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{{Infobox_gene}}
{{PBB_Controls
'''E3 ubiquitin-protein ligase RNF216''' is an [[enzyme]] that in humans is encoded by the ''RNF216'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRIAD3 TRIAD3 protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54476| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = TRIAD3 protein
| HGNCid = 
| Symbol = TRIAD3
| AltSymbols =; ZIN; U7I1; UBCE7IP1
| OMIM = 609948
| ECnumber = 
| Homologene = 19442
| MGIid = 1344349
| GeneAtlas_image1 = PBB_GE_TRIAD3_218426_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TRIAD3_218425_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046933 |text = hydrogen ion transporting ATP synthase activity, rotational mechanism}} {{GNF_GO|id=GO:0046961 |text = hydrogen ion transporting ATPase activity, rotational mechanism}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016469 |text = proton-transporting two-sector ATPase complex}}
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0015986 |text = ATP synthesis coupled proton transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54476
    | Hs_Ensembl = ENSG00000011275
    | Hs_RefseqProtein = NP_996994
    | Hs_RefseqmRNA = NM_207111
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 5629017
    | Hs_GenLoc_end = 5787818
    | Hs_Uniprot = Q9NWF9
    | Mm_EntrezGene = 108086
    | Mm_Ensembl = ENSMUSG00000045078
    | Mm_RefseqmRNA = XM_981910
    | Mm_RefseqProtein = XP_987004
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 143257789
    | Mm_GenLoc_end = 143378134
    | Mm_Uniprot = P58283
  }}
}}
'''TRIAD3 protein''', also known as '''TRIAD3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRIAD3 TRIAD3 protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54476| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.<ref name="entrez">{{cite web | title = Entrez Gene: TRIAD3 TRIAD3 protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54476| accessdate = }}</ref>
| summary_text = This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.<ref name="entrez" />
}}
}}


==See also==
==See also==
* [[RING finger domain]]
* [[RING finger domain]]
==Interactions==
RNF216 has been shown to [[Protein-protein interaction|interact]] with [[TLR9]]<ref name=pmid15107846>{{cite journal |last=Chuang |first=Tsung-Hsien |authorlink= |author2=Ulevitch Richard J  |date=May 2004 |title=Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors |journal=Nat. Immunol. |volume=5 |issue=5 |pages=495–502 |publisher= |location = United States| issn = 1529-2908| pmid = 15107846 |doi = 10.1038/ni1066 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[RIPK1]].<ref name=pmid11854271>{{cite journal |last=Chen |first=Danying |authorlink= |author2=Li Xiaoyan |author3=Zhai Zhonghe |author4=[[Shu Hongbing|Shu Hong-Bing]]  |date=May 2002 |title=A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation |journal=J. Biol. Chem. |volume=277 |issue=18 |pages=15985–91 |publisher= |location = United States| issn = 0021-9258| pmid = 11854271 |doi = 10.1074/jbc.M108675200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Lake JA, Carr J, Feng F, ''et al.'' |title=The role of Vif during HIV-1 infection: interaction with novel host cellular factors. |journal=J. Clin. Virol. |volume=26 |issue= 2 |pages= 143-52 |year= 2003 |pmid= 12600646 |doi=  }}
*{{cite journal   |vauthors=Lake JA, Carr J, Feng F, etal |title=The role of Vif during HIV-1 infection: interaction with novel host cellular factors |journal=J. Clin. Virol. |volume=26 |issue= 2 |pages= 143–52 |year= 2003 |pmid= 12600646 |doi=10.1016/S1386-6532(02)00113-0 }}
*{{cite journal | author=Matoba R, Okubo K, Hori N, ''et al.'' |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199-207 |year= 1994 |pmid= 8076819 |doi=  }}
*{{cite journal   |vauthors=Matoba R, Okubo K, Hori N, etal |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=10.1016/0378-1119(94)90293-3 }}
*{{cite journal  | author=van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH |title=TRIADs: a new class of proteins with a novel cysteine-rich signature. |journal=Protein Sci. |volume=8 |issue= 7 |pages= 1557-61 |year= 1999 |pmid= 10422847 |doi=  }}
*{{cite journal  |vauthors=van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH |title=TRIADs: a new class of proteins with a novel cysteine-rich signature |journal=Protein Sci. |volume=8 |issue= 7 |pages= 1557–61 |year= 1999 |pmid= 10422847 |doi=10.1110/ps.8.7.1557  | pmc=2144383 }}
*{{cite journal  | author=Wang X, Stollar BD |title=Immunoglobulin VH gene expression in human aging. |journal=Clin. Immunol. |volume=93 |issue= 2 |pages= 132-42 |year= 1999 |pmid= 10527689 |doi= 10.1006/clim.1999.4781 }}
*{{cite journal  |vauthors=Wang X, Stollar BD |title=Immunoglobulin VH gene expression in human aging |journal=Clin. Immunol. |volume=93 |issue= 2 |pages= 132–42 |year= 1999 |pmid= 10527689 |doi= 10.1006/clim.1999.4781 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
*{{cite journal  | author=Chen D, Li X, Zhai Z, Shu HB |title=A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15985-91 |year= 2002 |pmid= 11854271 |doi= 10.1074/jbc.M108675200 }}
*{{cite journal  |vauthors=Chen D, Li X, Zhai Z, Shu HB |title=A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15985–91 |year= 2002 |pmid= 11854271 |doi= 10.1074/jbc.M108675200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Chuang TH, Ulevitch RJ |title=Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 495-502 |year= 2004 |pmid= 15107846 |doi= 10.1038/ni1066 }}
*{{cite journal  |vauthors=Chuang TH, Ulevitch RJ |title=Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 495–502 |year= 2004 |pmid= 15107846 |doi= 10.1038/ni1066 }}
*{{cite journal | author=Feng F, Davis A, Lake JA, ''et al.'' |title=Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif. |journal=J. Virol. |volume=78 |issue= 19 |pages= 10574-81 |year= 2004 |pmid= 15367624 |doi= 10.1128/JVI.78.19.10574-10581.2004 }}
*{{cite journal   |vauthors=Feng F, Davis A, Lake JA, etal |title=Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif |journal=J. Virol. |volume=78 |issue= 19 |pages= 10574–81 |year= 2004 |pmid= 15367624 |doi= 10.1128/JVI.78.19.10574-10581.2004 | pmc=516435 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal   |vauthors=Oh JH, Yang JO, Hahn Y, etal |title=Transcriptome analysis of human gastric cancer |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal  | author=Fearns C, Pan Q, Mathison JC, Chuang TH |title=Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. |journal=J. Biol. Chem. |volume=281 |issue= 45 |pages= 34592-600 |year= 2006 |pmid= 16968706 |doi= 10.1074/jbc.M604019200 }}
*{{cite journal  |vauthors=Fearns C, Pan Q, Mathison JC, Chuang TH |title=Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding |journal=J. Biol. Chem. |volume=281 |issue= 45 |pages= 34592–600 |year= 2006 |pmid= 16968706 |doi= 10.1074/jbc.M604019200 }}
}}
}}
{{refend}}
{{refend}}
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* {{MeshName|RNF216+protein,+human}}
* {{MeshName|RNF216+protein,+human}}


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[[Category:RING finger proteins]]
 
 
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Revision as of 09:21, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene.[1]

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.[1]

See also

Interactions

RNF216 has been shown to interact with TLR9[2] and RIPK1.[3]

References

  1. ↑ 1.0 1.1 "Entrez Gene: TRIAD3 TRIAD3 protein".
  2. ↑ Chuang, Tsung-Hsien; Ulevitch Richard J (May 2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. United States. 5 (5): 495–502. doi:10.1038/ni1066. ISSN 1529-2908. PMID 15107846.
  3. ↑ Chen, Danying; Li Xiaoyan; Zhai Zhonghe; Shu Hong-Bing (May 2002). "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation". J. Biol. Chem. United States. 277 (18): 15985–91. doi:10.1074/jbc.M108675200. ISSN 0021-9258. PMID 11854271.

Further reading

External links


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