PSCA (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Prostate stem cell antigen''' is a [[protein]] that in humans is encoded by the ''PSCA'' [[gene]].<ref name="pmid9465086">{{cite journal | vauthors = Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON | title = Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 4 | pages = 1735–40 |date=Mar 1998 | pmid = 9465086 | pmc = 19171 | doi =10.1073/pnas.95.4.1735  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PSCA prostate stem cell antigen| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8000| accessdate = }}</ref>
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| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane [[glycoprotein]]. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene has a nonsynonymous nucleotide polymorphism at its start codon.<ref name="entrez"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Prostate stem cell antigen
| HGNCid = 9500
| Symbol = PSCA
| AltSymbols =; PRO232
| OMIM = 602470
| ECnumber = 
| Homologene = 4150
| MGIid = 1919623
| GeneAtlas_image1 = PBB_GE_PSCA_205319_at_tn.png
| Function = {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8000
    | Hs_Ensembl = ENSG00000167653
    | Hs_RefseqProtein = NP_005663
    | Hs_RefseqmRNA = NM_005672
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 143758926
    | Hs_GenLoc_end = 143761144
    | Hs_Uniprot = O43653
    | Mm_EntrezGene = 72373
    | Mm_Ensembl = ENSMUSG00000022598
    | Mm_RefseqmRNA = NM_028216
    | Mm_RefseqProtein = NP_082492
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 74542094
    | Mm_GenLoc_end = 74544324
    | Mm_Uniprot = Q9D7U0
  }}
}}
'''Prostate stem cell antigen''', also known as '''PSCA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PSCA prostate stem cell antigen| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8000| accessdate = }}</ref>


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== Clinical significance ==
{{PBB_Summary
 
| section_title =
This gene is up-regulated in a large proportion of [[prostate cancer]]s and is also detected in cancers of the bladder and pancreas.<ref name="entrez"/>
| summary_text = This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene has a nonsynonymous nucleotide polymorphism at its start codon.<ref name="entrez">{{cite web | title = Entrez Gene: PSCA prostate stem cell antigen| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8000| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Gu Z, Thomas G, Yamashiro J, etal |title=Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer. |journal=Oncogene |volume=19 |issue= 10 |pages= 1288–96 |year= 2000 |pmid= 10713670 |doi= 10.1038/sj.onc.1203426 }}
| citations =
*{{cite journal  | vauthors=Bahrenberg G, Brauers A, Joost HG, Jakse G |title=Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors. |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue= 3 |pages= 783–8 |year= 2000 |pmid= 10973799 |doi= 10.1006/bbrc.2000.3393 }}
*{{cite journal | author=Reiter RE, Gu Z, Watabe T, ''et al.'' |title=Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 4 |pages= 1735-40 |year= 1998 |pmid= 9465086 |doi= }}
*{{cite journal   |vauthors=Amara N, Palapattu GS, Schrage M, etal |title=Prostate stem cell antigen is overexpressed in human transitional cell carcinoma. |journal=Cancer Res. |volume=61 |issue= 12 |pages= 4660–5 |year= 2001 |pmid= 11406532 |doi= }}
*{{cite journal  | author=Gu Z, Thomas G, Yamashiro J, ''et al.'' |title=Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer. |journal=Oncogene |volume=19 |issue= 10 |pages= 1288-96 |year= 2000 |pmid= 10713670 |doi= 10.1038/sj.onc.1203426 }}
*{{cite journal   |vauthors=Watabe T, Lin M, Ide H, etal |title=Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 401–6 |year= 2002 |pmid= 11752398 |doi= 10.1073/pnas.012574899  | pmc=117572 }}
*{{cite journal | author=Bahrenberg G, Brauers A, Joost HG, Jakse G |title=Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors. |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue= 3 |pages= 783-8 |year= 2000 |pmid= 10973799 |doi= 10.1006/bbrc.2000.3393 }}
*{{cite journal   |vauthors=Ross S, Spencer SD, Holcomb I, etal |title=Prostate stem cell antigen as therapy target: tissue expression and in vivo efficacy of an immunoconjugate. |journal=Cancer Res. |volume=62 |issue= 9 |pages= 2546–53 |year= 2002 |pmid= 11980648 |doi= }}
*{{cite journal | author=Amara N, Palapattu GS, Schrage M, ''et al.'' |title=Prostate stem cell antigen is overexpressed in human transitional cell carcinoma. |journal=Cancer Res. |volume=61 |issue= 12 |pages= 4660-5 |year= 2001 |pmid= 11406532 |doi= }}
*{{cite journal   |vauthors=Jain A, Lam A, Vivanco I, etal |title=Identification of an androgen-dependent enhancer within the prostate stem cell antigen gene. |journal=Mol. Endocrinol. |volume=16 |issue= 10 |pages= 2323–37 |year= 2003 |pmid= 12351697 |doi=10.1210/me.2002-0004 }}
*{{cite journal | author=Watabe T, Lin M, Ide H, ''et al.'' |title=Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 401-6 |year= 2002 |pmid= 11752398 |doi= 10.1073/pnas.012574899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Ross S, Spencer SD, Holcomb I, ''et al.'' |title=Prostate stem cell antigen as therapy target: tissue expression and in vivo efficacy of an immunoconjugate. |journal=Cancer Res. |volume=62 |issue= 9 |pages= 2546-53 |year= 2002 |pmid= 11980648 |doi=  }}
*{{cite journal  | vauthors=Tran CP, Lin C, Yamashiro J, Reiter RE |title=Prostate stem cell antigen is a marker of late intermediate prostate epithelial cells. |journal=Mol. Cancer Res. |volume=1 |issue= 2 |pages= 113–21 |year= 2003 |pmid= 12496358 |doi= }}
*{{cite journal | author=Jain A, Lam A, Vivanco I, ''et al.'' |title=Identification of an androgen-dependent enhancer within the prostate stem cell antigen gene. |journal=Mol. Endocrinol. |volume=16 |issue= 10 |pages= 2323-37 |year= 2003 |pmid= 12351697 |doi=  }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Tran CP, Lin C, Yamashiro J, Reiter RE |title=Prostate stem cell antigen is a marker of late intermediate prostate epithelial cells. |journal=Mol. Cancer Res. |volume=1 |issue= 2 |pages= 113-21 |year= 2003 |pmid= 12496358 |doi=  }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504  | pmc=2286551 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Fraga MF, Ballestar E, Villar-Garea A, etal |title=Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. |journal=Nat. Genet. |volume=37 |issue= 4 |pages= 391–400 |year= 2005 |pmid= 15765097 |doi= 10.1038/ng1531 }}
*{{cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal   |vauthors=Lam JS, Yamashiro J, Shintaku IP, etal |title=Prostate stem cell antigen is overexpressed in prostate cancer metastases. |journal=Clin. Cancer Res. |volume=11 |issue= 7 |pages= 2591–6 |year= 2005 |pmid= 15814638 |doi= 10.1158/1078-0432.CCR-04-1842 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Zhigang Z, Wenlu S |title=Complete androgen ablation suppresses prostate stem cell antigen (PSCA) mRNA expression in human prostate carcinoma. |journal=Prostate |volume=65 |issue= 4 |pages= 299–305 |year= 2006 |pmid= 16015594 |doi= 10.1002/pros.20290 }}
*{{cite journal | author=Fraga MF, Ballestar E, Villar-Garea A, ''et al.'' |title=Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. |journal=Nat. Genet. |volume=37 |issue= 4 |pages= 391-400 |year= 2005 |pmid= 15765097 |doi= 10.1038/ng1531 }}
*{{cite journal   |vauthors=Wente MN, Jain A, Kono E, etal |title=Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer. |journal=Pancreas |volume=31 |issue= 2 |pages= 119–25 |year= 2006 |pmid= 16024997 |doi=10.1097/01.mpa.0000173459.81193.4d }}
*{{cite journal  | author=Lam JS, Yamashiro J, Shintaku IP, ''et al.'' |title=Prostate stem cell antigen is overexpressed in prostate cancer metastases. |journal=Clin. Cancer Res. |volume=11 |issue= 7 |pages= 2591-6 |year= 2005 |pmid= 15814638 |doi= 10.1158/1078-0432.CCR-04-1842 }}
*{{cite journal   |vauthors=Oh JH, Yang JO, Hahn Y, etal |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Zhigang Z, Wenlu S |title=Complete androgen ablation suppresses prostate stem cell antigen (PSCA) mRNA expression in human prostate carcinoma. |journal=Prostate |volume=65 |issue= 4 |pages= 299-305 |year= 2006 |pmid= 16015594 |doi= 10.1002/pros.20290 }}
*{{cite journal  | vauthors=Grubbs EG, Abdel-Wahab Z, Tyler DS, Pruitt SK |title=Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer. |journal=Ann. Surg. Oncol. |volume=13 |issue= 12 |pages= 1645–54 |year= 2007 |pmid= 16957968 |doi= 10.1245/s10434-006-9029-5 }}
*{{cite journal  | author=Wente MN, Jain A, Kono E, ''et al.'' |title=Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer. |journal=Pancreas |volume=31 |issue= 2 |pages= 119-25 |year= 2006 |pmid= 16024997 |doi= }}
*{{cite journal   |vauthors=Morgenroth A, Cartellieri M, Schmitz M, etal |title=Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells. |journal=Prostate |volume=67 |issue= 10 |pages= 1121–31 |year= 2007 |pmid= 17492652 |doi= 10.1002/pros.20608 }}
*{{cite journal | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal  | author=Grubbs EG, Abdel-Wahab Z, Tyler DS, Pruitt SK |title=Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer. |journal=Ann. Surg. Oncol. |volume=13 |issue= 12 |pages= 1645-54 |year= 2007 |pmid= 16957968 |doi= 10.1245/s10434-006-9029-5 }}
*{{cite journal | author=Morgenroth A, Cartellieri M, Schmitz M, ''et al.'' |title=Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells. |journal=Prostate |volume=67 |issue= 10 |pages= 1121-31 |year= 2007 |pmid= 17492652 |doi= 10.1002/pros.20608 }}
}}
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Latest revision as of 18:48, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Prostate stem cell antigen is a protein that in humans is encoded by the PSCA gene.[1][2]

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene has a nonsynonymous nucleotide polymorphism at its start codon.[2]

Clinical significance

This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas.[2]

References

  1. ↑ Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON (Mar 1998). "Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer". Proc Natl Acad Sci U S A. 95 (4): 1735–40. doi:10.1073/pnas.95.4.1735. PMC 19171. PMID 9465086.
  2. ↑ 2.0 2.1 2.2 "Entrez Gene: PSCA prostate stem cell antigen".

Further reading


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