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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transcription factor EB''' is a [[protein]] that in humans is encoded by the ''TFEB'' [[gene]].<ref name="pmid2115126">{{cite journal | vauthors = Carr CS, Sharp PA | title = A helix-loop-helix protein related to the immunoglobulin E box-binding proteins | journal = Molecular and Cellular Biology | volume = 10 | issue = 8 | pages = 4384–8 | date = Aug 1990 | pmid = 2115126 | pmc = 360994 | doi =  10.1128/mcb.10.8.4384}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TFEB transcription factor EB| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7942| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transcription factor EB
| HGNCid = 11753
| Symbol = TFEB
| AltSymbols =; AlphaTFEB; TCFEB
| OMIM = 600744
| ECnumber = 
| Homologene = 5182
| MGIid = 103270
| GeneAtlas_image1 = PBB_GE_TFEB_221866_at_tn.png
| GeneAtlas_image2 = PBB_GE_TFEB_50221_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7942
    | Hs_Ensembl = ENSG00000112561
    | Hs_RefseqProtein = NP_009093
    | Hs_RefseqmRNA = NM_007162
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 41759694
    | Hs_GenLoc_end = 41811975
    | Hs_Uniprot = P19484
    | Mm_EntrezGene = 21425
    | Mm_Ensembl = ENSMUSG00000023990
    | Mm_RefseqmRNA = NM_011549
    | Mm_RefseqProtein = NP_035679
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 47200298
    | Mm_GenLoc_end = 47255607
    | Mm_Uniprot = Q3U327
  }}
}}
'''Transcription factor EB''', also known as '''TFEB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TFEB transcription factor EB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7942| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
TFEB is a master gene for [[lysosome|lysosomal]] [[biogenesis]].<ref name="pmid19556463">{{cite journal | vauthors = Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, Di Malta C, Donaudy F, Embrione V, Polishchuk RS, Banfi S, Parenti G, Cattaneo E, Ballabio A | title = A gene network regulating lysosomal biogenesis and function | journal = Science | volume = 325 | issue = 5939 | pages = 473–7 | date = Jul 2009 | pmid = 19556463 | doi = 10.1126/science.1174447 }}</ref> It encodes a [[transcription factor]] that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in [[autophagy]].<ref name="pmid19556463"/> Under aberrant lysosomal storage conditions such as in [[lysosomal storage diseases]], TFEB translocates from the cytoplasm to the nucleus, resulting in the activation of its target genes.<ref name="pmid19556463"/> TFEB overexpression in cultured cells induces lysosomal biogenesis and increases the degradation of complex molecules, such as glycosaminoglycans and the pathogenic protein that causes [[Huntington's disease|Huntington disease]].<ref name="pmid19556463"/> TFEB is activated by [[PPARGC1A|PGC1-alpha]] and promotes reduction of htt aggregation and neurotoxicity in a mouse model of [[Huntington's disease|Huntington disease]].<ref name="pmid22786682">{{cite journal | vauthors = Tsunemi T, Ashe TD, Morrison BE, Soriano KR, Au J, Roque RA, Lazarowski ER, Damian VA, Masliah E, La Spada AR | title = PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function | journal = Science Translational Medicine | volume = 4 | issue = 142 | pages = 142ra97 | date = Jul 2012 | pmid = 22786682 | doi = 10.1126/scitranslmed.3003799 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
TFEB is a target of the protein kinase [[protein kinase B|AKT/PKB]].<ref name="Palmieri_2017">{{cite journal | vauthors = Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M | title = mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases | journal = Nature Communications | date = Feb 2017 | pmid = 28165011 | doi = 10.1038/ncomms14338}}</ref> [[protein kinase B|AKT/PKB]] phosphorylates TFEB at serine 467 and inhibits TFEB nuclear translocation.<ref name="Palmieri_2017" /> Pharmacological inhibition of [[protein kinase B|AKT/PKB]] activates TFEB, promotes lysosome biogenesis and autophagy, and ameliorates neuropathology in a mouse model of Juvenile [[Batten disease]].<ref name="Palmieri_2017" />
{{reflist|2}}
 
==Further reading==
Nuclear localization and activity of TFEB is inhibited by serine phosphorylation by [[mTORC1]] and extracellular signal–regulated kinase 2 ([[MAPK1|ERK2]]). mTORC1 phosphorylation of TFEB occurs at the lysosomal surface, both of which are localized there by interaction with the Rag GTPases. Phosphorylated TFEB is then retained in the cytosol by interaction with [[14-3-3 proteins]].<ref>{{cite journal | vauthors = Martina JA, Chen Y, Gucek M, Puertollano R | title = MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB | journal = Autophagy | volume = 8 | issue = 6 | pages = 903–14 | date = Jun 2012 | pmid = 22576015 | doi = 10.4161/auto.19653 | pmc=3427256}}</ref><ref>{{cite journal | vauthors = Martina JA, Puertollano R | title = RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis | journal = Autophagy | volume = 9 | issue = 6 | pages = 928–30 | date = Jun 2013 | pmid = 23524842 | doi = 10.4161/auto.24371 | pmc=3672304}}</ref><ref>{{cite journal | vauthors = Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM | title = The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis | journal = Science Signaling | volume = 5 | issue = 228 | pages = ra42 | date = Jun 2012 | pmid = 22692423 | doi = 10.1126/scisignal.2002790 | pmc=3437338}}</ref> These kinases are tuned to the levels of extracellular nutrients suggesting a coordination in regulation of autophagy and lysomal biogenesis and partnership of two distinct cellular organelles.<ref name="pmid21617040">{{cite journal | vauthors = Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, Sardiello M, Rubinsztein DC, Ballabio A | title = TFEB links autophagy to lysosomal biogenesis | journal = Science | volume = 332 | issue = 6036 | pages = 1429–33 | date = Jun 2011 | pmid = 21617040 | doi = 10.1126/science.1204592 }}</ref>  TFEB is activated in [[TREX1|Trex1]]-deficient cells via inhibition of [[mTOR|mTORC1]] activity, resulting in an expanded lysosomal compartment.<ref name="pmid23160154">{{cite journal | vauthors = Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N | title = Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes | journal = Nature Immunology | volume = 14 | issue = 1 | pages = 61–71 | date = Jan 2013 | pmid = 23160154 | doi = 10.1038/ni.2475 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Steingrímsson E, Sawadogo M, Gilbert DJ, Zervos AS, Brent R, Blanar MA, Fisher DE, Copeland NG, Jenkins NA | title = Murine chromosomal location of five bHLH-Zip transcription factor genes | journal = Genomics | volume = 28 | issue = 2 | pages = 179–83 | date = Jul 1995 | pmid = 8530024 | doi = 10.1006/geno.1995.1129 }}
| citations =
* {{cite journal | vauthors = Steingrímsson E, Tessarollo L, Reid SW, Jenkins NA, Copeland NG | title = The bHLH-Zip transcription factor Tfeb is essential for placental vascularization | journal = Development | volume = 125 | issue = 23 | pages = 4607–16 | date = Dec 1998 | pmid = 9806910 | doi =  }}
*{{cite journal | author=Carr CS, Sharp PA |title=A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. |journal=Mol. Cell. Biol. |volume=10 |issue= 8 |pages= 4384-8 |year= 1990 |pmid= 2115126 |doi=  }}
* {{cite journal | vauthors = Verastegui C, Bertolotto C, Bille K, Abbe P, Ortonne JP, Ballotti R | title = TFE3, a transcription factor homologous to microphthalmia, is a potential transcriptional activator of tyrosinase and TyrpI genes | journal = Molecular Endocrinology | volume = 14 | issue = 3 | pages = 449–56 | date = Mar 2000 | pmid = 10707962 | doi = 10.1210/me.14.3.449 }}
*{{cite journal  | author=Steingrímsson E, Sawadogo M, Gilbert DJ, ''et al.'' |title=Murine chromosomal location of five bHLH-Zip transcription factor genes. |journal=Genomics |volume=28 |issue= 2 |pages= 179-83 |year= 1996 |pmid= 8530024 |doi= 10.1006/geno.1995.1129 }}
* {{cite journal | vauthors = Davis IJ, Hsi BL, Arroyo JD, Vargas SO, Yeh YA, Motyckova G, Valencia P, Perez-Atayde AR, Argani P, Ladanyi M, Fletcher JA, Fisher DE | title = Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 10 | pages = 6051–6 | date = May 2003 | pmid = 12719541 | pmc = 156324 | doi = 10.1073/pnas.0931430100 }}
*{{cite journal | author=Steingrímsson E, Tessarollo L, Reid SW, ''et al.'' |title=The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. |journal=Development |volume=125 |issue= 23 |pages= 4607-16 |year= 1999 |pmid= 9806910 |doi=  }}
* {{cite journal | vauthors = Kuiper RP, Schepens M, Thijssen J, van Asseldonk M, van den Berg E, Bridge J, Schuuring E, Schoenmakers EF, van Kessel AG | title = Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution | journal = Human Molecular Genetics | volume = 12 | issue = 14 | pages = 1661–9 | date = Jul 2003 | pmid = 12837690 | doi = 10.1093/hmg/ddg178 }}
*{{cite journal | author=Verastegui C, Bertolotto C, Bille K, ''et al.'' |title=TFE3, a transcription factor homologous to microphthalmia, is a potential transcriptional activator of tyrosinase and TyrpI genes. |journal=Mol. Endocrinol. |volume=14 |issue= 3 |pages= 449-56 |year= 2000 |pmid= 10707962 |doi= }}
* {{cite journal | vauthors = Kuiper RP, Schepens M, Thijssen J, Schoenmakers EF, van Kessel AG | title = Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains | journal = Nucleic Acids Research | volume = 32 | issue = 8 | pages = 2315–22 | year = 2004 | pmid = 15118077 | pmc = 419459 | doi = 10.1093/nar/gkh571 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Argani P, Laé M, Hutchinson B, Reuter VE, Collins MH, Perentesis J, Tomaszewski JE, Brooks JS, Acs G, Bridge JA, Vargas SO, Davis IJ, Fisher DE, Ladanyi M | title = Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR | journal = The American Journal of Surgical Pathology | volume = 29 | issue = 2 | pages = 230–40 | date = Feb 2005 | pmid = 15644781 | doi = 10.1097/01.pas.0000146007.54092.37 }}
*{{cite journal | author=Davis IJ, Hsi BL, Arroyo JD, ''et al.'' |title=Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 10 |pages= 6051-6 |year= 2003 |pmid= 12719541 |doi= 10.1073/pnas.0931430100 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Kuiper RP, Schepens M, Thijssen J, ''et al.'' |title=Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution. |journal=Hum. Mol. Genet. |volume=12 |issue= 14 |pages= 1661-9 |year= 2003 |pmid= 12837690 |doi=  }}
* {{cite journal | vauthors = Pecciarini L, Cangi MG, Lo Cunsolo C, Macri' E, Dal Cin E, Martignoni G, Doglioni C | title = Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient | journal = Genes, Chromosomes & Cancer | volume = 46 | issue = 5 | pages = 419–26 | date = May 2007 | pmid = 17285572 | doi = 10.1002/gcc.20422 }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Kuiper RP, Schepens M, Thijssen J, ''et al.'' |title=Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains. |journal=Nucleic Acids Res. |volume=32 |issue= 8 |pages= 2315-22 |year= 2004 |pmid= 15118077 |doi= 10.1093/nar/gkh571 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Argani P, Laé M, Hutchinson B, ''et al.'' |title=Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. |journal=Am. J. Surg. Pathol. |volume=29 |issue= 2 |pages= 230-40 |year= 2005 |pmid= 15644781 |doi= }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Pecciarini L, Cangi MG, Lo Cunsolo C, ''et al.'' |title=Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient. |journal=Genes Chromosomes Cancer |volume=46 |issue= 5 |pages= 419-26 |year= 2007 |pmid= 17285572 |doi= 10.1002/gcc.20422 }}
}}
{{refend}}
{{refend}}


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Revision as of 02:43, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor EB is a protein that in humans is encoded by the TFEB gene.[1][2]

Function

TFEB is a master gene for lysosomal biogenesis.[3] It encodes a transcription factor that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in autophagy.[3] Under aberrant lysosomal storage conditions such as in lysosomal storage diseases, TFEB translocates from the cytoplasm to the nucleus, resulting in the activation of its target genes.[3] TFEB overexpression in cultured cells induces lysosomal biogenesis and increases the degradation of complex molecules, such as glycosaminoglycans and the pathogenic protein that causes Huntington disease.[3] TFEB is activated by PGC1-alpha and promotes reduction of htt aggregation and neurotoxicity in a mouse model of Huntington disease.[4]

TFEB is a target of the protein kinase AKT/PKB.[5] AKT/PKB phosphorylates TFEB at serine 467 and inhibits TFEB nuclear translocation.[5] Pharmacological inhibition of AKT/PKB activates TFEB, promotes lysosome biogenesis and autophagy, and ameliorates neuropathology in a mouse model of Juvenile Batten disease.[5]

Nuclear localization and activity of TFEB is inhibited by serine phosphorylation by mTORC1 and extracellular signal–regulated kinase 2 (ERK2). mTORC1 phosphorylation of TFEB occurs at the lysosomal surface, both of which are localized there by interaction with the Rag GTPases. Phosphorylated TFEB is then retained in the cytosol by interaction with 14-3-3 proteins.[6][7][8] These kinases are tuned to the levels of extracellular nutrients suggesting a coordination in regulation of autophagy and lysomal biogenesis and partnership of two distinct cellular organelles.[9] TFEB is activated in Trex1-deficient cells via inhibition of mTORC1 activity, resulting in an expanded lysosomal compartment.[10]

References

  1. ↑ Carr CS, Sharp PA (Aug 1990). "A helix-loop-helix protein related to the immunoglobulin E box-binding proteins". Molecular and Cellular Biology. 10 (8): 4384–8. doi:10.1128/mcb.10.8.4384. PMC 360994. PMID 2115126.
  2. ↑ "Entrez Gene: TFEB transcription factor EB".
  3. ↑ 3.0 3.1 3.2 3.3 Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, Di Malta C, Donaudy F, Embrione V, Polishchuk RS, Banfi S, Parenti G, Cattaneo E, Ballabio A (Jul 2009). "A gene network regulating lysosomal biogenesis and function". Science. 325 (5939): 473–7. doi:10.1126/science.1174447. PMID 19556463.
  4. ↑ Tsunemi T, Ashe TD, Morrison BE, Soriano KR, Au J, Roque RA, Lazarowski ER, Damian VA, Masliah E, La Spada AR (Jul 2012). "PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function". Science Translational Medicine. 4 (142): 142ra97. doi:10.1126/scitranslmed.3003799. PMID 22786682.
  5. ↑ 5.0 5.1 5.2 Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M (Feb 2017). "mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases". Nature Communications. doi:10.1038/ncomms14338. PMID 28165011.
  6. ↑ Martina JA, Chen Y, Gucek M, Puertollano R (Jun 2012). "MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB". Autophagy. 8 (6): 903–14. doi:10.4161/auto.19653. PMC 3427256. PMID 22576015.
  7. ↑ Martina JA, Puertollano R (Jun 2013). "RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis". Autophagy. 9 (6): 928–30. doi:10.4161/auto.24371. PMC 3672304. PMID 23524842.
  8. ↑ Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM (Jun 2012). "The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis". Science Signaling. 5 (228): ra42. doi:10.1126/scisignal.2002790. PMC 3437338. PMID 22692423.
  9. ↑ Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, Sardiello M, Rubinsztein DC, Ballabio A (Jun 2011). "TFEB links autophagy to lysosomal biogenesis". Science. 332 (6036): 1429–33. doi:10.1126/science.1204592. PMID 21617040.
  10. ↑ Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N (Jan 2013). "Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes". Nature Immunology. 14 (1): 61–71. doi:10.1038/ni.2475. PMID 23160154.

Further reading

  • Steingrímsson E, Sawadogo M, Gilbert DJ, Zervos AS, Brent R, Blanar MA, Fisher DE, Copeland NG, Jenkins NA (Jul 1995). "Murine chromosomal location of five bHLH-Zip transcription factor genes". Genomics. 28 (2): 179–83. doi:10.1006/geno.1995.1129. PMID 8530024.
  • Steingrímsson E, Tessarollo L, Reid SW, Jenkins NA, Copeland NG (Dec 1998). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization". Development. 125 (23): 4607–16. PMID 9806910.
  • Verastegui C, Bertolotto C, Bille K, Abbe P, Ortonne JP, Ballotti R (Mar 2000). "TFE3, a transcription factor homologous to microphthalmia, is a potential transcriptional activator of tyrosinase and TyrpI genes". Molecular Endocrinology. 14 (3): 449–56. doi:10.1210/me.14.3.449. PMID 10707962.
  • Davis IJ, Hsi BL, Arroyo JD, Vargas SO, Yeh YA, Motyckova G, Valencia P, Perez-Atayde AR, Argani P, Ladanyi M, Fletcher JA, Fisher DE (May 2003). "Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation". Proceedings of the National Academy of Sciences of the United States of America. 100 (10): 6051–6. doi:10.1073/pnas.0931430100. PMC 156324. PMID 12719541.
  • Kuiper RP, Schepens M, Thijssen J, van Asseldonk M, van den Berg E, Bridge J, Schuuring E, Schoenmakers EF, van Kessel AG (Jul 2003). "Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution". Human Molecular Genetics. 12 (14): 1661–9. doi:10.1093/hmg/ddg178. PMID 12837690.
  • Kuiper RP, Schepens M, Thijssen J, Schoenmakers EF, van Kessel AG (2004). "Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains". Nucleic Acids Research. 32 (8): 2315–22. doi:10.1093/nar/gkh571. PMC 419459. PMID 15118077.
  • Argani P, Laé M, Hutchinson B, Reuter VE, Collins MH, Perentesis J, Tomaszewski JE, Brooks JS, Acs G, Bridge JA, Vargas SO, Davis IJ, Fisher DE, Ladanyi M (Feb 2005). "Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR". The American Journal of Surgical Pathology. 29 (2): 230–40. doi:10.1097/01.pas.0000146007.54092.37. PMID 15644781.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Pecciarini L, Cangi MG, Lo Cunsolo C, Macri' E, Dal Cin E, Martignoni G, Doglioni C (May 2007). "Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient". Genes, Chromosomes & Cancer. 46 (5): 419–26. doi:10.1002/gcc.20422. PMID 17285572.


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