CSMD1: Difference between revisions

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Revision as of 10:06, 30 August 2017

CSMD1 CUB and Sushi multiple domains 1 (Homo sapiens) is a protein that in humans is encoded by the CSMD1 gene.^[1] It is a potential tumour suppressor, the deletion of which may result in head and neck carcinomas behaving more aggressively.

References

↑ "Entrez Gene: CSMD1 CUB and Sushi multiple domains 1".

External links

Human CSMD1 genome location and CSMD1 gene details page in the UCSC Genome Browser.

Smith DI, Zhu Y, McAvoy S, Kuhn R (2006). "Common fragile sites, extremely large genes, neural development and cancer". Cancer Lett. 232 (1): 48–57. doi:10.1016/j.canlet.2005.06.049. PMID 16221525.
Sun PC, Uppaluri R, Schmidt AP, et al. (2001). "Transcript map of the 8p23 putative tumor suppressor region". Genomics. 75 (1–3): 17–25. doi:10.1006/geno.2001.6587. PMID 11472063.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
Toomes C, Jackson A, Maguire K, et al. (2003). "The presence of multiple regions of homozygous deletion at the CSMD1 locus in oral squamous cell carcinoma question the role of CSMD1 in head and neck carcinogenesis". Genes Chromosomes Cancer. 37 (2): 132–40. doi:10.1002/gcc.10191. PMID 12696061.
Henshall SM, Afar DE, Hiller J, et al. (2003). "Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse". Cancer Res. 63 (14): 4196–203. PMID 12874026.
Lau WL, Scholnick SB (2004). "Identification of two new members of the CSMD gene family". Genomics. 82 (3): 412–5. doi:10.1016/S0888-7543(03)00149-6. PMID 12906867.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Scholnick SB, Richter TM (2003). "The role of CSMD1 in head and neck carcinogenesis". Genes Chromosomes Cancer. 38 (3): 281–3. doi:10.1002/gcc.10279. PMID 14506705.
Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Paris PL, Andaya A, Fridlyand J, et al. (2005). "Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors". Hum. Mol. Genet. 13 (13): 1303–13. doi:10.1093/hmg/ddh155. PMID 15138198.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Richter TM, Tong BD, Scholnick SB (2005). "Epigenetic inactivation and aberrant transcription of CSMD1 in squamous cell carcinoma cell lines". Cancer Cell Int. 5 (1): 29. doi:10.1186/1475-2867-5-29. PMC 1239921. PMID 16153303.
Blaveri E, Brewer JL, Roydasgupta R, et al. (2006). "Bladder cancer stage and outcome by array-based comparative genomic hybridization". Clin. Cancer Res. 11 (19 Pt 1): 7012–22. doi:10.1158/1078-0432.CCR-05-0177. PMID 16203795.
Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
Kraus DM, Elliott GS, Chute H, et al. (2006). "CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues". J. Immunol. 176 (7): 4419–30. doi:10.4049/jimmunol.176.7.4419. PMID 16547280.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[entrez-1] "Entrez Gene: CSMD1 CUB and Sushi multiple domains 1".

[1]

@@ Line 1: / Line 1: @@
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+'''CSMD1 CUB and Sushi multiple domains 1 ([[Homo sapiens]])''' is a [[protein]] that in humans is encoded by the ''CSMD1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CSMD1 CUB and Sushi multiple domains 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64478| accessdate = }}</ref> It is a potential tumour [[suppressor]], the deletion of which may result in head and neck [[carcinomas]] behaving more aggressively.
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = CUB and Sushi multiple domains 1
- | HGNCid = 14026
- | Symbol = CSMD1
- | AltSymbols =; KIAA1890
- | OMIM = 608397
- | ECnumber =
- | Homologene = 69536
- | MGIid = 2137383
- | GeneAtlas_image1 = PBB_GE_CSMD1_gnf1h09935_at_tn.png
- | GeneAtlas_image2 = PBB_GE_CSMD1_gnf1h09936_x_at_tn.png
- | Function =
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process =
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 64478
-    | Hs_Ensembl = ENSG00000183117
-    | Hs_RefseqProtein = NP_150094
-    | Hs_RefseqmRNA = NM_033225
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 8
-    | Hs_GenLoc_start = 2782790
-    | Hs_GenLoc_end = 3254536
-    | Hs_Uniprot = Q96PZ7
-    | Mm_EntrezGene = 94109
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA = XM_979938
-    | Mm_RefseqProtein = XP_985032
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''CUB and Sushi multiple domains 1''', also known as '''CSMD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CSMD1 CUB and Sushi multiple domains 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64478| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 56: / Line 10: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CSMD1}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Smith DI, Zhu Y, McAvoy S, Kuhn R |title=Common fragile sites, extremely large genes, neural development and cancer. |journal=Cancer Lett. |volume=232 |issue= 1 |pages= 48-57 |year= 2006 |pmid= 16221525 |doi= 10.1016/j.canlet.2005.06.049 }}
+*{{cite journal  | vauthors=Smith DI, Zhu Y, McAvoy S, Kuhn R |title=Common fragile sites, extremely large genes, neural development and cancer. |journal=Cancer Lett. |volume=232 |issue= 1 |pages= 48–57 |year= 2006 |pmid= 16221525 |doi= 10.1016/j.canlet.2005.06.049 }}
-*{{cite journal  | author=Sun PC, Uppaluri R, Schmidt AP, ''et al.'' |title=Transcript map of the 8p23 putative tumor suppressor region. |journal=Genomics |volume=75 |issue= 1-3 |pages= 17-25 |year= 2001 |pmid= 11472063 |doi= 10.1006/geno.2001.6587 }}
+*{{cite journal  | vauthors=Sun PC, Uppaluri R, Schmidt AP |title=Transcript map of the 8p23 putative tumor suppressor region. |journal=Genomics |volume=75 |issue= 1-3 |pages= 17–25 |year= 2001 |pmid= 11472063 |doi= 10.1006/geno.2001.6587 |display-authors=etal}}
-*{{cite journal  | author=Nagase T, Kikuno R, Ohara O |title=Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. |journal=DNA Res. |volume=8 |issue= 4 |pages= 179-87 |year= 2002 |pmid= 11572484 |doi=  }}
+*{{cite journal  | vauthors=Nagase T, Kikuno R, Ohara O |title=Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. |journal=DNA Res. |volume=8 |issue= 4 |pages= 179–87 |year= 2002 |pmid= 11572484 |doi=10.1093/dnares/8.4.179  }}
-*{{cite journal  | author=Toomes C, Jackson A, Maguire K, ''et al.'' |title=The presence of multiple regions of homozygous deletion at the CSMD1 locus in oral squamous cell carcinoma question the role of CSMD1 in head and neck carcinogenesis. |journal=Genes Chromosomes Cancer |volume=37 |issue= 2 |pages= 132-40 |year= 2003 |pmid= 12696061 |doi= 10.1002/gcc.10191 }}
+*{{cite journal  | vauthors=Toomes C, Jackson A, Maguire K |title=The presence of multiple regions of homozygous deletion at the CSMD1 locus in oral squamous cell carcinoma question the role of CSMD1 in head and neck carcinogenesis. |journal=Genes Chromosomes Cancer |volume=37 |issue= 2 |pages= 132–40 |year= 2003 |pmid= 12696061 |doi= 10.1002/gcc.10191 |display-authors=etal}}
-*{{cite journal  | author=Henshall SM, Afar DE, Hiller J, ''et al.'' |title=Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse. |journal=Cancer Res. |volume=63 |issue= 14 |pages= 4196-203 |year= 2003 |pmid= 12874026 |doi=  }}
+*{{cite journal  | vauthors=Henshall SM, Afar DE, Hiller J |title=Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse. |journal=Cancer Res. |volume=63 |issue= 14 |pages= 4196–203 |year= 2003 |pmid= 12874026 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Lau WL, Scholnick SB |title=Identification of two new members of the CSMD gene family small star, filled. |journal=Genomics |volume=82 |issue= 3 |pages= 412-5 |year= 2004 |pmid= 12906867 |doi=  }}
+*{{cite journal  | vauthors=Lau WL, Scholnick SB |title=Identification of two new members of the CSMD gene family. |journal=Genomics |volume=82 |issue= 3 |pages= 412–5 |year= 2004 |pmid= 12906867 |doi=10.1016/S0888-7543(03)00149-6  }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
+*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 |display-authors=etal}}
-*{{cite journal  | author=Scholnick SB, Richter TM |title=The role of CSMD1 in head and neck carcinogenesis. |journal=Genes Chromosomes Cancer |volume=38 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 14506705 |doi= 10.1002/gcc.10279 }}
+*{{cite journal  | vauthors=Scholnick SB, Richter TM |title=The role of CSMD1 in head and neck carcinogenesis. |journal=Genes Chromosomes Cancer |volume=38 |issue= 3 |pages= 281–3 |year= 2003 |pmid= 14506705 |doi= 10.1002/gcc.10279 }}
-*{{cite journal  | author=Clark AG, Glanowski S, Nielsen R, ''et al.'' |title=Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. |journal=Science |volume=302 |issue= 5652 |pages= 1960-3 |year= 2003 |pmid= 14671302 |doi= 10.1126/science.1088821 }}
+*{{cite journal  | vauthors=Clark AG, Glanowski S, Nielsen R |title=Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. |journal=Science |volume=302 |issue= 5652 |pages= 1960–3 |year= 2003 |pmid= 14671302 |doi= 10.1126/science.1088821 |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Paris PL, Andaya A, Fridlyand J, ''et al.'' |title=Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors. |journal=Hum. Mol. Genet. |volume=13 |issue= 13 |pages= 1303-13 |year= 2005 |pmid= 15138198 |doi= 10.1093/hmg/ddh155 }}
+*{{cite journal  | vauthors=Paris PL, Andaya A, Fridlyand J |title=Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors. |journal=Hum. Mol. Genet. |volume=13 |issue= 13 |pages= 1303–13 |year= 2005 |pmid= 15138198 |doi= 10.1093/hmg/ddh155 |display-authors=etal}}
-*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
+*{{cite journal  | vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 |display-authors=etal}}
-*{{cite journal  | author=Richter TM, Tong BD, Scholnick SB |title=Epigenetic inactivation and aberrant transcription of CSMD1 in squamous cell carcinoma cell lines. |journal=Cancer Cell Int. |volume=5 |issue=  |pages= 29 |year= 2005 |pmid= 16153303 |doi= 10.1186/1475-2867-5-29 }}
+*{{cite journal  | vauthors=Richter TM, Tong BD, Scholnick SB |title=Epigenetic inactivation and aberrant transcription of CSMD1 in squamous cell carcinoma cell lines. |journal=Cancer Cell Int. |volume=5 |issue=  1|pages= 29 |year= 2005 |pmid= 16153303 |doi= 10.1186/1475-2867-5-29  | pmc=1239921 }}
-*{{cite journal  | author=Blaveri E, Brewer JL, Roydasgupta R, ''et al.'' |title=Bladder cancer stage and outcome by array-based comparative genomic hybridization. |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 7012-22 |year= 2006 |pmid= 16203795 |doi= 10.1158/1078-0432.CCR-05-0177 }}
+*{{cite journal  | vauthors=Blaveri E, Brewer JL, Roydasgupta R |title=Bladder cancer stage and outcome by array-based comparative genomic hybridization. |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 7012–22 |year= 2006 |pmid= 16203795 |doi= 10.1158/1078-0432.CCR-05-0177 |display-authors=etal}}
-*{{cite journal  | author=Nusbaum C, Mikkelsen TS, Zody MC, ''et al.'' |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331-5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 }}
+*{{cite journal  | vauthors=Nusbaum C, Mikkelsen TS, Zody MC |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331–5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 |display-authors=etal}}
-*{{cite journal  | author=Kraus DM, Elliott GS, Chute H, ''et al.'' |title=CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues. |journal=J. Immunol. |volume=176 |issue= 7 |pages= 4419-30 |year= 2006 |pmid= 16547280 |doi=  }}
+*{{cite journal  | vauthors=Kraus DM, Elliott GS, Chute H |title=CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues. |journal=J. Immunol. |volume=176 |issue= 7 |pages= 4419–30 |year= 2006 |pmid= 16547280 |doi=  10.4049/jimmunol.176.7.4419|display-authors=etal}}
 }}
 {{refend}}
-{{protein-stub}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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+{{PBB_Controls
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+{{gene-8-stub}}

CSMD1: Difference between revisions

Revision as of 10:06, 30 August 2017

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