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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Procollagen C-endopeptidase enhancer 1''' is an [[enzyme]] that in humans is encoded by the ''PCOLCE'' [[gene]].<ref name="pmid8824813">{{cite journal | vauthors = Takahara K, Osborne L, Elliott RW, Tsui LC, Scherer SW, Greenspan DS | title = Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein | journal = Genomics | volume = 31 | issue = 2 | pages = 253–6 |date=Mar 1997 | pmid = 8824813 | pmc =  | doi = 10.1006/geno.1996.0043 }}</ref><ref name="pmid9799793">{{cite journal | vauthors = Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A | title = Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes | journal = Genome Res | volume = 8 | issue = 10 | pages = 1060–73 |date=Dec 1998 | pmid = 9799793 | pmc = 310788 | doi =  10.1101/gr.8.10.1060}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5118| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_PCOLCE_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uap.
| PDB = {{PDB2|1uap}}
| Name = Procollagen C-endopeptidase enhancer
| HGNCid = 8738
| Symbol = PCOLCE
| AltSymbols =; PCPE
| OMIM = 600270
| ECnumber =
| Homologene = 1946
| MGIid = 105099
  | GeneAtlas_image1 = PBB_GE_PCOLCE_202465_at_tn.png
| Function = {{GNF_GO|id=GO:0005518 |text = collagen binding}}  
| Component =
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5118
    | Hs_Ensembl = ENSG00000106333
    | Hs_RefseqProtein = NP_002584
    | Hs_RefseqmRNA = NM_002593
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 100037924
    | Hs_GenLoc_end = 100043730
    | Hs_Uniprot = Q15113
    | Mm_EntrezGene = 18542
    | Mm_Ensembl = ENSMUSG00000029718
    | Mm_RefseqmRNA = NM_008788
    | Mm_RefseqProtein = NP_032814
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 137834897
    | Mm_GenLoc_end = 137841156
    | Mm_Uniprot = Q3TX39
  }}
}}
'''Procollagen C-endopeptidase enhancer''', also known as '''PCOLCE''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5118| accessdate = }}</ref>


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<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.<ref name="entrez">{{cite web | title = Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5118| accessdate = }}</ref>
| summary_text = Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Takahara K, Kessler E, Biniaminov L, ''et al.'' |title=Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE). |journal=J. Biol. Chem. |volume=269 |issue= 42 |pages= 26280-5 |year= 1994 |pmid= 7523404 |doi=  }}
*{{cite journal   |vauthors=Takahara K, Kessler E, Biniaminov L, etal |title=Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE) |journal=J. Biol. Chem. |volume=269 |issue= 42 |pages= 26280–5 |year= 1994 |pmid= 7523404 |doi=  }}
*{{cite journal | author=Takahara K, Osborne L, Elliott RW, ''et al.'' |title=Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein. |journal=Genomics |volume=31 |issue= 2 |pages= 253-6 |year= 1997 |pmid= 8824813 |doi= 10.1006/geno.1996.0043 }}
*{{cite journal   |vauthors=Scott IC, Clark TG, Takahara K, etal |title=Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein |journal=Genomics |volume=55 |issue= 2 |pages= 229–34 |year= 1999 |pmid= 9933570 |doi= 10.1006/geno.1998.5663 }}
*{{cite journal  | author=Glöckner G, Scherer S, Schattevoy R, ''et al.'' |title=Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. |journal=Genome Res. |volume=8 |issue= 10 |pages= 1060-73 |year= 1998 |pmid= 9799793 |doi=  }}
*{{cite journal   |vauthors=Mott JD, Thomas CL, Rosenbach MT, etal |title=Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor |journal=J. Biol. Chem. |volume=275 |issue= 2 |pages= 1384–90 |year= 2000 |pmid= 10625689 |doi=10.1074/jbc.275.2.1384 }}
*{{cite journal  | author=Scott IC, Clark TG, Takahara K, ''et al.'' |title=Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein. |journal=Genomics |volume=55 |issue= 2 |pages= 229-34 |year= 1999 |pmid= 9933570 |doi= 10.1006/geno.1998.5663 }}
*{{cite journal   |vauthors=Ricard-Blum S, Bernocco S, Font B, etal |title=Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1 |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 33864–9 |year= 2002 |pmid= 12105202 |doi= 10.1074/jbc.M205018200 }}
*{{cite journal | author=Mott JD, Thomas CL, Rosenbach MT, ''et al.'' |title=Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor. |journal=J. Biol. Chem. |volume=275 |issue= 2 |pages= 1384-90 |year= 2000 |pmid= 10625689 |doi=  }}
*{{cite journal   |vauthors=Ligon AH, Scott IC, Takahara K, etal |title=PCOLCE deletion and expression analyses in uterine leiomyomata |journal=Cancer Genet. Cytogenet. |volume=137 |issue= 2 |pages= 133–7 |year= 2002 |pmid= 12393284 |doi=10.1016/S0165-4608(02)00547-2 }}
*{{cite journal | author=Ricard-Blum S, Bernocco S, Font B, ''et al.'' |title=Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 33864-9 |year= 2002 |pmid= 12105202 |doi= 10.1074/jbc.M205018200 }}
*{{cite journal  | vauthors=Steiglitz BM, Keene DR, Greenspan DS |title=PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1 |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49820–30 |year= 2003 |pmid= 12393877 |doi= 10.1074/jbc.M209891200 }}
*{{cite journal | author=Ligon AH, Scott IC, Takahara K, ''et al.'' |title=PCOLCE deletion and expression analyses in uterine leiomyomata. |journal=Cancer Genet. Cytogenet. |volume=137 |issue= 2 |pages= 133-7 |year= 2002 |pmid= 12393284 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Steiglitz BM, Keene DR, Greenspan DS |title=PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49820-30 |year= 2003 |pmid= 12393877 |doi= 10.1074/jbc.M209891200 }}
*{{cite journal   |vauthors=Bernocco S, Steiglitz BM, Svergun DI, etal |title=Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7199–205 |year= 2003 |pmid= 12486138 |doi= 10.1074/jbc.M210857200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Liepinsh E, Banyai L, Pintacuda G, etal |title=NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25982–9 |year= 2003 |pmid= 12670942 |doi= 10.1074/jbc.M302734200 }}
*{{cite journal | author=Bernocco S, Steiglitz BM, Svergun DI, ''et al.'' |title=Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7199-205 |year= 2003 |pmid= 12486138 |doi= 10.1074/jbc.M210857200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Liepinsh E, Banyai L, Pintacuda G, ''et al.'' |title=NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25982-9 |year= 2003 |pmid= 12670942 |doi= 10.1074/jbc.M302734200 }}
*{{cite journal  | vauthors=Petropoulou V, Garrigue-Antar L, Kadler KE |title=Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1) |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 22616–23 |year= 2005 |pmid= 15817489 |doi= 10.1074/jbc.M413468200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Ge G, Zhang Y, Steiglitz BM, Greenspan DS |title=Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains |journal=J. Biol. Chem. |volume=281 |issue= 16 |pages= 10786–98 |year= 2006 |pmid= 16507574 |doi= 10.1074/jbc.M511111200 }}
*{{cite journal  | author=Petropoulou V, Garrigue-Antar L, Kadler KE |title=Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1). |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 22616-23 |year= 2005 |pmid= 15817489 |doi= 10.1074/jbc.M413468200 }}
*{{cite journal   |vauthors=Blanc G, Font B, Eichenberger D, etal |title=Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity |journal=J. Biol. Chem. |volume=282 |issue= 23 |pages= 16924–33 |year= 2007 |pmid= 17446170 |doi= 10.1074/jbc.M701610200 }}
*{{cite journal  | author=Ge G, Zhang Y, Steiglitz BM, Greenspan DS |title=Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains. |journal=J. Biol. Chem. |volume=281 |issue= 16 |pages= 10786-98 |year= 2006 |pmid= 16507574 |doi= 10.1074/jbc.M511111200 }}
*{{cite journal | author=Blanc G, Font B, Eichenberger D, ''et al.'' |title=Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity. |journal=J. Biol. Chem. |volume=282 |issue= 23 |pages= 16924-33 |year= 2007 |pmid= 17446170 |doi= 10.1074/jbc.M701610200 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5118}}
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Latest revision as of 17:46, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Procollagen C-endopeptidase enhancer 1 is an enzyme that in humans is encoded by the PCOLCE gene.[1][2][3]

Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.[3]

References

  1. ↑ Takahara K, Osborne L, Elliott RW, Tsui LC, Scherer SW, Greenspan DS (Mar 1997). "Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein". Genomics. 31 (2): 253–6. doi:10.1006/geno.1996.0043. PMID 8824813.
  2. ↑ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
  3. ↑ 3.0 3.1 "Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer".

Further reading

  • Takahara K, Kessler E, Biniaminov L, et al. (1994). "Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE)". J. Biol. Chem. 269 (42): 26280–5. PMID 7523404.
  • Scott IC, Clark TG, Takahara K, et al. (1999). "Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein". Genomics. 55 (2): 229–34. doi:10.1006/geno.1998.5663. PMID 9933570.
  • Mott JD, Thomas CL, Rosenbach MT, et al. (2000). "Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor". J. Biol. Chem. 275 (2): 1384–90. doi:10.1074/jbc.275.2.1384. PMID 10625689.
  • Ricard-Blum S, Bernocco S, Font B, et al. (2002). "Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1". J. Biol. Chem. 277 (37): 33864–9. doi:10.1074/jbc.M205018200. PMID 12105202.
  • Ligon AH, Scott IC, Takahara K, et al. (2002). "PCOLCE deletion and expression analyses in uterine leiomyomata". Cancer Genet. Cytogenet. 137 (2): 133–7. doi:10.1016/S0165-4608(02)00547-2. PMID 12393284.
  • Steiglitz BM, Keene DR, Greenspan DS (2003). "PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1". J. Biol. Chem. 277 (51): 49820–30. doi:10.1074/jbc.M209891200. PMID 12393877.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bernocco S, Steiglitz BM, Svergun DI, et al. (2003). "Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein". J. Biol. Chem. 278 (9): 7199–205. doi:10.1074/jbc.M210857200. PMID 12486138.
  • Liepinsh E, Banyai L, Pintacuda G, et al. (2003). "NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding". J. Biol. Chem. 278 (28): 25982–9. doi:10.1074/jbc.M302734200. PMID 12670942.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Petropoulou V, Garrigue-Antar L, Kadler KE (2005). "Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1)". J. Biol. Chem. 280 (24): 22616–23. doi:10.1074/jbc.M413468200. PMID 15817489.
  • Ge G, Zhang Y, Steiglitz BM, Greenspan DS (2006). "Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains". J. Biol. Chem. 281 (16): 10786–98. doi:10.1074/jbc.M511111200. PMID 16507574.
  • Blanc G, Font B, Eichenberger D, et al. (2007). "Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity". J. Biol. Chem. 282 (23): 16924–33. doi:10.1074/jbc.M701610200. PMID 17446170.



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