PECI (gene): Difference between revisions

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{{Infobox_gene}}
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'''Peroxisomal 3,2-trans-enoyl-CoA isomerase''' is an [[enzyme]] that in humans is encoded by the ''PECI'' [[gene]].<ref name="pmid10419495">{{cite journal | vauthors = Geisbrecht BV, Zhang D, Schulz H, Gould SJ | title = Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes | journal = J Biol Chem | volume = 274 | issue = 31 | pages = 21797–803 |date=Aug 1999 | pmid = 10419495 | pmc =  | doi =10.1074/jbc.274.31.21797 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10455| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_PECI_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cqu.
| PDB = {{PDB2|2cqu}}, {{PDB2|2f6q}}
| Name = Peroxisomal D3,D2-enoyl-CoA isomerase
| HGNCid = 14601
| Symbol = PECI
| AltSymbols =; ACBD2; DRS1; HCA88; dJ1013A10.3
| OMIM = 608024
| ECnumber = 
| Homologene = 38145
| MGIid = 1346064
| GeneAtlas_image1 = PBB_GE_PECI_218025_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000062 |text = acyl-CoA binding}} {{GNF_GO|id=GO:0004165 |text = dodecenoyl-CoA delta-isomerase activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005777 |text = peroxisome}}
  | Process = {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10455
    | Hs_Ensembl = ENSG00000198721
    | Hs_RefseqProtein = NP_006108
    | Hs_RefseqmRNA = NM_006117
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 4060922
    | Hs_GenLoc_end = 4080830
    | Hs_Uniprot = O75521
    | Mm_EntrezGene = 23986
    | Mm_Ensembl = ENSMUSG00000021417
    | Mm_RefseqmRNA = NM_011868
    | Mm_RefseqProtein = NP_035998
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 34985214
    | Mm_GenLoc_end = 35001581
    | Mm_Uniprot = Q3TCD4
  }}
}}
'''Peroxisomal D3,D2-enoyl-CoA isomerase''', also known as '''PECI''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10455| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = PECI is an auxiliary enzyme that catalyzes an isomerization step required for the beta-oxidation of unsaturated fatty acids.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10455| accessdate = }}</ref>
| summary_text = PECI is an auxiliary enzyme that catalyzes an isomerization step required for the beta-oxidation of unsaturated fatty acids.[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suk K, Kim YH, Hwang DY, ''et al.'' |title=Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor. |journal=Biochim. Biophys. Acta |volume=1454 |issue= 1 |pages= 126-31 |year= 1999 |pmid= 10354522 |doi=  }}
*{{cite journal   |vauthors=Suk K, Kim YH, Hwang DY, etal |title=Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor |journal=Biochim. Biophys. Acta |volume=1454 |issue= 1 |pages= 126–31 |year= 1999 |pmid= 10354522 |doi=  10.1016/s0925-4439(99)00033-2}}
*{{cite journal  | author=Geisbrecht BV, Zhang D, Schulz H, Gould SJ |title=Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21797-803 |year= 1999 |pmid= 10419495 |doi=  }}
*{{cite journal   |vauthors=Scanlan MJ, Gordan JD, Williamson B, etal |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
*{{cite journal | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi=  }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal   |vauthors=Suzuki Y, Tsunoda T, Sese J, etal |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001 | pmc=311086 }}
*{{cite journal | author=Suzuki Y, Tsunoda T, Sese J, ''et al.'' |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677-84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001 }}
*{{cite journal  | vauthors=Janssen U, Stoffel W |title=Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19579–84 |year= 2002 |pmid= 11916962 |doi= 10.1074/jbc.M110993200 }}
*{{cite journal  | author=Janssen U, Stoffel W |title=Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19579-84 |year= 2002 |pmid= 11916962 |doi= 10.1074/jbc.M110993200 }}
*{{cite journal   |vauthors=Wang Y, Han KJ, Pang XW, etal |title=Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies |journal=J. Immunol. |volume=169 |issue= 2 |pages= 1102–9 |year= 2002 |pmid= 12097419 |doi=  10.4049/jimmunol.169.2.1102}}
*{{cite journal | author=Wang Y, Han KJ, Pang XW, ''et al.'' |title=Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. |journal=J. Immunol. |volume=169 |issue= 2 |pages= 1102-9 |year= 2002 |pmid= 12097419 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Feng X, Chuhjo T, Sugimori C, etal |title=Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells |journal=Blood |volume=104 |issue= 8 |pages= 2425–31 |year= 2004 |pmid= 15217832 |doi= 10.1182/blood-2004-05-1839 }}
*{{cite journal | author=Feng X, Chuhjo T, Sugimori C, ''et al.'' |title=Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. |journal=Blood |volume=104 |issue= 8 |pages= 2425-31 |year= 2004 |pmid= 15217832 |doi= 10.1182/blood-2004-05-1839 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=10455}}
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Revision as of 17:53, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Peroxisomal 3,2-trans-enoyl-CoA isomerase is an enzyme that in humans is encoded by the PECI gene.[1][2]

PECI is an auxiliary enzyme that catalyzes an isomerization step required for the beta-oxidation of unsaturated fatty acids.[supplied by OMIM][2]

References

  1. Geisbrecht BV, Zhang D, Schulz H, Gould SJ (Aug 1999). "Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes". J Biol Chem. 274 (31): 21797–803. doi:10.1074/jbc.274.31.21797. PMID 10419495.
  2. 2.0 2.1 "Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase".

Further reading