DEFB103A: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Beta-defensin 103''' is a [[protein]] that in humans is encoded by the ''DEFB103A'' [[gene]].<ref name="pmid11223260">{{cite journal | vauthors = Jia HP, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, Tack BF, Mitros JP, Rosenthal A, Ganz T, ((McCray PB Jr)) | title = Discovery of new human beta-defensins using a genomics-based approach | journal = Gene | volume = 263 | issue = 1–2 | pages = 211–8 |date=Mar 2001 | pmid = 11223260 | pmc =  | doi =10.1016/S0378-1119(00)00569-2  }}</ref><ref name="pmid11085990">{{cite journal | vauthors = Harder J, Bartels J, Christophers E, Schroder JM | title = Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic | journal = J Biol Chem | volume = 276 | issue = 8 | pages = 5707–13 |date=Feb 2001 | pmid = 11085990 | pmc = | doi = 10.1074/jbc.M008557200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DEFB103A defensin, beta 103A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55894| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_DEFB103A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kj6.
| PDB = {{PDB2|1kj6}}
| Name = Defensin, beta 103A
| HGNCid = 15967
| Symbol = DEFB103A
| AltSymbols =; DEFB103; DEFB3; HBD-3; HBD3; HBP-3; HBP3
| OMIM = 606611
| ECnumber = 
| Homologene = 10256
| MGIid = 2675345
| Function =  
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006965 |text = positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55894
    | Hs_Ensembl = ENSG00000176797
    | Hs_RefseqProtein = NP_061131
    | Hs_RefseqmRNA = NM_018661
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 7776136
    | Hs_GenLoc_end = 7777588
    | Hs_Uniprot = P81534
    | Mm_EntrezGene = 244332
    | Mm_Ensembl = ENSMUSG00000046354
    | Mm_RefseqmRNA = NM_183026
    | Mm_RefseqProtein = NP_898847
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 19194334
    | Mm_GenLoc_end = 19195189
    | Mm_Uniprot = Q14BD1
  }}
}}
'''Defensin, beta 103A''', also known as '''DEFB103A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DEFB103A defensin, beta 103A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55894| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Defensin]]s form a family of microbicidal and cytotoxic peptides made by [[neutrophil]]s. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
In dogs, the product of the same genetic locus, β-Defensin 103, also plays a role in pigmentation, being an [[agonist]] of the [[melanocortin 1 receptor]].<ref name="pmid17947548">{{cite journal | vauthors = Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, Kerns JA, Schmutz SM, Millhauser GL, Barsh GS | title = A -defensin mutation causes black coat color in domestic dogs | journal = Science | volume = 318 | issue = 5855 | pages = 1418–23 |date=November 2007 | pmid = 17947548 | pmc = 2906624 | doi = 10.1126/science.1147880 }}</ref>
| summary_text = Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense.<ref name="entrez">{{cite web | title = Entrez Gene: DEFB103A defensin, beta 103A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55894| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
| citations =
*{{cite journal  | vauthors=Tomita T, Nagase T |title=[Defensins as a mechanism of host defense and innate immunity] |journal=Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics |volume=38 |issue= 4 |pages= 440–3 |year= 2001 |pmid= 11523142 |doi= 10.3143/geriatrics.38.440}}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | vauthors=García JR, Jaumann F, Schulz S |title=Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction |journal=Cell Tissue Res. |volume=306 |issue= 2 |pages= 257–64 |year= 2002 |pmid= 11702237 |doi= 10.1007/s004410100433 |display-authors=etal}}
*{{cite journal  | author=Harder J, Bartels J, Christophers E, Schroder JM |title=Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5707-13 |year= 2001 |pmid= 11085990 |doi= 10.1074/jbc.M008557200 }}
*{{cite journal  | vauthors=Biragyn A, Surenhu M, Yang D |title=Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6644–53 |year= 2002 |pmid= 11714836 |doi=  10.4049/jimmunol.167.11.6644|display-authors=etal}}
*{{cite journal  | author=Jia HP, Schutte BC, Schudy A, ''et al.'' |title=Discovery of new human beta-defensins using a genomics-based approach. |journal=Gene |volume=263 |issue= 1-2 |pages= 211-8 |year= 2001 |pmid= 11223260 |doi= }}
*{{cite journal  | vauthors=Schibli DJ, Hunter HN, Aseyev V |title=The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8279–89 |year= 2002 |pmid= 11741980 |doi= 10.1074/jbc.M108830200 |display-authors=etal}}
*{{cite journal  | author=Tomita T, Nagase T |title=[Defensins as a mechanism of host defense and innate immunity] |journal=Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics |volume=38 |issue= 4 |pages= 440-3 |year= 2001 |pmid= 11523142 |doi=  }}
*{{cite journal  | vauthors=Dunsche A, Açil Y, Dommisch H |title=The novel human beta-defensin-3 is widely expressed in oral tissues |journal=Eur. J. Oral Sci. |volume=110 |issue= 2 |pages= 121–4 |year= 2002 |pmid= 12013554 |doi=10.1034/j.1600-0722.2002.11186.x |display-authors=etal}}
*{{cite journal  | author=García JR, Jaumann F, Schulz S, ''et al.'' |title=Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. |journal=Cell Tissue Res. |volume=306 |issue= 2 |pages= 257-64 |year= 2002 |pmid= 11702237 |doi= 10.1007/s004410100433 }}
*{{cite journal  | vauthors=Paulsen F, Pufe T, Conradi L |title=Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes |journal=J. Pathol. |volume=198 |issue= 3 |pages= 369–77 |year= 2003 |pmid= 12375270 |doi= 10.1002/path.1224 |display-authors=etal}}
*{{cite journal  | author=Biragyn A, Surenhu M, Yang D, ''et al.'' |title=Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6644-53 |year= 2002 |pmid= 11714836 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Schibli DJ, Hunter HN, Aseyev V, ''et al.'' |title=The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8279-89 |year= 2002 |pmid= 11741980 |doi= 10.1074/jbc.M108830200 }}
*{{cite journal  | vauthors=Abiko Y, Nishimura M, Kusano K |title=Upregulated expression of human beta defensin-1 and -3 mRNA during differentiation of keratinocyte immortalized cell lines, HaCaT and PHK16-0b |journal=J. Dermatol. Sci. |volume=31 |issue= 3 |pages= 225–8 |year= 2004 |pmid= 12727027 |doi=10.1016/S0923-1811(03)00007-0  |display-authors=etal}}
*{{cite journal  | author=Dunsche A, Açil Y, Dommisch H, ''et al.'' |title=The novel human beta-defensin-3 is widely expressed in oral tissues. |journal=Eur. J. Oral Sci. |volume=110 |issue= 2 |pages= 121-4 |year= 2002 |pmid= 12013554 |doi=  }}
*{{cite journal  | vauthors=Nishimura M, Abiko Y, Kusano K |title=Localization of human beta-defensin 3 mRNA in normal oral epithelium, leukoplakia, and lichen planus: an in situ hybridization study |journal=Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan |volume=36 |issue= 2 |pages= 94–7 |year= 2003 |pmid= 12825122 |doi= 10.1007/s00795-002-0206-8 |display-authors=etal}}
*{{cite journal  | author=Paulsen F, Pufe T, Conradi L, ''et al.'' |title=Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes. |journal=J. Pathol. |volume=198 |issue= 3 |pages= 369-77 |year= 2003 |pmid= 12375270 |doi= 10.1002/path.1224 }}
*{{cite journal  | vauthors=Wu Z, Hoover DM, Yang D |title=Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 8880–5 |year= 2003 |pmid= 12840147 |doi= 10.1073/pnas.1533186100  | pmc=166407 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=King AE, Fleming DC, Critchley HO, Kelly RW |title=Differential expression of the natural antimicrobials, beta-defensins 3 and 4, in human endometrium |journal=J. Reprod. Immunol. |volume=59 |issue= 1 |pages= 1–16 |year= 2004 |pmid= 12892899 |doi=10.1016/S0165-0378(02)00083-9  }}
*{{cite journal  | author=Abiko Y, Nishimura M, Kusano K, ''et al.'' |title=Upregulated expression of human beta defensin-1 and -3 mRNA during differentiation of keratinocyte immortalized cell lines, HaCaT and PHK16-0b. |journal=J. Dermatol. Sci. |volume=31 |issue= 3 |pages= 225-8 |year= 2004 |pmid= 12727027 |doi= }}
*{{cite journal  | vauthors=Chadebech P, Goidin D, Jacquet C |title=Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS |journal=Cell Biol. Toxicol. |volume=19 |issue= 5 |pages= 313–24 |year= 2004 |pmid= 14703118 |doi=10.1023/B:CBTO.0000004975.36521.c8  |display-authors=etal}}
*{{cite journal  | author=Nishimura M, Abiko Y, Kusano K, ''et al.'' |title=Localization of human beta-defensin 3 mRNA in normal oral epithelium, leukoplakia, and lichen planus: an in situ hybridization study. |journal=Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan |volume=36 |issue= 2 |pages= 94-7 |year= 2003 |pmid= 12825122 |doi= 10.1007/s00795-002-0206-8 }}
*{{cite journal  | vauthors=Pernet I, Reymermier C, Guezennec A |title=Calcium triggers beta-defensin (hBD-2 and hBD-3) and chemokine macrophage inflammatory protein-3 alpha (MIP-3alpha/CCL20) expression in monolayers of activated human keratinocytes |journal=Exp. Dermatol. |volume=12 |issue= 6 |pages= 755–60 |year= 2004 |pmid= 14714554 |doi=10.1111/j.0906-6705.2003.00086.x |display-authors=etal}}
*{{cite journal  | author=Wu Z, Hoover DM, Yang D, ''et al.'' |title=Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 8880-5 |year= 2003 |pmid= 12840147 |doi= 10.1073/pnas.1533186100 }}
*{{cite journal  | vauthors=Yoshimoto T, Yamaai T, Mizukawa N |title=Different expression patterns of beta-defensins in human squamous cell carcinomas |journal=Anticancer Res. |volume=23 |issue= 6C |pages= 4629–33 |year= 2004 |pmid= 14981906 |doi=  |display-authors=etal}}
*{{cite journal  | author=King AE, Fleming DC, Critchley HO, Kelly RW |title=Differential expression of the natural antimicrobials, beta-defensins 3 and 4, in human endometrium. |journal=J. Reprod. Immunol. |volume=59 |issue= 1 |pages= 1-16 |year= 2004 |pmid= 12892899 |doi=  }}
*{{cite journal  | vauthors=Joly S, Organ CC, Johnson GK |title=Correlation between beta-defensin expression and induction profiles in gingival keratinocytes |journal=Mol. Immunol. |volume=42 |issue= 9 |pages= 1073–84 |year= 2005 |pmid= 15829297 |doi= 10.1016/j.molimm.2004.11.001 |display-authors=etal}}
*{{cite journal  | author=Chadebech P, Goidin D, Jacquet C, ''et al.'' |title=Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS. |journal=Cell Biol. Toxicol. |volume=19 |issue= 5 |pages= 313-24 |year= 2004 |pmid= 14703118 |doi=  }}
*{{cite journal  | vauthors=Varoga D, Pufe T, Harder J |title=Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors |journal=Arthritis Rheum. |volume=52 |issue= 6 |pages= 1736–45 |year= 2005 |pmid= 15934078 |doi= 10.1002/art.21090 |display-authors=etal}}
*{{cite journal  | author=Pernet I, Reymermier C, Guezennec A, ''et al.'' |title=Calcium triggers beta-defensin (hBD-2 and hBD-3) and chemokine macrophage inflammatory protein-3 alpha (MIP-3alpha/CCL20) expression in monolayers of activated human keratinocytes. |journal=Exp. Dermatol. |volume=12 |issue= 6 |pages= 755-60 |year= 2004 |pmid= 14714554 |doi= }}
*{{cite journal  | vauthors=Niyonsaba F, Ushio H, Nagaoka I |title=The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes |journal=J. Immunol. |volume=175 |issue= 3 |pages= 1776–84 |year= 2005 |pmid= 16034119 |doi= 10.4049/jimmunol.175.3.1776|display-authors=etal}}
*{{cite journal  | author=Yoshimoto T, Yamaai T, Mizukawa N, ''et al.'' |title=Different expression patterns of beta-defensins in human squamous cell carcinomas. |journal=Anticancer Res. |volume=23 |issue= 6C |pages= 4629-33 |year= 2004 |pmid= 14981906 |doi= }}
*{{cite journal  | author=Joly S, Organ CC, Johnson GK, ''et al.'' |title=Correlation between beta-defensin expression and induction profiles in gingival keratinocytes. |journal=Mol. Immunol. |volume=42 |issue= 9 |pages= 1073-84 |year= 2005 |pmid= 15829297 |doi= 10.1016/j.molimm.2004.11.001 }}
*{{cite journal  | author=Varoga D, Pufe T, Harder J, ''et al.'' |title=Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors. |journal=Arthritis Rheum. |volume=52 |issue= 6 |pages= 1736-45 |year= 2005 |pmid= 15934078 |doi= 10.1002/art.21090 }}
*{{cite journal  | author=Niyonsaba F, Ushio H, Nagaoka I, ''et al.'' |title=The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes. |journal=J. Immunol. |volume=175 |issue= 3 |pages= 1776-84 |year= 2005 |pmid= 16034119 |doi=  }}
}}
{{refend}}
{{refend}}


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{{PDB Gallery|geneid=55894}}
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Revision as of 18:21, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-defensin 103 is a protein that in humans is encoded by the DEFB103A gene.[1][2][3]

Function

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense.[3]

In dogs, the product of the same genetic locus, β-Defensin 103, also plays a role in pigmentation, being an agonist of the melanocortin 1 receptor.[4]

References

  1. ↑ Jia HP, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, Tack BF, Mitros JP, Rosenthal A, Ganz T, McCray PB Jr (Mar 2001). "Discovery of new human beta-defensins using a genomics-based approach". Gene. 263 (1–2): 211–8. doi:10.1016/S0378-1119(00)00569-2. PMID 11223260.
  2. ↑ Harder J, Bartels J, Christophers E, Schroder JM (Feb 2001). "Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic". J Biol Chem. 276 (8): 5707–13. doi:10.1074/jbc.M008557200. PMID 11085990.
  3. ↑ 3.0 3.1 "Entrez Gene: DEFB103A defensin, beta 103A".
  4. ↑ Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, Kerns JA, Schmutz SM, Millhauser GL, Barsh GS (November 2007). "A -defensin mutation causes black coat color in domestic dogs". Science. 318 (5855): 1418–23. doi:10.1126/science.1147880. PMC 2906624. PMID 17947548.

Further reading


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