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{{Infobox_gene}}
{{PBB_Controls
'''Outer dense fiber protein 1''' is a [[protein]] that in humans is encoded by the ''ODF1'' [[gene]].<ref name="pmid8305202">{{cite journal |vauthors=Gastmann O, Burfeind P, Gunther E, Hameister H, Szpirer C, Hoyer-Fender S | title = Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene | journal = Mol Reprod Dev | volume = 36 | issue = 4 | pages = 407–418 |date=Mar 1994 | pmid = 8305202 | pmc =  | doi = 10.1002/mrd.1080360402 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ODF1 outer dense fiber of sperm tails 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4956| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Outer dense fiber of sperm tails 1
| HGNCid = 8113
| Symbol = ODF1
| AltSymbols =; HSPB10; MGC129928; MGC129929; ODF; ODF2; ODF27; ODFP; ODFPG; ODFPGA; ODFPGB; RT7; SODF
| OMIM = 182878
| ECnumber = 
| Homologene = 7456
| MGIid = 97424
| GeneAtlas_image1 = PBB_GE_ODF1_214485_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}
| Component = {{GNF_GO|id=GO:0001520 |text = outer dense fiber}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4956
    | Hs_Ensembl = ENSG00000155087
    | Hs_RefseqProtein = NP_077721
    | Hs_RefseqmRNA = NM_024410
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 103633042
    | Hs_GenLoc_end = 103642422
    | Hs_Uniprot = Q14990
    | Mm_EntrezGene = 18285
    | Mm_Ensembl = ENSMUSG00000061923
    | Mm_RefseqmRNA = NM_008757
    | Mm_RefseqProtein = NP_032783
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 38164019
    | Mm_GenLoc_end = 38171228
    | Mm_Uniprot = Q61999
  }}
}}
'''Outer dense fiber of sperm tails 1''', also known as '''ODF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ODF1 outer dense fiber of sperm tails 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4956| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein.<ref name="entrez">{{cite web | title = Entrez Gene: ODF1 outer dense fiber of sperm tails 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4956| accessdate = }}</ref>
| summary_text = The outer dense fibers are [[cytoskeletal]] structures that surround the [[axoneme]] in the middle piece and principal piece of the [[sperm]] tail. The fibers function in maintaining the elastic structure and recoil of the [[sperm]] tail as well as in protecting the tail from shear forces during epididymal transport and [[ejaculation]]. Defects in the outer dense fibers lead to abnormal sperm morphology and [[infertility]]. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kierszenbaum AL |title=Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells. |journal=Mol. Reprod. Dev. |volume=61 |issue= 1 |pages= 1-2 |year= 2002 |pmid= 11774369 |doi= 10.1002/mrd.1124 }}
*{{cite journal  | author=Kierszenbaum AL |title=Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells |journal=Mol. Reprod. Dev. |volume=61 |issue= 1 |pages= 1–2 |year= 2002 |pmid= 11774369 |doi= 10.1002/mrd.1124 }}
*{{cite journal  | author=Henkel R, Stalf T, Miska W |title=Isolation and partial characterization of the outer dense fiber proteins from human spermatozoa. |journal=Biol. Chem. Hoppe-Seyler |volume=373 |issue= 8 |pages= 685-9 |year= 1992 |pmid= 1418683 |doi=  }}
*{{cite journal  |vauthors=Henkel R, Stalf T, Miska W |title=Isolation and partial characterization of the outer dense fiber proteins from human spermatozoa |journal=Biol. Chem. Hoppe-Seyler |volume=373 |issue= 8 |pages= 685–9 |year= 1992 |pmid= 1418683 |doi=10.1515/bchm3.1992.373.2.685 }}
*{{cite journal  | author=Hofferbert S, Burfeind P, Hoyer-Fender S, ''et al.'' |title=A homozygous deletion of 27 basepairs in the coding region of the human outer dense fiber protein gene does not result in a pathologic phenotype. |journal=Hum. Mol. Genet. |volume=2 |issue= 12 |pages= 2167-70 |year= 1994 |pmid= 8111388 |doi=  }}
*{{cite journal  | author=Hofferbert S |title=A homozygous deletion of 27 basepairs in the coding region of the human outer dense fiber protein gene does not result in a pathologic phenotype |journal=Hum. Mol. Genet. |volume=2 |issue= 12 |pages= 2167–2170 |year= 1994 |pmid= 8111388 |doi=10.1093/hmg/2.12.2167 |name-list-format=vanc| author2=Burfeind P | author3=Hoyer-Fender S  | display-authors=3  | last4=Lange  | first4=Ricarda  | last5=Haldl  | first5=Gerhard  | last6=Engel  | first6=Wolfgang  }}
*{{cite journal  | author=Gastmann O, Burfeind P, Günther E, ''et al.'' |title=Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene. |journal=Mol. Reprod. Dev. |volume=36 |issue= 4 |pages= 407-18 |year= 1994 |pmid= 8305202 |doi= 10.1002/mrd.1080360402 }}
*{{cite journal  |vauthors=Burmester S, Hoyer-Fender S |title=Transcription and translation of the outer dense fiber gene (Odf1) during spermiogenesis in the rat. A study by in situ analyses and polysome fractionation |journal=Mol. Reprod. Dev. |volume=45 |issue= 1 |pages= 10–20 |year= 1997 |pmid= 8873064 |doi= 10.1002/(SICI)1098-2795(199609)45:1<10::AID-MRD2>3.0.CO;2-V }}
*{{cite journal  | author=Burmester S, Hoyer-Fender S |title=Transcription and translation of the outer dense fiber gene (Odf1) during spermiogenesis in the rat. A study by in situ analyses and polysome fractionation. |journal=Mol. Reprod. Dev. |volume=45 |issue= 1 |pages= 10-20 |year= 1997 |pmid= 8873064 |doi= 10.1002/(SICI)1098-2795(199609)45:1<10::AID-MRD2>3.0.CO;2-V }}
*{{cite journal  |vauthors=Shao X, van der Hoorn FA |title=Self-interaction of the major 27-kilodalton outer dense fiber protein is in part mediated by a leucine zipper domain in the rat |journal=Biol. Reprod. |volume=55 |issue= 6 |pages= 1343–1350 |year= 1997 |pmid= 8949892 |doi=10.1095/biolreprod55.6.1343 }}
*{{cite journal  | author=Shao X, van der Hoorn FA |title=Self-interaction of the major 27-kilodalton outer dense fiber protein is in part mediated by a leucine zipper domain in the rat. |journal=Biol. Reprod. |volume=55 |issue= 6 |pages= 1343-50 |year= 1997 |pmid= 8949892 |doi=  }}
*{{cite journal  | author=Shao X |title=Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27 |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6105–6113 |year= 1997 |pmid= 9045620 |doi=10.1074/jbc.272.10.6105  |name-list-format=vanc| author2=Tarnasky HA  | author3=Schalles U  | display-authors=3  | last4=Oko  | first4=R  | last5=Van Der Hoorn  | first5=FA }}
*{{cite journal  | author=Shao X, Tarnasky HA, Schalles U, ''et al.'' |title=Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6105-13 |year= 1997 |pmid= 9045620 |doi=  }}
*{{cite journal  | author=Shao X |title=Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme |journal=Dev. Biol. |volume=211 |issue= 1 |pages= 109–123 |year= 1999 |pmid= 10373309 |doi= 10.1006/dbio.1999.9297 |name-list-format=vanc| author2=Tarnasky HA  | author3=Lee JP  | display-authors=3  | last4=Oko  | first4=R  | last5=Van Der Hoorn  | first5=FA }}
*{{cite journal  | author=Shao X, Tarnasky HA, Lee JP, ''et al.'' |title=Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme. |journal=Dev. Biol. |volume=211 |issue= 1 |pages= 109-23 |year= 1999 |pmid= 10373309 |doi= 10.1006/dbio.1999.9297 }}
*{{cite journal  |vauthors=Petersen C, Füzesi L, Hoyer-Fender S |title=Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa |journal=Mol. Hum. Reprod. |volume=5 |issue= 7 |pages= 627–635 |year= 1999 |pmid= 10381817 |doi=10.1093/molehr/5.7.627 }}
*{{cite journal  | author=Petersen C, Füzesi L, Hoyer-Fender S |title=Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa. |journal=Mol. Hum. Reprod. |volume=5 |issue= 7 |pages= 627-35 |year= 1999 |pmid= 10381817 |doi=  }}
*{{cite journal  |vauthors=Shao X, Xue J, van der Hoorn FA |title=Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1 |journal=Mol. Reprod. Dev. |volume=59 |issue= 4 |pages= 410–416 |year= 2001 |pmid= 11468777 |doi= 10.1002/mrd.1047 }}
*{{cite journal  | author=Shao X, Xue J, van der Hoorn FA |title=Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1. |journal=Mol. Reprod. Dev. |volume=59 |issue= 4 |pages= 410-6 |year= 2001 |pmid= 11468777 |doi= 10.1002/mrd.1047 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Zarsky HA, Tarnasky HA, Cheng M, van der Hoorn FA |title=Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1 |journal=Biol. Reprod. |volume=68 |issue= 2 |pages= 543–552 |year= 2003 |pmid= 12533418 |doi=10.1095/biolreprod.102.009076 |pmc=3158802}}
*{{cite journal  | author=Zarsky HA, Tarnasky HA, Cheng M, van der Hoorn FA |title=Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1. |journal=Biol. Reprod. |volume=68 |issue= 2 |pages= 543-52 |year= 2003 |pmid= 12533418 |doi= }}
*{{cite journal  | author=Bhullar B |title=Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 16159–16168 |year= 2003 |pmid= 12594206 |doi= 10.1074/jbc.M213126200 |name-list-format=vanc| author2=Zhang Y  | author3=Junco A  | display-authors=3  | last4=Oko  | first4=R  | last5=Van Der Hoorn  | first5=FA | pmc=3178653}}
*{{cite journal  | author=Bhullar B, Zhang Y, Junco A, ''et al.'' |title=Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 16159-68 |year= 2003 |pmid= 12594206 |doi= 10.1074/jbc.M213126200 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 00:21, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Outer dense fiber protein 1 is a protein that in humans is encoded by the ODF1 gene.[1][2]

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein.[2]

References

  1. ↑ Gastmann O, Burfeind P, Gunther E, Hameister H, Szpirer C, Hoyer-Fender S (Mar 1994). "Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene". Mol Reprod Dev. 36 (4): 407–418. doi:10.1002/mrd.1080360402. PMID 8305202.
  2. ↑ 2.0 2.1 "Entrez Gene: ODF1 outer dense fiber of sperm tails 1".

Further reading



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