CDH17: Difference between revisions

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{{Infobox_gene}}
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'''Cadherin-17''' is a [[protein]] that in humans is encoded by the ''CDH17'' [[gene]].<ref name="pmid9615235">{{cite journal | vauthors = Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF | title = Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity | journal = Genomics | volume = 49 | issue = 3 | pages = 467–71 |date=Aug 1998 | pmid = 9615235 | pmc =  | doi = 10.1006/geno.1998.5281 }}</ref><ref name="pmid10191097">{{cite journal | vauthors = Chalmers IJ, Hofler H, Atkinson MJ | title = Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma | journal = Genomics | volume = 57 | issue = 1 | pages = 160–3 |date=Jun 1999 | pmid = 10191097 | pmc =  | doi = 10.1006/geno.1998.5717 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1015| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cadherin 17, LI cadherin (liver-intestine)
| HGNCid = 1756
| Symbol = CDH17
| AltSymbols =; CDH16; FLJ26931; HPT-1; HPT1; MGC138218; MGC142024
| OMIM = 603017
| ECnumber =
| Homologene = 56859
| MGIid = 1095414
  | GeneAtlas_image1 = PBB_GE_CDH17_209847_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005427 |text = proton-dependent oligopeptide secondary active transmembrane transporter activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006857 |text = oligopeptide transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0016339 |text = calcium-dependent cell-cell adhesion}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1015
    | Hs_Ensembl = ENSG00000079112
    | Hs_RefseqProtein = NP_004054
    | Hs_RefseqmRNA = NM_004063
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 95208566
    | Hs_GenLoc_end = 95289986
    | Hs_Uniprot = Q12864
    | Mm_EntrezGene = 12557
    | Mm_Ensembl = ENSMUSG00000028217
    | Mm_RefseqmRNA = NM_019753
    | Mm_RefseqProtein = NP_062727
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 11685362
    | Mm_GenLoc_end = 11745042
    | Mm_Uniprot = Q3TAN0
  }}
}}
'''Cadherin 17, LI cadherin (liver-intestine)''', also known as '''CDH17''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1015| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.<ref name="entrez">{{cite web | title = Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1015| accessdate = }}</ref>
| summary_text = This gene is a member of the [[cadherin]] superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved [[Cadherin cytoplasmic region|cytoplasmic domain]]. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.<ref name="entrez">{{cite web | title = Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1015| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gessner R, Tauber R |title=Intestinal cell adhesion molecules. Liver-intestine cadherin. |journal=Ann. N. Y. Acad. Sci. |volume=915 |issue=  |pages= 136-43 |year= 2001 |pmid= 11193569 |doi=  }}
*{{cite journal  | vauthors=Gessner R, Tauber R |title=Intestinal cell adhesion molecules. Liver-intestine cadherin. |journal=Ann. N. Y. Acad. Sci. |volume=915 |issue=  |pages= 136–43 |year= 2001 |pmid= 11193569 |doi=10.1111/j.1749-6632.2000.tb05236.x }}
*{{cite journal  | author=Gilston A |title=Reducing the hazard of disconnected tubes. |journal=Anaesthesia |volume=32 |issue= 9 |pages= 922 |year= 1978 |pmid= 603017 |doi=  }}
*{{cite journal  | author=Gilston A |title=Reducing the hazard of disconnected tubes. |journal=Anaesthesia |volume=32 |issue= 9 |pages= 922 |year= 1978 |pmid= 603017 |doi=10.1111/j.1365-2044.1977.tb10133.x }}
*{{cite journal  | author=Dantzig AH, Hoskins JA, Tabas LB, ''et al.'' |title=Association of intestinal peptide transport with a protein related to the cadherin superfamily. |journal=Science |volume=264 |issue= 5157 |pages= 430-3 |year= 1994 |pmid= 8153632 |doi=  }}
*{{cite journal  | vauthors=Dantzig AH, Hoskins JA, Tabas LB |title=Association of intestinal peptide transport with a protein related to the cadherin superfamily. |journal=Science |volume=264 |issue= 5157 |pages= 430–3 |year= 1994 |pmid= 8153632 |doi=10.1126/science.8153632 |display-authors=etal}}
*{{cite journal  | author=Kremmidiotis G, Baker E, Crawford J, ''et al.'' |title=Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. |journal=Genomics |volume=49 |issue= 3 |pages= 467-71 |year= 1998 |pmid= 9615235 |doi= 10.1006/geno.1998.5281 }}
*{{cite journal  | vauthors=Suzuki Y, Tsunoda T, Sese J |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001 | pmc=311086 |display-authors=etal}}
*{{cite journal | author=Chalmers IJ, Höfler H, Atkinson MJ |title=Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. |journal=Genomics |volume=57 |issue= 1 |pages= 160-3 |year= 1999 |pmid= 10191097 |doi= 10.1006/geno.1998.5717 }}
*{{cite journal  | vauthors=Grötzinger C, Kneifel J, Patschan D |title=LI-cadherin: a marker of gastric metaplasia and neoplasia. |journal=Gut |volume=49 |issue= 1 |pages= 73–81 |year= 2001 |pmid= 11413113 |doi=10.1136/gut.49.1.73  | pmc=1728355 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Tsunoda T, Sese J, ''et al.'' |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677-84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Grötzinger C, Kneifel J, Patschan D, ''et al.'' |title=LI-cadherin: a marker of gastric metaplasia and neoplasia. |journal=Gut |volume=49 |issue= 1 |pages= 73-81 |year= 2001 |pmid= 11413113 |doi=  }}
*{{cite journal  | vauthors=Takamura M, Sakamoto M, Ino Y |title=Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas. |journal=Cancer Sci. |volume=94 |issue= 5 |pages= 425–30 |year= 2003 |pmid= 12824888 |doi=10.1111/j.1349-7006.2003.tb01459.x |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Wendeler MW, Praus M, Jung R |title=Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. |journal=Exp. Cell Res. |volume=294 |issue= 2 |pages= 345–55 |year= 2004 |pmid= 15023525 |doi= 10.1016/j.yexcr.2003.11.022 |display-authors=etal}}
*{{cite journal  | author=Takamura M, Sakamoto M, Ino Y, ''et al.'' |title=Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas. |journal=Cancer Sci. |volume=94 |issue= 5 |pages= 425-30 |year= 2003 |pmid= 12824888 |doi=  }}
*{{cite journal  | vauthors=Ko S, Chu KM, Luk JM |title=Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 2 |pages= 562–8 |year= 2004 |pmid= 15178443 |doi= 10.1016/j.bbrc.2004.04.197 |display-authors=etal}}
*{{cite journal  | author=Wendeler MW, Praus M, Jung R, ''et al.'' |title=Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. |journal=Exp. Cell Res. |volume=294 |issue= 2 |pages= 345-55 |year= 2004 |pmid= 15023525 |doi= 10.1016/j.yexcr.2003.11.022 }}
*{{cite journal  | vauthors=Takamura M, Ichida T, Matsuda Y |title=Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. |journal=Cancer Lett. |volume=212 |issue= 2 |pages= 253–9 |year= 2004 |pmid= 15279905 |doi= 10.1016/j.canlet.2004.03.016 |display-authors=etal}}
*{{cite journal  | author=Ko S, Chu KM, Luk JM, ''et al.'' |title=Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 2 |pages= 562-8 |year= 2004 |pmid= 15178443 |doi= 10.1016/j.bbrc.2004.04.197 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
*{{cite journal  | author=Takamura M, Ichida T, Matsuda Y, ''et al.'' |title=Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. |journal=Cancer Lett. |volume=212 |issue= 2 |pages= 253-9 |year= 2004 |pmid= 15279905 |doi= 10.1016/j.canlet.2004.03.016 }}
*{{cite journal  | vauthors=Wang XQ, Luk JM, Leung PP |title=Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma. |journal=Clin. Cancer Res. |volume=11 |issue= 2 Pt 1 |pages= 483–9 |year= 2005 |pmid= 15701831 |doi=  |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Wang XQ, Luk JM, Garcia-Barcelo M |title=Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma. |journal=Clin. Cancer Res. |volume=12 |issue= 17 |pages= 5248–52 |year= 2007 |pmid= 16951245 |doi= 10.1158/1078-0432.CCR-06-0558 |display-authors=etal}}
*{{cite journal  | author=Wang XQ, Luk JM, Leung PP, ''et al.'' |title=Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma. |journal=Clin. Cancer Res. |volume=11 |issue= 2 Pt 1 |pages= 483-9 |year= 2005 |pmid= 15701831 |doi=  }}
*{{cite journal  | author=Wang XQ, Luk JM, Garcia-Barcelo M, ''et al.'' |title=Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma. |journal=Clin. Cancer Res. |volume=12 |issue= 17 |pages= 5248-52 |year= 2007 |pmid= 16951245 |doi= 10.1158/1078-0432.CCR-06-0558 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|CDH17}}
* {{UCSC gene details|CDH17}}
* {{UCSC gene info|CDH16}}
 
{{Cell adhesion molecules}}
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Revision as of 09:28, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.[1][2][3]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.[3]

References

  1. ↑ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
  2. ↑ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
  3. ↑ 3.0 3.1 "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)".

Further reading

External links


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