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{{Infobox_gene}}
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'''Fatty acid-binding protein, epidermal''' is a [[protein]] that in humans is encoded by the ''FABP5'' [[gene]].<ref name="pmid1512466">{{cite journal | vauthors = Madsen P, Rasmussen HH, Leffers H, Honore B, Celis JE | title = Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins | journal = J Invest Dermatol | volume = 99 | issue = 3 | pages = 299–305 |date=Sep 1992 | pmid = 1512466 | pmc =  | doi =10.1111/1523-1747.ep12616641 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FABP5 fatty acid binding protein 5 (psoriasis-associated)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2171| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_FABP5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b56.
| PDB = {{PDB2|1b56}}, {{PDB2|1jjj}}
| Name = Fatty acid binding protein 5 (psoriasis-associated)
| HGNCid = 3560
| Symbol = FABP5
| AltSymbols =; E-FABP; EFABP; PA-FABP; PAFABP
| OMIM = 605168
| ECnumber = 
| Homologene = 88646
| MGIid = 
| Function = {{GNF_GO|id=GO:0005504 |text = fatty acid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0008544 |text = epidermis development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2171
    | Hs_Ensembl =   
    | Hs_RefseqProtein = NP_001435
    | Hs_RefseqmRNA = NM_001444
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 628298
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = NM_001081334
    | Mm_RefseqProtein = NP_001074803
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Fatty acid binding protein 5 (psoriasis-associated)''', also known as '''FABP5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FABP5 fatty acid binding protein 5 (psoriasis-associated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2171| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.<ref name="entrez">{{cite web | title = Entrez Gene: FABP5 fatty acid binding protein 5 (psoriasis-associated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2171| accessdate = }}</ref>
| summary_text = This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in [[psoriasis]] tissue. [[Fatty acid binding protein]]s are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.<ref name="entrez"/>
}}
}}
==Interactions==
FABP5 has been shown to [[Protein-protein interaction|interact]] with [[S100A7]].<ref name=pmid12839573>{{cite journal |last=Ruse |first=Monica |author2=Broome Ann-Marie|author3=Eckert Richard L |date=Jul 2003 |title=S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes |journal=J. Invest. Dermatol. |volume=121 |issue=1 |pages=132–41 |publisher= |location = United States| issn = 0022-202X| pmid = 12839573 |doi = 10.1046/j.1523-1747.2003.12309.x | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10331666>{{cite journal |last=Hagens |first=G |author2=Roulin K|author3=Hotz R|author4=Saurat J H|author5=Hellman U|author6=Siegenthaler G |date=Feb 1999 |title=Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales |journal=Mol. Cell. Biochem. |volume=192 |issue=1–2 |pages=123–8 |publisher= |location = NETHERLANDS| issn = 0300-8177| pmid = 10331666 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1023/A:1006894909694 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Rasmussen HH, van Damme J, Puype M, ''et al.'' |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960-9 |year= 1993 |pmid= 1286667 |doi=  }}
*{{cite journal  | vauthors=Rasmussen HH, van Damme J, Puype M |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=10.1002/elps.11501301199 |display-authors=etal}}
*{{cite journal  | author=Madsen P, Rasmussen HH, Leffers H, ''et al.'' |title=Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. |journal=J. Invest. Dermatol. |volume=99 |issue= 3 |pages= 299-305 |year= 1992 |pmid= 1512466 |doi=  }}
*{{cite journal  | vauthors=Siegenthaler G, Hotz R, Chatellard-Gruaz D |title=Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro |journal=Biochem. J. |volume=302 |issue= 2|pages= 363–71 |year= 1994 |pmid= 8092987 |doi=  | pmc=1137237  |display-authors=etal}}
*{{cite journal  | author=Siegenthaler G, Hotz R, Chatellard-Gruaz D, ''et al.'' |title=Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro. |journal=Biochem. J. |volume=302 ( Pt 2) |issue= |pages= 363-71 |year= 1994 |pmid= 8092987 |doi= }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Siegenthaler G, Hotz R, Chatellard-Gruaz D |title=Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP) |journal=Biochem. Biophys. Res. Commun. |volume=190 |issue= 2 |pages= 482–7 |year= 1993 |pmid= 8427590 |doi=10.1006/bbrc.1993.1073  |display-authors=etal}}
*{{cite journal  | author=Siegenthaler G, Hotz R, Chatellard-Gruaz D, ''et al.'' |title=Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP). |journal=Biochem. Biophys. Res. Commun. |volume=190 |issue= 2 |pages= 482-7 |year= 1993 |pmid= 8427590 |doi=  }}
*{{cite journal  | vauthors=Masouyé I, Saurat JH, Siegenthaler G |title=Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study |journal=Dermatology |volume=192 |issue= 3 |pages= 208–13 |year= 1996 |pmid= 8726632 |doi=  10.1159/000246367}}
*{{cite journal  | author=Masouyé I, Saurat JH, Siegenthaler G |title=Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study. |journal=Dermatology (Basel) |volume=192 |issue= 3 |pages= 208-13 |year= 1996 |pmid= 8726632 |doi=  }}
*{{cite journal  | vauthors=Jaworski C, Wistow G |title=LP2, a differentiation-associated lipid-binding protein expressed in bovine lens |journal=Biochem. J. |volume=320 |issue= 1|pages= 49–54 |year= 1997 |pmid= 8947466 |doi= | pmc=1217896 }}
*{{cite journal  | author=Jaworski C, Wistow G |title=LP2, a differentiation-associated lipid-binding protein expressed in bovine lens. |journal=Biochem. J. |volume=320 ( Pt 1) |issue= |pages= 49-54 |year= 1997 |pmid= 8947466 |doi=  }}
*{{cite journal  | vauthors=Masouyé I, Hagens G, Van Kuppevelt TH |title=Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein |journal=Circ. Res. |volume=81 |issue= 3 |pages= 297–303 |year= 1997 |pmid= 9285630 |doi=  10.1161/01.res.81.3.297|display-authors=etal}}
*{{cite journal  | author=Masouyé I, Hagens G, Van Kuppevelt TH, ''et al.'' |title=Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein. |journal=Circ. Res. |volume=81 |issue= 3 |pages= 297-303 |year= 1997 |pmid= 9285630 |doi= }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | vauthors=Watanabe R, Fujii H, Yamamoto A |title=Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin |journal=J. Dermatol. Sci. |volume=16 |issue= 1 |pages= 17–22 |year= 1998 |pmid= 9438903 |doi=10.1016/S0923-1811(97)00615-4  |display-authors=etal}}
*{{cite journal  | author=Watanabe R, Fujii H, Yamamoto A, ''et al.'' |title=Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin. |journal=J. Dermatol. Sci. |volume=16 |issue= 1 |pages= 17-22 |year= 1998 |pmid= 9438903 |doi=  }}
*{{cite journal  | vauthors=Hagens G, Masouyé I, Augsburger E |title=Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes |journal=Biochem. J. |volume=339 |issue= 2|pages= 419–27 |year= 1999 |pmid= 10191275 |doi=10.1042/0264-6021:3390419  | pmc=1220173 |display-authors=etal}}
*{{cite journal  | author=Hagens G, Masouyé I, Augsburger E, ''et al.'' |title=Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes. |journal=Biochem. J. |volume=339 ( Pt 2) |issue= |pages= 419-27 |year= 1999 |pmid= 10191275 |doi=  }}
*{{cite journal  | vauthors=Hagens G, Roulin K, Hotz R |title=Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales |journal=Mol. Cell. Biochem. |volume=192 |issue= 1–2 |pages= 123–8 |year= 1999 |pmid= 10331666 |doi=10.1023/A:1006894909694 |display-authors=etal}}
*{{cite journal  | author=Hagens G, Roulin K, Hotz R, ''et al.'' |title=Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales. |journal=Mol. Cell. Biochem. |volume=192 |issue= 1-2 |pages= 123-8 |year= 1999 |pmid= 10331666 |doi=  }}
*{{cite journal  | vauthors=Hohoff C, Börchers T, Rüstow B |title=Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein |journal=Biochemistry |volume=38 |issue= 38 |pages= 12229–39 |year= 1999 |pmid= 10493790 |doi=10.1021/bi990305u |display-authors=etal}}
*{{cite journal  | author=Hohoff C, Börchers T, Rüstow B, ''et al.'' |title=Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein. |journal=Biochemistry |volume=38 |issue= 38 |pages= 12229-39 |year= 1999 |pmid= 10493790 |doi=  }}
*{{cite journal  | vauthors=O'Shaughnessy RF, Seery JP, Celis JE |title=PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation |journal=FEBS Lett. |volume=486 |issue= 2 |pages= 149–54 |year= 2001 |pmid= 11113456 |doi=10.1016/S0014-5793(00)02252-3 |display-authors=etal}}
*{{cite journal  | author=O'Shaughnessy RF, Seery JP, Celis JE, ''et al.'' |title=PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation. |journal=FEBS Lett. |volume=486 |issue= 2 |pages= 149-54 |year= 2001 |pmid= 11113456 |doi=  }}
*{{cite journal  | vauthors=Gutiérrez-González LH, Ludwig C, Hohoff C |title=Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP) |journal=Biochem. J. |volume=364 |issue= Pt 3 |pages= 725–37 |year= 2002 |pmid= 12049637 |doi= 10.1042/BJ20020039 | pmc=1222622 |display-authors=etal}}
*{{cite journal  | author=Gutiérrez-González LH, Ludwig C, Hohoff C, ''et al.'' |title=Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP). |journal=Biochem. J. |volume=364 |issue= Pt 3 |pages= 725-37 |year= 2002 |pmid= 12049637 |doi= 10.1042/BJ20020039 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | vauthors=Ruse M, Broome AM, Eckert RL |title=S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes |journal=J. Invest. Dermatol. |volume=121 |issue= 1 |pages= 132–41 |year= 2003 |pmid= 12839573 |doi= 10.1046/j.1523-1747.2003.12309.x }}
*{{cite journal  | author=Ruse M, Broome AM, Eckert RL |title=S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes. |journal=J. Invest. Dermatol. |volume=121 |issue= 1 |pages= 132-41 |year= 2003 |pmid= 12839573 |doi= 10.1046/j.1523-1747.2003.12309.x }}
*{{cite journal  | vauthors=Ha MK, Chung KY, Lee JH |title=Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells |journal=Exp. Dermatol. |volume=13 |issue= 9 |pages= 543–50 |year= 2005 |pmid= 15335354 |doi= 10.1111/j.0906-6705.2004.00196.x |display-authors=etal}}
*{{cite journal  | author=Ha MK, Chung KY, Lee JH, ''et al.'' |title=Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells. |journal=Exp. Dermatol. |volume=13 |issue= 9 |pages= 543-50 |year= 2005 |pmid= 15335354 |doi= 10.1111/j.0906-6705.2004.00196.x }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
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{{PDB Gallery|geneid=2171}}
{{Carrier proteins}}
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Revision as of 00:50, 2 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5 gene.[1][2]

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.[2]

Interactions

FABP5 has been shown to interact with S100A7.[3][4]

References

  1. Madsen P, Rasmussen HH, Leffers H, Honore B, Celis JE (Sep 1992). "Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins". J Invest Dermatol. 99 (3): 299–305. doi:10.1111/1523-1747.ep12616641. PMID 1512466.
  2. 2.0 2.1 "Entrez Gene: FABP5 fatty acid binding protein 5 (psoriasis-associated)".
  3. Ruse, Monica; Broome Ann-Marie; Eckert Richard L (Jul 2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". J. Invest. Dermatol. United States. 121 (1): 132–41. doi:10.1046/j.1523-1747.2003.12309.x. ISSN 0022-202X. PMID 12839573.
  4. Hagens, G; Roulin K; Hotz R; Saurat J H; Hellman U; Siegenthaler G (Feb 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Mol. Cell. Biochem. NETHERLANDS. 192 (1–2): 123–8. doi:10.1023/A:1006894909694. ISSN 0300-8177. PMID 10331666.

Further reading