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{{Infobox_gene}}
{{PBB_Controls
'''Docking protein 2''' is a [[protein]] that in humans is encoded by the ''DOK2'' [[gene]].<ref name="pmid9478921">{{cite journal | vauthors = Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD | title = Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins | journal = J Biol Chem | volume = 273 | issue = 9 | pages = 4827–30 |date=March 1998 | pmid = 9478921 | pmc =  | doi =10.1074/jbc.273.9.4827  }}</ref><ref name="pmid14645010">{{cite journal | vauthors = Garcia A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N | title = Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins | journal = Blood | volume = 103 | issue = 6 | pages = 2088–95 |date=March 2004 | pmid = 14645010 | pmc =  | doi = 10.1182/blood-2003-07-2392 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DOK2 docking protein 2, 56kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9046| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_DOK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2d9w.
| PDB = {{PDB2|2d9w}}, {{PDB2|2dlw}}
| Name = Docking protein 2, 56kDa
| HGNCid = 2991
| Symbol = DOK2
| AltSymbols =; p56DOK; p56dok-2
| OMIM = 604997
| ECnumber = 
| Homologene = 2957
| MGIid = 1332623
| GeneAtlas_image1 = PBB_GE_DOK2_214054_at_tn.png
| Function = {{GNF_GO|id=GO:0005069 |text = transmembrane receptor protein tyrosine kinase docking protein activity}} {{GNF_GO|id=GO:0005158 |text = insulin receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9046
    | Hs_Ensembl = ENSG00000147443
    | Hs_RefseqProtein = NP_003965
    | Hs_RefseqmRNA = NM_003974
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 21822336
    | Hs_GenLoc_end = 21827151
    | Hs_Uniprot = O60496
    | Mm_EntrezGene = 13449
    | Mm_Ensembl = ENSMUSG00000022102
    | Mm_RefseqmRNA = NM_010071
    | Mm_RefseqProtein = NP_034201
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 69509461
    | Mm_GenLoc_end = 69513574
    | Mm_Uniprot = Q3TX09
  }}
}}
'''Docking protein 2, 56kDa''', also known as '''DOK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DOK2 docking protein 2, 56kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9046| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.<ref name="entrez">{{cite web | title = Entrez Gene: DOK2 docking protein 2, 56kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9046| accessdate = }}</ref>
 
}}
DOK2 has been shown to [[Protein-protein interaction|interact]] with [[INPP5D]]<ref name="pmid10822173">{{cite journal | vauthors = Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD | title = The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells | journal = Cell. Signal. | volume = 12 | issue = 5 | pages = 317–26 | year = 2000 | pmid = 10822173 | doi = 10.1016/S0898-6568(00)00073-5 }}</ref> and [[TEK tyrosine kinase]].<ref name="pmid9764820">{{cite journal | vauthors = Jones N, Dumont DJ | title = The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R | journal = Oncogene | volume = 17 | issue = 9 | pages = 1097–108 | year = 1998 | pmid = 9764820 | doi = 10.1038/sj.onc.1202115 }}</ref><ref name="pmid11689432">{{cite journal | vauthors = Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ | title = Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak | journal = EMBO J. | volume = 20 | issue = 21 | pages = 5919–28 | year = 2001 | pmid = 11689432 | pmc = 125712 | doi = 10.1093/emboj/20.21.5919 }}</ref>
 
== References ==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Jiang H, Harris MB, Rothman P |title=IL-4/IL-13 signaling beyond JAK/STAT. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 6 Pt 1 |pages= 1063–70 |year= 2000 |pmid= 10856136 |doi=10.1067/mai.2000.107604 }}
| citations =
*{{cite journal  | vauthors=Jones N, Dumont DJ |title=The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. |journal=Oncogene |volume=17 |issue= 9 |pages= 1097–108 |year= 1998 |pmid= 9764820 |doi= 10.1038/sj.onc.1202115 }}
*{{cite journal  | author=Jiang H, Harris MB, Rothman P |title=IL-4/IL-13 signaling beyond JAK/STAT. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 6 Pt 1 |pages= 1063-70 |year= 2000 |pmid= 10856136 |doi=  }}
*{{cite journal  | vauthors=Jones N, Dumont DJ |title=Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation. |journal=Curr. Biol. |volume=9 |issue= 18 |pages= 1057–60 |year= 2000 |pmid= 10508618 |doi=10.1016/S0960-9822(99)80458-8  }}
*{{cite journal  | author=Di Cristofano A, Carpino N, Dunant N, ''et al.'' |title=Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins. |journal=J. Biol. Chem. |volume=273 |issue= 9 |pages= 4827-30 |year= 1998 |pmid= 9478921 |doi= }}
*{{cite journal  | vauthors=Némorin JG, Duplay P |title=Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14590–7 |year= 2000 |pmid= 10799545 |doi=10.1074/jbc.275.19.14590 }}
*{{cite journal  | author=Jones N, Dumont DJ |title=The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. |journal=Oncogene |volume=17 |issue= 9 |pages= 1097-108 |year= 1998 |pmid= 9764820 |doi= 10.1038/sj.onc.1202115 }}
*{{cite journal  | vauthors=Dunant NM, Wisniewski D, Strife A |title=The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. |journal=Cell. Signal. |volume=12 |issue= 5 |pages= 317–26 |year= 2000 |pmid= 10822173 |doi=10.1016/S0898-6568(00)00073-5 |display-authors=etal}}
*{{cite journal  | author=Jones N, Dumont DJ |title=Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation. |journal=Curr. Biol. |volume=9 |issue= 18 |pages= 1057-60 |year= 2000 |pmid= 10508618 |doi=  }}
*{{cite journal  | vauthors=Némorin JG, Laporte P, Bérubé G, Duplay P |title=p62dok negatively regulates CD2 signaling in Jurkat cells. |journal=J. Immunol. |volume=166 |issue= 7 |pages= 4408–15 |year= 2001 |pmid= 11254695 |doi=  10.4049/jimmunol.166.7.4408}}
*{{cite journal  | author=Némorin JG, Duplay P |title=Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14590-7 |year= 2000 |pmid= 10799545 |doi=  }}
*{{cite journal  | vauthors=Grimm J, Sachs M, Britsch S |title=Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. |journal=J. Cell Biol. |volume=154 |issue= 2 |pages= 345–54 |year= 2001 |pmid= 11470823 |doi=10.1083/jcb.200102032  | pmc=2150770 |display-authors=etal}}
*{{cite journal  | author=Dunant NM, Wisniewski D, Strife A, ''et al.'' |title=The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. |journal=Cell. Signal. |volume=12 |issue= 5 |pages= 317-26 |year= 2000 |pmid= 10822173 |doi=  }}
*{{cite journal  | vauthors=Master Z, Jones N, Tran J |title=Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak. |journal=EMBO J. |volume=20 |issue= 21 |pages= 5919–28 |year= 2001 |pmid= 11689432 |doi= 10.1093/emboj/20.21.5919 | pmc=125712 |display-authors=etal}}
*{{cite journal  | author=Némorin JG, Laporte P, Bérubé G, Duplay P |title=p62dok negatively regulates CD2 signaling in Jurkat cells. |journal=J. Immunol. |volume=166 |issue= 7 |pages= 4408-15 |year= 2001 |pmid= 11254695 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Grimm J, Sachs M, Britsch S, ''et al.'' |title=Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. |journal=J. Cell Biol. |volume=154 |issue= 2 |pages= 345-54 |year= 2001 |pmid= 11470823 |doi=  }}
*{{cite journal  | vauthors=Salomon AR, Ficarro SB, Brill LM |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443–8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100  | pmc=141014 |display-authors=etal}}
*{{cite journal  | author=Master Z, Jones N, Tran J, ''et al.'' |title=Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak. |journal=EMBO J. |volume=20 |issue= 21 |pages= 5919-28 |year= 2001 |pmid= 11689432 |doi= 10.1093/emboj/20.21.5919 }}
*{{cite journal  | vauthors=Jones N, Chen SH, Sturk C |title=A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function. |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2658–68 |year= 2003 |pmid= 12665569 |doi=10.1128/MCB.23.8.2658-2668.2003  | pmc=152553  |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Master Z, Tran J, Bishnoi A |title=Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30170–9 |year= 2003 |pmid= 12777393 |doi= 10.1074/jbc.M301339200 |display-authors=etal}}
*{{cite journal  | author=Salomon AR, Ficarro SB, Brill LM, ''et al.'' |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443-8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100 }}
*{{cite journal  | vauthors=Gérard A, Favre C, Garçon F |title=Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase. |journal=Oncogene |volume=23 |issue= 8 |pages= 1594–8 |year= 2004 |pmid= 14647425 |doi= 10.1038/sj.onc.1207283 |display-authors=etal}}
*{{cite journal  | author=Jones N, Chen SH, Sturk C, ''et al.'' |title=A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function. |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2658-68 |year= 2003 |pmid= 12665569 |doi= }}
*{{cite journal  | vauthors=Brill LM, Salomon AR, Ficarro SB |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |display-authors=etal}}
*{{cite journal  | author=Master Z, Tran J, Bishnoi A, ''et al.'' |title=Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30170-9 |year= 2003 |pmid= 12777393 |doi= 10.1074/jbc.M301339200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=García A, Prabhakar S, Hughan S, ''et al.'' |title=Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. |journal=Blood |volume=103 |issue= 6 |pages= 2088-95 |year= 2004 |pmid= 14645010 |doi= 10.1182/blood-2003-07-2392 }}
*{{cite journal  | vauthors=Rush J, Moritz A, Lee KA |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |display-authors=etal}}
*{{cite journal  | author=Gérard A, Favre C, Garçon F, ''et al.'' |title=Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase. |journal=Oncogene |volume=23 |issue= 8 |pages= 1594-8 |year= 2004 |pmid= 14647425 |doi= 10.1038/sj.onc.1207283 }}
*{{cite journal  | vauthors=Van Slyke P, Coll ML, Master Z |title=Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk. |journal=Mol. Cell. Biol. |volume=25 |issue= 9 |pages= 3831–41 |year= 2005 |pmid= 15831486 |doi= 10.1128/MCB.25.9.3831-3841.2005 | pmc=1084282 |display-authors=etal}}
*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | author=Van Slyke P, Coll ML, Master Z, ''et al.'' |title=Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk. |journal=Mol. Cell. Biol. |volume=25 |issue= 9 |pages= 3831-41 |year= 2005 |pmid= 15831486 |doi= 10.1128/MCB.25.9.3831-3841.2005 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=9046}}
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{{gene-8-stub}}

Revision as of 18:40, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.[1][2][3]

Function

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.[3]

Interactions

DOK2 has been shown to interact with INPP5D[4] and TEK tyrosine kinase.[5][6]

References

  1. ↑ Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD (March 1998). "Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins". J Biol Chem. 273 (9): 4827–30. doi:10.1074/jbc.273.9.4827. PMID 9478921.
  2. ↑ Garcia A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N (March 2004). "Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins". Blood. 103 (6): 2088–95. doi:10.1182/blood-2003-07-2392. PMID 14645010.
  3. ↑ 3.0 3.1 "Entrez Gene: DOK2 docking protein 2, 56kDa".
  4. ↑ Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/S0898-6568(00)00073-5. PMID 10822173.
  5. ↑ Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID 9764820.
  6. ↑ Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. PMC 125712. PMID 11689432.

Further reading


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