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{{Infobox_gene}}
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'''Pre-mRNA-splicing regulator WTAP''' is a [[protein]] that in humans is encoded by the ''WTAP'' [[gene]].<ref name="pmid7788527">{{cite journal |vauthors=Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, etal | title = Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res | volume = 2 | issue = 1 | pages = 37–43 |date=Jul 1995 | pmid = 7788527 | pmc =  | doi =10.1093/dnares/2.1.37 }}</ref><ref name="pmid11001926">{{cite journal | vauthors = Little NA, Hastie ND, Davies RC | title = Identification of WTAP, a novel Wilms' tumour 1-associating protein | journal = Hum Mol Genet | volume = 9 | issue = 15 | pages = 2231–9 |date=Oct 2000 | pmid = 11001926 | pmc =  | doi =  10.1093/oxfordjournals.hmg.a018914}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WTAP Wilms tumor 1 associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9589| accessdate = }}</ref>
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{{GNF_Protein_box
  | image =
| image_source =
| PDB =
| Name = Wilms tumor 1 associated protein
| HGNCid = 16846
| Symbol = WTAP
| AltSymbols =; DKFZp686F20131; KIAA0105; MGC3925
| OMIM = 605442
| ECnumber =
| Homologene = 68422
| MGIid = 1926395
  | GeneAtlas_image1 = PBB_GE_WTAP_210285_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_WTAP_203137_at_tn.png
| GeneAtlas_image3 = PBB_GE_WTAP_gnf1h04654_at_tn.png
  | Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0031965 |text = nuclear membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9589
    | Hs_Ensembl = ENSG00000146457
    | Hs_RefseqProtein = NP_004897
    | Hs_RefseqmRNA = NM_004906
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 160066607
    | Hs_GenLoc_end = 160097341
    | Hs_Uniprot = Q15007
    | Mm_EntrezGene = 60532
    | Mm_Ensembl = ENSMUSG00000061897
    | Mm_RefseqmRNA = NM_175394
    | Mm_RefseqProtein = NP_780603
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 179106833
    | Mm_GenLoc_end = 179107288
    | Mm_Uniprot =   
  }}
}}
'''Wilms tumor 1 associated protein''', also known as '''WTAP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WTAP Wilms tumor 1 associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9589| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.<ref name="entrez">{{cite web | title = Entrez Gene: WTAP Wilms tumor 1 associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9589| accessdate = }}</ref>
| summary_text = The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.<ref name="entrez" />
}}
}}
==Interactions==
WTAP (gene) has been shown to [[Protein-protein interaction|interact]] with [[WT1]].<ref name=pmid11001926 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Small TW, Bolender Z, Bueno C, ''et al.'' |title=Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. |journal=Circ. Res. |volume=99 |issue= 12 |pages= 1338-46 |year= 2007 |pmid= 17095724 |doi= 10.1161/01.RES.0000252289.79841.d3 }}
*{{cite journal   |vauthors=Small TW, Bolender Z, Bueno C, etal |title=Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells |journal=Circ. Res. |volume=99 |issue= 12 |pages= 1338–46 |year= 2007 |pmid= 17095724 |doi= 10.1161/01.RES.0000252289.79841.d3 }}
*{{cite journal | author=Horiuchi K, Umetani M, Minami T, ''et al.'' |title=Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 46 |pages= 17278-83 |year= 2007 |pmid= 17088532 |doi= 10.1073/pnas.0608357103 }}
*{{cite journal   |vauthors=Horiuchi K, Umetani M, Minami T, etal |title=Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 46 |pages= 17278–83 |year= 2007 |pmid= 17088532 |doi= 10.1073/pnas.0608357103 | pmc=1634838 }}
*{{cite journal | author=Rong Y, Cheng L, Ning H, ''et al.'' |title=Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor. |journal=Cancer Res. |volume=66 |issue= 16 |pages= 8049-57 |year= 2007 |pmid= 16912181 |doi= 10.1158/0008-5472.CAN-06-1172 }}
*{{cite journal   |vauthors=Rong Y, Cheng L, Ning H, etal |title=Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor |journal=Cancer Res. |volume=66 |issue= 16 |pages= 8049–57 |year= 2007 |pmid= 16912181 |doi= 10.1158/0008-5472.CAN-06-1172 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Obuse C, Yang H, Nozaki N, ''et al.'' |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105-20 |year= 2004 |pmid= 15009096 |doi=  }}
*{{cite journal   |vauthors=Obuse C, Yang H, Nozaki N, etal |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=10.1111/j.1365-2443.2004.00705.x }}
*{{cite journal | author=Utsch B, Kaya A, Ozburun A, ''et al.'' |title=Exclusion of WTAP and HOXA13 as candidate genes for isolated hypospadias. |journal=Scand. J. Urol. Nephrol. |volume=37 |issue= 6 |pages= 498-501 |year= 2004 |pmid= 14675924 |doi= 10.1080/00365590310014517 }}
*{{cite journal   |vauthors=Utsch B, Kaya A, Ozburun A, etal |title=Exclusion of WTAP and HOXA13 as candidate genes for isolated hypospadias |journal=Scand. J. Urol. Nephrol. |volume=37 |issue= 6 |pages= 498–501 |year= 2004 |pmid= 14675924 |doi= 10.1080/00365590310014517 }}
*{{cite journal  | author=Tomsig JL, Snyder SL, Creutz CE |title=Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10048-54 |year= 2003 |pmid= 12522145 |doi= 10.1074/jbc.M212632200 }}
*{{cite journal  | vauthors=Tomsig JL, Snyder SL, Creutz CE |title=Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10048–54 |year= 2003 |pmid= 12522145 |doi= 10.1074/jbc.M212632200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Ortega A, Niksic M, Bachi A, ''et al.'' |title=Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3040-7 |year= 2003 |pmid= 12444081 |doi= 10.1074/jbc.M210737200 }}
*{{cite journal   |vauthors=Ortega A, Niksic M, Bachi A, etal |title=Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3040–7 |year= 2003 |pmid= 12444081 |doi= 10.1074/jbc.M210737200 }}
*{{cite journal  | author=Little NA, Hastie ND, Davies RC |title=Identification of WTAP, a novel Wilms' tumour 1-associating protein. |journal=Hum. Mol. Genet. |volume=9 |issue= 15 |pages= 2231-9 |year= 2001 |pmid= 11001926 |doi=  }}
*{{cite journal  | vauthors=Hoja MR, Wahlestedt C, Höög C |title=A visual intracellular classification strategy for uncharacterized human proteins |journal=Exp. Cell Res. |volume=259 |issue= 1 |pages= 239–46 |year= 2000 |pmid= 10942595 |doi= 10.1006/excr.2000.4948 }}
*{{cite journal  | author=Hoja MR, Wahlestedt C, Höög C |title=A visual intracellular classification strategy for uncharacterized human proteins. |journal=Exp. Cell Res. |volume=259 |issue= 1 |pages= 239-46 |year= 2000 |pmid= 10942595 |doi= 10.1006/excr.2000.4948 }}
*{{cite journal  | author=Nagase T, Miyajima N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 1 |pages= 37-43 |year= 1995 |pmid= 7788527 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 22:54, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.[1][2][3]

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.[3]

Interactions

WTAP (gene) has been shown to interact with WT1.[2]

References

  1. ↑ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  2. ↑ 2.0 2.1 Little NA, Hastie ND, Davies RC (Oct 2000). "Identification of WTAP, a novel Wilms' tumour 1-associating protein". Hum Mol Genet. 9 (15): 2231–9. doi:10.1093/oxfordjournals.hmg.a018914. PMID 11001926.
  3. ↑ 3.0 3.1 "Entrez Gene: WTAP Wilms tumor 1 associated protein".

Further reading



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