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{{ | '''Protein kinase C and casein kinase substrate in neurons protein 1''' is an [[enzyme]] that in humans is encoded by the ''PACSIN1'' [[gene]].<ref name="pmid11179684">{{cite journal | vauthors = Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M | title = PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family | journal = Gene | volume = 262 | issue = 1-2 | pages = 199–205 | date = Jan 2001 | pmid = 11179684 | pmc = | doi = 10.1016/S0378-1119(00)00531-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PACSIN1 protein kinase C and casein kinase substrate in neurons 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29993| accessdate = }}</ref> | ||
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== Interactions == | |||
< | PACSIN1 has been shown to [[Protein-protein interaction|interact]] with: | ||
{{ | * [[DNM1]],<ref name = pmid15252009>{{cite journal | vauthors = Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N | title = A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis | journal = The Journal of Biological Chemistry | volume = 279 | issue = 38 | pages = 40091–9 | date = Sep 2004 | pmid = 15252009 | doi = 10.1074/jbc.M404899200 }}</ref><ref name = pmid11082044>{{cite journal | vauthors = Modregger J, Ritter B, Witter B, Paulsson M, Plomann M | title = All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis | journal = Journal of Cell Science | volume = 113 | issue = 24| pages = 4511–21 | date = Dec 2000 | pmid = 11082044 | doi = }}</ref> | ||
| | * [[Huntingtin]]<ref name = pmid12354780>{{cite journal | vauthors = Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M | title = PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains | journal = Human Molecular Genetics | volume = 11 | issue = 21 | pages = 2547–58 | date = Oct 2002 | pmid = 12354780 | doi = 10.1093/hmg/11.21.2547}}</ref> | ||
| | * [[PACSIN2]],<ref name = pmid11082044/><ref name = pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref> and | ||
}} | * [[PACSIN3]].<ref name = pmid11082044/> | ||
==References== | == References == | ||
{{ | {{Reflist}} | ||
{{protein- | == Further reading == | ||
{{ | {{Refbegin | 2}} | ||
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = Jun 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }} | |||
* {{cite journal | vauthors = Qualmann B, Roos J, DiGregorio PJ, Kelly RB | title = Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein | journal = Molecular Biology of the Cell | volume = 10 | issue = 2 | pages = 501–13 | date = Feb 1999 | pmid = 9950691 | pmc = 25183 | doi = 10.1091/mbc.10.2.501 }} | |||
* {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 7 | issue = 1 | pages = 65–73 | date = Feb 2000 | pmid = 10718198 | doi = 10.1093/dnares/7.1.65 }} | |||
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }} | |||
* {{cite journal | vauthors = Modregger J, Ritter B, Witter B, Paulsson M, Plomann M | title = All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis | journal = Journal of Cell Science | volume = 113 | issue = 24 | pages = 4511–21 | date = Dec 2000 | pmid = 11082044 | doi = }} | |||
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }} | |||
* {{cite journal | vauthors = Zucconi A, Dente L, Santonico E, Castagnoli L, Cesareni G | title = Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1 | journal = Journal of Molecular Biology | volume = 307 | issue = 5 | pages = 1329–39 | date = Apr 2001 | pmid = 11292345 | doi = 10.1006/jmbi.2001.4572 }} | |||
* {{cite journal | vauthors = Wasiak S, Quinn CC, Ritter B, de Heuvel E, Baranes D, Plomann M, McPherson PS | title = The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton | journal = The Journal of Biological Chemistry | volume = 276 | issue = 28 | pages = 26622–8 | date = Jul 2001 | pmid = 11352907 | doi = 10.1074/jbc.M100591200 }} | |||
* {{cite journal | vauthors = Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M | title = PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains | journal = Human Molecular Genetics | volume = 11 | issue = 21 | pages = 2547–58 | date = Oct 2002 | pmid = 12354780 | doi = 10.1093/hmg/11.21.2547 }} | |||
* {{cite journal | vauthors = Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N | title = A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis | journal = The Journal of Biological Chemistry | volume = 279 | issue = 38 | pages = 40091–9 | date = Sep 2004 | pmid = 15252009 | doi = 10.1074/jbc.M404899200 }} | |||
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }} | |||
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }} | |||
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }} | |||
* {{cite journal | vauthors = Cuajungco MP, Grimm C, Oshima K, D'hoedt D, Nilius B, Mensenkamp AR, Bindels RJ, Plomann M, Heller S | title = PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 27 | pages = 18753–62 | date = Jul 2006 | pmid = 16627472 | doi = 10.1074/jbc.M602452200 }} | |||
{{Refend}} | |||
{{Gene-6-stub}} |
Latest revision as of 16:24, 8 October 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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Protein kinase C and casein kinase substrate in neurons protein 1 is an enzyme that in humans is encoded by the PACSIN1 gene.[1][2]
Interactions
PACSIN1 has been shown to interact with:
References
- ↑ Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M (Jan 2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
- ↑ "Entrez Gene: PACSIN1 protein kinase C and casein kinase substrate in neurons 1".
- ↑ Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N (Sep 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". The Journal of Biological Chemistry. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
- ↑ 4.0 4.1 4.2 Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Dec 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". Journal of Cell Science. 113 (24): 4511–21. PMID 11082044.
- ↑ Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M (Oct 2002). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains". Human Molecular Genetics. 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. PMID 12354780.
- ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Further reading
- Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Qualmann B, Roos J, DiGregorio PJ, Kelly RB (Feb 1999). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein". Molecular Biology of the Cell. 10 (2): 501–13. doi:10.1091/mbc.10.2.501. PMC 25183. PMID 9950691.
- Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Feb 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Dec 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". Journal of Cell Science. 113 (24): 4511–21. PMID 11082044.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Zucconi A, Dente L, Santonico E, Castagnoli L, Cesareni G (Apr 2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". Journal of Molecular Biology. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
- Wasiak S, Quinn CC, Ritter B, de Heuvel E, Baranes D, Plomann M, McPherson PS (Jul 2001). "The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton". The Journal of Biological Chemistry. 276 (28): 26622–8. doi:10.1074/jbc.M100591200. PMID 11352907.
- Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M (Oct 2002). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains". Human Molecular Genetics. 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. PMID 12354780.
- Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N (Sep 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". The Journal of Biological Chemistry. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
- Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Cuajungco MP, Grimm C, Oshima K, D'hoedt D, Nilius B, Mensenkamp AR, Bindels RJ, Plomann M, Heller S (Jul 2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4". The Journal of Biological Chemistry. 281 (27): 18753–62. doi:10.1074/jbc.M602452200. PMID 16627472.
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