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{{ | '''Fatty acid-binding protein, epidermal''' is a [[protein]] that in humans is encoded by the ''FABP5'' [[gene]].<ref name="pmid1512466">{{cite journal | vauthors = Madsen P, Rasmussen HH, Leffers H, Honore B, Celis JE | title = Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins | journal = J Invest Dermatol | volume = 99 | issue = 3 | pages = 299–305 |date=Sep 1992 | pmid = 1512466 | pmc = | doi =10.1111/1523-1747.ep12616641 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FABP5 fatty acid binding protein 5 (psoriasis-associated)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2171| accessdate = }}</ref> | ||
}} | |||
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{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding | | summary_text = This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in [[psoriasis]] tissue. [[Fatty acid binding protein]]s are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.<ref name="entrez"/> | ||
}} | }} | ||
==Interactions== | |||
FABP5 has been shown to [[Protein-protein interaction|interact]] with [[S100A7]].<ref name=pmid12839573>{{cite journal |last=Ruse |first=Monica |author2=Broome Ann-Marie|author3=Eckert Richard L |date=Jul 2003 |title=S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes |journal=J. Invest. Dermatol. |volume=121 |issue=1 |pages=132–41 |publisher= |location = United States| issn = 0022-202X| pmid = 12839573 |doi = 10.1046/j.1523-1747.2003.12309.x | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10331666>{{cite journal |last=Hagens |first=G |author2=Roulin K|author3=Hotz R|author4=Saurat J H|author5=Hellman U|author6=Siegenthaler G |date=Feb 1999 |title=Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales |journal=Mol. Cell. Biochem. |volume=192 |issue=1–2 |pages=123–8 |publisher= |location = NETHERLANDS| issn = 0300-8177| pmid = 10331666 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1023/A:1006894909694 }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Rasmussen HH, van Damme J, Puype M |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=10.1002/elps.11501301199 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Siegenthaler G, Hotz R, Chatellard-Gruaz D |title=Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro |journal=Biochem. J. |volume=302 |issue= 2|pages= 363–71 |year= 1994 |pmid= 8092987 |doi= | pmc=1137237 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Siegenthaler G, Hotz R, Chatellard-Gruaz D |title=Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP) |journal=Biochem. Biophys. Res. Commun. |volume=190 |issue= 2 |pages= 482–7 |year= 1993 |pmid= 8427590 |doi=10.1006/bbrc.1993.1073 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Masouyé I, Saurat JH, Siegenthaler G |title=Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study |journal=Dermatology |volume=192 |issue= 3 |pages= 208–13 |year= 1996 |pmid= 8726632 |doi= 10.1159/000246367}} | ||
*{{cite journal | | *{{cite journal | vauthors=Jaworski C, Wistow G |title=LP2, a differentiation-associated lipid-binding protein expressed in bovine lens |journal=Biochem. J. |volume=320 |issue= 1|pages= 49–54 |year= 1997 |pmid= 8947466 |doi= | pmc=1217896 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Masouyé I, Hagens G, Van Kuppevelt TH |title=Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein |journal=Circ. Res. |volume=81 |issue= 3 |pages= 297–303 |year= 1997 |pmid= 9285630 |doi= 10.1161/01.res.81.3.297|display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Watanabe R, Fujii H, Yamamoto A |title=Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin |journal=J. Dermatol. Sci. |volume=16 |issue= 1 |pages= 17–22 |year= 1998 |pmid= 9438903 |doi=10.1016/S0923-1811(97)00615-4 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Hagens G, Masouyé I, Augsburger E |title=Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes |journal=Biochem. J. |volume=339 |issue= 2|pages= 419–27 |year= 1999 |pmid= 10191275 |doi=10.1042/0264-6021:3390419 | pmc=1220173 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Hagens G, Roulin K, Hotz R |title=Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales |journal=Mol. Cell. Biochem. |volume=192 |issue= 1–2 |pages= 123–8 |year= 1999 |pmid= 10331666 |doi=10.1023/A:1006894909694 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Hohoff C, Börchers T, Rüstow B |title=Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein |journal=Biochemistry |volume=38 |issue= 38 |pages= 12229–39 |year= 1999 |pmid= 10493790 |doi=10.1021/bi990305u |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=O'Shaughnessy RF, Seery JP, Celis JE |title=PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation |journal=FEBS Lett. |volume=486 |issue= 2 |pages= 149–54 |year= 2001 |pmid= 11113456 |doi=10.1016/S0014-5793(00)02252-3 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gutiérrez-González LH, Ludwig C, Hohoff C |title=Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP) |journal=Biochem. J. |volume=364 |issue= Pt 3 |pages= 725–37 |year= 2002 |pmid= 12049637 |doi= 10.1042/BJ20020039 | pmc=1222622 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Ruse M, Broome AM, Eckert RL |title=S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes |journal=J. Invest. Dermatol. |volume=121 |issue= 1 |pages= 132–41 |year= 2003 |pmid= 12839573 |doi= 10.1046/j.1523-1747.2003.12309.x }} | ||
*{{cite journal | | *{{cite journal | vauthors=Ha MK, Chung KY, Lee JH |title=Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells |journal=Exp. Dermatol. |volume=13 |issue= 9 |pages= 543–50 |year= 2005 |pmid= 15335354 |doi= 10.1111/j.0906-6705.2004.00196.x |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=2171}} | |||
{{Carrier proteins}} | |||
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Revision as of 00:50, 2 November 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5 gene.[1][2]
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.[2]
Interactions
FABP5 has been shown to interact with S100A7.[3][4]
References
- ↑ Madsen P, Rasmussen HH, Leffers H, Honore B, Celis JE (Sep 1992). "Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins". J Invest Dermatol. 99 (3): 299–305. doi:10.1111/1523-1747.ep12616641. PMID 1512466.
- ↑ 2.0 2.1 "Entrez Gene: FABP5 fatty acid binding protein 5 (psoriasis-associated)".
- ↑ Ruse, Monica; Broome Ann-Marie; Eckert Richard L (Jul 2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". J. Invest. Dermatol. United States. 121 (1): 132–41. doi:10.1046/j.1523-1747.2003.12309.x. ISSN 0022-202X. PMID 12839573.
- ↑ Hagens, G; Roulin K; Hotz R; Saurat J H; Hellman U; Siegenthaler G (Feb 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Mol. Cell. Biochem. NETHERLANDS. 192 (1–2): 123–8. doi:10.1023/A:1006894909694. ISSN 0300-8177. PMID 10331666.
Further reading
- Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
- Siegenthaler G, Hotz R, Chatellard-Gruaz D, et al. (1994). "Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro". Biochem. J. 302 (2): 363–71. PMC 1137237. PMID 8092987.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Siegenthaler G, Hotz R, Chatellard-Gruaz D, et al. (1993). "Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP)". Biochem. Biophys. Res. Commun. 190 (2): 482–7. doi:10.1006/bbrc.1993.1073. PMID 8427590.
- Masouyé I, Saurat JH, Siegenthaler G (1996). "Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study". Dermatology. 192 (3): 208–13. doi:10.1159/000246367. PMID 8726632.
- Jaworski C, Wistow G (1997). "LP2, a differentiation-associated lipid-binding protein expressed in bovine lens". Biochem. J. 320 (1): 49–54. PMC 1217896. PMID 8947466.
- Masouyé I, Hagens G, Van Kuppevelt TH, et al. (1997). "Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein". Circ. Res. 81 (3): 297–303. doi:10.1161/01.res.81.3.297. PMID 9285630.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Watanabe R, Fujii H, Yamamoto A, et al. (1998). "Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin". J. Dermatol. Sci. 16 (1): 17–22. doi:10.1016/S0923-1811(97)00615-4. PMID 9438903.
- Hagens G, Masouyé I, Augsburger E, et al. (1999). "Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes". Biochem. J. 339 (2): 419–27. doi:10.1042/0264-6021:3390419. PMC 1220173. PMID 10191275.
- Hagens G, Roulin K, Hotz R, et al. (1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Mol. Cell. Biochem. 192 (1–2): 123–8. doi:10.1023/A:1006894909694. PMID 10331666.
- Hohoff C, Börchers T, Rüstow B, et al. (1999). "Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein". Biochemistry. 38 (38): 12229–39. doi:10.1021/bi990305u. PMID 10493790.
- O'Shaughnessy RF, Seery JP, Celis JE, et al. (2001). "PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation". FEBS Lett. 486 (2): 149–54. doi:10.1016/S0014-5793(00)02252-3. PMID 11113456.
- Gutiérrez-González LH, Ludwig C, Hohoff C, et al. (2002). "Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP)". Biochem. J. 364 (Pt 3): 725–37. doi:10.1042/BJ20020039. PMC 1222622. PMID 12049637.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Ruse M, Broome AM, Eckert RL (2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". J. Invest. Dermatol. 121 (1): 132–41. doi:10.1046/j.1523-1747.2003.12309.x. PMID 12839573.
- Ha MK, Chung KY, Lee JH, et al. (2005). "Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells". Exp. Dermatol. 13 (9): 543–50. doi:10.1111/j.0906-6705.2004.00196.x. PMID 15335354.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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