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{{ | '''U6 snRNA-associated Sm-like protein LSm8''' is a [[protein]] that in humans is encoded by the ''LSM8'' [[gene]].<ref name="pmid10523320">{{cite journal |vauthors=Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R | title = A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro | journal = EMBO J | volume = 18 | issue = 20 | pages = 5789–802 |date=Dec 1999 | pmid = 10523320 | pmc = 1171645 | doi = 10.1093/emboj/18.20.5789 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51691| accessdate = }}</ref> | ||
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| summary_text = This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.<ref name="entrez" | | summary_text = This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.<ref name="entrez"/> | ||
}} | }} | ||
==Interactions== | |||
LSM8 has been shown to [[Protein-protein interaction|interact]] with [[LSM2]].<ref name=pmid15231747>{{cite journal |last=Lehner |first=Ben |authorlink= |author2=Sanderson Christopher M |date=Jul 2004 |title=A protein interaction framework for human mRNA degradation |journal=Genome Res. |volume=14 |issue=7 |pages=1315–23 |publisher= |location = United States| issn = 1088-9051| pmid = 15231747 |doi = 10.1101/gr.2122004 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=442147 }}</ref><ref name=pmid14667819>{{cite journal |doi=10.1016/S0888-7543(03)00235-0 |last=Lehner |first=Ben |authorlink= |author2=Semple Jennifer I |author3=Brown Stephanie E |author4=Counsell Damian |author5=Campbell R Duncan |author6=Sanderson Christopher M |date=Jan 2004 |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue=1 |pages=153–67 |publisher= |location = United States| issn = 0888-7543| pmid = 14667819 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Khusial P, Plaag R, Zieve GW |title=LSm proteins form heptameric rings that bind to RNA via repeating motifs. |journal=Trends Biochem. Sci. |volume=30 |issue= 9 |pages= 522–8 |year= 2005 |pmid= 16051491 |doi= 10.1016/j.tibs.2005.07.006 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }} | ||
*{{cite journal | *{{cite journal |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097}} | ||
*{{cite journal | | *{{cite journal |vauthors=Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B |title=Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3451–62 |year= 1999 |pmid= 10369684 |doi= 10.1093/emboj/18.12.3451 | pmc=1171424 }} | ||
*{{cite journal |vauthors=Eystathioy T, Peebles CL, Hamel JC, etal |title=Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera. |journal=Arthritis Rheum. |volume=46 |issue= 3 |pages= 726–34 |year= 2002 |pmid= 11920408 |doi= 10.1002/art.10220 }} | |||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 }} | ||
*{{cite journal | *{{cite journal |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }} | ||
*{{cite journal | *{{cite journal |vauthors=Lehner B, Semple JI, Brown SE, etal |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 }} | ||
*{{cite journal | *{{cite journal |vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} | ||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Revision as of 18:11, 2 September 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.[1][2]
This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.[2]
Interactions
LSM8 has been shown to interact with LSM2.[3][4]
References
- ↑ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
- ↑ 2.0 2.1 "Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
- ↑ Lehner, Ben; Sanderson Christopher M (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Res. United States. 14 (7): 1315–23. doi:10.1101/gr.2122004. ISSN 1088-9051. PMC 442147. PMID 15231747.
- ↑ Lehner, Ben; Semple Jennifer I; Brown Stephanie E; Counsell Damian; Campbell R Duncan; Sanderson Christopher M (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. United States. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. ISSN 0888-7543. PMID 14667819.
Further reading
- Khusial P, Plaag R, Zieve GW (2005). "LSm proteins form heptameric rings that bind to RNA via repeating motifs". Trends Biochem. Sci. 30 (9): 522–8. doi:10.1016/j.tibs.2005.07.006. PMID 16051491.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B (1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
- Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi:10.1002/art.10220. PMID 11920408.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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