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{{Infobox_gene}}
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'''Transcription initiation factor TFIID subunit 8''' is a [[protein]] that in humans is encoded by the ''TAF8'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TBN taube nuss homolog (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=129685| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Taube nuss homolog (mouse)
| HGNCid = 17300
| Symbol = TBN
| AltSymbols =; FLJ32821; TAF8; TAFII43
| OMIM = 609514
| ECnumber = 
| Homologene = 11094
| MGIid = 1926879
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0051457 |text = maintenance of protein localization in nucleus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 129685
    | Hs_Ensembl = ENSG00000137413
    | Hs_RefseqProtein = NP_612639
    | Hs_RefseqmRNA = NM_138572
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 42126238
    | Hs_GenLoc_end = 42163177
    | Hs_Uniprot = 
    | Mm_EntrezGene = 63856
    | Mm_Ensembl = ENSMUSG00000023980
    | Mm_RefseqmRNA = NM_022015
    | Mm_RefseqProtein = NP_071298
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 46951473
    | Mm_GenLoc_end = 46965478
    | Mm_Uniprot = 
  }}
}}
'''Taube nuss homolog (mouse)''', also known as '''TBN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TBN taube nuss homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=129685| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: TBN taube nuss homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=129685| accessdate = }}</ref>
| summary_text = This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Zhou Q, Sharp PA |title=Novel mechanism and factor for regulation by HIV-1 Tat. |journal=EMBO J. |volume=14 |issue= 2 |pages= 321-8 |year= 1995 |pmid= 7835343 |doi=  }}
*{{cite journal  |vauthors=Zhou Q, Sharp PA |title=Novel mechanism and factor for regulation by HIV-1 Tat |journal=EMBO J. |volume=14 |issue= 2 |pages= 321–8 |year= 1995 |pmid= 7835343 |doi= | pmc=398086 }}
*{{cite journal  | author=Parada CA, Yoon JB, Roeder RG |title=A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro. |journal=J. Biol. Chem. |volume=270 |issue= 5 |pages= 2274-83 |year= 1995 |pmid= 7836461 |doi=  }}
*{{cite journal  |vauthors=Parada CA, Yoon JB, Roeder RG |title=A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro |journal=J. Biol. Chem. |volume=270 |issue= 5 |pages= 2274–83 |year= 1995 |pmid= 7836461 |doi=10.1074/jbc.270.5.2274 }}
*{{cite journal  | author=Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB |title=Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. |journal=J. Virol. |volume=68 |issue= 11 |pages= 7188-99 |year= 1994 |pmid= 7933101 |doi=  }}
*{{cite journal  |vauthors=Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB |title=Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function |journal=J. Virol. |volume=68 |issue= 11 |pages= 7188–99 |year= 1994 |pmid= 7933101 |doi= | pmc=237158 }}
*{{cite journal  | author=Kashanchi F, Piras G, Radonovich MF, ''et al.'' |title=Direct interaction of human TFIID with the HIV-1 transactivator tat. |journal=Nature |volume=367 |issue= 6460 |pages= 295-9 |year= 1994 |pmid= 8121496 |doi= 10.1038/367295a0 }}
*{{cite journal  | author=Kashanchi F |title=Direct interaction of human TFIID with the HIV-1 transactivator tat |journal=Nature |volume=367 |issue= 6460 |pages= 295–9 |year= 1994 |pmid= 8121496 |doi= 10.1038/367295a0 |name-list-format=vanc| author2=Piras G  | author3=Radonovich MF  | display-authors=3  | last4=Duvall  | first4=Janet F.  | last5=Fattaey  | first5=Ali  | last6=Chiang  | first6=Cheng-Ming  | last7=Roeder  | first7=Robert G.  | last8=Brady  | first8=John N. }}
*{{cite journal  | author=Wang Z, Morris GF, Rice AP, ''et al.'' |title=Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=12 |issue= 2 |pages= 128-38 |year= 1996 |pmid= 8680883 |doi=  }}
*{{cite journal  | author=Wang Z |title=Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=12 |issue= 2 |pages= 128–38 |year= 1996 |pmid= 8680883 |doi=10.1097/00042560-199606010-00005  |name-list-format=vanc| author2=Morris GF  | author3=Rice AP  | display-authors=3  | last4=Xiong  | first4=W  | last5=Morris  | first5=CB }}
*{{cite journal  | author=Pendergrast PS, Morrison D, Tansey WP, Hernandez N |title=Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly. |journal=J. Virol. |volume=70 |issue= 8 |pages= 5025-34 |year= 1996 |pmid= 8764009 |doi=  }}
*{{cite journal  |vauthors=Pendergrast PS, Morrison D, Tansey WP, Hernandez N |title=Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly |journal=J. Virol. |volume=70 |issue= 8 |pages= 5025–34 |year= 1996 |pmid= 8764009 |doi= | pmc=190456 }}
*{{cite journal  | author=Kashanchi F, Khleif SN, Duvall JF, ''et al.'' |title=Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex. |journal=J. Virol. |volume=70 |issue= 8 |pages= 5503-10 |year= 1996 |pmid= 8764062 |doi=  }}
*{{cite journal  | author=Kashanchi F |title=Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex |journal=J. Virol. |volume=70 |issue= 8 |pages= 5503–10 |year= 1996 |pmid= 8764062 |doi= | pmc=190508  |name-list-format=vanc| author2=Khleif SN  | author3=Duvall JF  | display-authors=3  | last4=Sadaie  | first4=MR  | last5=Radonovich  | first5=MF  | last6=Cho  | first6=M  | last7=Martin  | first7=MA  | last8=Chen  | first8=SY  | last9=Weinmann  | first9=R }}
*{{cite journal  | author=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. |journal=Science |volume=274 |issue= 5287 |pages= 605-10 |year= 1996 |pmid= 8849451 |doi=  }}
*{{cite journal  |vauthors=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat |journal=Science |volume=274 |issue= 5287 |pages= 605–10 |year= 1996 |pmid= 8849451 |doi=10.1126/science.274.5287.605 }}
*{{cite journal  | author=García-Martínez LF, Ivanov D, Gaynor RB |title=Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes. |journal=J. Biol. Chem. |volume=272 |issue= 11 |pages= 6951-8 |year= 1997 |pmid= 9054383 |doi=  }}
*{{cite journal  |vauthors=García-Martínez LF, Ivanov D, Gaynor RB |title=Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes |journal=J. Biol. Chem. |volume=272 |issue= 11 |pages= 6951–8 |year= 1997 |pmid= 9054383 |doi=10.1074/jbc.272.11.6951 }}
*{{cite journal  | author=Purrello M, Di Pietro C, Viola A, ''et al.'' |title=Genomics and transcription analysis of human TFIID. |journal=Oncogene |volume=16 |issue= 12 |pages= 1633-8 |year= 1998 |pmid= 9569032 |doi= 10.1038/sj.onc.1201673 }}
*{{cite journal  | author=Purrello M |title=Genomics and transcription analysis of human TFIID |journal=Oncogene |volume=16 |issue= 12 |pages= 1633–8 |year= 1998 |pmid= 9569032 |doi= 10.1038/sj.onc.1201673 |name-list-format=vanc| author2=Di Pietro C  | author3=Viola A  | display-authors=3  | last4=Rapisarda  | first4=Antonella  | last5=Stevens  | first5=Sean  | last6=Guermah  | first6=Mohamed  | last7=Tao  | first7=Yong  | last8=Bonaiuto  | first8=Corrada  | last9=Arcidiacono  | first9=Antonio }}
*{{cite journal  | author=Guermah M, Tao Y, Roeder RG |title=Positive and negative TAF(II) functions that suggest a dynamic TFIID structure and elicit synergy with traps in activator-induced transcription. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6882-94 |year= 2001 |pmid= 11564872 |doi= 10.1128/MCB.21.20.6882-6894.2001 }}
*{{cite journal  |vauthors=Guermah M, Tao Y, Roeder RG |title=Positive and Negative TAFII Functions That Suggest a Dynamic TFIID Structure and Elicit Synergy with TRAPs in Activator-Induced Transcription |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6882–94 |year= 2001 |pmid= 11564872 |doi= 10.1128/MCB.21.20.6882-6894.2001 | pmc=99865 }}
*{{cite journal  | author=Tora L |title=A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription. |journal=Genes Dev. |volume=16 |issue= 6 |pages= 673-5 |year= 2002 |pmid= 11963920 |doi=  }}
*{{cite journal  | author=Tora L |title=A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription |journal=Genes Dev. |volume=16 |issue= 6 |pages= 673–5 |year= 2002 |pmid= 11963920 |doi=10.1101/gad.976402 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Guermah M, Ge K, Chiang CM, Roeder RG |title=The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. |journal=Mol. Cell |volume=12 |issue= 4 |pages= 991-1001 |year= 2003 |pmid= 14580349 |doi=  }}
*{{cite journal  |vauthors=Guermah M, Ge K, Chiang CM, Roeder RG |title=The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis |journal=Mol. Cell |volume=12 |issue= 4 |pages= 991–1001 |year= 2003 |pmid= 14580349 |doi=10.1016/S1097-2765(03)00396-4 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Soutoglou E, Demény MA, Scheer E, ''et al.'' |title=The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. |journal=Mol. Cell. Biol. |volume=25 |issue= 10 |pages= 4092-104 |year= 2005 |pmid= 15870280 |doi= 10.1128/MCB.25.10.4092-4104.2005 }}
*{{cite journal  | author=Soutoglou E |title=The Nuclear Import of TAF10 Is Regulated by One of Its Three Histone Fold Domain-Containing Interaction Partners |journal=Mol. Cell. Biol. |volume=25 |issue= 10 |pages= 4092–104 |year= 2005 |pmid= 15870280 |doi= 10.1128/MCB.25.10.4092-4104.2005 | pmc=1087738  |name-list-format=vanc| author2=Demény MA  | author3=Scheer E  | display-authors=3  | last4=Fienga  | first4=G.  | last5=Sassone-Corsi  | first5=P.  | last6=Tora  | first6=L. }}
}}
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Latest revision as of 11:32, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription initiation factor TFIID subunit 8 is a protein that in humans is encoded by the TAF8 gene.[1]

This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: TBN taube nuss homolog (mouse)".

Further reading



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