PRIM2: Difference between revisions

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{{Infobox_gene}}
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'''DNA primase large subunit''' is an [[enzyme]] that in humans is encoded by the ''PRIM2'' [[gene]].<ref name="pmid8530050">{{cite journal | vauthors = Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H| title = Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12 | journal = Genomics | volume = 28 | issue = 2 | pages = 350–3 |date=Feb 1996 | pmid = 8530050 | pmc =  | doi =10.1006/geno.1995.1155 |display-authors=etal}}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Primase, polypeptide 2A, 58kDa
| HGNCid = 9370
| Symbol = PRIM2A
| AltSymbols =; p58; MGC75142; PRIM2
| OMIM = 176636
| ECnumber = 
| Homologene = 731
| MGIid = 97758
| GeneAtlas_image1 = PBB_GE_PRIM2A_205628_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRIM2A_215708_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003896 |text = DNA primase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005658 |text = alpha DNA polymerase:primase complex}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006269 |text = DNA replication, synthesis of RNA primer}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5558
    | Hs_Ensembl = ENSG00000146143
    | Hs_RefseqProtein = XP_001134297
    | Hs_RefseqmRNA = XM_001134297
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 57287562
    | Hs_GenLoc_end = 57620646
    | Hs_Uniprot = P49643
    | Mm_EntrezGene = 19076
    | Mm_Ensembl = ENSMUSG00000026134
    | Mm_RefseqmRNA = NM_008922
    | Mm_RefseqProtein = NP_032948
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 33398361
    | Mm_GenLoc_end = 33614326
    | Mm_Uniprot = Q3THK0
  }}
}}
'''Primase, polypeptide 2A, 58kDa''', also known as '''PRIM2A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5558| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.<ref name="entrez">{{cite web | title = Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5558| accessdate = }}</ref>
| summary_text = The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.<ref name="entrez">{{cite web | title = Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5558| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Stadlbauer F, Brueckner A, Rehfuess C, ''et al.'' |title=DNA replication in vitro by recombinant DNA-polymerase-alpha-primase. |journal=Eur. J. Biochem. |volume=222 |issue= 3 |pages= 781-93 |year= 1994 |pmid= 8026492 |doi=  }}
*{{cite journal   |vauthors=Stadlbauer F, Brueckner A, Rehfuess C, etal |title=DNA replication in vitro by recombinant DNA-polymerase-alpha-primase. |journal=Eur. J. Biochem. |volume=222 |issue= 3 |pages= 781–93 |year= 1994 |pmid= 8026492 |doi=10.1111/j.1432-1033.1994.tb18925.x }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Shiratori A, Okumura K, Nogami M, ''et al.'' |title=Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12. |journal=Genomics |volume=28 |issue= 2 |pages= 350-3 |year= 1996 |pmid= 8530050 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Coll JM, Hickey RJ, Cronkey EA, etal |title=Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome |journal=Oncol. Res. |volume=9 |issue= 11–12 |pages= 629–39 |year= 1998 |pmid= 9563011 |doi=  }}
*{{cite journal | author=Coll JM, Hickey RJ, Cronkey EA, ''et al.'' |title=Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome. |journal=Oncol. Res. |volume=9 |issue= 11-12 |pages= 629-39 |year= 1998 |pmid= 9563011 |doi=  }}
*{{cite journal   |vauthors=Schneider A, Smith RW, Kautz AR, etal |title=Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21608–15 |year= 1998 |pmid= 9705292 |doi=10.1074/jbc.273.34.21608 }}
*{{cite journal | author=Schneider A, Smith RW, Kautz AR, ''et al.'' |title=Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21608-15 |year= 1998 |pmid= 9705292 |doi=  }}
*{{cite journal  | vauthors=Arezi B, Kirk BW, Copeland WC, Kuchta RD |title=Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit |journal=Biochemistry |volume=38 |issue= 39 |pages= 12899–907 |year= 1999 |pmid= 10504261 |doi=10.1021/bi9908991 }}
*{{cite journal  | author=Arezi B, Kirk BW, Copeland WC, Kuchta RD |title=Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit. |journal=Biochemistry |volume=38 |issue= 39 |pages= 12899-907 |year= 1999 |pmid= 10504261 |doi=  }}
*{{cite journal  | vauthors=Smith RW, Nasheuer HP |title=Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180 |journal=FEBS Lett. |volume=527 |issue= 1–3 |pages= 143–6 |year= 2002 |pmid= 12220650 |doi=10.1016/S0014-5793(02)03197-6 }}
*{{cite journal  | author=Smith RW, Nasheuer HP |title=Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 143-6 |year= 2002 |pmid= 12220650 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
}}
}}
{{refend}}
{{refend}}


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{{DNA replication}}
 
 
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Latest revision as of 18:40, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.[1][2]

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.[2]

References

  1. ↑ Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics. 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050.
  2. ↑ 2.0 2.1 "Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa".

Further reading



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