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{{ | '''Quaking homolog, KH domain RNA binding (mouse)''', also known as '''QKI''', is a [[protein]] which in humans is encoded by the ''QKI'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: QKI quaking homolog, KH domain RNA binding (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9444| accessdate = }}</ref><ref name="pmid10535969">{{cite journal | vauthors = Saccomanno L, Loushin C, Jan E, Punkay E, Artzt K, Goodwin EB | title = The STAR protein QKI-6 is a translational repressor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 22 | pages = 12605–10 |date=October 1999 | pmid = 10535969 | pmc = 23011 | doi = 10.1073/pnas.96.22.12605| url = | bibcode = 1999PNAS...9612605S }}</ref> | ||
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QKI belongs to a family of RNA-binding proteins called STAR proteins for '''S'''ignal '''T'''ransduction and '''A'''ctivation of '''R'''NA.<ref name="pmid9433137">{{cite journal | vauthors = Vernet C, Artzt K | title = STAR, a gene family involved in signal transduction and activation of RNA | journal = Trends Genet. | volume = 13 | issue = 12 | pages = 479–84 |date=December 1997 | pmid = 9433137 | doi = 10.1016/S0168-9525(97)01269-9| url = }}</ref> They have an [[HNRPK|HNRNPK]] homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 ([[KHDRBS1]]) and [[SF1 (gene)|SF1]] .<ref name="pmid9671495">{{cite journal | vauthors = Chen T, Richard S | title = Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization | journal = Mol. Cell. Biol. | volume = 18 | issue = 8 | pages = 4863–71 |date=August 1998 | pmid = 9671495 | pmc = 109071 | doi = | url = http://mcb.asm.org/cgi/pmidlookup?view=long&pmid=9671495 | issn = }}</ref> Two more new members are [[KHDRBS3]]<ref name="pmid10332027">{{cite journal | vauthors = Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC | title = T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis | journal = Hum. Mol. Genet. | volume = 8 | issue = 6 | pages = 959–69 |date=June 1999 | pmid = 10332027 | doi = 10.1093/hmg/8.6.959| url = }}</ref> and [[KHDRBS2]].<ref name="pmid12549823">{{cite journal | vauthors = Wang L, Xu J, Zeng L, Ye X, Wu Q, Dai J, Ji C, Gu S, Zhao C, Xie Y, Mao Y | title = Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2 | journal = Mol. Biol. Rep. | volume = 29 | issue = 4 | pages = 369–75 |date=December 2002 | pmid = 12549823 | doi = 10.1023/A:1021246109101| url = }}</ref> | |||
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The QKI gene is implicated as being important in schizophrenia,<ref>{{cite journal |vauthors=Aberg K, Saetre P, Jareborg N, Jazin E |title=Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue=19 |pages=7482–7 |date=May 2006 |pmid=16641098 |pmc=1464365 |doi=10.1073/pnas.0601213103 |url=|bibcode=2006PNAS..103.7482A }}</ref><ref>{{cite journal |vauthors=Haroutunian V, Katsel P, Dracheva S, Davis KL |title=The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia |journal=Am J Psychiatry |volume=163 |issue=10 |pages=1834–7 |date=October 2006 |pmid=17012699 |doi=10.1176/ajp.2006.163.10.1834}}</ref> and QKI controls translation of many oligodendrocyte-related genes. | |||
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==References== | ==References== | ||
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==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, etal |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }} | ||
*{{cite journal | *{{cite journal |vauthors=Saccomanno L, Loushin C, Jan E, etal |title=The STAR protein QKI-6 is a translational repressor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 22 |pages= 12605–10 |year= 1999 |pmid= 10535969 |doi=10.1073/pnas.96.22.12605 | pmc=23011 |bibcode=1999PNAS...9612605S }} | ||
*{{cite journal | *{{cite journal |vauthors=Li ZZ, Kondo T, Murata T, etal |title=Expression of Hqk encoding a KH RNA binding protein is altered in human glioma. |journal=Jpn. J. Cancer Res. |volume=93 |issue= 2 |pages= 167–77 |year= 2002 |pmid= 11856480 |doi= 10.1111/j.1349-7006.2002.tb01255.x}} | ||
*{{cite journal | | *{{cite journal | vauthors=Wu JI, Reed RB, Grabowski PJ, Artzt K |title=Function of quaking in myelination: regulation of alternative splicing |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 7 |pages= 4233–8 |year= 2002 |pmid= 11917126 |doi= 10.1073/pnas.072090399 | pmc=123631 |bibcode=2002PNAS...99.4233W }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal | *{{cite journal |vauthors=Moore FL, Jaruzelska J, Fox MS, etal |title=Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 538–43 |year= 2003 |pmid= 12511597 |doi= 10.1073/pnas.0234478100 | pmc=141031 |bibcode=2003PNAS..100..538M }} | ||
*{{cite journal | *{{cite journal |vauthors=Côté J, Boisvert FM, Boulanger MC, etal |title=Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. |journal=Mol. Biol. Cell |volume=14 |issue= 1 |pages= 274–87 |year= 2003 |pmid= 12529443 |doi= 10.1091/mbc.E02-08-0484 | pmc=140244 }} | ||
*{{cite journal | *{{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }} | ||
*{{cite journal | *{{cite journal |vauthors=Ichimura K, Mungall AJ, Fiegler H, etal |title=Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH. |journal=Oncogene |volume=25 |issue= 8 |pages= 1261–71 |year= 2006 |pmid= 16205629 |doi= 10.1038/sj.onc.1209156 | pmc=2760128 }} | ||
*{{cite journal | *{{cite journal |vauthors=Aberg K, Saetre P, Lindholm E, etal |title=Human QKI, a new candidate gene for schizophrenia involved in myelination. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 1 |pages= 84–90 |year= 2006 |pmid= 16342280 |doi= 10.1002/ajmg.b.30243 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Aberg K, Saetre P, Jareborg N, Jazin E |title=Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 19 |pages= 7482–7 |year= 2006 |pmid= 16641098 |doi= 10.1073/pnas.0601213103 | pmc=1464365 |bibcode=2006PNAS..103.7482A }} | ||
*{{cite journal | *{{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Haroutunian V, Katsel P, Dracheva S, Davis KL |title=The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia. |journal=The American Journal of Psychiatry |volume=163 |issue= 10 |pages= 1834–7 |year= 2006 |pmid= 17012699 |doi= 10.1176/ajp.2006.163.10.1834 }} | ||
*{{cite journal | *{{cite journal |vauthors=Zhao L, Tian D, Xia M, etal |title=Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI. |journal=J. Neurosci. |volume=26 |issue= 44 |pages= 11278–86 |year= 2006 |pmid= 17079655 |doi= 10.1523/JNEUROSCI.2677-06.2006 }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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Location (UCSC) | n/a | n/a | |||||
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Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.[1][2]
QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA.[3] They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1 .[4] Two more new members are KHDRBS3[5] and KHDRBS2.[6]
The QKI gene is implicated as being important in schizophrenia,[7][8] and QKI controls translation of many oligodendrocyte-related genes.
References
- ↑ "Entrez Gene: QKI quaking homolog, KH domain RNA binding (mouse)".
- ↑ Saccomanno L, Loushin C, Jan E, Punkay E, Artzt K, Goodwin EB (October 1999). "The STAR protein QKI-6 is a translational repressor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605–10. Bibcode:1999PNAS...9612605S. doi:10.1073/pnas.96.22.12605. PMC 23011. PMID 10535969.
- ↑ Vernet C, Artzt K (December 1997). "STAR, a gene family involved in signal transduction and activation of RNA". Trends Genet. 13 (12): 479–84. doi:10.1016/S0168-9525(97)01269-9. PMID 9433137.
- ↑ Chen T, Richard S (August 1998). "Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization". Mol. Cell. Biol. 18 (8): 4863–71. PMC 109071. PMID 9671495.
- ↑ Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC (June 1999). "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis". Hum. Mol. Genet. 8 (6): 959–69. doi:10.1093/hmg/8.6.959. PMID 10332027.
- ↑ Wang L, Xu J, Zeng L, Ye X, Wu Q, Dai J, Ji C, Gu S, Zhao C, Xie Y, Mao Y (December 2002). "Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2". Mol. Biol. Rep. 29 (4): 369–75. doi:10.1023/A:1021246109101. PMID 12549823.
- ↑ Aberg K, Saetre P, Jareborg N, Jazin E (May 2006). "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7482–7. Bibcode:2006PNAS..103.7482A. doi:10.1073/pnas.0601213103. PMC 1464365. PMID 16641098.
- ↑ Haroutunian V, Katsel P, Dracheva S, Davis KL (October 2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". Am J Psychiatry. 163 (10): 1834–7. doi:10.1176/ajp.2006.163.10.1834. PMID 17012699.
Further reading
- Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
- Saccomanno L, Loushin C, Jan E, et al. (1999). "The STAR protein QKI-6 is a translational repressor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605–10. Bibcode:1999PNAS...9612605S. doi:10.1073/pnas.96.22.12605. PMC 23011. PMID 10535969.
- Li ZZ, Kondo T, Murata T, et al. (2002). "Expression of Hqk encoding a KH RNA binding protein is altered in human glioma". Jpn. J. Cancer Res. 93 (2): 167–77. doi:10.1111/j.1349-7006.2002.tb01255.x. PMID 11856480.
- Wu JI, Reed RB, Grabowski PJ, Artzt K (2002). "Function of quaking in myelination: regulation of alternative splicing". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4233–8. Bibcode:2002PNAS...99.4233W. doi:10.1073/pnas.072090399. PMC 123631. PMID 11917126.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Moore FL, Jaruzelska J, Fox MS, et al. (2003). "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 538–43. Bibcode:2003PNAS..100..538M. doi:10.1073/pnas.0234478100. PMC 141031. PMID 12511597.
- Côté J, Boisvert FM, Boulanger MC, et al. (2003). "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1". Mol. Biol. Cell. 14 (1): 274–87. doi:10.1091/mbc.E02-08-0484. PMC 140244. PMID 12529443.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- Ichimura K, Mungall AJ, Fiegler H, et al. (2006). "Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH". Oncogene. 25 (8): 1261–71. doi:10.1038/sj.onc.1209156. PMC 2760128. PMID 16205629.
- Aberg K, Saetre P, Lindholm E, et al. (2006). "Human QKI, a new candidate gene for schizophrenia involved in myelination". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (1): 84–90. doi:10.1002/ajmg.b.30243. PMID 16342280.
- Aberg K, Saetre P, Jareborg N, Jazin E (2006). "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7482–7. Bibcode:2006PNAS..103.7482A. doi:10.1073/pnas.0601213103. PMC 1464365. PMID 16641098.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Haroutunian V, Katsel P, Dracheva S, Davis KL (2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". The American Journal of Psychiatry. 163 (10): 1834–7. doi:10.1176/ajp.2006.163.10.1834. PMID 17012699.
- Zhao L, Tian D, Xia M, et al. (2006). "Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI". J. Neurosci. 26 (44): 11278–86. doi:10.1523/JNEUROSCI.2677-06.2006. PMID 17079655.
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