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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''NEDD4-like E3 ubiquitin-protein ligase WWP1''' is an [[enzyme]] that in humans is encoded by the ''WWP1'' [[gene]].<ref name="pmid9169421">{{cite journal | vauthors = Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM | title = Identification of novel human WW domain-containing proteins by cloning of ligand targets | journal = J Biol Chem | volume = 272 | issue = 23 | pages = 14611–6 | date = June 1997 | pmid = 9169421 | pmc =  | doi = 10.1074/jbc.272.23.14611 }}</ref><ref name="pmid9647693">{{cite journal | vauthors = Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA | title = Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins | journal = Mol Cell Neurosci | volume = 11 | issue = 3 | pages = 149–60 | date = July 1998 | pmid = 9647693 | pmc =  | doi = 10.1006/mcne.1998.0677 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11059| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_WWP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nd7.
| PDB = {{PDB2|1nd7}}
| Name = WW domain containing E3 ubiquitin protein ligase 1
| HGNCid = 17004
| Symbol = WWP1
| AltSymbols =; AIP5; DKFZp434D2111; Tiul1; hSDRP1
| OMIM = 602307
| ECnumber = 
| Homologene = 21385
| MGIid = 
| GeneAtlas_image1 = PBB_GE_WWP1_212637_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_WWP1_212638_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0030217 |text = T cell differentiation}} {{GNF_GO|id=GO:0030324 |text = lung development}} {{GNF_GO|id=GO:0046718 |text = entry of virus into host cell}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11059
    | Hs_Ensembl = ENSG00000123124
    | Hs_RefseqProtein = NP_008944
    | Hs_RefseqmRNA = NM_007013
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 87455386
    | Hs_GenLoc_end = 87548821
    | Hs_Uniprot = Q9H0M0
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''WW domain containing E3 ubiquitin protein ligase 1''', also known as '''WWP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11059| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.<ref name="entrez">{{cite web | title = Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11059| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | author=Pirozzi G, McConnell SJ, Uveges AJ, ''et al.'' |title=Identification of novel human WW domain-containing proteins by cloning of ligand targets. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14611-6 |year= 1997 |pmid= 9169421 |doi=  }}
*{{cite journal  | author=Wood JD, Yuan J, Margolis RL, ''et al.'' |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149-60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677 }}
*{{cite journal  | author=Mosser EA, Kasanov JD, Forsberg EC, ''et al.'' |title=Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains. |journal=Biochemistry |volume=37 |issue= 39 |pages= 13686-95 |year= 1998 |pmid= 9753456 |doi= 10.1021/bi981310l }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | author=Conkright MD, Wani MA, Lingrel JB |title=Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29299-306 |year= 2001 |pmid= 11375995 |doi= 10.1074/jbc.M103670200 }}
*{{cite journal  | author=Flasza M, Gorman P, Roylance R, ''et al.'' |title=Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue= 1 |pages= 431-7 |year= 2002 |pmid= 11779188 |doi= 10.1006/bbrc.2001.6206 }}
*{{cite journal  | author=Galinier R, Gout E, Lortat-Jacob H, ''et al.'' |title=Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. |journal=Biochemistry |volume=41 |issue= 48 |pages= 14299-305 |year= 2003 |pmid= 12450395 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Verdecia MA, Joazeiro CA, Wells NJ, ''et al.'' |title=Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. |journal=Mol. Cell |volume=11 |issue= 1 |pages= 249-59 |year= 2003 |pmid= 12535537 |doi=  }}
*{{cite journal  | author=Komuro A, Imamura T, Saitoh M, ''et al.'' |title=Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). |journal=Oncogene |volume=23 |issue= 41 |pages= 6914-23 |year= 2004 |pmid= 15221015 |doi= 10.1038/sj.onc.1207885 }}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Seo SR, Lallemand F, Ferrand N, ''et al.'' |title=The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. |journal=EMBO J. |volume=23 |issue= 19 |pages= 3780-92 |year= 2005 |pmid= 15359284 |doi= 10.1038/sj.emboj.7600398 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Chen C, Sun X, Guo P, ''et al.'' |title=Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41553-61 |year= 2006 |pmid= 16223724 |doi= 10.1074/jbc.M506183200 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | author=Flasza M, Nguyen Huu NS, Mazaleyrat S, ''et al.'' |title=Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch. |journal=Mol. Membr. Biol. |volume=23 |issue= 3 |pages= 269-76 |year= 2006 |pmid= 16785210 |doi= 10.1080/09687860600665010 }}
*{{cite journal  | author=Laine A, Ronai Z |title=Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1. |journal=Oncogene |volume=26 |issue= 10 |pages= 1477-83 |year= 2007 |pmid= 16924229 |doi= 10.1038/sj.onc.1209924 }}
*{{cite journal  | author=Chen C, Sun X, Guo P, ''et al.'' |title=Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. |journal=Oncogene |volume=26 |issue= 16 |pages= 2386-94 |year= 2007 |pmid= 17016436 |doi= 10.1038/sj.onc.1210021 }}
}}
{{refend}}


{{protein-stub}}
WWP1 has been shown to [[Protein-protein interaction|interact]] with:
* [[CPSF6]],<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M|authorlink30=Huda Zoghbi | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
* [[KLF2]],<ref name = pmid11375995>{{cite journal | vauthors = Conkright MD, Wani MA, Lingrel JB | title = Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase | journal = J. Biol. Chem. | volume = 276 | issue = 31 | pages = 29299–306 | date = August 2001 | pmid = 11375995 | doi = 10.1074/jbc.M103670200 }}</ref>  and
* [[Reticulon 4]]<ref name = pmid19035836>{{cite journal | vauthors = Qin H, Pu HX, Li M, Ahmed S, Song J | title = Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration | journal = Biochemistry | volume = 47 | issue = 51 | pages = 13647–58 | date = Dec 2008 | pmid = 19035836 | doi = 10.1021/bi8017976 }}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery. | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Mosser EA, Kasanov JD, Forsberg EC, Kay BK, Ney PA, Bresnick EH | title = Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains. | journal = Biochemistry | volume = 37 | issue = 39 | pages = 13686–95 | year = 1998 | pmid = 9753456 | doi = 10.1021/bi981310l }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
* {{cite journal | vauthors = Conkright MD, Wani MA, Lingrel JB | title = Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. | journal = J. Biol. Chem. | volume = 276 | issue = 31 | pages = 29299–306 | year = 2001 | pmid = 11375995 | doi = 10.1074/jbc.M103670200 }}
* {{cite journal | vauthors = Flasza M, Gorman P, Roylance R, Canfield AE, Baron M | title = Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. | journal = Biochem. Biophys. Res. Commun. | volume = 290 | issue = 1 | pages = 431–7 | year = 2002 | pmid = 11779188 | doi = 10.1006/bbrc.2001.6206 }}
* {{cite journal | vauthors = Galinier R, Gout E, Lortat-Jacob H, Wood J, Chroboczek J | title = Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. | journal = Biochemistry | volume = 41 | issue = 48 | pages = 14299–305 | year = 2003 | pmid = 12450395 | doi = 10.1021/bi020125b }}
* {{cite journal | vauthors = Verdecia MA, Joazeiro CA, Wells NJ, Ferrer JL, Bowman ME, Hunter T, Noel JP | title = Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. | journal = Mol. Cell | volume = 11 | issue = 1 | pages = 249–59 | year = 2003 | pmid = 12535537 | doi = 10.1016/S1097-2765(02)00774-8 }}
* {{cite journal | vauthors = Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K, Miyazawa K | title = Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). | journal = Oncogene | volume = 23 | issue = 41 | pages = 6914–23 | year = 2004 | pmid = 15221015 | doi = 10.1038/sj.onc.1207885 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway. | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Seo SR, Lallemand F, Ferrand N, Pessah M, L'Hoste S, Camonis J, Atfi A | title = The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. | journal = EMBO J. | volume = 23 | issue = 19 | pages = 3780–92 | year = 2005 | pmid = 15359284 | pmc = 522797 | doi = 10.1038/sj.emboj.7600398 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Chen C, Sun X, Guo P, Dong XY, Sethi P, Cheng X, Zhou J, Ling J, Simons JW, Lingrel JB, Dong JT | title = Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. | journal = J. Biol. Chem. | volume = 280 | issue = 50 | pages = 41553–61 | year = 2006 | pmid = 16223724 | doi = 10.1074/jbc.M506183200 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
* {{cite journal | vauthors = Flasza M, Nguyen Huu NS, Mazaleyrat S, Clémence S, Villemant C, Clarke R, Baron M | title = Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch. | journal = Mol. Membr. Biol. | volume = 23 | issue = 3 | pages = 269–76 | year = 2006 | pmid = 16785210 | doi = 10.1080/09687860600665010 }}
* {{cite journal | vauthors = Laine A, Ronai Z | title = Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1. | journal = Oncogene | volume = 26 | issue = 10 | pages = 1477–83 | year = 2007 | pmid = 16924229 | pmc = 2997392 | doi = 10.1038/sj.onc.1209924 }}
* {{cite journal | vauthors = Chen C, Sun X, Guo P, Dong XY, Sethi P, Zhou W, Zhou Z, Petros J, Frierson HF, Vessella RL, Atfi A, Dong JT | title = Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. | journal = Oncogene | volume = 26 | issue = 16 | pages = 2386–94 | year = 2007 | pmid = 17016436 | doi = 10.1038/sj.onc.1210021 }}
{{Refend}}
{{PDB Gallery|geneid=11059}}

Latest revision as of 02:05, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.[1][2][3]

Function

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.[3]

Interactions

WWP1 has been shown to interact with:

References

  1. ↑ Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM (June 1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J Biol Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.
  2. ↑ Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (July 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol Cell Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.
  3. ↑ 3.0 3.1 "Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1".
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  5. ↑ Conkright MD, Wani MA, Lingrel JB (August 2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase". J. Biol. Chem. 276 (31): 29299–306. doi:10.1074/jbc.M103670200. PMID 11375995.
  6. ↑ Qin H, Pu HX, Li M, Ahmed S, Song J (Dec 2008). "Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration". Biochemistry. 47 (51): 13647–58. doi:10.1021/bi8017976. PMID 19035836.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=WWP1&oldid=1422148"