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{{Underlinked|date=March 2014}}
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{{Infobox_gene}}
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'''Leukocyte-specific transcript 1 protein''' is a [[protein]] that in humans is encoded by the ''LST1'' [[gene]].<ref name="pmid8824804">{{cite journal |vauthors=Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM | title = Genes in a 220-kb region spanning the TNF cluster in human MHC | journal = Genomics | volume = 31 | issue = 2 | pages = 215–22 |date=Mar 1997 | pmid = 8824804 | pmc =  | doi = 10.1006/geno.1996.0034 }}</ref><ref name="pmid9367684">{{cite journal |vauthors=de Baey A, Fellerhoff B, Maier S, Martinozzi S, Weidle U, Weiss EH | title = Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing | journal = Genomics | volume = 45 | issue = 3 | pages = 591–600 |date=Jan 1998 | pmid = 9367684 | pmc =  | doi = 10.1006/geno.1997.4963 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LST1 leukocyte specific transcript 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7940| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Leukocyte specific transcript 1
| HGNCid = 14189
| Symbol = LST1
| AltSymbols =; B144; D6S49E; LST-1; MGC119006; MGC119007
| OMIM = 109170
| ECnumber = 
| Homologene = 
| MGIid = 
| GeneAtlas_image1 = PBB_GE_LST1_210629_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_LST1_211581_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_LST1_211582_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0000902 |text = cell morphogenesis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0016358 |text = dendrite development}} {{GNF_GO|id=GO:0050672 |text = negative regulation of lymphocyte proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7940
    | Hs_Ensembl = ENSG00000204482
    | Hs_RefseqProtein = NP_009092
    | Hs_RefseqmRNA = NM_007161
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 31661880
    | Hs_GenLoc_end = 31664665
    | Hs_Uniprot = O00453
    | Mm_EntrezGene =   
    | Mm_Ensembl =
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Leukocyte specific transcript 1''', also known as '''LST1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LST1 leukocyte specific transcript 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7940| accessdate = }}</ref>
 
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==References==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Abraham LJ, Grimsley G, Zhang WJ, ''et al.'' |title=Polymorphism in the human B144 gene in different MHC haplotypes. |journal=Eur. J. Immunogenet. |volume=19 |issue= 3 |pages= 165-8 |year= 1992 |pmid= 1352700 |doi=  }}
*{{cite journal   |vauthors=Abraham LJ, Grimsley G, Zhang WJ, etal |title=Polymorphism in the human B144 gene in different MHC haplotypes. |journal=Eur. J. Immunogenet. |volume=19 |issue= 3 |pages= 165–8 |year= 1992 |pmid= 1352700 |doi=10.1111/j.1744-313X.1992.tb00055.x }}
*{{cite journal | author=Holzinger I, de Baey A, Messer G, ''et al.'' |title=Cloning and genomic characterization of LST1: a new gene in the human TNF region. |journal=Immunogenetics |volume=42 |issue= 5 |pages= 315-22 |year= 1995 |pmid= 7590964 |doi=  }}
*{{cite journal   |vauthors=Holzinger I, de Baey A, Messer G, etal |title=Cloning and genomic characterization of LST1: a new gene in the human TNF region. |journal=Immunogenetics |volume=42 |issue= 5 |pages= 315–22 |year= 1995 |pmid= 7590964 |doi=  10.1007/BF00179392}}
*{{cite journal  | author=Nalabolu SR, Shukla H, Nallur G, ''et al.'' |title=Genes in a 220-kb region spanning the TNF cluster in human MHC. |journal=Genomics |volume=31 |issue= 2 |pages= 215-22 |year= 1997 |pmid= 8824804 |doi= 10.1006/geno.1996.0034 }}
*{{cite journal   |vauthors=Pende D, Parolini S, Pessino A, etal |title=Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells |journal=J. Exp. Med. |volume=190 |issue= 10 |pages= 1505–16 |year= 1999 |pmid= 10562324 |doi= 10.1084/jem.190.10.1505| pmc=2195691 }}
*{{cite journal  | author=de Baey A, Fellerhoff B, Maier S, ''et al.'' |title=Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing. |journal=Genomics |volume=45 |issue= 3 |pages= 591-600 |year= 1998 |pmid= 9367684 |doi= 10.1006/geno.1997.4963 }}
*{{cite journal  |vauthors=Neville MJ, Campbell RD |title=Alternative splicing of the LST-1 gene located in the Major Histocompatibility Complex on human chromosome 6 |journal=DNA Seq. |volume=8 |issue= 3 |pages= 155–60 |year= 2000 |pmid= 10668961 |doi= 10.3109/10425179709034067 }}
*{{cite journal | author=Pende D, Parolini S, Pessino A, ''et al.'' |title=Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. |journal=J. Exp. Med. |volume=190 |issue= 10 |pages= 1505-16 |year= 1999 |pmid= 10562324 |doi=  }}
*{{cite journal   |vauthors=Rollinger-Holzinger I, Eibl B, Pauly M, etal |title=LST1: a gene with extensive alternative splicing and immunomodulatory function |journal=J. Immunol. |volume=164 |issue= 6 |pages= 3169–76 |year= 2000 |pmid= 10706707 |doi=  10.4049/jimmunol.164.6.3169}}
*{{cite journal  | author=Neville MJ, Campbell RD |title=Alternative splicing of the LST-1 gene located in the Major Histocompatibility Complex on human chromosome 6. |journal=DNA Seq. |volume=8 |issue= 3 |pages= 155-60 |year= 2000 |pmid= 10668961 |doi= }}
*{{cite journal  |vauthors=Yu X, Weissman SM |title=Characterization of the promoter of human leukocyte-specific transcript 1. A small gene with a complex pattern of alternative transcripts |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34597–608 |year= 2000 |pmid= 10944527 |doi= 10.1074/jbc.M004700200 }}
*{{cite journal | author=Rollinger-Holzinger I, Eibl B, Pauly M, ''et al.'' |title=LST1: a gene with extensive alternative splicing and immunomodulatory function. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 3169-76 |year= 2000 |pmid= 10706707 |doi=  }}
*{{cite journal   |vauthors=Raghunathan A, Sivakamasundari R, Wolenski J, etal |title=Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells |journal=Exp. Cell Res. |volume=268 |issue= 2 |pages= 230–44 |year= 2001 |pmid= 11478849 |doi= 10.1006/excr.2001.5290 }}
*{{cite journal  | author=Yu X, Weissman SM |title=Characterization of the promoter of human leukocyte-specific transcript 1. A small gene with a complex pattern of alternative transcripts. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34597-608 |year= 2000 |pmid= 10944527 |doi= 10.1074/jbc.M004700200 }}
*{{cite journal   |vauthors=Ferlazzo G, Tsang ML, Moretta L, etal |title=Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells |journal=J. Exp. Med. |volume=195 |issue= 3 |pages= 343–51 |year= 2002 |pmid= 11828009 |doi= 10.1084/jem.20011149| pmc=2193591 }}
*{{cite journal | author=Raghunathan A, Sivakamasundari R, Wolenski J, ''et al.'' |title=Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells. |journal=Exp. Cell Res. |volume=268 |issue= 2 |pages= 230-44 |year= 2001 |pmid= 11478849 |doi= 10.1006/excr.2001.5290 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Ferlazzo G, Tsang ML, Moretta L, ''et al.'' |title=Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. |journal=J. Exp. Med. |volume=195 |issue= 3 |pages= 343-51 |year= 2002 |pmid= 11828009 |doi=  }}
*{{cite journal   |vauthors=Castriconi R, Cantoni C, Della Chiesa M, etal |title=Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4120–5 |year= 2003 |pmid= 12646700 |doi= 10.1073/pnas.0730640100 | pmc=153058 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Castriconi R, Cantoni C, Della Chiesa M, ''et al.'' |title=Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4120-5 |year= 2003 |pmid= 12646700 |doi= 10.1073/pnas.0730640100 }}
*{{cite journal   |vauthors=Xie T, Rowen L, Aguado B, etal |title=Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 | pmc=403804 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Lehner B, Semple JI, Brown SE, etal |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 }}
*{{cite journal | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621-36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 }}
*{{cite journal  |vauthors=Harrison RE, Sikorski BA, Jongstra J |title=Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton |journal=J. Cell Sci. |volume=117 |issue= Pt 10 |pages= 2151–7 |year= 2005 |pmid= 15090600 |doi= 10.1242/jcs.00955 }}
*{{cite journal | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi=  }}
*{{cite journal   |vauthors=Marafioti T, Mancini C, Ascani S, etal |title=Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin's disease |journal=Haematologica |volume=89 |issue= 8 |pages= 957–64 |year= 2006 |pmid= 15339679 |doi=  }}
*{{cite journal  | author=Harrison RE, Sikorski BA, Jongstra J |title=Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton. |journal=J. Cell. Sci. |volume=117 |issue= Pt 10 |pages= 2151-7 |year= 2005 |pmid= 15090600 |doi= 10.1242/jcs.00955 }}
*{{cite journal   |vauthors=Mulcahy H, O'Rourke KP, Adams C, etal |title=LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection |journal=Immunogenetics |volume=57 |issue= 12 |pages= 893–903 |year= 2006 |pmid= 16362817 |doi= 10.1007/s00251-005-0057-2 }}
*{{cite journal | author=Marafioti T, Mancini C, Ascani S, ''et al.'' |title=Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin's disease. |journal=Haematologica |volume=89 |issue= 8 |pages= 957-64 |year= 2006 |pmid= 15339679 |doi=  }}
*{{cite journal | author=Mulcahy H, O'Rourke KP, Adams C, ''et al.'' |title=LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection. |journal=Immunogenetics |volume=57 |issue= 12 |pages= 893-903 |year= 2006 |pmid= 16362817 |doi= 10.1007/s00251-005-0057-2 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 00:49, 11 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Leukocyte-specific transcript 1 protein is a protein that in humans is encoded by the LST1 gene.[1][2][3]

References

  1. ↑ Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (Mar 1997). "Genes in a 220-kb region spanning the TNF cluster in human MHC". Genomics. 31 (2): 215–22. doi:10.1006/geno.1996.0034. PMID 8824804.
  2. ↑ de Baey A, Fellerhoff B, Maier S, Martinozzi S, Weidle U, Weiss EH (Jan 1998). "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing". Genomics. 45 (3): 591–600. doi:10.1006/geno.1997.4963. PMID 9367684.
  3. ↑ "Entrez Gene: LST1 leukocyte specific transcript 1".

Further reading



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