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{{Infobox_gene}}
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'''Vascular non-inflammatory molecule 2''' is a [[protein]] that in humans is encoded by the ''VNN2'' [[gene]].<ref name="pmid9790769">{{cite journal | vauthors = Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P | title = Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6 | journal = Genomics | volume = 53 | issue = 2 | pages = 203–13 |date=Dec 1998 | pmid = 9790769 | pmc = | doi = 10.1006/geno.1998.5481 }}</ref><ref name="pmid11491533">{{cite journal | vauthors = Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F | title = Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes | journal = Immunogenetics | volume = 53 | issue = 4 | pages = 296–306 |date=Aug 2001 | pmid = 11491533 | pmc =  | doi =10.1007/s002510100327  }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Vanin 2
| HGNCid = 12706
| Symbol = VNN2
| AltSymbols =; FOAP-4; GPI-80
| OMIM = 603571
| ECnumber = 
| Homologene = 48295
| MGIid = 1347055
| GeneAtlas_image1 = PBB_GE_VNN2_205922_at_tn.png
| Function = {{GNF_GO|id=GO:0016811 |text = hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006807 |text = nitrogen compound metabolic process}} {{GNF_GO|id=GO:0006928 |text = cell motility}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8875
    | Hs_Ensembl = ENSG00000112303
    | Hs_RefseqProtein = NP_004656
    | Hs_RefseqmRNA = NM_004665
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 133106702
    | Hs_GenLoc_end = 133120726
    | Hs_Uniprot = O95498
    | Mm_EntrezGene = 26464
    | Mm_Ensembl = ENSMUSG00000020010
    | Mm_RefseqmRNA = NM_011979
    | Mm_RefseqProtein = NP_036109
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 23540888
    | Mm_GenLoc_end = 23559257
    | Mm_Uniprot = Q2T9H5
  }}
}}
'''Vanin 2''', also known as '''VNN2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VNN2 vanin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8875| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Two transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: VNN2 vanin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8875| accessdate = }}</ref>
| summary_text = This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Two transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: VNN2 vanin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8875| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Galland F, Malergue F, Bazin H, ''et al.'' |title=Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. |journal=Genomics |volume=53 |issue= 2 |pages= 203-13 |year= 1998 |pmid= 9790769 |doi= 10.1006/geno.1998.5481 }}
*{{cite journal   |vauthors=Suzuki K, Watanabe T, Sakurai S, etal |title=A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 4277–84 |year= 1999 |pmid= 10201959 |doi=  }}
*{{cite journal  | author=Suzuki K, Watanabe T, Sakurai S, ''et al.'' |title=A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 4277-84 |year= 1999 |pmid= 10201959 |doi=  }}
*{{cite journal  | vauthors=Dahlgren C, Karlsson A, Sendo F |title=Neutrophil secretory vesicles are the intracellular reservoir for GPI-80, a protein with adhesion-regulating potential. |journal=J. Leukoc. Biol. |volume=69 |issue= 1 |pages= 57–62 |year= 2001 |pmid= 11200068 |doi=  }}
*{{cite journal  | author=Dahlgren C, Karlsson A, Sendo F |title=Neutrophil secretory vesicles are the intracellular reservoir for GPI-80, a protein with adhesion-regulating potential. |journal=J. Leukoc. Biol. |volume=69 |issue= 1 |pages= 57-62 |year= 2001 |pmid= 11200068 |doi=  }}
*{{cite journal  | vauthors=Watanabe T, Sendo F |title=Physical association of beta 2 integrin with GPI-80, a novel glycosylphosphatidylinositol-anchored protein with potential for regulating adhesion and migration. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 3 |pages= 692–4 |year= 2002 |pmid= 12056825 |doi= 10.1016/S0006-291X(02)00538-7 }}
*{{cite journal  | author=Martin F, Malergue F, Pitari G, ''et al.'' |title=Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. |journal=Immunogenetics |volume=53 |issue= 4 |pages= 296-306 |year= 2001 |pmid= 11491533 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Watanabe T, Sendo F |title=Physical association of beta 2 integrin with GPI-80, a novel glycosylphosphatidylinositol-anchored protein with potential for regulating adhesion and migration. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 3 |pages= 692-4 |year= 2002 |pmid= 12056825 |doi= 10.1016/S0006-291X(02)00538-7 }}
*{{cite journal   |vauthors=Takeda Y, Fu J, Suzuki K, etal |title=Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells |journal=Exp. Cell Res. |volume=286 |issue= 2 |pages= 199–208 |year= 2003 |pmid= 12749849 |doi=10.1016/S0014-4827(03)00071-5 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Sendo D, Takeda Y, Ishikawa H, etal |title=Localization of GPI-80, a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein, on strongly CD14-positive human monocytes |journal=Immunobiology |volume=207 |issue= 3 |pages= 217–21 |year= 2004 |pmid= 12777063 |doi=10.1078/0171-2985-00235 }}
*{{cite journal | author=Takeda Y, Fu J, Suzuki K, ''et al.'' |title=Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells. |journal=Exp. Cell Res. |volume=286 |issue= 2 |pages= 199-208 |year= 2003 |pmid= 12749849 |doi=  }}
*{{cite journal   |vauthors=Sasaki H, Ide N, Sendo F, etal |title=Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage |journal=Cancer Sci. |volume=94 |issue= 9 |pages= 809–13 |year= 2004 |pmid= 12967480 |doi=10.1111/j.1349-7006.2003.tb01523.x }}
*{{cite journal | author=Sendo D, Takeda Y, Ishikawa H, ''et al.'' |title=Localization of GPI-80, a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein, on strongly CD14-positive human monocytes. |journal=Immunobiology |volume=207 |issue= 3 |pages= 217-21 |year= 2004 |pmid= 12777063 |doi=  }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Sasaki H, Ide N, Sendo F, ''et al.'' |title=Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage. |journal=Cancer Sci. |volume=94 |issue= 9 |pages= 809-13 |year= 2004 |pmid= 12967480 |doi=  }}
*{{cite journal   |vauthors=Yoshitake H, Takeda Y, Nitto T, etal |title=GPI-80, a beta2 integrin associated glycosylphosphatidylinositol-anchored protein, concentrates on pseudopodia without association with beta2 integrin during neutrophil migration |journal=Immunobiology |volume=208 |issue= 4 |pages= 391–9 |year= 2004 |pmid= 14748512 |doi=10.1078/0171-2985-00281 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Yoshitake H, Takeda Y, Nitto T, ''et al.'' |title=GPI-80, a beta2 integrin associated glycosylphosphatidylinositol-anchored protein, concentrates on pseudopodia without association with beta2 integrin during neutrophil migration. |journal=Immunobiology |volume=208 |issue= 4 |pages= 391-9 |year= 2004 |pmid= 14748512 |doi=  }}
*{{cite journal   |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Nitto T, Takeda Y, Yoshitake H, etal |title=Structural divergence of GPI-80 in activated human neutrophils |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 2 |pages= 227–33 |year= 2007 |pmid= 17543284 |doi= 10.1016/j.bbrc.2007.05.087 }}
*{{cite journal | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal | author=Nitto T, Takeda Y, Yoshitake H, ''et al.'' |title=Structural divergence of GPI-80 in activated human neutrophils. |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 2 |pages= 227-33 |year= 2007 |pmid= 17543284 |doi= 10.1016/j.bbrc.2007.05.087 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 15:37, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Vascular non-inflammatory molecule 2 is a protein that in humans is encoded by the VNN2 gene.[1][2][3]

This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Two transcript variants encoding different isoforms have been described for this gene.[3]

References

  1. ↑ Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769.
  2. ↑ Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F (Aug 2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533.
  3. ↑ 3.0 3.1 "Entrez Gene: VNN2 vanin 2".

Further reading



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