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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Nuclear envelope pore membrane protein POM 121''' is a [[protein]] that in humans is encoded by the ''POM121'' [[gene]].<ref name="pmid8335683">{{cite journal | vauthors = Hallberg E, Wozniak RW, Blobel G | title = An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region | journal = J Cell Biol | volume = 122 | issue = 3 | pages = 513–21 |date=Aug 1993 | pmid = 8335683 | pmc = 2119659 | doi =10.1083/jcb.122.3.513  }}</ref><ref name="pmid9734811">{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 3 | pages = 169–76 |date=Dec 1998 | pmid = 9734811 | pmc =  | doi =10.1093/dnares/5.3.169  }}</ref><ref name="pmid17900573">{{cite journal | vauthors = Funakoshi T, Maeshima K, Yahata K, Sugano S, Imamoto F, Imamoto N | title = Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes | journal = FEBS Lett | volume = 581 | issue = 25 | pages = 4910–6 |date=Oct 2007 | pmid = 17900573 | pmc = | doi = 10.1016/j.febslet.2007.09.021 }}</ref> Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.<ref name="entrez"/>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = POM121 membrane glycoprotein (rat)
| HGNCid = 19702
| Symbol = POM121
| AltSymbols =; DKFZP586G1822; DKFZP586P2220; KIAA0618; MGC3792
| OMIM = 
| ECnumber = 
| Homologene = 70878
| MGIid = 2137624
| GeneAtlas_image1 = PBB_GE_POM121_212178_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_POM121_213360_s_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006605 |text = protein targeting}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0051028 |text = mRNA transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9883
    | Hs_Ensembl = ENSG00000196313
    | Hs_RefseqProtein = XP_001130619
    | Hs_RefseqmRNA = XM_001130619
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 71987872
    | Hs_GenLoc_end = 72056773
    | Hs_Uniprot = 
    | Mm_EntrezGene = 107939
    | Mm_Ensembl = ENSMUSG00000053293
    | Mm_RefseqmRNA = NM_148932
    | Mm_RefseqProtein = NP_683734
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 135660768
    | Mm_GenLoc_end = 135679137
    | Mm_Uniprot = Q3U425
  }}
}}
'''POM121 membrane glycoprotein (rat)''', also known as '''POM121''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POM121 POM121 membrane glycoprotein (rat)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9883| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[nuclear envelope]] creates distinct [[cell nucleus|nuclear]] and [[cytoplasmic]] compartments in eukaryotic cells. It consists of two concentric membranes perforated by [[nuclear pore]]s, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the [[nucleoporin]] family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an [[integral membrane protein]] that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope.<ref name="entrez">{{cite web | title = Entrez Gene: POM121 POM121 membrane glycoprotein (homo sapiens) | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9883| accessdate = }}</ref>
{{PBB_Summary
 
| section_title =
Antibodies against this protein can be used to identify the nuclear envelope in [[immunofluorescence]] experiments.<ref name="pmid11707516">{{cite journal | vauthors = Kihlmark M, Imreh G, Hallberg E | title = Sequential degradation of proteins from the nuclear envelope during apoptosis | journal = J. Cell Sci. | volume = 114 | issue = Pt 20 | pages = 3643–53 |date=October 2001 | pmid = 11707516 | doi =  }}</ref>
| summary_text = The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: POM121 POM121 membrane glycoprotein (rat)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9883| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Bodoor K, Shaikh S, Enarson P, etal |title=Function and assembly of nuclear pore complex proteins |journal=Biochem. Cell Biol. |volume=77 |issue= 4 |pages= 321–9 |year= 1999 |pmid= 10546895 |doi=10.1139/bcb-77-4-321 }}
| citations =
*{{cite journal   |vauthors=Kipersztok S, Osawa GA, Liang LF, etal |title=POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue |journal=Genomics |volume=25 |issue= 2 |pages= 354–9 |year= 1995 |pmid= 7789967 |doi=10.1016/0888-7543(95)80033-I }}
*{{cite journal | author=Bodoor K, Shaikh S, Enarson P, ''et al.'' |title=Function and assembly of nuclear pore complex proteins. |journal=Biochem. Cell Biol. |volume=77 |issue= 4 |pages= 321-9 |year= 1999 |pmid= 10546895 |doi=  }}
*{{cite journal   |vauthors=Fouchier RA, Meyer BE, Simon JH, etal |title=Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex |journal=J. Virol. |volume=72 |issue= 7 |pages= 6004–13 |year= 1998 |pmid= 9621063 |doi=  | pmc=110405 }}
*{{cite journal | author=Kipersztok S, Osawa GA, Liang LF, ''et al.'' |title=POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. |journal=Genomics |volume=25 |issue= 2 |pages= 354-9 |year= 1995 |pmid= 7789967 |doi= }}
*{{cite journal   |vauthors=Daigle N, Beaudouin J, Hartnell L, etal |title=Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells |journal=J. Cell Biol. |volume=154 |issue= 1 |pages= 71–84 |year= 2001 |pmid= 11448991 |doi=10.1083/jcb.200101089  | pmc=2196857 }}
*{{cite journal  | author=Hallberg E, Wozniak RW, Blobel G |title=An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region. |journal=J. Cell Biol. |volume=122 |issue= 3 |pages= 513-21 |year= 1993 |pmid= 8335683 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Fouchier RA, Meyer BE, Simon JH, ''et al.'' |title=Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex. |journal=J. Virol. |volume=72 |issue= 7 |pages= 6004-13 |year= 1998 |pmid= 9621063 |doi=  }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Daigle N, Beaudouin J, Hartnell L, ''et al.'' |title=Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells. |journal=J. Cell Biol. |volume=154 |issue= 1 |pages= 71-84 |year= 2001 |pmid= 11448991 |doi= }}
*{{cite journal  | vauthors=Eriksson C, Rustum C, Hallberg E |title=Dynamic properties of nuclear pore complex proteins in gp210 deficient cells |journal=FEBS Lett. |volume=572 |issue= 1–3 |pages= 261–5 |year= 2004 |pmid= 15304359 |doi= 10.1016/j.febslet.2004.07.044 }}
*{{cite journal  | author=Kihlmark M, Imreh G, Hallberg E |title=Sequential degradation of proteins from the nuclear envelope during apoptosis. |journal=J. Cell. Sci. |volume=114 |issue= Pt 20 |pages= 3643-53 |year= 2002 |pmid= 11707516 |doi=  }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Eriksson C, Rustum C, Hallberg E |title=Dynamic properties of nuclear pore complex proteins in gp210 deficient cells. |journal=FEBS Lett. |volume=572 |issue= 1-3 |pages= 261-5 |year= 2004 |pmid= 15304359 |doi= 10.1016/j.febslet.2004.07.044 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Nuclear pore complex]]
{{WikiDoc Sources}}
 
 
{{gene-7-stub}}

Latest revision as of 20:36, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene.[1][2][3] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[4]

Function

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope.[4]

Antibodies against this protein can be used to identify the nuclear envelope in immunofluorescence experiments.[5]

References

  1. ↑ Hallberg E, Wozniak RW, Blobel G (Aug 1993). "An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region". J Cell Biol. 122 (3): 513–21. doi:10.1083/jcb.122.3.513. PMC 2119659. PMID 8335683.
  2. ↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  3. ↑ Funakoshi T, Maeshima K, Yahata K, Sugano S, Imamoto F, Imamoto N (Oct 2007). "Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes". FEBS Lett. 581 (25): 4910–6. doi:10.1016/j.febslet.2007.09.021. PMID 17900573.
  4. ↑ 4.0 4.1 "Entrez Gene: POM121 POM121 membrane glycoprotein (homo sapiens)".
  5. ↑ Kihlmark M, Imreh G, Hallberg E (October 2001). "Sequential degradation of proteins from the nuclear envelope during apoptosis". J. Cell Sci. 114 (Pt 20): 3643–53. PMID 11707516.

Further reading


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