CYC1: Difference between revisions

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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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'''Cytochrome c1, heme protein, mitochondrial''' is a [[protein]] that in humans is encoded by the ''CYC1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CYC1 cytochrome c-1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1537| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_CYC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bcc.
| PDB = {{PDB2|1bcc}}, {{PDB2|1be3}}, {{PDB2|1bgy}}, {{PDB2|1l0l}}, {{PDB2|1l0n}}, {{PDB2|1ntk}}, {{PDB2|1ntm}}, {{PDB2|1ntz}}, {{PDB2|1nu1}}, {{PDB2|1pp9}}, {{PDB2|1ppj}}, {{PDB2|1sqb}}, {{PDB2|1sqp}}, {{PDB2|1sqq}}, {{PDB2|1sqv}}, {{PDB2|1sqx}}, {{PDB2|2a06}}, {{PDB2|2bcc}}, {{PDB2|2fyu}}, {{PDB2|3bcc}}
| Name = Cytochrome c-1
| HGNCid = 2579
| Symbol = CYC1
| AltSymbols =;
| OMIM = 123980
| ECnumber = 
| Homologene = 55617
| MGIid = 1913695
| GeneAtlas_image1 = PBB_GE_CYC1_201066_at_tn.png
| GeneAtlas_image2 = PBB_GE_CYC1_gnf1h06139_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0045155 |text = electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005746 |text = mitochondrial respiratory chain}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1537
    | Hs_Ensembl = ENSG00000179091
    | Hs_RefseqProtein = NP_001907
    | Hs_RefseqmRNA = NM_001916
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 145221968
    | Hs_GenLoc_end = 145224415
    | Hs_Uniprot = P08574
    | Mm_EntrezGene = 66445
    | Mm_Ensembl = ENSMUSG00000022551
    | Mm_RefseqmRNA = NM_025567
    | Mm_RefseqProtein = NP_079843
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 76170778
    | Mm_GenLoc_end = 76173189
    | Mm_Uniprot = Q3TDC5
  }}
}}
'''Cytochrome c-1''', also known as '''CYC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CYC1 cytochrome c-1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1537| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CYC1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Moon HS, Yang JS |title=Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells. |journal=Mol. Cells |volume=21 |issue= 1 |pages= 7-20 |year= 2006 |pmid= 16511342 |doi=  }}
*{{cite journal  | vauthors=Moon HS, Yang JS |title=Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells. |journal=Mol. Cells |volume=21 |issue= 1 |pages= 7–20 |year= 2006 |pmid= 16511342 |doi=  }}
*{{cite journal  | author=Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T |title=Structural organization of the human mitochondrial cytochrome c1 gene. |journal=J. Biol. Chem. |volume=264 |issue= 3 |pages= 1368-74 |year= 1989 |pmid= 2536365 |doi=  }}
*{{cite journal  | vauthors=Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T |title=Structural organization of the human mitochondrial cytochrome c1 gene. |journal=J. Biol. Chem. |volume=264 |issue= 3 |pages= 1368–74 |year= 1989 |pmid= 2536365 |doi=  }}
*{{cite journal  | author=Nishikimi M, Ohta S, Suzuki H, ''et al.'' |title=Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1. |journal=Nucleic Acids Res. |volume=16 |issue= 8 |pages= 3577 |year= 1988 |pmid= 2836796 |doi=  }}
*{{cite journal  | vauthors=Nishikimi M, Ohta S, Suzuki H |title=Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 |journal=Nucleic Acids Res. |volume=16 |issue= 8 |pages= 3577 |year= 1988 |pmid= 2836796 |doi=10.1093/nar/16.8.3577 | pmc=336517  |display-authors=etal}}
*{{cite journal  | author=Tanaka Y, Ashikari T, Shibano Y, ''et al.'' |title=Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae. |journal=J. Biochem. |volume=103 |issue= 6 |pages= 954-61 |year= 1988 |pmid= 2844747 |doi=  }}
*{{cite journal  | vauthors=Tanaka Y, Ashikari T, Shibano Y |title=Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae |journal=J. Biochem. |volume=103 |issue= 6 |pages= 954–61 |year= 1988 |pmid= 2844747 |doi=  |display-authors=etal}}
*{{cite journal  | author=Shimomura Y, Nishikimi M, Ozawa T |title=Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1. |journal=J. Biol. Chem. |volume=260 |issue= 28 |pages= 15075-80 |year= 1986 |pmid= 2999105 |doi=  }}
*{{cite journal  | vauthors=Shimomura Y, Nishikimi M, Ozawa T |title=Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1 |journal=J. Biol. Chem. |volume=260 |issue= 28 |pages= 15075–80 |year= 1986 |pmid= 2999105 |doi=  }}
*{{cite journal  | author=Nishikimi M, Suzuki H, Ohta S, ''et al.'' |title=Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library. |journal=Biochem. Biophys. Res. Commun. |volume=145 |issue= 1 |pages= 34-9 |year= 1987 |pmid= 3036122 |doi= }}
*{{cite journal  | vauthors=Nishikimi M, Suzuki H, Ohta S |title=Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library |journal=Biochem. Biophys. Res. Commun. |volume=145 |issue= 1 |pages= 34–9 |year= 1987 |pmid= 3036122 |doi=10.1016/0006-291X(87)91283-6  |display-authors=etal}}
*{{cite journal  | author=Smith HT, Ahmed AJ, Millett F |title=Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase. |journal=J. Biol. Chem. |volume=256 |issue= 10 |pages= 4984-90 |year= 1981 |pmid= 6262312 |doi=  }}
*{{cite journal  | vauthors=Smith HT, Ahmed AJ, Millett F |title=Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase |journal=J. Biol. Chem. |volume=256 |issue= 10 |pages= 4984–90 |year= 1981 |pmid= 6262312 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Duncan AM, Ozawa T, Suzuki H, Rozen R |title=Assignment of the gene for the cytochrome c1 subunit of the mitochondrial cytochrome bc1 complex (CYC1) to human chromosome 8q24.3. |journal=Genomics |volume=19 |issue= 2 |pages= 400-1 |year= 1994 |pmid= 8188279 |doi= 10.1006/geno.1994.1084 }}
*{{cite journal  | vauthors=Duncan AM, Ozawa T, Suzuki H, Rozen R |title=Assignment of the gene for the cytochrome c1 subunit of the mitochondrial cytochrome bc1 complex (CYC1) to human chromosome 8q24.3 |journal=Genomics |volume=19 |issue= 2 |pages= 400–1 |year= 1994 |pmid= 8188279 |doi= 10.1006/geno.1994.1084 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Valnot I, Kassis J, Chretien D, ''et al.'' |title=A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency. |journal=Hum. Genet. |volume=104 |issue= 6 |pages= 460-6 |year= 1999 |pmid= 10453733 |doi=  }}
*{{cite journal  | vauthors=Valnot I, Kassis J, Chretien D |title=A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency |journal=Hum. Genet. |volume=104 |issue= 6 |pages= 460–6 |year= 1999 |pmid= 10453733 |doi=10.1007/s004390050988 |display-authors=etal}}
*{{cite journal  | author=Jacotot E, Ferri KF, El Hamel C, ''et al.'' |title=Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2. |journal=J. Exp. Med. |volume=193 |issue= 4 |pages= 509-19 |year= 2001 |pmid= 11181702 |doi=  }}
*{{cite journal  | vauthors=Jacotot E, Ferri KF, El Hamel C |title=Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2 |journal=J. Exp. Med. |volume=193 |issue= 4 |pages= 509–19 |year= 2001 |pmid= 11181702 |doi=10.1084/jem.193.4.509 | pmc=2195906  |display-authors=etal}}
*{{cite journal  | author=Tafani M, Karpinich NO, Hurster KA, ''et al.'' |title=Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10073-82 |year= 2002 |pmid= 11790791 |doi= 10.1074/jbc.M111350200 }}
*{{cite journal  | vauthors=Tafani M, Karpinich NO, Hurster KA |title=Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10073–82 |year= 2002 |pmid= 11790791 |doi= 10.1074/jbc.M111350200 |display-authors=etal}}
*{{cite journal  | author=Muthumani K, Hwang DS, Desai BM, ''et al.'' |title=HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37820-31 |year= 2002 |pmid= 12095993 |doi= 10.1074/jbc.M205313200 }}
*{{cite journal  | vauthors=Muthumani K, Hwang DS, Desai BM |title=HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37820–31 |year= 2002 |pmid= 12095993 |doi= 10.1074/jbc.M205313200 |display-authors=etal}}
*{{cite journal  | author=Muthumani K, Zhang D, Hwang DS, ''et al.'' |title=Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines. |journal=Oncogene |volume=21 |issue= 30 |pages= 4613-25 |year= 2002 |pmid= 12096338 |doi= 10.1038/sj.onc.1205549 }}
*{{cite journal  | vauthors=Muthumani K, Zhang D, Hwang DS |title=Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines |journal=Oncogene |volume=21 |issue= 30 |pages= 4613–25 |year= 2002 |pmid= 12096338 |doi= 10.1038/sj.onc.1205549 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Brenner C, Kroemer G |title=The mitochondriotoxic domain of Vpr determines HIV-1 virulence. |journal=J. Clin. Invest. |volume=111 |issue= 10 |pages= 1455-7 |year= 2003 |pmid= 12750393 |doi=  }}
*{{cite journal  | vauthors=Brenner C, Kroemer G |title=The mitochondriotoxic domain of Vpr determines HIV-1 virulence |journal=J. Clin. Invest. |volume=111 |issue= 10 |pages= 1455–7 |year= 2003 |pmid= 12750393 |doi=10.1172/JCI18609  | pmc=155055 }}
*{{cite journal  | author=Lum JJ, Cohen OJ, Nie Z, ''et al.'' |title=Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis. |journal=J. Clin. Invest. |volume=111 |issue= 10 |pages= 1547-54 |year= 2003 |pmid= 12750404 |doi=  }}
*{{cite journal  | vauthors=Lum JJ, Cohen OJ, Nie Z |title=Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis |journal=J. Clin. Invest. |volume=111 |issue= 10 |pages= 1547–54 |year= 2003 |pmid= 12750404 |doi=10.1172/JCI16233 | pmc=155040  |display-authors=etal}}
*{{cite journal  | author=Yuan J, Murrell GA, Trickett A, Wang MX |title=Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts. |journal=Biochim. Biophys. Acta |volume=1641 |issue= 1 |pages= 35-41 |year= 2003 |pmid= 12788227 |doi=  }}
*{{cite journal  | vauthors=Yuan J, Murrell GA, Trickett A, Wang MX |title=Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts |journal=Biochim. Biophys. Acta |volume=1641 |issue= 1 |pages= 35–41 |year= 2003 |pmid= 12788227 |doi=10.1016/S0167-4889(03)00047-8 }}
*{{cite journal  | author=An J, Chen Y, Huang Z |title=Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19133-40 |year= 2004 |pmid= 14966123 |doi= 10.1074/jbc.M400295200 }}
*{{cite journal  | vauthors=An J, Chen Y, Huang Z |title=Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19133–40 |year= 2004 |pmid= 14966123 |doi= 10.1074/jbc.M400295200 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1537}}
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Revision as of 10:14, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cytochrome c1, heme protein, mitochondrial is a protein that in humans is encoded by the CYC1 gene.[1]


References

  1. "Entrez Gene: CYC1 cytochrome c-1".

External links

Further reading