HIST1H2AL: Difference between revisions

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{{Infobox_gene}}
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'''Histone H2A type 1''' is a [[protein]] that in humans is encoded by the ''HIST1H2AL'' [[gene]].<ref name="pmid9439656">{{cite journal |vauthors=Albig W, Doenecke D | title = The human histone gene cluster at the D6S105 locus | journal = Hum Genet | volume = 101 | issue = 3 | pages = 284–94 |date=Feb 1998 | pmid = 9439656 | pmc =  | doi =10.1007/s004390050630 }}</ref><ref name="pmid9031620">{{cite journal |vauthors=Albig W, Meergans T, Doenecke D | title = Characterization of the H1.5 gene completes the set of human H1 subtype genes | journal = Gene | volume = 184 | issue = 2 | pages = 141–8 |date=Mar 1997 | pmid = 9031620 | pmc =  | doi =10.1016/S0378-1119(96)00582-3 }}</ref><ref name="pmid12408966">{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | pmc =  | doi =10.1016/S0888-7543(02)96850-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2AL histone cluster 1, H2al| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8332| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_HIST1H2AL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aoi.
| PDB = {{PDB2|1aoi}}, {{PDB2|1eqz}}, {{PDB2|1hio}}, {{PDB2|1hq3}}, {{PDB2|1kx3}}, {{PDB2|1kx4}}, {{PDB2|1kx5}}, {{PDB2|1m18}}, {{PDB2|1m19}}, {{PDB2|1m1a}}, {{PDB2|1p34}}, {{PDB2|1p3a}}, {{PDB2|1p3b}}, {{PDB2|1p3f}}, {{PDB2|1p3g}}, {{PDB2|1p3i}}, {{PDB2|1p3k}}, {{PDB2|1p3l}}, {{PDB2|1p3m}}, {{PDB2|1p3o}}, {{PDB2|1p3p}}, {{PDB2|1s32}}, {{PDB2|1tzy}}, {{PDB2|1zbb}}, {{PDB2|1zla}}, {{PDB2|2aro}}, {{PDB2|2cv5}}, {{PDB2|2f8n}}, {{PDB2|2fj7}}, {{PDB2|2hio}}, {{PDB2|2nzd}}
| Name = Histone cluster 1, H2al
| HGNCid = 4730
| Symbol = HIST1H2AL
| AltSymbols =; H2A.i; H2A/i; H2AFI; HIST1H2AM; dJ193B12.9
| OMIM = 602793
| ECnumber =
| Homologene = 74476
| MGIid = 3646032
  | Function =  
  | Component =  
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8332
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_003502
    | Hs_RefseqmRNA = NM_003511
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =   
    | Hs_GenLoc_start =   
    | Hs_GenLoc_end =
    | Hs_Uniprot =
    | Mm_EntrezGene = 667728
    | Mm_Ensembl =
    | Mm_RefseqmRNA = XM_992084
    | Mm_RefseqProtein = XP_997178
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr =
    | Mm_GenLoc_start =
    | Mm_GenLoc_end =   
    | Mm_Uniprot =   
  }}
}}
'''Histone cluster 1, H2al''', also known as '''HIST1H2AL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2AL histone cluster 1, H2al| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8332| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2AL histone cluster 1, H2al| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8332| accessdate = }}</ref>
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2AL histone cluster 1, H2al| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8332| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Du Clos TW, Zlock LT, Marnell L |title=Definition of a C-reactive protein binding determinant on histones. |journal=J. Biol. Chem. |volume=266 |issue= 4 |pages= 2167-71 |year= 1991 |pmid= 1989977 |doi=  }}
*{{cite journal  |vauthors=Du Clos TW, Zlock LT, Marnell L |title=Definition of a C-reactive protein binding determinant on histones. |journal=J. Biol. Chem. |volume=266 |issue= 4 |pages= 2167–71 |year= 1991 |pmid= 1989977 |doi=  }}
*{{cite journal  | author=Albig W, Meergans T, Doenecke D |title=Characterization of the H1.5 gene completes the set of human H1 subtype genes. |journal=Gene |volume=184 |issue= 2 |pages= 141-8 |year= 1997 |pmid= 9031620 |doi=  }}
*{{cite journal  |vauthors=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi= 10.1128/mcb.18.5.2535| pmc=110633 }}
*{{cite journal  | author=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus. |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284-94 |year= 1998 |pmid= 9439656 |doi=  }}
*{{cite journal   |vauthors=Zhang Y, Sun ZW, Iratni R, etal |title=SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. |journal=Mol. Cell |volume=1 |issue= 7 |pages= 1021–31 |year= 1998 |pmid= 9651585 |doi=10.1016/S1097-2765(00)80102-1 }}
*{{cite journal  | author=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535-44 |year= 1998 |pmid= 9566873 |doi=  }}
*{{cite journal   |vauthors=Carrier F, Georgel PT, Pourquier P, etal |title=Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1673–85 |year= 1999 |pmid= 10022855 |doi= | pmc=83961 }}
*{{cite journal | author=Zhang Y, Sun ZW, Iratni R, ''et al.'' |title=SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. |journal=Mol. Cell |volume=1 |issue= 7 |pages= 1021-31 |year= 1998 |pmid= 9651585 |doi=  }}
*{{cite journal   |vauthors=Albig W, Trappe R, Kardalinou E, etal |title=The human H2A and H2B histone gene complement. |journal=Biol. Chem. |volume=380 |issue= 1 |pages= 7–18 |year= 1999 |pmid= 10064132 |doi=10.1515/BC.1999.002 }}
*{{cite journal | author=Carrier F, Georgel PT, Pourquier P, ''et al.'' |title=Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1673-85 |year= 1999 |pmid= 10022855 |doi=  }}
*{{cite journal   |vauthors=Deng L, de la Fuente C, Fu P, etal |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 }}
*{{cite journal | author=Albig W, Trappe R, Kardalinou E, ''et al.'' |title=The human H2A and H2B histone gene complement. |journal=Biol. Chem. |volume=380 |issue= 1 |pages= 7-18 |year= 1999 |pmid= 10064132 |doi=  }}
*{{cite journal   |vauthors=Deng L, Wang D, de la Fuente C, etal |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 }}
*{{cite journal | author=Deng L, de la Fuente C, Fu P, ''et al.'' |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278-95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Deng L, Wang D, de la Fuente C, ''et al.'' |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312-26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 }}
*{{cite journal  |vauthors=Kzhyshkowska J, Rusch A, Wolf H, Dobner T |title=Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. |journal=Biochem. J. |volume=371 |issue= Pt 2 |pages= 385–93 |year= 2003 |pmid= 12489984 |doi= 10.1042/BJ20021281 | pmc=1223277 }}
*{{cite journal | author=Marzluff WF, Gongidi P, Woods KR, ''et al.'' |title=The human and mouse replication-dependent histone genes. |journal=Genomics |volume=80 |issue= 5 |pages= 487-98 |year= 2003 |pmid= 12408966 |doi=  }}
*{{cite journal  |vauthors=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 | pmc=291826 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Kzhyshkowska J, Rusch A, Wolf H, Dobner T |title=Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. |journal=Biochem. J. |volume=371 |issue= Pt 2 |pages= 385-93 |year= 2003 |pmid= 12489984 |doi= 10.1042/BJ20021281 }}
*{{cite journal  | author=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550-61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=8332}}
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Latest revision as of 13:38, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AL gene.[1][2][3][4]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[4]

References

  1. ↑ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
  2. ↑ Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.
  3. ↑ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  4. ↑ 4.0 4.1 "Entrez Gene: HIST1H2AL histone cluster 1, H2al".

Further reading



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