Defensin, beta 1: Difference between revisions

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{{Infobox_gene}}
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'''Beta-defensin 1''' is a [[protein]] that in humans is encoded by the ''DEFB1'' [[gene]].<ref name="pmid7628632">{{cite journal | vauthors = Bensch KW, Raida M, Magert HJ, Schulz-Knappe P, Forssmann WG | title = hBD-1: a novel beta-defensin from human plasma | journal = FEBS Lett | volume = 368 | issue = 2 | pages = 331–5 |date=Sep 1995 | pmid = 7628632 | pmc =  | doi =10.1016/0014-5793(95)00687-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DEFB1 defensin, beta 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1672| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_DEFB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e4s.
| PDB = {{PDB2|1e4s}}, {{PDB2|1iju}}, {{PDB2|1ijv}}, {{PDB2|1kj5}}, {{PDB2|2nlb}}, {{PDB2|2nlc}}, {{PDB2|2nld}}, {{PDB2|2nle}}, {{PDB2|2nlf}}, {{PDB2|2nlg}}, {{PDB2|2nlh}}, {{PDB2|2nlp}}, {{PDB2|2nlq}}, {{PDB2|2nls}}
| Name = Defensin, beta 1
| HGNCid = 2766
| Symbol = DEFB1
| AltSymbols =; BD1; DEFB-1; DEFB101; HBD1; MGC51822
| OMIM = 602056
| ECnumber = 
| Homologene = 88476
| MGIid = 
| GeneAtlas_image1 = PBB_GE_DEFB1_210397_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1672
    | Hs_Ensembl = ENSG00000164825
    | Hs_RefseqProtein = NP_005209
    | Hs_RefseqmRNA = NM_005218
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 6715511
    | Hs_GenLoc_end = 6722939
    | Hs_Uniprot = P60022
    | Mm_EntrezGene =   
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot =   
  }}
}}
'''Defensin, beta 1''', also known as '''DEFB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DEFB1 defensin, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1672| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Defensins form a family of microbicidal and cytotoxic peptides made by [[Neutrophil granulocyte|neutrophils]]. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of [[Epithelium|epithelial surfaces]] to microbial colonization. This gene maps in close proximity to defensin family member defensin, alpha 1, and has been implicated in the pathogenesis of [[cystic fibrosis]].<ref name="entrez">{{cite web | title = Entrez Gene: DEFB1 defensin, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1672| accessdate = }}</ref>
| summary_text = Defensins form a family of microbicidal and cytotoxic peptides made by [[Neutrophil granulocyte|neutrophils]]. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of [[Epithelium|epithelial surfaces]] to microbial colonization. This gene maps in close proximity to defensin family member defensin, alpha 1, and has been implicated in the pathogenesis of [[cystic fibrosis]].<ref name="entrez">{{cite web | title = Entrez Gene: DEFB1 defensin, beta 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1672| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ganz T, Lehrer RI |title=Defensins. |journal=Pharmacol. Ther. |volume=66 |issue= 2 |pages= 191-205 |year= 1995 |pmid= 7667395 |doi= }}
*{{cite journal  | vauthors=Ganz T, Lehrer RI |title=Defensins. |journal=Pharmacol. Ther. |volume=66 |issue= 2 |pages= 191–205 |year= 1995 |pmid= 7667395 |doi=10.1016/0163-7258(94)00076-F }}
*{{cite journal  | author=Bensch KW, Raida M, Mägert HJ, ''et al.'' |title=hBD-1: a novel beta-defensin from human plasma. |journal=FEBS Lett. |volume=368 |issue= 2 |pages= 331-5 |year= 1995 |pmid= 7628632 |doi= }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Goldman MJ, Anderson GM, Stolzenberg ED |title=Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. |journal=Cell |volume=88 |issue= 4 |pages= 553–60 |year= 1997 |pmid= 9038346 |doi=10.1016/S0092-8674(00)81895-4 |display-authors=etal}}
*{{cite journal  | author=Goldman MJ, Anderson GM, Stolzenberg ED, ''et al.'' |title=Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. |journal=Cell |volume=88 |issue= 4 |pages= 553-60 |year= 1997 |pmid= 9038346 |doi=  }}
*{{cite journal  | vauthors=McCray PB, Bentley L |title=Human airway epithelia express a beta-defensin. |journal=Am. J. Respir. Cell Mol. Biol. |volume=16 |issue= 3 |pages= 343–9 |year= 1997 |pmid= 9070620 |doi=  10.1165/ajrcmb.16.3.9070620}}
*{{cite journal  | author=McCray PB, Bentley L |title=Human airway epithelia express a beta-defensin. |journal=Am. J. Respir. Cell Mol. Biol. |volume=16 |issue= 3 |pages= 343-9 |year= 1997 |pmid= 9070620 |doi=  }}
*{{cite journal  | vauthors=Liu L, Zhao C, Heng HH, Ganz T |title=The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. |journal=Genomics |volume=43 |issue= 3 |pages= 316–20 |year= 1997 |pmid= 9268634 |doi= 10.1006/geno.1997.4801 }}
*{{cite journal  | author=Liu L, Zhao C, Heng HH, Ganz T |title=The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. |journal=Genomics |volume=43 |issue= 3 |pages= 316-20 |year= 1997 |pmid= 9268634 |doi= 10.1006/geno.1997.4801 }}
*{{cite journal  | vauthors=Valore EV, Park CH, Quayle AJ |title=Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. |journal=J. Clin. Invest. |volume=101 |issue= 8 |pages= 1633–42 |year= 1998 |pmid= 9541493 |doi=10.1172/JCI1861  | pmc=508744 |display-authors=etal}}
*{{cite journal  | author=Valore EV, Park CH, Quayle AJ, ''et al.'' |title=Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. |journal=J. Clin. Invest. |volume=101 |issue= 8 |pages= 1633-42 |year= 1998 |pmid= 9541493 |doi=  }}
*{{cite journal  | vauthors=Schnapp D, Reid CJ, Harris A |title=Localization of expression of human beta defensin-1 in the pancreas and kidney. |journal=J. Pathol. |volume=186 |issue= 1 |pages= 99–103 |year= 1999 |pmid= 9875146 |doi= 10.1002/(SICI)1096-9896(199809)186:1<99::AID-PATH133>3.0.CO;2-# }}
*{{cite journal  | author=Schnapp D, Reid CJ, Harris A |title=Localization of expression of human beta defensin-1 in the pancreas and kidney. |journal=J. Pathol. |volume=186 |issue= 1 |pages= 99-103 |year= 1999 |pmid= 9875146 |doi= 10.1002/(SICI)1096-9896(199809)186:1<99::AID-PATH133>3.0.CO;2-# }}
*{{cite journal  | vauthors=Hiratsuka T, Nakazato M, Ashitani J, Matsukura S |title=[A study of human beta-defensin-1 and human beta-defensin-2 in airway mucosal defense] |journal=Kansenshogaku Zasshi |volume=73 |issue= 2 |pages= 156–62 |year= 1999 |pmid= 10213993 |doi=  10.11150/kansenshogakuzasshi1970.73.156}}
*{{cite journal  | author=Hiratsuka T, Nakazato M, Ashitani J, Matsukura S |title=[A study of human beta-defensin-1 and human beta-defensin-2 in airway mucosal defense] |journal=Kansenshogaku Zasshi |volume=73 |issue= 2 |pages= 156-62 |year= 1999 |pmid= 10213993 |doi=  }}
*{{cite journal  | vauthors=Gropp R, Frye M, Wagner TO, Bargon J |title=Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy. |journal=Hum. Gene Ther. |volume=10 |issue= 6 |pages= 957–64 |year= 1999 |pmid= 10223729 |doi= 10.1089/10430349950018355 }}
*{{cite journal  | author=Gropp R, Frye M, Wagner TO, Bargon J |title=Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy. |journal=Hum. Gene Ther. |volume=10 |issue= 6 |pages= 957-64 |year= 1999 |pmid= 10223729 |doi= 10.1089/10430349950018355 }}
*{{cite journal  | vauthors=Mathews M, Jia HP, Guthmiller JM |title=Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. |journal=Infect. Immun. |volume=67 |issue= 6 |pages= 2740–5 |year= 1999 |pmid= 10338476 |doi=  | pmc=96577  |display-authors=etal}}
*{{cite journal  | author=Mathews M, Jia HP, Guthmiller JM, ''et al.'' |title=Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. |journal=Infect. Immun. |volume=67 |issue= 6 |pages= 2740-5 |year= 1999 |pmid= 10338476 |doi=  }}
*{{cite journal  | vauthors=Bøe R, Silvola J, Yang J |title=Human beta-defensin-1 mRNA is transcribed in tympanic membrane and adjacent auditory canal epithelium. |journal=Infect. Immun. |volume=67 |issue= 9 |pages= 4843–6 |year= 1999 |pmid= 10456939 |doi=  | pmc=96817  |display-authors=etal}}
*{{cite journal  | author=Bøe R, Silvola J, Yang J, ''et al.'' |title=Human beta-defensin-1 mRNA is transcribed in tympanic membrane and adjacent auditory canal epithelium. |journal=Infect. Immun. |volume=67 |issue= 9 |pages= 4843-6 |year= 1999 |pmid= 10456939 |doi=  }}
*{{cite journal  | vauthors=Yang D, Chertov O, Bykovskaia SN |title=Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. |journal=Science |volume=286 |issue= 5439 |pages= 525–8 |year= 1999 |pmid= 10521347 |doi=10.1126/science.286.5439.525 |display-authors=etal}}
*{{cite journal  | author=Yang D, Chertov O, Bykovskaia SN, ''et al.'' |title=Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. |journal=Science |volume=286 |issue= 5439 |pages= 525-8 |year= 1999 |pmid= 10521347 |doi=  }}
*{{cite journal  | vauthors=Tunzi CR, Harper PA, Bar-Oz B |title=Beta-defensin expression in human mammary gland epithelia. |journal=Pediatr. Res. |volume=48 |issue= 1 |pages= 30–5 |year= 2000 |pmid= 10879797 |doi=10.1203/00006450-200007000-00008 |display-authors=etal}}
*{{cite journal  | author=Tunzi CR, Harper PA, Bar-Oz B, ''et al.'' |title=Beta-defensin expression in human mammary gland epithelia. |journal=Pediatr. Res. |volume=48 |issue= 1 |pages= 30-5 |year= 2000 |pmid= 10879797 |doi=  }}
*{{cite journal  | vauthors=Sahasrabudhe KS, Kimball JR, Morton TH |title=Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva. |journal=J. Dent. Res. |volume=79 |issue= 9 |pages= 1669–74 |year= 2000 |pmid= 11023262 |doi=10.1177/00220345000790090601 |display-authors=etal}}
*{{cite journal  | author=Sahasrabudhe KS, Kimball JR, Morton TH, ''et al.'' |title=Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva. |journal=J. Dent. Res. |volume=79 |issue= 9 |pages= 1669-74 |year= 2000 |pmid= 11023262 |doi=  }}
*{{cite journal  | vauthors=Jia HP, Starner T, Ackermann M |title=Abundant human beta-defensin-1 expression in milk and mammary gland epithelium. |journal=J. Pediatr. |volume=138 |issue= 1 |pages= 109–12 |year= 2001 |pmid= 11148522 |doi= 10.1067/mpd.2001.109375 |display-authors=etal}}
*{{cite journal  | author=Jia HP, Starner T, Ackermann M, ''et al.'' |title=Abundant human beta-defensin-1 expression in milk and mammary gland epithelium. |journal=J. Pediatr. |volume=138 |issue= 1 |pages= 109-12 |year= 2001 |pmid= 11148522 |doi= 10.1067/mpd.2001.109375 }}
*{{cite journal  | vauthors=Ali RS, Falconer A, Ikram M |title=Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin. |journal=J. Invest. Dermatol. |volume=117 |issue= 1 |pages= 106–11 |year= 2001 |pmid= 11442756 |doi= 10.1046/j.0022-202x.2001.01401.x |display-authors=etal}}
*{{cite journal  | author=Ali RS, Falconer A, Ikram M, ''et al.'' |title=Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin. |journal=J. Invest. Dermatol. |volume=117 |issue= 1 |pages= 106-11 |year= 2001 |pmid= 11442756 |doi= 10.1046/j.0022-202x.2001.01401.x }}
*{{cite journal  | vauthors=Carothers DG, Graham SM, Jia HP |title=Production of beta-defensin antimicrobial peptides by maxillary sinus mucosa. |journal=American journal of rhinology |volume=15 |issue= 3 |pages= 175–9 |year= 2001 |pmid= 11453504 |doi=10.2500/105065801779954238 |display-authors=etal}}
*{{cite journal  | author=Carothers DG, Graham SM, Jia HP, ''et al.'' |title=Production of beta-defensin antimicrobial peptides by maxillary sinus mucosa. |journal=American journal of rhinology |volume=15 |issue= 3 |pages= 175-9 |year= 2001 |pmid= 11453504 |doi=  }}
*{{cite journal  | vauthors=Hoover DM, Chertov O, Lubkowski J |title=The structure of human beta-defensin-1: new insights into structural properties of beta-defensins. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39021–6 |year= 2001 |pmid= 11486002 |doi= 10.1074/jbc.M103830200 }}
*{{cite journal  | author=Hoover DM, Chertov O, Lubkowski J |title=The structure of human beta-defensin-1: new insights into structural properties of beta-defensins. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39021-6 |year= 2001 |pmid= 11486002 |doi= 10.1074/jbc.M103830200 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1672}}
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Latest revision as of 00:49, 2 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-defensin 1 is a protein that in humans is encoded by the DEFB1 gene.[1][2]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member defensin, alpha 1, and has been implicated in the pathogenesis of cystic fibrosis.[2]

References

  1. ↑ Bensch KW, Raida M, Magert HJ, Schulz-Knappe P, Forssmann WG (Sep 1995). "hBD-1: a novel beta-defensin from human plasma". FEBS Lett. 368 (2): 331–5. doi:10.1016/0014-5793(95)00687-5. PMID 7628632.
  2. ↑ 2.0 2.1 "Entrez Gene: DEFB1 defensin, beta 1".

Further reading



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