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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''TRAF and TNF receptor-associated protein''' is a [[protein]] that in humans is encoded by the ''TTRAP'' [[gene]].<ref name="pmid11478795">{{cite journal | vauthors = Rodrigues-Lima F, Josephs M, Katan M, Cassinat B | title = Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases | journal = Biochem. Biophys. Res. Commun. | volume = 285 | issue = 5 | pages = 1274–9  | date = July 2001 | pmid = 11478795 | pmc =  | doi = 10.1006/bbrc.2001.5328 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TTRAP TRAF and TNF receptor associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51567| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = TRAF and TNF receptor associated protein
| HGNCid = 17768
| Symbol = TTRAP
| AltSymbols =; EAP2; AD022; MGC111021; MGC9099; dJ30M3.3
| OMIM = 605764
| ECnumber = 
| Homologene = 9591
| MGIid = 1860486
| GeneAtlas_image1 = PBB_GE_TTRAP_202266_at_tn.png
| Function = {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51567
    | Hs_Ensembl = ENSG00000111802
    | Hs_RefseqProtein = NP_057698
    | Hs_RefseqmRNA = NM_016614
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 24758184
    | Hs_GenLoc_end = 24775240
    | Hs_Uniprot = O95551
    | Mm_EntrezGene = 56196
    | Mm_Ensembl = ENSMUSG00000035958
    | Mm_RefseqmRNA = NM_019551
    | Mm_RefseqProtein = NP_062424
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 24839150
    | Mm_GenLoc_end = 24849611
    | Mm_Uniprot = Q3TIU5
  }}
}}
'''TRAF and TNF receptor associated protein''', also known as '''TTRAP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TTRAP TRAF and TNF receptor associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51567| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.<ref name="entrez">{{cite web | title = Entrez Gene: TTRAP TRAF and TNF receptor associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51567| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TTRAP has been shown to [[Protein-protein interaction|interact]] with [[ETS1]],<ref name=pmid12743594>{{cite journal | vauthors = Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R | title = EAPII interacts with ETS1 and modulates its transcriptional function | journal = Oncogene | volume = 22 | issue = 18 | pages = 2699–709  | date = May 2003 | pmid = 12743594 | doi = 10.1038/sj.onc.1206374 }}</ref> [[TNFRSF1B]]<ref name=pmid10764746>{{cite journal | vauthors = Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE | title = TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation | journal = J. Biol. Chem. | volume = 275 | issue = 24 | pages = 18586–93  | date = June 2000 | pmid = 10764746 | doi = 10.1074/jbc.M000531200 }}</ref> and [[CD40 (protein)|CD40]].<ref name=pmid10764746/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE | title = TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation | journal = J. Biol. Chem. | volume = 275 | issue = 24 | pages = 18586–93 | year = 2000 | pmid = 10764746 | doi = 10.1074/jbc.M000531200 }}
| citations =
* {{cite journal | vauthors = Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL | title = Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 17 | pages = 9543–8 | year = 2000 | pmid = 10931946 | pmc = 16901 | doi = 10.1073/pnas.160270997 }}
*{{cite journal | author=Pype S, Declercq W, Ibrahimi A, ''et al.'' |title=TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18586-93 |year= 2000 |pmid= 10764746 |doi= 10.1074/jbc.M000531200 }}
* {{cite journal | vauthors = Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R | title = EAPII interacts with ETS1 and modulates its transcriptional function | journal = Oncogene | volume = 22 | issue = 18 | pages = 2699–709 | year = 2003 | pmid = 12743594 | doi = 10.1038/sj.onc.1206374 }}
*{{cite journal | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
* {{cite journal | vauthors = Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J | title = Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules | journal = Virus Res. | volume = 98 | issue = 1 | pages = 83–91 | year = 2003 | pmid = 14609633 | doi = 10.1016/j.virusres.2003.09.001 }}
*{{cite journal  | author=Rodrigues-Lima F, Josephs M, Katan M, Cassinat B |title=Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases. |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 5 |pages= 1274-9 |year= 2001 |pmid= 11478795 |doi= 10.1006/bbrc.2001.5328 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Luciano M, Lind PA, Duffy DL, Castles A, Wright MJ, Montgomery GW, Martin NG, Bates TC | title = A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability | journal = Biol. Psychiatry | volume = 62 | issue = 7 | pages = 811–7 | year = 2007 | pmid = 17597587 | doi = 10.1016/j.biopsych.2007.03.007 }}
*{{cite journal | author=Pei H, Yordy JS, Leng Q, ''et al.'' |title=EAPII interacts with ETS1 and modulates its transcriptional function. |journal=Oncogene |volume=22 |issue= 18 |pages= 2699-709 |year= 2003 |pmid= 12743594 |doi= 10.1038/sj.onc.1206374 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Lee BH, Yoshimatsu K, Maeda A, ''et al.'' |title=Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules. |journal=Virus Res. |volume=98 |issue= 1 |pages= 83-91 |year= 2004 |pmid= 14609633 |doi= }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Luciano M, Lind PA, Duffy DL, ''et al.'' |title=A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability. |journal=Biol. Psychiatry |volume=62 |issue= 7 |pages= 811-7 |year= 2007 |pmid= 17597587 |doi= 10.1016/j.biopsych.2007.03.007 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:15, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TRAF and TNF receptor-associated protein is a protein that in humans is encoded by the TTRAP gene.[1][2]

Function

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.[2]

Interactions

TTRAP has been shown to interact with ETS1,[3] TNFRSF1B[4] and CD40.[4]

References

  1. ↑ Rodrigues-Lima F, Josephs M, Katan M, Cassinat B (July 2001). "Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases". Biochem. Biophys. Res. Commun. 285 (5): 1274–9. doi:10.1006/bbrc.2001.5328. PMID 11478795.
  2. ↑ 2.0 2.1 "Entrez Gene: TTRAP TRAF and TNF receptor associated protein".
  3. ↑ Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R (May 2003). "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene. 22 (18): 2699–709. doi:10.1038/sj.onc.1206374. PMID 12743594.
  4. ↑ 4.0 4.1 Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (June 2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.

Further reading

  • Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.
  • Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R (2003). "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene. 22 (18): 2699–709. doi:10.1038/sj.onc.1206374. PMID 12743594.
  • Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J (2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Luciano M, Lind PA, Duffy DL, Castles A, Wright MJ, Montgomery GW, Martin NG, Bates TC (2007). "A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability". Biol. Psychiatry. 62 (7): 811–7. doi:10.1016/j.biopsych.2007.03.007. PMID 17597587.


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