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{{ | '''Golgi-associated PDZ and coiled-coil motif-containing protein''' is a [[protein]] that in humans is encoded by the ''GOPC'' [[gene]].<ref name="pmid11162552">{{cite journal |vauthors=Neudauer CL, Joberty G, Macara IG | title = PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10 | journal = Biochem Biophys Res Commun | volume = 280 | issue = 2 | pages = 541–7 |date=Feb 2001 | pmid = 11162552 | pmc = | doi = 10.1006/bbrc.2000.4160 }}</ref><ref name="pmid11520064">{{cite journal |vauthors=Yao R, Maeda T, Takada S, Noda T | title = Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled | journal = Biochem Biophys Res Commun | volume = 286 | issue = 4 | pages = 771–8 |date=Aug 2001 | pmid = 11520064 | pmc = | doi = 10.1006/bbrc.2001.5430 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57120| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM]<ref name="entrez" | | summary_text = PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM]<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
GOPC has been shown to [[Protein-protein interaction|interact]] with [[GRID2]],<ref name=pmid12372286>{{cite journal |last=Yue |first=Zhenyu |authorlink= |author2=Horton Antony |author3=Bravin Monica |author4=DeJager Philip L |author5=Selimi Fekrije |author6=Heintz Nathaniel |date=Aug 2002 |title=A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice |journal=Neuron |volume=35 |issue=5 |pages=921–33 |publisher= |location = United States| issn = 0896-6273| pmid = 12372286 |doi=10.1016/S0896-6273(02)00861-9 }}</ref> [[BECN1]],<ref name=pmid12372286/> [[RHOQ]],<ref name=pmid11162552 />[[ACCN3]],<ref name=pmid15317815>{{cite journal |last=Hruska-Hageman |first=Alesia M |authorlink= |author2=Benson Christopher J |author3=Leonard A Soren |author4=Price Margaret P |author5=Welsh Michael J |date=Nov 2004 |title=PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current |journal=J. Biol. Chem. |volume=279 |issue=45 |pages=46962–8 |publisher= |location = United States| issn = 0021-9258| pmid = 15317815 |doi = 10.1074/jbc.M405874200 }}</ref> [[Cystic fibrosis transmembrane conductance regulator]]<ref name=pmid11707463>{{cite journal |last=Cheng |first=Jie |authorlink= |author2=Moyer Bryan D |author3=Milewski Michal |author4=Loffing Johannes |author5=Ikeda Masahiro |author6=Mickle John E |author7=Cutting Garry R |author8=Li Min |author9=Stanton Bruce A |author10=Guggino William B |date=Feb 2002 |title=A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression |journal=J. Biol. Chem. |volume=277 |issue=5 |pages=3520–9 |publisher= |location = United States| issn = 0021-9258| pmid = 11707463 |doi = 10.1074/jbc.M110177200 }}</ref><ref name=pmid12471024>{{cite journal |last=Gentzsch |first=Martina |authorlink= |author2=Cui Liying |author3=Mengos April |author4=Chang Xiu-Bao |author5=Chen Jey-Hsin |author6=Riordan John R |date=Feb 2003 |title=The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins |journal=J. Biol. Chem. |volume=278 |issue=8 |pages=6440–9 |publisher= |location = United States| issn = 0021-9258| pmid = 12471024 |doi = 10.1074/jbc.M211050200 }}</ref> and [[CSPG5]].<ref name=pmid12885772>{{cite journal |last=Hassel |first=Burkhard |authorlink= |author2=Schreff Matthias |author3=Stube Eva-Maria |author4=Blaich Uta |author5=Schumacher Stefan |date=Oct 2003 |title=CALEB/NGC interacts with the Golgi-associated protein PIST |journal=J. Biol. Chem. |volume=278 |issue=41 |pages=40136–43 |publisher= |location = United States| issn = 0021-9258| pmid = 12885772 |doi = 10.1074/jbc.M305577200 }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Loo MA, Jensen TJ, Cui L |title=Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome |journal=EMBO J. |volume=17 |issue= 23 |pages= 6879–87 |year= 1999 |pmid= 9843494 |doi= 10.1093/emboj/17.23.6879 | pmc=1171036 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Charest A, Lane K, McMahon K, Housman DE |title=Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6 |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29456–65 |year= 2001 |pmid= 11384996 |doi= 10.1074/jbc.M104137200 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Cheng J, Moyer BD, Milewski M |title=A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3520–9 |year= 2002 |pmid= 11707463 |doi= 10.1074/jbc.M110177200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Yao R, Ito C, Natsume Y |title=Lack of acrosome formation in mice lacking a Golgi protein, GOPC |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 17 |pages= 11211–6 |year= 2002 |pmid= 12149515 |doi= 10.1073/pnas.162027899 | pmc=123235 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Yue Z, Horton A, Bravin M |title=A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice |journal=Neuron |volume=35 |issue= 5 |pages= 921–33 |year= 2002 |pmid= 12372286 |doi=10.1016/S0896-6273(02)00861-9 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Gentzsch M, Cui L, Mengos A |title=The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6440–9 |year= 2003 |pmid= 12471024 |doi= 10.1074/jbc.M211050200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Charest A, Kheifets V, Park J |title=Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 916–21 |year= 2003 |pmid= 12538861 |doi= 10.1073/pnas.242741799 | pmc=298701 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Charest A, Lane K, McMahon K |title=Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21) |journal=Genes Chromosomes Cancer |volume=37 |issue= 1 |pages= 58–71 |year= 2003 |pmid= 12661006 |doi= 10.1002/gcc.10207 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Hassel B, Schreff M, Stube EM |title=CALEB/NGC interacts with the Golgi-associated protein PIST |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 40136–43 |year= 2003 |pmid= 12885772 |doi= 10.1074/jbc.M305577200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Cheng J, Wang H, Guggino WB |title=Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL |journal=J. Biol. Chem. |volume=279 |issue= 3 |pages= 1892–8 |year= 2004 |pmid= 14570915 |doi= 10.1074/jbc.M308640200 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Brill LM, Salomon AR, Ficarro SB |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Hruska-Hageman AM, Benson CJ, Leonard AS |title=PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46962–8 |year= 2004 |pmid= 15317815 |doi= 10.1074/jbc.M405874200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=He J, Bellini M, Xu J |title=Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression |journal=J. Biol. Chem. |volume=279 |issue= 48 |pages= 50190–6 |year= 2005 |pmid= 15358775 |doi= 10.1074/jbc.M404876200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal |vauthors=Cheng J, Wang H, Guggino WB |title=Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10 |journal=J. Biol. Chem. |volume=280 |issue= 5 |pages= 3731–9 |year= 2005 |pmid= 15546864 |doi= 10.1074/jbc.M410026200 }} | |||
*{{cite journal |vauthors=Hicks SW, Machamer CE |title=Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 28944–51 |year= 2005 |pmid= 15951434 |doi= 10.1074/jbc.M504937200 }} | |||
*{{cite journal | | |||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=57120}} | |||
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{{ | {{gene-6-stub}} | ||
Latest revision as of 08:54, 31 August 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.[1][2][3]
PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM][3]
Interactions
GOPC has been shown to interact with GRID2,[4] BECN1,[4] RHOQ,[1]ACCN3,[5] Cystic fibrosis transmembrane conductance regulator[6][7] and CSPG5.[8]
References
- ↑ 1.0 1.1 Neudauer CL, Joberty G, Macara IG (Feb 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem Biophys Res Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
- ↑ Yao R, Maeda T, Takada S, Noda T (Aug 2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem Biophys Res Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064.
- ↑ 3.0 3.1 "Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing".
- ↑ 4.0 4.1 Yue, Zhenyu; Horton Antony; Bravin Monica; DeJager Philip L; Selimi Fekrije; Heintz Nathaniel (Aug 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. United States. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. ISSN 0896-6273. PMID 12372286.
- ↑ Hruska-Hageman, Alesia M; Benson Christopher J; Leonard A Soren; Price Margaret P; Welsh Michael J (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. United States. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. ISSN 0021-9258. PMID 15317815.
- ↑ Cheng, Jie; Moyer Bryan D; Milewski Michal; Loffing Johannes; Ikeda Masahiro; Mickle John E; Cutting Garry R; Li Min; Stanton Bruce A; Guggino William B (Feb 2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression". J. Biol. Chem. United States. 277 (5): 3520–9. doi:10.1074/jbc.M110177200. ISSN 0021-9258. PMID 11707463.
- ↑ Gentzsch, Martina; Cui Liying; Mengos April; Chang Xiu-Bao; Chen Jey-Hsin; Riordan John R (Feb 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. United States. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. ISSN 0021-9258. PMID 12471024.
- ↑ Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. United States. 278 (41): 40136–43. doi:10.1074/jbc.M305577200. ISSN 0021-9258. PMID 12885772.
Further reading
- Loo MA, Jensen TJ, Cui L, et al. (1999). "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome". EMBO J. 17 (23): 6879–87. doi:10.1093/emboj/17.23.6879. PMC 1171036. PMID 9843494.
- Charest A, Lane K, McMahon K, Housman DE (2001). "Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6". J. Biol. Chem. 276 (31): 29456–65. doi:10.1074/jbc.M104137200. PMID 11384996.
- Cheng J, Moyer BD, Milewski M, et al. (2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression". J. Biol. Chem. 277 (5): 3520–9. doi:10.1074/jbc.M110177200. PMID 11707463.
- Yao R, Ito C, Natsume Y, et al. (2002). "Lack of acrosome formation in mice lacking a Golgi protein, GOPC". Proc. Natl. Acad. Sci. U.S.A. 99 (17): 11211–6. doi:10.1073/pnas.162027899. PMC 123235. PMID 12149515.
- Yue Z, Horton A, Bravin M, et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. PMID 12372286.
- Gentzsch M, Cui L, Mengos A, et al. (2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. PMID 12471024.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Charest A, Kheifets V, Park J, et al. (2003). "Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 916–21. doi:10.1073/pnas.242741799. PMC 298701. PMID 12538861.
- Charest A, Lane K, McMahon K, et al. (2003). "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)". Genes Chromosomes Cancer. 37 (1): 58–71. doi:10.1002/gcc.10207. PMID 12661006.
- Hassel B, Schreff M, Stube EM, et al. (2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. 278 (41): 40136–43. doi:10.1074/jbc.M305577200. PMID 12885772.
- Cheng J, Wang H, Guggino WB (2004). "Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL". J. Biol. Chem. 279 (3): 1892–8. doi:10.1074/jbc.M308640200. PMID 14570915.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
- Hruska-Hageman AM, Benson CJ, Leonard AS, et al. (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
- He J, Bellini M, Xu J, et al. (2005). "Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression". J. Biol. Chem. 279 (48): 50190–6. doi:10.1074/jbc.M404876200. PMID 15358775.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Cheng J, Wang H, Guggino WB (2005). "Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10". J. Biol. Chem. 280 (5): 3731–9. doi:10.1074/jbc.M410026200. PMID 15546864.
- Hicks SW, Machamer CE (2005). "Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST". J. Biol. Chem. 280 (32): 28944–51. doi:10.1074/jbc.M504937200. PMID 15951434.
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