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{{Infobox_gene}}
'''Sclerostin domain-containing protein 1''' is a [[protein]] that in humans is encoded by the ''SOSTDC1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOSTDC1 sclerostin domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25928| accessdate = }}</ref>


== Function ==


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This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.<ref name="entrez" />
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== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Sclerostin domain containing 1
| HGNCid = 21748
| Symbol = SOSTDC1
| AltSymbols =; CDA019; DKFZp564D206; ECTODIN; USAG1
| OMIM = 609675
| ECnumber = 
| Homologene = 9154
| MGIid = 1913292
| GeneAtlas_image1 = PBB_GE_SOSTDC1_213456_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007389 |text = pattern specification process}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0030514 |text = negative regulation of BMP signaling pathway}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25928
    | Hs_Ensembl = ENSG00000171243
    | Hs_RefseqProtein = NP_056279
    | Hs_RefseqmRNA = NM_015464
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 16467633
    | Hs_GenLoc_end = 16471999
    | Hs_Uniprot = Q6X4U4
    | Mm_EntrezGene = 66042
    | Mm_Ensembl = ENSMUSG00000036169
    | Mm_RefseqmRNA = XM_990396
    | Mm_RefseqProtein = XP_995490
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 36824492
    | Mm_GenLoc_end = 36828711
    | Mm_Uniprot = Q9CQN4
  }}
}}
'''Sclerostin domain containing 1''', also known as '''SOSTDC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOSTDC1 sclerostin domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25928| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Further reading ==
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.<ref name="entrez">{{cite web | title = Entrez Gene: SOSTDC1 sclerostin domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25928| accessdate = }}</ref>
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yanagita M | title = BMP antagonists: their roles in development and involvement in pathophysiology | journal = Cytokine & Growth Factor Reviews | volume = 16 | issue = 3 | pages = 309–17 | date = June 2005 | pmid = 15951218 | doi = 10.1016/j.cytogfr.2005.02.007 }}
| citations =
* {{cite journal | vauthors = Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N | title = Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot | journal = Developmental Biology | volume = 264 | issue = 1 | pages = 91–105 | date = December 2003 | pmid = 14623234 | doi = 10.1016/j.ydbio.2003.08.011 }}
*{{cite journal | author=Yanagita M |title=BMP antagonists: their roles in development and involvement in pathophysiology. |journal=Cytokine Growth Factor Rev. |volume=16 |issue= 3 |pages= 309-17 |year= 2006 |pmid= 15951218 |doi= 10.1016/j.cytogfr.2005.02.007 }}
* {{cite journal | vauthors = Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T | title = USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney | journal = Biochemical and Biophysical Research Communications | volume = 316 | issue = 2 | pages = 490–500 | date = April 2004 | pmid = 15020244 | doi = 10.1016/j.bbrc.2004.02.075 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Goto M, Eddy EM | title = Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 40 | pages = 42128–38 | date = October 2004 | pmid = 15280373 | doi = 10.1074/jbc.M403190200 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Laurikkala J, Kassai Y, Pakkasjärvi L, ''et al.'' |title=Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. |journal=Dev. Biol. |volume=264 |issue= 1 |pages= 91-105 |year= 2004 |pmid= 14623234 |doi= }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Yanagita M, Oka M, Watabe T, ''et al.'' |title=USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 2 |pages= 490-500 |year= 2004 |pmid= 15020244 |doi= 10.1016/j.bbrc.2004.02.075 }}
*{{cite journal | author=Goto M, Eddy EM |title=Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 42128-38 |year= 2004 |pmid= 15280373 |doi= 10.1074/jbc.M403190200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 04:03, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.[1]

Function

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: SOSTDC1 sclerostin domain containing 1".

Further reading

  • Yanagita M (June 2005). "BMP antagonists: their roles in development and involvement in pathophysiology". Cytokine & Growth Factor Reviews. 16 (3): 309–17. doi:10.1016/j.cytogfr.2005.02.007. PMID 15951218.
  • Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N (December 2003). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Developmental Biology. 264 (1): 91–105. doi:10.1016/j.ydbio.2003.08.011. PMID 14623234.
  • Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T (April 2004). "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochemical and Biophysical Research Communications. 316 (2): 490–500. doi:10.1016/j.bbrc.2004.02.075. PMID 15020244.
  • Goto M, Eddy EM (October 2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". The Journal of Biological Chemistry. 279 (40): 42128–38. doi:10.1074/jbc.M403190200. PMID 15280373.
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