SLURP1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Secreted Ly-6/uPAR-related protein 1''' is a [[protein]] that in humans is encoded by the ''SLURP1'' [[gene]].<ref name="pmid11285253">{{cite journal | vauthors = Fischer J, Bouadjar B, Heilig R, Huber M, Lefèvre C, Jobard F, Macari F, Bakija-Konsuo A, Ait-Belkacem F, Weissenbach J, Lathrop M, Hohl D, Prud'homme JF | title = Mutations in the gene encoding SLURP-1 in Mal de Meleda | journal = Human Molecular Genetics | volume = 10 | issue = 8 | pages = 875–80 | date = April 2001 | pmid = 11285253 | pmc =  | doi = 10.1093/hmg/10.8.875 }}</ref><ref name="pmid10211827">{{cite journal | vauthors = Adermann K, Wattler F, Wattler S, Heine G, Meyer M, Forssmann WG, Nehls M | title = Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily | journal = Protein Science | volume = 8 | issue = 4 | pages = 810–9 | date = April 1999 | pmid = 10211827 | pmc = 2144295 | doi = 10.1110/ps.8.4.810 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57152| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Secreted LY6/PLAUR domain containing 1
| HGNCid = 18746
| Symbol = SLURP1
| AltSymbols =; ARS; ANUP; ArsB; LY6LS; MDM
| OMIM = 606119
| ECnumber = 
| Homologene = 10710
| MGIid = 1930923
| GeneAtlas_image1 = PBB_GE_SLURP1_214536_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001775 |text = cell activation}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57152
    | Hs_Ensembl = ENSG00000126233
    | Hs_RefseqProtein = NP_065160
    | Hs_RefseqmRNA = NM_020427
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 143819364
    | Hs_GenLoc_end = 143820831
    | Hs_Uniprot = P55000
    | Mm_EntrezGene = 57277
    | Mm_Ensembl = ENSMUSG00000022596
    | Mm_RefseqmRNA = NM_020519
    | Mm_RefseqProtein = NP_065265
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 74551573
    | Mm_GenLoc_end = 74555289
    | Mm_Uniprot = Q2TA55
  }}
}}
'''Secreted LY6/PLAUR domain containing 1''', also known as '''SLURP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57152| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with [[Mal de Meleda]], a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.<ref name="entrez">{{cite web | title = Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57152| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ridge RJ, Sloane NH | title = Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes | journal = Cytokine | volume = 8 | issue = 1 | pages = 1–5 | date = January 1996 | pmid = 8742060 | doi = 10.1006/cyto.1996.0001 }}
| citations =
* {{cite journal | vauthors = Fischer J, Bouadjar B, Heilig R, Fizames C, Prud'homme JF, Weissenbach J | title = Genetic linkage of Meleda disease to chromosome 8qter | journal = European Journal of Human Genetics | volume = 6 | issue = 6 | pages = 542–7 | year = 1999 | pmid = 9887370 | doi = 10.1038/sj.ejhg.5200254 }}
*{{cite journal | author=Ridge RJ, Sloane NH |title=Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes. |journal=Cytokine |volume=8 |issue= 1 |pages= 1-5 |year= 1996 |pmid= 8742060 |doi= 10.1006/cyto.1996.0001 }}
* {{cite journal | vauthors = Eckl KM, Stevens HP, Lestringant GG, Westenberger-Treumann M, Traupe H, Hinz B, Frossard PM, Stadler R, Leigh IM, Nürnberg P, Reis A, Hennies HC | title = Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates | journal = Human Genetics | volume = 112 | issue = 1 | pages = 50–6 | date = January 2003 | pmid = 12483299 | doi = 10.1007/s00439-002-0838-8 }}
*{{cite journal | author=Fischer J, Bouadjar B, Heilig R, ''et al.'' |title=Genetic linkage of Meleda disease to chromosome 8qter. |journal=Eur. J. Hum. Genet. |volume=6 |issue= 6 |pages= 542-7 |year= 1999 |pmid= 9887370 |doi= 10.1038/sj.ejhg.5200254 }}
* {{cite journal | vauthors = Marrakchi S, Audebert S, Bouadjar B, Has C, Lefèvre C, Munro C, Cure S, Jobard F, Morlot S, Hohl D, Prud'homme JF, Zahaf A, Turki H, Fischer J | title = Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda | journal = The Journal of Investigative Dermatology | volume = 120 | issue = 3 | pages = 351–5 | date = March 2003 | pmid = 12603845 | doi = 10.1046/j.1523-1747.2003.12062.x }}
*{{cite journal | author=Adermann K, Wattler F, Wattler S, ''et al.'' |title=Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. |journal=Protein Sci. |volume=8 |issue= 4 |pages= 810-9 |year= 1999 |pmid= 10211827 |doi=  }}
* {{cite journal | vauthors = Hu G, Yildirim M, Baysal V, Yerebakan O, Yilmaz E, Inaloz HS, Martinez-Mir A, Christiano AM, Celebi JT | title = A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect | journal = The Journal of Investigative Dermatology | volume = 120 | issue = 6 | pages = 967–9 | date = June 2003 | pmid = 12787122 | doi = 10.1046/j.1523-1747.2003.12248.x }}
*{{cite journal  | author=Fischer J, Bouadjar B, Heilig R, ''et al.'' |title=Mutations in the gene encoding SLURP-1 in Mal de Meleda. |journal=Hum. Mol. Genet. |volume=10 |issue= 8 |pages= 875-80 |year= 2001 |pmid= 11285253 |doi=  }}
* {{cite journal | vauthors = Chimienti F, Hogg RC, Plantard L, Lehmann C, Brakch N, Fischer J, Huber M, Bertrand D, Hohl D | title = Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda | journal = Human Molecular Genetics | volume = 12 | issue = 22 | pages = 3017–24 | date = November 2003 | pmid = 14506129 | doi = 10.1093/hmg/ddg320 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Charfeddine C, Mokni M, Ben Mousli R, Elkares R, Bouchlaka C, Boubaker S, Ghedamsi S, Baccouche D, Ben Osman A, Dellagi K, Abdelhak S | title = A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia | journal = The British Journal of Dermatology | volume = 149 | issue = 6 | pages = 1108–15 | date = December 2003 | pmid = 14674887 | doi = 10.1111/j.1365-2133.2003.05606.x }}
*{{cite journal  | author=Eckl KM, Stevens HP, Lestringant GG, ''et al.'' |title=Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates. |journal=Hum. Genet. |volume=112 |issue= 1 |pages= 50-6 |year= 2003 |pmid= 12483299 |doi= 10.1007/s00439-002-0838-8 }}
* {{cite journal | vauthors = Mastrangeli R, Donini S, Kelton CA, He C, Bressan A, Milazzo F, Ciolli V, Borrelli F, Martelli F, Biffoni M, Serlupi-Crescenzi O, Serani S, Micangeli E, El Tayar N, Vaccaro R, Renda T, Lisciani R, Rossi M, Papoian R | title = ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda | journal = European Journal of Dermatology | volume = 13 | issue = 6 | pages = 560–70 | year = 2004 | pmid = 14721776 | doi =  }}
*{{cite journal | author=Marrakchi S, Audebert S, Bouadjar B, ''et al.'' |title=Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda. |journal=J. Invest. Dermatol. |volume=120 |issue= 3 |pages= 351-5 |year= 2003 |pmid= 12603845 |doi= 10.1046/j.1523-1747.2003.12062.x }}
* {{cite journal | vauthors = Mokni M, Charfeddine C, Ben Mously R, Baccouche D, Kaabi B, Ben Osman A, Dellagi K, Abdelhak S | title = Heterozygous manifestations in female carriers of Mal de Meleda | journal = Clinical Genetics | volume = 65 | issue = 3 | pages = 244–6 | date = March 2004 | pmid = 14756676 | doi = 10.1111/j.0009-9163.2004.00224.x }}
*{{cite journal | author=Hu G, Yildirim M, Baysal V, ''et al.'' |title=A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect. |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 967-9 |year= 2003 |pmid= 12787122 |doi= 10.1046/j.1523-1747.2003.12248.x }}
* {{cite journal | vauthors = Chao SC, Lai FJ, Yang MH, Lee JY | title = Mal de Meleda in a taiwanese | journal = Journal of the Formosan Medical Association = Taiwan Yi Zhi | volume = 104 | issue = 4 | pages = 276–8 | date = April 2005 | pmid = 15909066 | doi =  }}
*{{cite journal | author=Chimienti F, Hogg RC, Plantard L, ''et al.'' |title=Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. |journal=Hum. Mol. Genet. |volume=12 |issue= 22 |pages= 3017-24 |year= 2004 |pmid= 14506129 |doi= 10.1093/hmg/ddg320 }}
* {{cite journal | vauthors = Arredondo J, Chernyavsky AI, Webber RJ, Grando SA | title = Biological effects of SLURP-1 on human keratinocytes | journal = The Journal of Investigative Dermatology | volume = 125 | issue = 6 | pages = 1236–41 | date = December 2005 | pmid = 16354194 | doi = 10.1111/j.0022-202X.2005.23973.x }}
*{{cite journal | author=Charfeddine C, Mokni M, Ben Mousli R, ''et al.'' |title=A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia. |journal=Br. J. Dermatol. |volume=149 |issue= 6 |pages= 1108-15 |year= 2004 |pmid= 14674887 |doi= }}
* {{cite journal | vauthors = Arredondo J, Chernyavsky AI, Grando SA | title = Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells | journal = Biochemical Pharmacology | volume = 74 | issue = 8 | pages = 1315–9 | date = October 2007 | pmid = 17643396 | pmc = 2046218 | doi = 10.1016/j.bcp.2007.06.026 }}
*{{cite journal | author=Mastrangeli R, Donini S, Kelton CA, ''et al.'' |title=ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda. |journal=European journal of dermatology : EJD |volume=13 |issue= 6 |pages= 560-70 |year= 2004 |pmid= 14721776 |doi=  }}
*{{cite journal | author=Mokni M, Charfeddine C, Ben Mously R, ''et al.'' |title=Heterozygous manifestations in female carriers of Mal de Meleda. |journal=Clin. Genet. |volume=65 |issue= 3 |pages= 244-6 |year= 2004 |pmid= 14756676 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Chao SC, Lai FJ, Yang MH, Lee JY |title=Mal de Meleda in a taiwanese. |journal=J. Formos. Med. Assoc. |volume=104 |issue= 4 |pages= 276-8 |year= 2006 |pmid= 15909066 |doi=  }}
*{{cite journal | author=Arredondo J, Chernyavsky AI, Webber RJ, Grando SA |title=Biological effects of SLURP-1 on human keratinocytes. |journal=J. Invest. Dermatol. |volume=125 |issue= 6 |pages= 1236-41 |year= 2006 |pmid= 16354194 |doi= 10.1111/j.0022-202X.2005.23973.x }}
*{{cite journal | author=Arredondo J, Chernyavsky AI, Grando SA |title=Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells. |journal=Biochem. Pharmacol. |volume=74 |issue= 8 |pages= 1315-9 |year= 2007 |pmid= 17643396 |doi= 10.1016/j.bcp.2007.06.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-8-stub}}
{{WikiDoc Sources}}

Revision as of 02:27, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Secreted Ly-6/uPAR-related protein 1 is a protein that in humans is encoded by the SLURP1 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.[3]

References

  1. ↑ Fischer J, Bouadjar B, Heilig R, Huber M, Lefèvre C, Jobard F, Macari F, Bakija-Konsuo A, Ait-Belkacem F, Weissenbach J, Lathrop M, Hohl D, Prud'homme JF (April 2001). "Mutations in the gene encoding SLURP-1 in Mal de Meleda". Human Molecular Genetics. 10 (8): 875–80. doi:10.1093/hmg/10.8.875. PMID 11285253.
  2. ↑ Adermann K, Wattler F, Wattler S, Heine G, Meyer M, Forssmann WG, Nehls M (April 1999). "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily". Protein Science. 8 (4): 810–9. doi:10.1110/ps.8.4.810. PMC 2144295. PMID 10211827.
  3. ↑ 3.0 3.1 "Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1".

Further reading

  • Ridge RJ, Sloane NH (January 1996). "Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes". Cytokine. 8 (1): 1–5. doi:10.1006/cyto.1996.0001. PMID 8742060.
  • Fischer J, Bouadjar B, Heilig R, Fizames C, Prud'homme JF, Weissenbach J (1999). "Genetic linkage of Meleda disease to chromosome 8qter". European Journal of Human Genetics. 6 (6): 542–7. doi:10.1038/sj.ejhg.5200254. PMID 9887370.
  • Eckl KM, Stevens HP, Lestringant GG, Westenberger-Treumann M, Traupe H, Hinz B, Frossard PM, Stadler R, Leigh IM, Nürnberg P, Reis A, Hennies HC (January 2003). "Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates". Human Genetics. 112 (1): 50–6. doi:10.1007/s00439-002-0838-8. PMID 12483299.
  • Marrakchi S, Audebert S, Bouadjar B, Has C, Lefèvre C, Munro C, Cure S, Jobard F, Morlot S, Hohl D, Prud'homme JF, Zahaf A, Turki H, Fischer J (March 2003). "Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda". The Journal of Investigative Dermatology. 120 (3): 351–5. doi:10.1046/j.1523-1747.2003.12062.x. PMID 12603845.
  • Hu G, Yildirim M, Baysal V, Yerebakan O, Yilmaz E, Inaloz HS, Martinez-Mir A, Christiano AM, Celebi JT (June 2003). "A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect". The Journal of Investigative Dermatology. 120 (6): 967–9. doi:10.1046/j.1523-1747.2003.12248.x. PMID 12787122.
  • Chimienti F, Hogg RC, Plantard L, Lehmann C, Brakch N, Fischer J, Huber M, Bertrand D, Hohl D (November 2003). "Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda". Human Molecular Genetics. 12 (22): 3017–24. doi:10.1093/hmg/ddg320. PMID 14506129.
  • Charfeddine C, Mokni M, Ben Mousli R, Elkares R, Bouchlaka C, Boubaker S, Ghedamsi S, Baccouche D, Ben Osman A, Dellagi K, Abdelhak S (December 2003). "A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia". The British Journal of Dermatology. 149 (6): 1108–15. doi:10.1111/j.1365-2133.2003.05606.x. PMID 14674887.
  • Mastrangeli R, Donini S, Kelton CA, He C, Bressan A, Milazzo F, Ciolli V, Borrelli F, Martelli F, Biffoni M, Serlupi-Crescenzi O, Serani S, Micangeli E, El Tayar N, Vaccaro R, Renda T, Lisciani R, Rossi M, Papoian R (2004). "ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda". European Journal of Dermatology. 13 (6): 560–70. PMID 14721776.
  • Mokni M, Charfeddine C, Ben Mously R, Baccouche D, Kaabi B, Ben Osman A, Dellagi K, Abdelhak S (March 2004). "Heterozygous manifestations in female carriers of Mal de Meleda". Clinical Genetics. 65 (3): 244–6. doi:10.1111/j.0009-9163.2004.00224.x. PMID 14756676.
  • Chao SC, Lai FJ, Yang MH, Lee JY (April 2005). "Mal de Meleda in a taiwanese". Journal of the Formosan Medical Association = Taiwan Yi Zhi. 104 (4): 276–8. PMID 15909066.
  • Arredondo J, Chernyavsky AI, Webber RJ, Grando SA (December 2005). "Biological effects of SLURP-1 on human keratinocytes". The Journal of Investigative Dermatology. 125 (6): 1236–41. doi:10.1111/j.0022-202X.2005.23973.x. PMID 16354194.
  • Arredondo J, Chernyavsky AI, Grando SA (October 2007). "Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells". Biochemical Pharmacology. 74 (8): 1315–9. doi:10.1016/j.bcp.2007.06.026. PMC 2046218. PMID 17643396.
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