RCP9: Difference between revisions

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DNA-directed RNA polymerase III subunit RPC9 is an enzyme that in humans is encoded by the CRCP gene.^[1]^[2]^[3]^[4]

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[4]

References

↑ Luebke AE, Dahl GP, Roos BA, Dickerson IM (Jun 1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay". Proc Natl Acad Sci U S A. 93 (8): 3455–60. doi:10.1073/pnas.93.8.3455. PMC 39630. PMID 8622957.
↑ Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459–69. doi:10.1210/en.140.3.1459. PMID 10067875.
↑ Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C (Dec 2002). "An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP". Mol Cell Biol. 23 (1): 195–205. doi:10.1128/MCB.23.1.195-205.2003. PMC 140662. PMID 12482973.
↑ ^4.0 ^4.1 "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein".

Yallampalli C, Chauhan M, Thota CS, et al. (2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity". Trends Endocrinol. Metab. 13 (6): 263–9. doi:10.1016/s1043-2760(02)00563-5. PMID 12128288.
Evans BN, Rosenblatt MI, Mnayer LO, et al. (2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors". J. Biol. Chem. 275 (40): 31438–43. doi:10.1074/jbc.M005604200. PMID 10903324.
Prado MA, Evans-Bain B, Oliver KR, Dickerson IM (2002). "The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction". Peptides. 22 (11): 1773–81. doi:10.1016/S0196-9781(01)00517-4. PMID 11754963.
Moreno MJ, Terrón JA, Stanimirovic DB, et al. (2002). "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture". Neuropharmacology. 42 (2): 270–80. doi:10.1016/S0028-3908(01)00176-9. PMID 11804624.
Harzenetter MD, Keller U, Beer S, et al. (2002). "Regulation and function of the CGRP receptor complex in human granulopoiesis". Exp. Hematol. 30 (4): 306–12. doi:10.1016/S0301-472X(02)00772-5. PMID 11937264.
Hu P, Wu S, Sun Y, et al. (2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits". Mol. Cell. Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hasbak P, Saetrum Opgaard O, Eskesen K, et al. (2003). "Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist". J. Pharmacol. Exp. Ther. 304 (1): 326–33. doi:10.1124/jpet.102.037754. PMID 12490608.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Zuccarello D, Morini E, Douzgou S, et al. (2005). "Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism". J. Endocrinol. Invest. 27 (8): 760–4. doi:10.1007/bf03347519. PMID 15636430.
Krämer HH, Schmidt K, Leis S, et al. (2006). "Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin". Peptides. 27 (4): 917–20. doi:10.1016/j.peptides.2005.08.007. PMID 16406141.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[pmid8622957-1] Luebke AE, Dahl GP, Roos BA, Dickerson IM (Jun 1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay". Proc Natl Acad Sci U S A. 93 (8): 3455–60. doi:10.1073/pnas.93.8.3455. PMC 39630. PMID 8622957.

[pmid10067875-2] Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459–69. doi:10.1210/en.140.3.1459. PMID 10067875.

[pmid12482973-3] Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C (Dec 2002). "An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP". Mol Cell Biol. 23 (1): 195–205. doi:10.1128/MCB.23.1.195-205.2003. PMC 140662. PMID 12482973.

[entrez-4] 4.0 ^4.1 "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein".

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=March 2014}}
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+{{Infobox_gene}}
-| update_page = yes
+'''DNA-directed RNA polymerase III subunit RPC9''' is an [[enzyme]] that in humans is encoded by the ''CRCP'' [[gene]].<ref name="pmid8622957">{{cite journal | vauthors = Luebke AE, Dahl GP, Roos BA, Dickerson IM | title = Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 8 | pages = 3455–60 |date=Jun 1996 | pmid = 8622957 | pmc = 39630 | doi =10.1073/pnas.93.8.3455  }}</ref><ref name="pmid10067875">{{cite journal | vauthors = Balkan W, Oates EL, Howard GA, Roos BA | title = Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein | journal = Endocrinology | volume = 140 | issue = 3 | pages = 1459–69 |date=Mar 1999 | pmid = 10067875 | pmc =  | doi =10.1210/en.140.3.1459  }}</ref><ref name="pmid12482973">{{cite journal | vauthors = Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C | title = An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP | journal = Mol Cell Biol | volume = 23 | issue = 1 | pages = 195–205 |date=Dec 2002 | pmid = 12482973 | pmc = 140662 | doi =10.1128/MCB.23.1.195-205.2003  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27297| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Calcitonin gene-related peptide-receptor component protein
- | HGNCid =
- | Symbol = RCP9
- | AltSymbols =; RCP; CGRP-RCP; CRCP; MGC111194
- | OMIM = 606121
- | ECnumber =
- | Homologene = 40587
- | MGIid = 1100818
- | GeneAtlas_image1 = PBB_GE_RCP9_203898_at_tn.png
- | GeneAtlas_image2 = PBB_GE_RCP9_203899_s_at_tn.png
-  | Function = {{GNF_GO|id=GO:0004948 |text = calcitonin receptor activity}}
- | Component = {{GNF_GO|id=GO:0001669 |text = acrosome}} {{GNF_GO|id=GO:0005575 |text = cellular_component}}
- | Process = {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007340 |text = acrosome reaction}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 27297
-    | Hs_Ensembl = ENSG00000126522
-    | Hs_RefseqProtein = NP_001035737
-    | Hs_RefseqmRNA = NM_001040647
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 7
-    | Hs_GenLoc_start = 65217294
-    | Hs_GenLoc_end = 65255697
-    | Hs_Uniprot = O75575
-    | Mm_EntrezGene = 12909
-    | Mm_Ensembl = ENSMUSG00000025532
-    | Mm_RefseqmRNA = NM_007761
-    | Mm_RefseqProtein = NP_031787
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 130314009
-    | Mm_GenLoc_end = 130345492
-    | Mm_Uniprot = O35427
-  }}
-}}
-'''Calcitonin gene-related peptide-receptor component protein''', also known as '''RCP9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27297| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27297| accessdate = }}</ref>
+| summary_text = This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Yallampalli C, Chauhan M, Thota CS, ''et al.'' |title=Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity. |journal=Trends Endocrinol. Metab. |volume=13 |issue= 6 |pages= 263-9 |year= 2003 |pmid= 12128288 |doi=  }}
+*{{cite journal   |vauthors=Yallampalli C, Chauhan M, Thota CS, etal |title=Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity |journal=Trends Endocrinol. Metab. |volume=13 |issue= 6 |pages= 263–9 |year= 2003 |pmid= 12128288 |doi=  10.1016/s1043-2760(02)00563-5}}
-*{{cite journal  | author=Luebke AE, Dahl GP, Roos BA, Dickerson IM |title=Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3455-60 |year= 1996 |pmid= 8622957 |doi=  }}
+*{{cite journal   |vauthors=Evans BN, Rosenblatt MI, Mnayer LO, etal |title=CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31438–43 |year= 2000 |pmid= 10903324 |doi= 10.1074/jbc.M005604200 }}
-*{{cite journal  | author=Balkan W, Oates EL, Howard GA, Roos BA |title=Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein. |journal=Endocrinology |volume=140 |issue= 3 |pages= 1459-69 |year= 1999 |pmid= 10067875 |doi=  }}
+*{{cite journal  | vauthors=Prado MA, Evans-Bain B, Oliver KR, Dickerson IM |title=The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction |journal=Peptides |volume=22 |issue= 11 |pages= 1773–81 |year= 2002 |pmid= 11754963 |doi=10.1016/S0196-9781(01)00517-4  }}
-*{{cite journal  | author=Evans BN, Rosenblatt MI, Mnayer LO, ''et al.'' |title=CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31438-43 |year= 2000 |pmid= 10903324 |doi= 10.1074/jbc.M005604200 }}
+*{{cite journal   |vauthors=Moreno MJ, Terrón JA, Stanimirovic DB, etal |title=Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture |journal=Neuropharmacology |volume=42 |issue= 2 |pages= 270–80 |year= 2002 |pmid= 11804624 |doi=10.1016/S0028-3908(01)00176-9  }}
-*{{cite journal  | author=Prado MA, Evans-Bain B, Oliver KR, Dickerson IM |title=The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction. |journal=Peptides |volume=22 |issue= 11 |pages= 1773-81 |year= 2002 |pmid= 11754963 |doi=  }}
+*{{cite journal   |vauthors=Harzenetter MD, Keller U, Beer S, etal |title=Regulation and function of the CGRP receptor complex in human granulopoiesis |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 306–12 |year= 2002 |pmid= 11937264 |doi=10.1016/S0301-472X(02)00772-5  }}
-*{{cite journal  | author=Moreno MJ, Terrón JA, Stanimirovic DB, ''et al.'' |title=Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture. |journal=Neuropharmacology |volume=42 |issue= 2 |pages= 270-80 |year= 2002 |pmid= 11804624 |doi=  }}
+*{{cite journal   |vauthors=Hu P, Wu S, Sun Y, etal |title=Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 8044–55 |year= 2002 |pmid= 12391170 |doi=10.1128/MCB.22.22.8044-8055.2002  | pmc=134740  }}
-*{{cite journal  | author=Harzenetter MD, Keller U, Beer S, ''et al.'' |title=Regulation and function of the CGRP receptor complex in human granulopoiesis. |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 306-12 |year= 2002 |pmid= 11937264 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Hu P, Wu S, Sun Y, ''et al.'' |title=Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 8044-55 |year= 2002 |pmid= 12391170 |doi=  }}
+*{{cite journal   |vauthors=Hasbak P, Saetrum Opgaard O, Eskesen K, etal |title=Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 1 |pages= 326–33 |year= 2003 |pmid= 12490608 |doi= 10.1124/jpet.102.037754 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Siaut M, Zaros C, Levivier E, ''et al.'' |title=An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 195-205 |year= 2003 |pmid= 12482973 |doi=  }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Hasbak P, Saetrum Opgaard O, Eskesen K, ''et al.'' |title=Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist. |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 1 |pages= 326-33 |year= 2003 |pmid= 12490608 |doi= 10.1124/jpet.102.037754 }}
+*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Zuccarello D, Morini E, Douzgou S, etal |title=Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism |journal=J. Endocrinol. Invest. |volume=27 |issue= 8 |pages= 760–4 |year= 2005 |pmid= 15636430 |doi=  10.1007/bf03347519}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Krämer HH, Schmidt K, Leis S, etal |title=Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin |journal=Peptides |volume=27 |issue= 4 |pages= 917–20 |year= 2006 |pmid= 16406141 |doi= 10.1016/j.peptides.2005.08.007 }}
-*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
-*{{cite journal  | author=Zuccarello D, Morini E, Douzgou S, ''et al.'' |title=Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism. |journal=J. Endocrinol. Invest. |volume=27 |issue= 8 |pages= 760-4 |year= 2005 |pmid= 15636430 |doi=  }}
-*{{cite journal  | author=Krämer HH, Schmidt K, Leis S, ''et al.'' |title=Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin. |journal=Peptides |volume=27 |issue= 4 |pages= 917-20 |year= 2006 |pmid= 16406141 |doi= 10.1016/j.peptides.2005.08.007 }}
 }}
 {{refend}}
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+| require_manual_inspection = no
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RCP9: Difference between revisions

Revision as of 09:02, 10 September 2017

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