RNF19A: Difference between revisions

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{{Infobox_gene}}
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'''E3 ubiquitin-protein ligase RNF19A''' is an [[enzyme]] that in humans is encoded by the ''RNF19A'' [[gene]].<ref name="pmid11237715">{{cite journal | vauthors = Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G | title = A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity | journal = Biochem Biophys Res Commun | volume = 281 | issue = 3 | pages = 706–13 |date=Mar 2001 | pmid = 11237715 | pmc =  | doi = 10.1006/bbrc.2001.4414 }}</ref><ref name="pmid10976766">{{cite journal | vauthors = Gunther M, Laithier M, Brison O | title = A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening | journal = Mol Cell Biochem | volume = 210 | issue = 1–2 | pages = 131–42 |date=Dec 2000 | pmid = 10976766 | pmc =  | doi =10.1023/A:1007177623283 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RNF19 ring finger protein 19| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25897| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =   
| image_source =
| PDB =
| Name = Ring finger protein 19
| HGNCid = 13432
| Symbol = RNF19
| AltSymbols =; DKFZp566B1346; DORFIN
| OMIM = 607119
| ECnumber =
| Homologene = 8501
| MGIid = 1353623
  | GeneAtlas_image1 = PBB_GE_RNF19_220483_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005813 |text = centrosome}}
  | Process = {{GNF_GO|id=GO:0000226 |text = microtubule cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25897
    | Hs_Ensembl = ENSG00000034677
    | Hs_RefseqProtein = NP_056250
    | Hs_RefseqmRNA = NM_015435
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 101338464
    | Hs_GenLoc_end = 101391503
    | Hs_Uniprot = Q9NV58
    | Mm_EntrezGene = 30945
    | Mm_Ensembl = ENSMUSG00000022280
    | Mm_RefseqmRNA = NM_013923
    | Mm_RefseqProtein = NP_038951
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 36184523
    | Mm_GenLoc_end = 36210618
    | Mm_Uniprot = Q3TM18
  }}
}}
'''Ring finger protein 19''', also known as '''RNF19''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNF19 ring finger protein 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25897| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: RNF19 ring finger protein 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25897| accessdate = }}</ref>
| summary_text = The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies (LBs), neuronal inclusions characteristic of Parkinson's disease (PD). This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript variants encoding the same protein have been reported.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Gunther M, Laithier M, Brison O |title=A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. |journal=Mol. Cell. Biochem. |volume=210 |issue= 1-2 |pages= 131-42 |year= 2000 |pmid= 10976766 |doi=  }}
*{{cite journal   |vauthors=Niwa J, Ishigaki S, Hishikawa N, etal |title=Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36793–8 |year= 2002 |pmid= 12145308 |doi=10.1074/jbc.M206559200 }}
*{{cite journal  | author=Niwa  J, Ishigaki S, Doyu M, ''et al.'' |title=A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 3 |pages= 706-13 |year= 2001 |pmid= 11237715 |doi= 10.1006/bbrc.2001.4414 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Niwa J, Ishigaki S, Hishikawa N, ''et al.'' |title=Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36793-8 |year= 2002 |pmid= 12145308 |doi= 10.1074/jbc. M206559200 }}
*{{cite journal   |vauthors=Ito T, Niwa J, Hishikawa N, etal |title=Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1 |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29106–14 |year= 2003 |pmid= 12750386 |doi=10.1074/jbc.M302763200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hishikawa N, Niwa J, Doyu M, etal |title=Dorfin Localizes to the Ubiquitylated Inclusions in Parkinson's Disease, Dementia with Lewy Bodies, Multiple System Atrophy, and Amyotrophic Lateral Sclerosis |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 609–19 |year= 2003 |pmid= 12875980 |doi= 10.1016/S0002-9440(10)63688-7| pmc=1868225 }}
*{{cite journal | author=Ito T, Niwa J, Hishikawa N, ''et al.'' |title=Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29106-14 |year= 2003 |pmid= 12750386 |doi= 10.1074/jbc. M302763200 }}
*{{cite journal   |vauthors=Paces-Fessy M, Boucher D, Petit E, etal |title=The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins |journal=Biochem. J. |volume=378 |issue= Pt 2 |pages= 353–62 |year= 2004 |pmid= 14611647 |doi= 10.1042/BJ20030786 | pmc=1223961 }}
*{{cite journal | author=Hishikawa N, Niwa J, Doyu M, ''et al.'' |title=Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 609-19 |year= 2003 |pmid= 12875980 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Paces-Fessy M, Boucher D, Petit E, ''et al.'' |title=The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. |journal=Biochem. J. |volume=378 |issue= Pt 2 |pages= 353-62 |year= 2004 |pmid= 14611647 |doi= 10.1042/BJ20030786 }}
*{{cite journal   |vauthors=Takeuchi H, Niwa J, Hishikawa N, etal |title=Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis |journal=J. Neurochem. |volume=89 |issue= 1 |pages= 64–72 |year= 2004 |pmid= 15030390 |doi= 10.1046/j.1471-4159.2003.02289.x }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ishigaki S, Hishikawa N, Niwa J, etal |title=Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 51376–85 |year= 2005 |pmid= 15456787 |doi=10.1074/jbc.M406683200 }}
*{{cite journal | author=Takeuchi H, Niwa J, Hishikawa N, ''et al.'' |title=Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis. |journal=J. Neurochem. |volume=89 |issue= 1 |pages= 64-72 |year= 2004 |pmid= 15030390 |doi= 10.1046/j.1471-4159.2003.02289.x }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ishigaki S, Hishikawa N, Niwa J, ''et al.'' |title=Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 51376-85 |year= 2005 |pmid= 15456787 |doi= 10.1074/jbc. M406683200 }}
*{{cite journal  | vauthors=Huang Y, Niwa J, Sobue G, Breitwieser GE |title=Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin |journal=J. Biol. Chem. |volume=281 |issue= 17 |pages= 11610–7 |year= 2006 |pmid= 16513638 |doi=10.1074/jbc.M513552200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Ishigaki S, Niwa J, Yamada S, etal |title=Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity |journal=Neurobiol. Dis. |volume=25 |issue= 2 |pages= 331–41 |year= 2007 |pmid= 17157513 |doi= 10.1016/j.nbd.2006.09.017 }}
*{{cite journal  | author=Huang Y, Niwa J, Sobue G, Breitwieser GE |title=Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin. |journal=J. Biol. Chem. |volume=281 |issue= 17 |pages= 11610-7 |year= 2006 |pmid= 16513638 |doi= 10.1074/jbc. M513552200 }}
*{{cite journal | author=Ishigaki S, Niwa J, Yamada S, ''et al.'' |title=Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity. |journal=Neurobiol. Dis. |volume=25 |issue= 2 |pages= 331-41 |year= 2007 |pmid= 17157513 |doi= 10.1016/j.nbd.2006.09.017 }}
}}
}}
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{{refend}}
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* {{MeshName|RNF19A+protein,+human}}
* {{MeshName|RNF19A+protein,+human}}


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[[Category:RING finger proteins]]
 
 
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Latest revision as of 09:20, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.[1][2][3]

The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies (LBs), neuronal inclusions characteristic of Parkinson's disease (PD). This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript variants encoding the same protein have been reported.[3]

See also

References

  1. ↑ Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G (Mar 2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem Biophys Res Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID 11237715.
  2. ↑ Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766.
  3. ↑ 3.0 3.1 "Entrez Gene: RNF19 ring finger protein 19".

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=RNF19A&oldid=1422225"