PBK (gene): Difference between revisions

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'''Lymphokine-activated killer T-cell-originated protein kinase''' is an [[enzyme]] that in humans is encoded by the ''PBK'' [[gene]].<ref name="pmid10781613">{{cite journal | vauthors = Abe Y, Matsumoto S, Kito K, Ueda N | title = Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells | journal = J Biol Chem | volume = 275 | issue = 28 | pages = 21525–31 |date=Aug 2000 | pmid = 10781613 | pmc =  | doi = 10.1074/jbc.M909629199 }}</ref><ref name="pmid10779557">{{cite journal | vauthors = Gaudet S, Branton D, Lue RA | title = Characterization of PDZ-binding kinase, a mitotic kinase | journal = Proc Natl Acad Sci U S A | volume = 97 | issue = 10 | pages = 5167–72 |date=Jun 2000 | pmid = 10779557 | pmc = 25800 | doi = 10.1073/pnas.090102397 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PBK PDZ binding kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55872| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = PDZ binding kinase
| HGNCid = 18282
| Symbol = PBK
| AltSymbols =; SPK; FLJ14385; Nori-3; TOPK
| OMIM =
| ECnumber =
| Homologene = 32415
| MGIid = 1289156
  | GeneAtlas_image1 = PBB_GE_PBK_219148_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007067 |text = mitosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55872
    | Hs_Ensembl = ENSG00000168078
    | Hs_RefseqProtein = NP_060962
    | Hs_RefseqmRNA = NM_018492
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 27723056
    | Hs_GenLoc_end = 27751435
    | Hs_Uniprot = Q96KB5
    | Mm_EntrezGene = 52033
    | Mm_Ensembl = ENSMUSG00000022033
    | Mm_RefseqmRNA = XM_994462
    | Mm_RefseqProtein = XP_999556
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 64759949
    | Mm_GenLoc_end = 64771905
    | Mm_Uniprot = Q9JJ78
  }}
}}
'''PDZ binding kinase''', also known as '''PBK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PBK PDZ binding kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55872| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: PBK PDZ binding kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55872| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: PBK PDZ binding kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55872| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Gaudet S, Branton D, Lue RA |title=Characterization of PDZ-binding kinase, a mitotic kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 10 |pages= 5167-72 |year= 2000 |pmid= 10779557 |doi= 10.1073/pnas.090102397 }}
*{{cite journal   |vauthors=Zhao S, Dai J, Zhao W, etal |title=PDZ-binding kinase participates in spermatogenesis. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 6 |pages= 631–6 |year= 2001 |pmid= 11378444 |doi=10.1016/S1357-2725(01)00005-X  }}
*{{cite journal | author=Abe Y, Matsumoto S, Kito K, Ueda N |title=Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21525-31 |year= 2000 |pmid= 10781613 |doi= 10.1074/jbc.M909629199 }}
*{{cite journal   |vauthors=Simons-Evelyn M, Bailey-Dell K, Toretsky JA, etal |title=PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells. |journal=Blood Cells Mol. Dis. |volume=27 |issue= 5 |pages= 825–9 |year= 2003 |pmid= 11783945 |doi= 10.1006/bcmd.2001.0452 }}
*{{cite journal | author=Zhao S, Dai J, Zhao W, ''et al.'' |title=PDZ-binding kinase participates in spermatogenesis. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 6 |pages= 631-6 |year= 2001 |pmid= 11378444 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Simons-Evelyn M, Bailey-Dell K, Toretsky JA, ''et al.'' |title=PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells. |journal=Blood Cells Mol. Dis. |volume=27 |issue= 5 |pages= 825-9 |year= 2003 |pmid= 11783945 |doi= 10.1006/bcmd.2001.0452 }}
*{{cite journal  | vauthors=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=10.1016/S0888-7543(02)00008-3  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112-25 |year= 2003 |pmid= 12620389 |doi= }}
*{{cite journal  | vauthors=Nandi A, Tidwell M, Karp J, Rapoport AP |title=Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells. |journal=Blood Cells Mol. Dis. |volume=32 |issue= 1 |pages= 240–5 |year= 2004 |pmid= 14757441 |doi=10.1016/j.bcmd.2003.10.004  }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Nandi A, Tidwell M, Karp J, Rapoport AP |title=Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells. |journal=Blood Cells Mol. Dis. |volume=32 |issue= 1 |pages= 240-5 |year= 2004 |pmid= 14757441 |doi= }}
*{{cite journal   |vauthors=Matsumoto S, Abe Y, Fujibuchi T, etal |title=Characterization of a MAPKK-like protein kinase TOPK. |journal=Biochem. Biophys. Res. Commun. |volume=325 |issue= 3 |pages= 997–1004 |year= 2005 |pmid= 15541388 |doi= 10.1016/j.bbrc.2004.10.133 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Sabio G, Arthur JS, Kuma Y, etal |title=p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. |journal=EMBO J. |volume=24 |issue= 6 |pages= 1134–45 |year= 2005 |pmid= 15729360 |doi= 10.1038/sj.emboj.7600578  | pmc=556394 }}
*{{cite journal  | author=Matsumoto S, Abe Y, Fujibuchi T, ''et al.'' |title=Characterization of a MAPKK-like protein kinase TOPK. |journal=Biochem. Biophys. Res. Commun. |volume=325 |issue= 3 |pages= 997-1004 |year= 2005 |pmid= 15541388 |doi= 10.1016/j.bbrc.2004.10.133 }}
*{{cite journal   |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal  | author=Sabio G, Arthur JS, Kuma Y, ''et al.'' |title=p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. |journal=EMBO J. |volume=24 |issue= 6 |pages= 1134-45 |year= 2005 |pmid= 15729360 |doi= 10.1038/sj.emboj.7600578 }}
*{{cite journal  | vauthors=Kim J, Bhinge AA, Morgan XC, Iyer VR |title=Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. |journal=Nat. Methods |volume=2 |issue= 1 |pages= 47–53 |year= 2005 |pmid= 15782160 |doi= 10.1038/nmeth726 }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  | author=Kim J, Bhinge AA, Morgan XC, Iyer VR |title=Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. |journal=Nat. Methods |volume=2 |issue= 1 |pages= 47-53 |year= 2005 |pmid= 15782160 |doi= 10.1038/nmeth726 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal   |vauthors=Dougherty JD, Garcia AD, Nakano I, etal |title=PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. |journal=J. Neurosci. |volume=25 |issue= 46 |pages= 10773–85 |year= 2006 |pmid= 16291951 |doi= 10.1523/JNEUROSCI.3207-05.2005 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Dougherty JD, Garcia AD, Nakano I, ''et al.'' |title=PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. |journal=J. Neurosci. |volume=25 |issue= 46 |pages= 10773-85 |year= 2006 |pmid= 16291951 |doi= 10.1523/JNEUROSCI.3207-05.2005 }}
*{{cite journal   |vauthors=Nandi AK, Ford T, Fleksher D, etal |title=Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 1 |pages= 181–8 |year= 2007 |pmid= 17482142 |doi= 10.1016/j.bbrc.2007.04.125 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Oh SM, Zhu F, Cho YY, etal |title=T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. |journal=Cancer Res. |volume=67 |issue= 11 |pages= 5186–94 |year= 2007 |pmid= 17545598 |doi= 10.1158/0008-5472.CAN-06-4506 }}
*{{cite journal | author=Nandi AK, Ford T, Fleksher D, ''et al.'' |title=Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 1 |pages= 181-8 |year= 2007 |pmid= 17482142 |doi= 10.1016/j.bbrc.2007.04.125 }}
*{{cite journal   |vauthors=Zhu F, Zykova TA, Kang BS, etal |title=Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. |journal=Gastroenterology |volume=133 |issue= 1 |pages= 219–31 |year= 2007 |pmid= 17631144 |doi= 10.1053/j.gastro.2007.04.048 }}
*{{cite journal | author=Oh SM, Zhu F, Cho YY, ''et al.'' |title=T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. |journal=Cancer Res. |volume=67 |issue= 11 |pages= 5186-94 |year= 2007 |pmid= 17545598 |doi= 10.1158/0008-5472.CAN-06-4506 }}
*{{cite journal | author=Zhu F, Zykova TA, Kang BS, ''et al.'' |title=Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. |journal=Gastroenterology |volume=133 |issue= 1 |pages= 219-31 |year= 2007 |pmid= 17631144 |doi= 10.1053/j.gastro.2007.04.048 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 17:36, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lymphokine-activated killer T-cell-originated protein kinase is an enzyme that in humans is encoded by the PBK gene.[1][2][3]

The protein encoded by this gene is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.[3]

References

  1. ↑ Abe Y, Matsumoto S, Kito K, Ueda N (Aug 2000). "Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells". J Biol Chem. 275 (28): 21525–31. doi:10.1074/jbc.M909629199. PMID 10781613.
  2. ↑ Gaudet S, Branton D, Lue RA (Jun 2000). "Characterization of PDZ-binding kinase, a mitotic kinase". Proc Natl Acad Sci U S A. 97 (10): 5167–72. doi:10.1073/pnas.090102397. PMC 25800. PMID 10779557.
  3. ↑ 3.0 3.1 "Entrez Gene: PBK PDZ binding kinase".

Further reading



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