CYP2W1: Difference between revisions
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'''CYP2W1''' ('''cy'''tochrome '''P'''450, family '''2''', subfamily '''W''', polypeptide '''1''') is a [[protein]] that in humans is encoded by the ''CYP2W1'' [[gene]].<ref name="pmid15489334">{{cite journal | vauthors = Gerhard DS, Wagner L, Feingold EA | title = The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2121–7 |date=October 2004 | pmid = 15489334 | pmc = 528928 | doi = 10.1101/gr.2596504 | url = |display-authors=etal}}</ref> | |||
This gene encodes a member of the [[cytochrome P450]] superfamily of [[enzyme]]s. The cytochrome P450 proteins are [[monooxygenase]]s which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.<ref name="entrez_2532">{{cite web | title = Entrez Gene: CYP2W1 | url =https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54905 | accessdate = }}</ref> CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue. | |||
==References== | ==References== | ||
{{Reflist}} | {{Reflist}} | ||
==External links== | |||
* {{UCSC gene info|CYP2W1}} | |||
==Further reading== | |||
{{refbegin | 2}} | |||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |display-authors=etal}} | |||
*{{cite journal |vauthors=Hanzawa Y, Sasaki T, Mizugaki M |title=Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population |journal=Drug Metab. Dispos. |volume=36 |issue= 2 |pages= 349–52 |year= 2008 |pmid= 17998294 |doi= 10.1124/dmd.107.019141 |display-authors=etal}} | |||
*{{cite journal |vauthors=Yoshioka H, Kasai N, Ikushiro S |title=Enzymatic properties of human CYP2W1 expressed in Escherichia coli |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 1 |pages= 169–74 |year= 2006 |pmid= 16677611 |doi= 10.1016/j.bbrc.2006.04.080 |display-authors=etal}} | |||
*{{cite journal |vauthors=Karlgren M, Gomez A, Stark K |title=Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1 |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 2 |pages= 451–8 |year= 2006 |pmid= 16426568 |doi= 10.1016/j.bbrc.2005.12.200 |display-authors=etal}} | |||
*{{cite journal |vauthors=Gomez A, Karlgren M, Edler D |title=Expression of CYP2W1 in colon tumors: regulation by gene methylation |journal=Pharmacogenomics |volume=8 |issue= 10 |pages= 1315–25 |year= 2007 |pmid= 17979506 |doi= 10.2217/14622416.8.10.1315 |display-authors=etal}} | |||
*{{cite journal |vauthors=Nelson DR, Zeldin DC, Hoffman SM |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1–18 |year= 2004 |pmid= 15128046 |doi=10.1097/00008571-200401000-00001 |display-authors=etal}} | |||
{{refend}} | |||
{{NLM content}} | {{NLM content}} | ||
{{Cytochrome P450}} | {{Cytochrome P450}} | ||
{{ | {{gene-7-stub}} | ||
Latest revision as of 10:15, 30 August 2017
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CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.[2] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.
References
- ↑ Gerhard DS, Wagner L, Feingold EA, et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- ↑ "Entrez Gene: CYP2W1".
External links
- Human CYP2W1 genome location and CYP2W1 gene details page in the UCSC Genome Browser.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hanzawa Y, Sasaki T, Mizugaki M, et al. (2008). "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. doi:10.1124/dmd.107.019141. PMID 17998294.
- Yoshioka H, Kasai N, Ikushiro S, et al. (2006). "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. doi:10.1016/j.bbrc.2006.04.080. PMID 16677611.
- Karlgren M, Gomez A, Stark K, et al. (2006). "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. doi:10.1016/j.bbrc.2005.12.200. PMID 16426568.
- Gomez A, Karlgren M, Edler D, et al. (2007). "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics. 8 (10): 1315–25. doi:10.2217/14622416.8.10.1315. PMID 17979506.
- Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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