VPS28: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Vacuolar protein sorting-associated protein 28 homolog''' is a [[protein]] that in humans is encoded by the '''VPS28''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51160| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_VPS28_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2j9w.
| PDB = {{PDB2|2j9w}}
| Name = Vacuolar protein sorting 28 homolog (S. cerevisiae)
| HGNCid = 18178
| Symbol = VPS28
| AltSymbols =; MGC60323
| OMIM = 
| ECnumber = 
| Homologene = 69205
| MGIid = 1914164
| GeneAtlas_image1 = PBB_GE_VPS28_218679_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51160
    | Hs_Ensembl = ENSG00000160948
    | Hs_RefseqProtein = NP_057292
    | Hs_RefseqmRNA = NM_016208
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 145619996
    | Hs_GenLoc_end = 145624735
    | Hs_Uniprot = Q9UK41
    | Mm_EntrezGene = 66914
    | Mm_Ensembl = ENSMUSG00000062381
    | Mm_RefseqmRNA = NM_025842
    | Mm_RefseqProtein = NP_080118
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 76449364
    | Mm_GenLoc_end = 76453329
    | Mm_Uniprot = Q8BMZ7
  }}
}}
'''Vacuolar protein sorting 28 homolog (S. cerevisiae)''', also known as '''VPS28''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51160| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein involved in endosomal sorting  of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the [[ESCRT-I]] complex (endosomal complexes required for transport) involved in the sorting of [[ubiquitin|ubiquitinated protein]]. The two other subunits of ESCRT-I are vacuolar protein sorting 23 (VPS23), also known as [[TSG101|tumor susceptibility gene 101]] (TSG101), and [[VPS37A|vacuolar protein sorting 37]] (VPS37). Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein involved in endosomal sorting  of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated proteins. The two other subunits of ESCRT-I are vesicular protein sorting 23, also known as tumor susceptibility gene 101 (TSG101), and vesicular protein sorting 37. Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally.<ref name="entrez">{{cite web | title = Entrez Gene: VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51160| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Raiborg C, Rusten TE, Stenmark H |title=Protein sorting into multivesicular endosomes. |journal=Curr. Opin. Cell Biol. |volume=15 |issue= 4 |pages= 446-55 |year= 2004 |pmid= 12892785 |doi=  }}
*{{cite journal  | author=Bishop N, Woodman P |title=TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 11735-42 |year= 2001 |pmid= 11134028 |doi= 10.1074/jbc.M009863200 }}
*{{cite journal  | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
*{{cite journal  | author=Bishop N, Horman A, Woodman P |title=Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. |journal=J. Cell Biol. |volume=157 |issue= 1 |pages= 91-101 |year= 2002 |pmid= 11916981 |doi= 10.1083/jcb.200112080 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Martin-Serrano J, Zang T, Bieniasz PD |title=Role of ESCRT-I in retroviral budding. |journal=J. Virol. |volume=77 |issue= 8 |pages= 4794-804 |year= 2003 |pmid= 12663786 |doi=  }}
*{{cite journal  | author=Tanzi GO, Piefer AJ, Bates P |title=Equine infectious anemia virus utilizes host vesicular protein sorting machinery during particle release. |journal=J. Virol. |volume=77 |issue= 15 |pages= 8440-7 |year= 2003 |pmid= 12857913 |doi=  }}
*{{cite journal  | author=Martin-Serrano J, Yarovoy A, Perez-Caballero D, ''et al.'' |title=Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 21 |pages= 12414-9 |year= 2003 |pmid= 14519844 |doi= 10.1073/pnas.2133846100 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Stuchell MD, Garrus JE, Müller B, ''et al.'' |title=The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 36059-71 |year= 2005 |pmid= 15218037 |doi= 10.1074/jbc.M405226200 }}
*{{cite journal  | author=Bache KG, Slagsvold T, Cabezas A, ''et al.'' |title=The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. |journal=Mol. Biol. Cell |volume=15 |issue= 9 |pages= 4337-46 |year= 2005 |pmid= 15240819 |doi= 10.1091/mbc.E04-03-0250 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Eastman SW, Martin-Serrano J, Chung W, ''et al.'' |title=Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. |journal=J. Biol. Chem. |volume=280 |issue= 1 |pages= 628-36 |year= 2005 |pmid= 15509564 |doi= 10.1074/jbc.M410384200 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Hui EK, Barman S, Tang DH, ''et al.'' |title=YRKL sequence of influenza virus M1 functions as the L domain motif and interacts with VPS28 and Cdc42. |journal=J. Virol. |volume=80 |issue= 5 |pages= 2291-308 |year= 2006 |pmid= 16474136 |doi= 10.1128/JVI.80.5.2291-2308.2006 }}
}}
{{refend}}


{{protein-stub}}
VPS28 has been shown to [[Protein-protein interaction|interact]] with [[TSG101]].<ref name = pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name = pmid15218037>{{cite journal | vauthors = Stuchell MD, Garrus JE, Müller B, Stray KM, Ghaffarian S, McKinnon R, Kräusslich HG, Morham SG, Sundquist WI | title = The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding | journal = J. Biol. Chem. | volume = 279 | issue = 34 | pages = 36059–71 | date = August 2004 | pmid = 15218037 | doi = 10.1074/jbc.M405226200 }}</ref><ref name = pmid11134028>{{cite journal | vauthors = Bishop N, Woodman P | title = TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11735–42 | date = April 2001 | pmid = 11134028 | doi = 10.1074/jbc.M009863200 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Raiborg C, Rusten TE, Stenmark H | title = Protein sorting into multivesicular endosomes | journal = Curr. Opin. Cell Biol. | volume = 15 | issue = 4 | pages = 446–55 | year = 2004 | pmid = 12892785 | doi = 10.1016/S0955-0674(03)00080-2 }}
* {{cite journal | vauthors = Bishop N, Woodman P | title = TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11735–42 | year = 2001 | pmid = 11134028 | doi = 10.1074/jbc.M009863200 }}
* {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs | journal = Genome Res. | volume = 11 | issue = 10 | pages = 1758–65 | year = 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
* {{cite journal | vauthors = Bishop N, Horman A, Woodman P | title = Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates | journal = J. Cell Biol. | volume = 157 | issue = 1 | pages = 91–101 | year = 2002 | pmid = 11916981 | pmc = 2173266 | doi = 10.1083/jcb.200112080 }}
* {{cite journal | vauthors = Martin-Serrano J, Zang T, Bieniasz PD | title = Role of ESCRT-I in Retroviral Budding | journal = J. Virol. | volume = 77 | issue = 8 | pages = 4794–804 | year = 2003 | pmid = 12663786 | pmc = 152150 | doi = 10.1128/JVI.77.8.4794-4804.2003 }}
* {{cite journal | vauthors = Tanzi GO, Piefer AJ, Bates P | title = Equine Infectious Anemia Virus Utilizes Host Vesicular Protein Sorting Machinery during Particle Release | journal = J. Virol. | volume = 77 | issue = 15 | pages = 8440–7 | year = 2003 | pmid = 12857913 | pmc = 165230 | doi = 10.1128/JVI.77.15.8440-8447.2003 }}
* {{cite journal | vauthors = Martin-Serrano J, Yarovoy A, Perez-Caballero D, Bieniasz PD, Yaravoy A | title = Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 21 | pages = 12414–9 | year = 2003 | pmid = 14519844 | pmc = 218772 | doi = 10.1073/pnas.2133846100 }}
* {{cite journal | vauthors = Stuchell MD, Garrus JE, Müller B, Stray KM, Ghaffarian S, McKinnon R, Kräusslich HG, Morham SG, Sundquist WI | title = The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding | journal = J. Biol. Chem. | volume = 279 | issue = 34 | pages = 36059–71 | year = 2005 | pmid = 15218037 | doi = 10.1074/jbc.M405226200 }}
* {{cite journal | vauthors = Bache KG, Slagsvold T, Cabezas A, Rosendal KR, Raiborg C, Stenmark H | title = The Growth-Regulatory Protein HCRP1/hVps37A Is a Subunit of Mammalian ESCRT-I and Mediates Receptor Down-Regulation | journal = Mol. Biol. Cell | volume = 15 | issue = 9 | pages = 4337–46 | year = 2005 | pmid = 15240819 | pmc = 515363 | doi = 10.1091/mbc.E04-03-0250 }}
* {{cite journal | vauthors = Eastman SW, Martin-Serrano J, Chung W, Zang T, Bieniasz PD | title = Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding | journal = J. Biol. Chem. | volume = 280 | issue = 1 | pages = 628–36 | year = 2005 | pmid = 15509564 | doi = 10.1074/jbc.M410384200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}<!--close PBB_Further_reading-->
 
{{Refend}}
{{PDB Gallery|geneid=51160}}
 
 
{{Gene-8-stub}}

Latest revision as of 02:26, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene.[1]

Function

This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated protein. The two other subunits of ESCRT-I are vacuolar protein sorting 23 (VPS23), also known as tumor susceptibility gene 101 (TSG101), and vacuolar protein sorting 37 (VPS37). Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally.[1]

Interactions

VPS28 has been shown to interact with TSG101.[2][3][4]

References

  1. ↑ 1.0 1.1 "Entrez Gene: VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)".
  2. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  3. ↑ Stuchell MD, Garrus JE, Müller B, Stray KM, Ghaffarian S, McKinnon R, Kräusslich HG, Morham SG, Sundquist WI (August 2004). "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding". J. Biol. Chem. 279 (34): 36059–71. doi:10.1074/jbc.M405226200. PMID 15218037.
  4. ↑ Bishop N, Woodman P (April 2001). "TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes". J. Biol. Chem. 276 (15): 11735–42. doi:10.1074/jbc.M009863200. PMID 11134028.

Further reading


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