RNF5: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''E3 ubiquitin-protein ligase RNF5''' is an [[enzyme]] that in humans is encoded by the ''RNF5'' [[gene]].<ref name="pmid9533025">{{cite journal | vauthors = Kyushiki H, Kuga Y, Suzuki M, Takahashi E, Horie M | title = Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans | journal = Cytogenet Cell Genet | volume = 79 | issue = 1–2 | pages = 114–7 |date=Apr 1998 | pmid = 9533025 | pmc =  | doi =10.1159/000134695 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RNF5 ring finger protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6048| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ring finger protein 5
| HGNCid = 10068
| Symbol = RNF5
| AltSymbols =; RING5; RMA1
| OMIM = 602677
| ECnumber = 
| Homologene = 56004
| MGIid = 1860076
| GeneAtlas_image1 = PBB_GE_RNF5_209111_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6048
    | Hs_Ensembl = ENSG00000183574
    | Hs_RefseqProtein = NP_008844
    | Hs_RefseqmRNA = NM_006913
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = c6_QBL
    | Hs_GenLoc_start = 32246607
    | Hs_GenLoc_end = 32249017
    | Hs_Uniprot = Q99942
    | Mm_EntrezGene = 54197
    | Mm_Ensembl = ENSMUSG00000015478
    | Mm_RefseqmRNA = NM_019403
    | Mm_RefseqProtein = NP_062276
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 34209153
    | Mm_GenLoc_end = 34211627
    | Mm_Uniprot = O35445
  }}
}}
'''Ring finger protein 5''', also known as '''RNF5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNF5 ring finger protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6048| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.<ref name="entrez">{{cite web | title = Entrez Gene: RNF5 ring finger protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6048| accessdate = }}</ref>
| summary_text = The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kendall E, Sargent CA, Campbell RD |title=Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci. |journal=Nucleic Acids Res. |volume=18 |issue= 24 |pages= 7251-7 |year= 1991 |pmid= 2259622 |doi=  }}
*{{cite journal  | vauthors=Kendall E, Sargent CA, Campbell RD |title=Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci |journal=Nucleic Acids Res. |volume=18 |issue= 24 |pages= 7251–7 |year= 1991 |pmid= 2259622 |doi=10.1093/nar/18.24.7251  | pmc=332860 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Kyushiki H, Kuga Y, Suzuki M, ''et al.'' |title=Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 114-7 |year= 1998 |pmid= 9533025 |doi= }}
*{{cite journal   |vauthors=Barritt DS, Pearn MT, Zisch AH, etal |title=The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2 |journal=J. Cell. Biochem. |volume=79 |issue= 2 |pages= 213–24 |year= 2000 |pmid= 10967549 |doi=10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G |pmc=3501957}}
*{{cite journal | author=Barritt DS, Pearn MT, Zisch AH, ''et al.'' |title=The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. |journal=J. Cell. Biochem. |volume=79 |issue= 2 |pages= 213-24 |year= 2000 |pmid= 10967549 |doi= }}
*{{cite journal  | vauthors=Matsuda N, Suzuki T, Tanaka K, Nakano A |title=Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase |journal=J. Cell Sci. |volume=114 |issue= Pt 10 |pages= 1949–57 |year= 2001 |pmid= 11329381 |doi=  }}
*{{cite journal  | author=Matsuda N, Suzuki T, Tanaka K, Nakano A |title=Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase. |journal=J. Cell. Sci. |volume=114 |issue= Pt 10 |pages= 1949-57 |year= 2001 |pmid= 11329381 |doi=  }}
*{{cite journal   |vauthors=Pouly S, Prat A, Blain M, etal |title=NG2 immunoreactivity on human brain endothelial cells |journal=Acta Neuropathol. |volume=102 |issue= 4 |pages= 313–20 |year= 2002 |pmid= 11603805 |doi= 10.1007/s004010000350 }}
*{{cite journal | author=Pouly S, Prat A, Blain M, ''et al.'' |title=NG2 immunoreactivity on human brain endothelial cells. |journal=Acta Neuropathol. |volume=102 |issue= 4 |pages= 313-20 |year= 2002 |pmid= 11603805 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Didier C, Broday L, Bhoumik A, etal |title=RNF5, a RING Finger Protein That Regulates Cell Motility by Targeting Paxillin Ubiquitination and Altered Localization |journal=Mol. Cell. Biol. |volume=23 |issue= 15 |pages= 5331–45 |year= 2003 |pmid= 12861019 |doi=10.1128/MCB.23.15.5331-5345.2003  | pmc=165736 }}
*{{cite journal | author=Didier C, Broday L, Bhoumik A, ''et al.'' |title=RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. |journal=Mol. Cell. Biol. |volume=23 |issue= 15 |pages= 5331-45 |year= 2003 |pmid= 12861019 |doi=  }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Xie T, Rowen L, Aguado B, etal |title=Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 | pmc=403804 }}
*{{cite journal | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621-36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 }}
*{{cite journal   |vauthors=Lehner B, Semple JI, Brown SE, etal |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 }}
*{{cite journal | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi=  }}
*{{cite journal  | vauthors=Liu AM, Wong YH |title=G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53196–204 |year= 2005 |pmid= 15485865 |doi= 10.1074/jbc.M410196200 }}
*{{cite journal  | author=Liu AM, Wong YH |title=G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53196-204 |year= 2005 |pmid= 15485865 |doi= 10.1074/jbc.M410196200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal   |vauthors=Zhang Y, Higashide W, Dai S, etal |title=Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1 |journal=J. Biol. Chem. |volume=280 |issue= 46 |pages= 38682–8 |year= 2006 |pmid= 16176924 |doi= 10.1074/jbc.M506309200 }}
*{{cite journal | author=Zhang Y, Higashide W, Dai S, ''et al.'' |title=Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1. |journal=J. Biol. Chem. |volume=280 |issue= 46 |pages= 38682-8 |year= 2006 |pmid= 16176924 |doi= 10.1074/jbc.M506309200 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Younger JM, Chen L, Ren HY, etal |title=Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator |journal=Cell |volume=126 |issue= 3 |pages= 571–82 |year= 2006 |pmid= 16901789 |doi= 10.1016/j.cell.2006.06.041 }}
*{{cite journal | author=Younger JM, Chen L, Ren HY, ''et al.'' |title=Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator. |journal=Cell |volume=126 |issue= 3 |pages= 571-82 |year= 2006 |pmid= 16901789 |doi= 10.1016/j.cell.2006.06.041 }}
*{{cite journal   |vauthors=Bromberg KD, Kluger HM, Delaunay A, etal |title=Increased Expression of the E3 Ubiquitin Ligase RNF5 Is Associated with Decreased Survival in Breast Cancer |journal=Cancer Res. |volume=67 |issue= 17 |pages= 8172–9 |year= 2007 |pmid= 17804730 |doi= 10.1158/0008-5472.CAN-07-0045 | pmc=2962863 }}
*{{cite journal | author=Bromberg KD, Kluger HM, Delaunay A, ''et al.'' |title=Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer. |journal=Cancer Res. |volume=67 |issue= 17 |pages= 8172-9 |year= 2007 |pmid= 17804730 |doi= 10.1158/0008-5472.CAN-07-0045 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|RNF5+protein,+human}}
* {{MeshName|RNF5+protein,+human}}
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[[Category:RING finger proteins]]


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Revision as of 20:44, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene.[1][2]

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.[2]

See also

References

  1. ↑ Kyushiki H, Kuga Y, Suzuki M, Takahashi E, Horie M (Apr 1998). "Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans". Cytogenet Cell Genet. 79 (1–2): 114–7. doi:10.1159/000134695. PMID 9533025.
  2. ↑ 2.0 2.1 "Entrez Gene: RNF5 ring finger protein 5".

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=RNF5&oldid=1421050"