008 |doi= }}
*{{cite journal  | vauthors=Johnson RE, Prakash S, Prakash L |title=The human DINB1 gene encodes the DNA polymerase Polθ |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 3838–43 |year= 2000 |pmid= 10760255 |doi=10.1073/pnas.97.8.3838  | pmc=18103  }}
*{{cite journal  | author=Johnson RE, Prakash S, Prakash L |title=The human DINB1 gene encodes the DNA polymerase Poltheta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 3838-43 |year= 2000 |pmid= 10760255 |doi= }}
*{{cite journal  | vauthors=Gerlach VL, Feaver WJ, Fischhaber PL, Friedberg EC |title=Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 92–8 |year= 2001 |pmid= 11024016 |doi= 10.1074/jbc.M004413200 }}
*{{cite journal | author=Ohashi E, Ogi T, Kusumoto R, ''et al.'' |title=Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa. |journal=Genes Dev. |volume=14 |issue= 13 |pages= 1589-94 |year= 2000 |pmid= 10887153 |doi= }}
*{{cite journal   |vauthors=Haracska L, Unk I, Johnson RE, etal |title=Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 784–91 |year= 2002 |pmid= 11784855 |doi=10.1128/MCB.22.3.784-791.2002  | pmc=133560  }}
*{{cite journal  | author=Gerlach VL, Feaver WJ, Fischhaber PL, Friedberg EC |title=Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 92-8 |year= 2001 |pmid= 11024016 |doi= 10.1074/jbc.M004413200 }}
*{{cite journal  | vauthors=Washington MT, Johnson RE, Prakash L, Prakash S |title=Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 4 |pages= 1910–4 |year= 2002 |pmid= 11842189 |doi= 10.1073/pnas.032594399  | pmc=122293 }}
*{{cite journal | author=Haracska L, Unk I, Johnson RE, ''et al.'' |title=Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 784-91 |year= 2002 |pmid= 11784855 |doi=  }}
*{{cite journal   |vauthors=Suzuki N, Ohashi E, Kolbanovskiy A, etal |title=Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(−)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene) |journal=Biochemistry |volume=41 |issue= 19 |pages= 6100–6 |year= 2002 |pmid= 11994005 |doi=10.1021/bi020049c  }}
*{{cite journal  | author=Washington MT, Johnson RE, Prakash L, Prakash S |title=Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 4 |pages= 1910-4 |year= 2002 |pmid= 11842189 |doi= 10.1073/pnas.032594399 }}
*{{cite journal   |vauthors=Fischhaber PL, Gerlach VL, Feaver WJ, etal |title=Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37604–11 |year= 2002 |pmid= 12145297 |doi= 10.1074/jbc.M206027200 }}
*{{cite journal | author=Suzuki N, Ohashi E, Kolbanovskiy A, ''et al.'' |title=Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene). |journal=Biochemistry |volume=41 |issue= 19 |pages= 6100-6 |year= 2002 |pmid= 11994005 |doi=  }}
*{{cite journal  |vauthors=Bergoglio V, Bavoux C, Verbiest V, etal |title=Localisation of human DNA polymerase kappa to replication foci |journal=J. Cell Sci. |volume=115 |issue= Pt 23 |pages= 4413–8 |year= 2003 |pmid= 12414988 |doi=10.1242/jcs.00162 }}
*{{cite journal  | author=Fischhaber PL, Gerlach VL, Feaver WJ, ''et al.'' |title=Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37604-11 |year= 2002 |pmid= 12145297 |doi= 10.1074/jbc.M206027200 }}
*{{cite journal  | vauthors=Haracska L, Prakash L, Prakash S |title=Role of human DNA polymerase κ as an extender in translesion synthesis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 25 |pages= 16000–5 |year= 2003 |pmid= 12444249 |doi= 10.1073/pnas.252524999  | pmc=138554 }}
*{{cite journal | author=Bergoglio V, Bavoux C, Verbiest V, ''et al.'' |title=Localisation of human DNA polymerase kappa to replication foci. |journal=J. Cell. Sci. |volume=115 |issue= Pt 23 |pages= 4413-8 |year= 2003 |pmid= 12414988 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Haracska L, Prakash L, Prakash S |title=Role of human DNA polymerase kappa as an extender in translesion synthesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 25 |pages= 16000-5 |year= 2003 |pmid= 12444249 |doi= 10.1073/pnas.252524999 }}
*{{cite journal  | vauthors=Wolfle WT, Washington MT, Prakash L, Prakash S |title=Human DNA polymerase κ uses template–primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions |journal=Genes Dev. |volume=17 |issue= 17 |pages= 2191–9 |year= 2003 |pmid= 12952891 |doi= 10.1101/gad.1108603  | pmc=196459 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Haracska L, Prakash L, Prakash S |title=A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair |journal=Genes Dev. |volume=17 |issue= 22 |pages= 2777–85 |year= 2003 |pmid= 14630940 |doi= 10.1101/gad.1146103  | pmc=280626 }}
*{{cite journal | author=Wolfle WT, Washington MT, Prakash L, Prakash S |title=Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions. |journal=Genes Dev. |volume=17 |issue= 17 |pages= 2191-9 |year= 2003 |pmid= 12952891 |doi= 10.1101/gad.1108603 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Haracska L, Prakash L, Prakash S |title=A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair. |journal=Genes Dev. |volume=17 |issue= 22 |pages= 2777-85 |year= 2003 |pmid= 14630940 |doi= 10.1101/gad.1146103 }}
*{{cite journal   |vauthors=Suzuki N, Itoh S, Poon K, etal |title=Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa |journal=Biochemistry |volume=43 |issue= 20 |pages= 6304–11 |year= 2004 |pmid= 15147214 |doi= 10.1021/bi0360298 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ohashi E, Murakumo Y, Kanjo N, etal |title=Interaction of hREV1 with three human Y-family DNA polymerases |journal=Genes Cells |volume=9 |issue= 6 |pages= 523–31 |year= 2005 |pmid= 15189446 |doi= 10.1111/j.1356-9597.2004.00747.x }}
*{{cite journal | author=Suzuki N, Itoh S, Poon K, ''et al.'' |title=Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa. |journal=Biochemistry |volume=43 |issue= 20 |pages= 6304-11 |year= 2004 |pmid= 15147214 |doi= 10.1021/bi0360298 }}
*{{cite journal   |vauthors=Washington MT, Minko IG, Johnson RE, etal |title=Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ |journal=Mol. Cell. Biol. |volume=24 |issue= 13 |pages= 5687–93 |year= 2004 |pmid= 15199127 |doi= 10.1128/MCB.24.13.5687-5693.2004  | pmc=480884 }}
*{{cite journal  | author=Ohashi E, Murakumo Y, Kanjo N, ''et al.'' |title=Interaction of hREV1 with three human Y-family DNA polymerases. |journal=Genes Cells |volume=9 |issue= 6 |pages= 523-31 |year= 2005 |pmid= 15189446 |doi= 10.1111/j.1356-9597.2004.00747.x }}
*{{cite journal   |vauthors=Uljon SN, Johnson RE, Edwards TA, etal |title=Crystal structure of the catalytic core of human DNA polymerase kappa |journal=Structure |volume=12 |issue= 8 |pages= 1395–404 |year= 2005 |pmid= 15296733 |doi= 10.1016/j.str.2004.05.011 }}
*{{cite journal  | author=Washington MT, Minko IG, Johnson RE, ''et al.'' |title=Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. |journal=Mol. Cell. Biol. |volume=24 |issue= 13 |pages= 5687-93 |year= 2004 |pmid= 15199127 |doi= 10.1128/MCB.24.13.5687-5693.2004 }}
*{{cite journal | author=Uljon SN, Johnson RE, Edwards TA, ''et al.'' |title=Crystal structure of the catalytic core of human DNA polymerase kappa. |journal=Structure |volume=12 |issue= 8 |pages= 1395-404 |year= 2005 |pmid= 15296733 |doi= 10.1016/j.str.2004.05.011 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=51426}}
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[[Category:DNA repair]]
[[Category:DNA-binding proteins]]


{{protein-stub}}
{{gene-5-stub}}
{{WikiDoc Sources}}

Revision as of 20:35, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA polymerase kappa is an DNA polymerase that in humans is encoded by the POLK gene. It is involved in translesion synthesis.[1][2][3]


References

  1. Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H (Aug 2000). "Error-prone bypass of certain DNA lesions by the human DNA polymerase κ". Genes Dev. 14 (13): 1589–94. doi:10.1101/gad.14.13.1589. PMC 316741. PMID 10887153.
  2. Gerlach VL, Aravind L, Gotway G, Schultz RA, Koonin EV, Friedberg EC (Nov 1999). "Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily". Proc Natl Acad Sci U S A. 96 (21): 11922–7. doi:10.1073/pnas.96.21.11922. PMC 18388. PMID 10518552.
  3. "Entrez Gene: POLK Polymerase (DNA directed) kappa".

Further reading