CARD11: Difference between revisions

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Latest revision as of 09:12, 30 August 2017

Caspase recruitment domain-containing protein 11 also known as CARD-containing MAGUK protein 1 (Carma 1) is a protein that in humans is encoded by the CARD11 gene.^[1]^[2]^[3]

Function

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activates NF-kappaB and induces the phosphorylation of BCL10.^[3]

Interactions

CARD11 has been shown to interact with BCL10.^[4]

References

↑ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (Apr 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.
↑ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.
↑ ^3.0 ^3.1 "Entrez Gene: CARD11 caspase recruitment domain family, member 11".
↑ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.

External links

Human CARD11 genome location and CARD11 gene details page in the UCSC Genome Browser.

Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS, Nuñez G, Bertin J, Lin X (2002). "A requirement for CARMA1 in TCR-induced NF-kappa B activation". Nat. Immunol. 3 (9): 830–5. doi:10.1038/ni824. PMID 12154356.
Gaide O, Favier B, Legler DF, Bonnet D, Brissoni B, Valitutti S, Bron C, Tschopp J, Thome M (2002). "CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation". Nat. Immunol. 3 (9): 836–43. doi:10.1038/ni830. PMID 12154360.
Pomerantz JL, Denny EM, Baltimore D (2002). "CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex". EMBO J. 21 (19): 5184–94. doi:10.1093/emboj/cdf505. PMC 129028. PMID 12356734.
Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen SL, Lin X (2004). "CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1". Mol. Cell. Biol. 24 (1): 164–71. doi:10.1128/MCB.24.1.164-171.2003. PMC 303359. PMID 14673152.
Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P (2004). "Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator". J. Biol. Chem. 279 (33): 34323–31. doi:10.1074/jbc.M402244200. PMID 15184390.
Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S (2005). "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation". Science. 308 (5718): 114–8. doi:10.1126/science.1107107. PMID 15802604.
Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H, Sakurai H, Kurosaki T (2005). "PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1". J. Exp. Med. 202 (10): 1423–31. doi:10.1084/jem.20051591. PMC 2212994. PMID 16301747.
Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ (2005). "Phosphorylation of the CARMA1 linker controls NF-kappaB activation". Immunity. 23 (6): 561–74. doi:10.1016/j.immuni.2005.09.014. PMID 16356855.
Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X (2005). "Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation". Immunity. 23 (6): 575–85. doi:10.1016/j.immuni.2005.10.007. PMID 16356856.
Narayan P, Holt B, Tosti R, Kane LP (2006). "CARMA1 is required for Akt-mediated NF-kappaB activation in T cells". Mol. Cell. Biol. 26 (6): 2327–36. doi:10.1128/MCB.26.6.2327-2336.2006. PMC 1430296. PMID 16508008.
Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R (2006). "Nore1B regulates TCR signaling via Ras and Carma1". Cell. Signal. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMC 3204664. PMID 16520020.
Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, Cao Z, Lu N, Takafumi A, Goto H, Daly MJ, Xavier RJ (2006). "Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation". Mol. Cell. Biol. 26 (14): 5497–508. doi:10.1128/MCB.02469-05. PMC 1592706. PMID 16809782.

[pmid11278692-1] Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (Apr 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.

[pmid11356195-2] Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.

[entrez-3] 3.0 ^3.1 "Entrez Gene: CARD11 caspase recruitment domain family, member 11".

[autogenerated1-4] Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.

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[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Caspase recruitment domain-containing protein 11''' also known as '''CARD-containing MAGUK protein 1''' (Carma 1) is a [[protein]] that in humans is encoded by the ''CARD11'' [[gene]].<ref name="pmid11278692">{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82  | date = Apr 2001 | pmid = 11278692 | pmc =  | doi = 10.1074/jbc.M010512200 }}</ref><ref name="pmid11356195">{{cite journal | vauthors = Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J | title = Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation | journal = FEBS Lett. | volume = 496 | issue = 2-3 | pages = 121–7  | date = May 2001 | pmid = 11356195 | pmc =  | doi = 10.1016/S0014-5793(01)02414-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CARD11 caspase recruitment domain family, member 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84433| accessdate = }}</ref>
-| update_page = yes
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-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Caspase recruitment domain family, member 11
- | HGNCid = 16393
- | Symbol = CARD11
- | AltSymbols =; BIMP3; CARMA1; MGC133069
- | OMIM = 607210
- | ECnumber =
- | Homologene = 13024
- | MGIid = 1916978
- | Function =
- | Component =
- | Process =
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 84433
-    | Hs_Ensembl = ENSG00000198286
-    | Hs_RefseqProtein = NP_115791
-    | Hs_RefseqmRNA = NM_032415
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 7
-    | Hs_GenLoc_start = 2912309
-    | Hs_GenLoc_end = 3050025
-    | Hs_Uniprot = Q9BXL7
-    | Mm_EntrezGene = 108723
-    | Mm_Ensembl = ENSMUSG00000036526
-    | Mm_RefseqmRNA = XM_981066
-    | Mm_RefseqProtein = XP_986160
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 141125799
-    | Mm_GenLoc_end = 141165891
-    | Mm_Uniprot =
-  }}
-}}
-'''Caspase recruitment domain family, member 11''', also known as '''CARD11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CARD11 caspase recruitment domain family, member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84433| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain ([[CARD domain|CARD]]). This protein has a domain structure similar to that of [[CARD14]] protein. The CARD domains of both proteins have been shown to specifically interact with [[BCL10]], a protein known to function as a positive regulator of cell apoptosis and [[NF-κB]] activation. When expressed in cells, this protein activates NF-kappaB and induces the [[phosphorylation]] of BCL10.<ref name="entrez"/>
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.<ref name="entrez">{{cite web | title = Entrez Gene: CARD11 caspase recruitment domain family, member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84433| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+CARD11 has been shown to [[Protein-protein interaction|interact]] with [[BCL10]].<ref name=autogenerated1>{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82  | date = April 2001 | pmid = 11278692 | doi = 10.1074/jbc.M010512200 }}</ref>
+== References ==
+{{reflist}}
+==External links==
+* {{UCSC gene info|CARD11}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Res. | volume = 6 | issue = 9 | pages = 807–28 | year = 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}
-| citations =
+* {{cite journal | vauthors =  | title = Toward a complete human genome sequence | journal = Genome Res. | volume = 8 | issue = 11 | pages = 1097–108 | year = 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
-*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
+* {{cite journal | vauthors = Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J | title = Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 21405–9 | year = 2001 | pmid = 11259443 | doi = 10.1074/jbc.M102488200 }}
-*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
+* {{cite journal | vauthors = Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS, Nuñez G, Bertin J, Lin X | title = A requirement for CARMA1 in TCR-induced NF-kappa B activation | journal = Nat. Immunol. | volume = 3 | issue = 9 | pages = 830–5 | year = 2002 | pmid = 12154356 | doi = 10.1038/ni824 }}
-*{{cite journal  | author=Wang L, Guo Y, Huang WJ, ''et al.'' |title=Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21405-9 |year= 2001 |pmid= 11259443 |doi= 10.1074/jbc.M102488200 }}
+* {{cite journal | vauthors = Gaide O, Favier B, Legler DF, Bonnet D, Brissoni B, Valitutti S, Bron C, Tschopp J, Thome M | title = CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation | journal = Nat. Immunol. | volume = 3 | issue = 9 | pages = 836–43 | year = 2002 | pmid = 12154360 | doi = 10.1038/ni830 }}
-*{{cite journal  | author=Bertin J, Wang L, Guo Y, ''et al.'' |title=CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 11877-82 |year= 2001 |pmid= 11278692 |doi= 10.1074/jbc.M010512200 }}
+* {{cite journal | vauthors = Pomerantz JL, Denny EM, Baltimore D | title = CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex | journal = EMBO J. | volume = 21 | issue = 19 | pages = 5184–94 | year = 2002 | pmid = 12356734 | pmc = 129028 | doi = 10.1093/emboj/cdf505 }}
-*{{cite journal  | author=Gaide O, Martinon F, Micheau O, ''et al.'' |title=Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. |journal=FEBS Lett. |volume=496 |issue= 2-3 |pages= 121-7 |year= 2001 |pmid= 11356195 |doi=  }}
+* {{cite journal | vauthors = Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen SL, Lin X | title = CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1 | journal = Mol. Cell. Biol. | volume = 24 | issue = 1 | pages = 164–71 | year = 2004 | pmid = 14673152 | pmc = 303359 | doi = 10.1128/MCB.24.1.164-171.2003 }}
-*{{cite journal  | author=Wang D, You Y, Case SM, ''et al.'' |title=A requirement for CARMA1 in TCR-induced NF-kappa B activation. |journal=Nat. Immunol. |volume=3 |issue= 9 |pages= 830-5 |year= 2002 |pmid= 12154356 |doi= 10.1038/ni824 }}
+* {{cite journal | vauthors = Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P | title = Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator | journal = J. Biol. Chem. | volume = 279 | issue = 33 | pages = 34323–31 | year = 2004 | pmid = 15184390 | doi = 10.1074/jbc.M402244200 }}
-*{{cite journal  | author=Gaide O, Favier B, Legler DF, ''et al.'' |title=CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. |journal=Nat. Immunol. |volume=3 |issue= 9 |pages= 836-43 |year= 2002 |pmid= 12154360 |doi= 10.1038/ni830 }}
+* {{cite journal | vauthors = Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S | title = PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation | journal = Science | volume = 308 | issue = 5718 | pages = 114–8 | year = 2005 | pmid = 15802604 | doi = 10.1126/science.1107107 }}
-*{{cite journal  | author=Pomerantz JL, Denny EM, Baltimore D |title=CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. |journal=EMBO J. |volume=21 |issue= 19 |pages= 5184-94 |year= 2002 |pmid= 12356734 |doi=  }}
+* {{cite journal | vauthors = Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H, Sakurai H, Kurosaki T | title = PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1 | journal = J. Exp. Med. | volume = 202 | issue = 10 | pages = 1423–31 | year = 2005 | pmid = 16301747 | pmc = 2212994 | doi = 10.1084/jem.20051591 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ | title = Phosphorylation of the CARMA1 linker controls NF-kappaB activation | journal = Immunity | volume = 23 | issue = 6 | pages = 561–74 | year = 2005 | pmid = 16356855 | doi = 10.1016/j.immuni.2005.09.014 }}
-*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
+* {{cite journal | vauthors = Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X | title = Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation | journal = Immunity | volume = 23 | issue = 6 | pages = 575–85 | year = 2005 | pmid = 16356856 | doi = 10.1016/j.immuni.2005.10.007 }}
-*{{cite journal  | author=Wang D, Matsumoto R, You Y, ''et al.'' |title=CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. |journal=Mol. Cell. Biol. |volume=24 |issue= 1 |pages= 164-71 |year= 2004 |pmid= 14673152 |doi=  }}
+* {{cite journal | vauthors = Narayan P, Holt B, Tosti R, Kane LP | title = CARMA1 is required for Akt-mediated NF-kappaB activation in T cells | journal = Mol. Cell. Biol. | volume = 26 | issue = 6 | pages = 2327–36 | year = 2006 | pmid = 16508008 | pmc = 1430296 | doi = 10.1128/MCB.26.6.2327-2336.2006 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+* {{cite journal | vauthors = Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R | title = Nore1B regulates TCR signaling via Ras and Carma1 | journal = Cell. Signal. | volume = 18 | issue = 10 | pages = 1647–54 | year = 2006 | pmid = 16520020 | pmc = 3204664 | doi = 10.1016/j.cellsig.2006.01.015 }}
-*{{cite journal  | author=Stilo R, Liguoro D, Di Jeso B, ''et al.'' |title=Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator. |journal=J. Biol. Chem. |volume=279 |issue= 33 |pages= 34323-31 |year= 2004 |pmid= 15184390 |doi= 10.1074/jbc.M402244200 }}
+* {{cite journal | vauthors = Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, Cao Z, Lu N, Takafumi A, Goto H, Daly MJ, Xavier RJ | title = Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation | journal = Mol. Cell. Biol. | volume = 26 | issue = 14 | pages = 5497–508 | year = 2006 | pmid = 16809782 | pmc = 1592706 | doi = 10.1128/MCB.02469-05 }}
-*{{cite journal  | author=Lee KY, D'Acquisto F, Hayden MS, ''et al.'' |title=PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. |journal=Science |volume=308 |issue= 5718 |pages= 114-8 |year= 2005 |pmid= 15802604 |doi= 10.1126/science.1107107 }}
-*{{cite journal  | author=Shinohara H, Yasuda T, Aiba Y, ''et al.'' |title=PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. |journal=J. Exp. Med. |volume=202 |issue= 10 |pages= 1423-31 |year= 2006 |pmid= 16301747 |doi= 10.1084/jem.20051591 }}
-*{{cite journal  | author=Sommer K, Guo B, Pomerantz JL, ''et al.'' |title=Phosphorylation of the CARMA1 linker controls NF-kappaB activation. |journal=Immunity |volume=23 |issue= 6 |pages= 561-74 |year= 2006 |pmid= 16356855 |doi= 10.1016/j.immuni.2005.09.014 }}
-*{{cite journal  | author=Matsumoto R, Wang D, Blonska M, ''et al.'' |title=Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. |journal=Immunity |volume=23 |issue= 6 |pages= 575-85 |year= 2006 |pmid= 16356856 |doi= 10.1016/j.immuni.2005.10.007 }}
-*{{cite journal  | author=Narayan P, Holt B, Tosti R, Kane LP |title=CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. |journal=Mol. Cell. Biol. |volume=26 |issue= 6 |pages= 2327-36 |year= 2006 |pmid= 16508008 |doi= 10.1128/MCB.26.6.2327-2336.2006 }}
-*{{cite journal  | author=Ishiguro K, Avruch J, Landry A, ''et al.'' |title=Nore1B regulates TCR signaling via Ras and Carma1. |journal=Cell. Signal. |volume=18 |issue= 10 |pages= 1647-54 |year= 2006 |pmid= 16520020 |doi= 10.1016/j.cellsig.2006.01.015 }}
-*{{cite journal  | author=Ishiguro K, Green T, Rapley J, ''et al.'' |title=Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation. |journal=Mol. Cell. Biol. |volume=26 |issue= 14 |pages= 5497-508 |year= 2006 |pmid= 16809782 |doi= 10.1128/MCB.02469-05 }}
-}}
 {{refend}}
-{{protein-stub}}
+[[Category:Proteins]]
-{{WikiDoc Sources}}

CARD11: Difference between revisions

Latest revision as of 09:12, 30 August 2017

Contents

Function

Interactions

References

External links

Further reading

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