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{{Infobox_gene}}
{{PBB_Controls
'''Beta-1-syntrophin''' is a [[protein]] that in humans is encoded by the ''SNTB1'' [[gene]].<ref name="pmid8183929">{{cite journal | vauthors = Ahn AH, Yoshida M, Anderson MS, Feener CA, Selig S, Hagiwara Y, Ozawa E, Kunkel LM | title = Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24 | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 10 | pages = 4446–50 | date = Jun 1994 | pmid = 8183929 | pmc = 43802 | doi = 10.1073/pnas.91.10.4446 }}</ref><ref name="pmid9482110">{{cite journal | vauthors = Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P | title = The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins | journal = Oncogene | volume = 16 | issue = 5 | pages = 643–54 | date = Mar 1998 | pmid = 9482110 | pmc = | doi = 10.1038/sj.onc.1201567 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6641| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
| HGNCid = 11168
| Symbol = SNTB1
| AltSymbols =; A1B; 59-DAP; BSYN2; DAPA1B; FLJ22442; MGC111389; SNT2; SNT2B1; TIP-43
| OMIM = 600026
| ECnumber = 
| Homologene = 9618
| MGIid = 101781
| GeneAtlas_image1 = PBB_GE_SNTB1_208608_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SNTB1_214708_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0016010 |text = dystrophin-associated glycoprotein complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6641
    | Hs_Ensembl = ENSG00000172164
    | Hs_RefseqProtein = NP_066301
    | Hs_RefseqmRNA = NM_021021
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 121619297
    | Hs_GenLoc_end = 121893264
    | Hs_Uniprot = Q13884
    | Mm_EntrezGene = 20649
    | Mm_Ensembl = ENSMUSG00000060429
    | Mm_RefseqmRNA = XM_001004146
    | Mm_RefseqProtein = XP_001004146
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 55469237
    | Mm_GenLoc_end = 55737032
    | Mm_Uniprot = Q99L88
  }}
}}
'''Syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)''', also known as '''SNTB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6641| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally related genes.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes.<ref name="entrez">{{cite web | title = Entrez Gene: SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6641| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SNTB1 has been shown to [[Protein-protein interaction|interact]] with [[Dystrophin]].<ref name=pmid7844150>{{cite journal | vauthors = Ahn AH, Kunkel LM | title = Syntrophin binds to an alternatively spliced exon of dystrophin | journal = J. Cell Biol. | volume = 128 | issue = 3 | pages = 363–71 | date = Feb 1995 | pmid = 7844150 | pmc = 2120343 | doi = 10.1083/jcb.128.3.363 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ahn AH, Kunkel LM | title = Syntrophin binds to an alternatively spliced exon of dystrophin. | journal = J. Cell Biol. | volume = 128 | issue = 3 | pages = 363–71 | year = 1995 | pmid = 7844150 | pmc = 2120343 | doi = 10.1083/jcb.128.3.363 }}
| citations =
* {{cite journal | vauthors = Yang B, Ibraghimov-Beskrovnaya O, Moomaw CR, Slaughter CA, Campbell KP | title = Heterogeneity of the 59-kDa dystrophin-associated protein revealed by cDNA cloning and expression. | journal = J. Biol. Chem. | volume = 269 | issue = 8 | pages = 6040–4 | year = 1994 | pmid = 8119949 | doi =  }}
*{{cite journal | author=Ahn AH, Kunkel LM |title=Syntrophin binds to an alternatively spliced exon of dystrophin. |journal=J. Cell Biol. |volume=128 |issue= 3 |pages= 363-71 |year= 1995 |pmid= 7844150 |doi= }}
* {{cite journal | vauthors = Ahn AH, Freener CA, Gussoni E, Yoshida M, Ozawa E, Kunkel LM | title = The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. | journal = J. Biol. Chem. | volume = 271 | issue = 5 | pages = 2724–30 | year = 1996 | pmid = 8576247 | doi = 10.1074/jbc.271.5.2724 }}
*{{cite journal | author=Yang B, Ibraghimov-Beskrovnaya O, Moomaw CR, ''et al.'' |title=Heterogeneity of the 59-kDa dystrophin-associated protein revealed by cDNA cloning and expression. |journal=J. Biol. Chem. |volume=269 |issue= 8 |pages= 6040-4 |year= 1994 |pmid= 8119949 |doi=  }}
* {{cite journal | vauthors = Gee SH, Madhavan R, Levinson SR, Caldwell JH, Sealock R, Froehner SC | title = Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. | journal = J. Neurosci. | volume = 18 | issue = 1 | pages = 128–37 | year = 1998 | pmid = 9412493 | doi =  }}
*{{cite journal | author=Ahn AH, Yoshida M, Anderson MS, ''et al.'' |title=Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 10 |pages= 4446-50 |year= 1994 |pmid= 8183929 |doi=  }}
* {{cite journal | vauthors = Hasegawa M, Cuenda A, Spillantini MG, Thomas GM, Buée-Scherrer V, Cohen P, Goedert M | title = Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. | journal = J. Biol. Chem. | volume = 274 | issue = 18 | pages = 12626–31 | year = 1999 | pmid = 10212242 | doi = 10.1074/jbc.274.18.12626 }}
*{{cite journal  | author=Ahn AH, Freener CA, Gussoni E, ''et al.'' |title=The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2724-30 |year= 1996 |pmid= 8576247 |doi= }}
* {{cite journal | vauthors = Blake DJ, Hawkes R, Benson MA, Beesley PW | title = Different dystrophin-like complexes are expressed in neurons and glia. | journal = J. Cell Biol. | volume = 147 | issue = 3 | pages = 645–58 | year = 1999 | pmid = 10545507 | pmc = 2151186 | doi = 10.1083/jcb.147.3.645 }}
*{{cite journal | author=Gee SH, Madhavan R, Levinson SR, ''et al.'' |title=Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. |journal=J. Neurosci. |volume=18 |issue= 1 |pages= 128-37 |year= 1998 |pmid= 9412493 |doi=  }}
* {{cite journal | vauthors = Newey SE, Benson MA, Ponting CP, Davies KE, Blake DJ | title = Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex. | journal = Curr. Biol. | volume = 10 | issue = 20 | pages = 1295–8 | year = 2001 | pmid = 11069112 | doi = 10.1016/S0960-9822(00)00760-0 }}
*{{cite journal | author=Rousset R, Fabre S, Desbois C, ''et al.'' |title=The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. |journal=Oncogene |volume=16 |issue= 5 |pages= 643-54 |year= 1998 |pmid= 9482110 |doi= 10.1038/sj.onc.1201567 }}
* {{cite journal | vauthors = Marchand S, Stetzkowski-Marden F, Cartaud J | title = Differential targeting of components of the dystrophin complex to the postsynaptic membrane. | journal = Eur. J. Neurosci. | volume = 13 | issue = 2 | pages = 221–9 | year = 2001 | pmid = 11168526 | doi = 10.1046/j.1460-9568.2001.01373.x }}
*{{cite journal  | author=Hasegawa M, Cuenda A, Spillantini MG, ''et al.'' |title=Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12626-31 |year= 1999 |pmid= 10212242 |doi= }}
* {{cite journal | vauthors = Hogan A, Shepherd L, Chabot J, Quenneville S, Prescott SM, Topham MK, Gee SH | title = Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 26526–33 | year = 2001 | pmid = 11352924 | doi = 10.1074/jbc.M104156200 }}
*{{cite journal | author=Blake DJ, Hawkes R, Benson MA, Beesley PW |title=Different dystrophin-like complexes are expressed in neurons and glia. |journal=J. Cell Biol. |volume=147 |issue= 3 |pages= 645-58 |year= 1999 |pmid= 10545507 |doi= }}
* {{cite journal | vauthors = Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER | title = NotI flanking sequences: a tool for gene discovery and verification of the human genome. | journal = Nucleic Acids Res. | volume = 30 | issue = 14 | pages = 3163–70 | year = 2002 | pmid = 12136098 | pmc = 135748 | doi = 10.1093/nar/gkf428 }}
*{{cite journal | author=Newey SE, Benson MA, Ponting CP, ''et al.'' |title=Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex. |journal=Curr. Biol. |volume=10 |issue= 20 |pages= 1295-8 |year= 2001 |pmid= 11069112 |doi= }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2004 | pmid = 12665801 | doi = 10.1038/nbt810 }}
*{{cite journal | author=Marchand S, Stetzkowski-Marden F, Cartaud J |title=Differential targeting of components of the dystrophin complex to the postsynaptic membrane. |journal=Eur. J. Neurosci. |volume=13 |issue= 2 |pages= 221-9 |year= 2001 |pmid= 11168526 |doi= }}
* {{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | year = 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}
*{{cite journal | author=Hogan A, Shepherd L, Chabot J, ''et al.'' |title=Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26526-33 |year= 2001 |pmid= 11352924 |doi= 10.1074/jbc.M104156200 }}
* {{cite journal | vauthors = Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW | title = Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. | journal = J. Biol. Chem. | volume = 280 | issue = 47 | pages = 39653–64 | year = 2006 | pmid = 16192269 | doi = 10.1074/jbc.M510187200 }}
*{{cite journal | author=Kutsenko AS, Gizatullin RZ, Al-Amin AN, ''et al.'' |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163-70 |year= 2002 |pmid= 12136098 |doi= }}
* {{cite journal | vauthors = Kawai-Yamada M, Saito Y, Jin L, Ogawa T, Kim KM, Yu LH, Tone Y, Hirata A, Umeda M, Uchimiya H | title = A novel Arabidopsis gene causes Bax-like lethality in Saccharomyces cerevisiae. | journal = J. Biol. Chem. | volume = 280 | issue = 47 | pages = 39468–73 | year = 2006 | pmid = 16192270 | doi = 10.1074/jbc.M509632200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ejtehadi HD, Freimanis GL, Ali HA, Bowman S, Alavi A, Axford J, Callaghan R, Nelson PN | title = The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary study. | journal = Ann. Rheum. Dis. | volume = 65 | issue = 5 | pages = 612–6 | year = 2006 | pmid = 16192292 | pmc = 1798125 | doi = 10.1136/ard.2004.031146 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
* {{cite journal | vauthors = Chen Z, Hague C, Hall RA, Minneman KP | title = Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. | journal = J. Biol. Chem. | volume = 281 | issue = 18 | pages = 12414–20 | year = 2006 | pmid = 16533813 | doi = 10.1074/jbc.M508651200 }}
*{{cite journal | author=Leonoudakis D, Conti LR, Anderson S, ''et al.'' |title=Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22331-46 |year= 2004 |pmid= 15024025 |doi= 10.1074/jbc.M400285200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Okuhira K, Fitzgerald ML, Sarracino DA, ''et al.'' |title=Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39653-64 |year= 2006 |pmid= 16192269 |doi= 10.1074/jbc.M510187200 }}
*{{cite journal | author=Kawai-Yamada M, Saito Y, Jin L, ''et al.'' |title=A novel Arabidopsis gene causes Bax-like lethality in Saccharomyces cerevisiae. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39468-73 |year= 2006 |pmid= 16192270 |doi= 10.1074/jbc.M509632200 }}
*{{cite journal | author=Ejtehadi HD, Freimanis GL, Ali HA, ''et al.'' |title=The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary study. |journal=Ann. Rheum. Dis. |volume=65 |issue= 5 |pages= 612-6 |year= 2006 |pmid= 16192292 |doi= 10.1136/ard.2004.031146 }}
*{{cite journal | author=Chen Z, Hague C, Hall RA, Minneman KP |title=Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12414-20 |year= 2006 |pmid= 16533813 |doi= 10.1074/jbc.M508651200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Muscle tissue}}
{{WikiDoc Sources}}
 
 
{{gene-8-stub}}

Latest revision as of 06:46, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-1-syntrophin is a protein that in humans is encoded by the SNTB1 gene.[1][2][3]

Function

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally related genes.[3]

Interactions

SNTB1 has been shown to interact with Dystrophin.[4]

References

  1. ↑ Ahn AH, Yoshida M, Anderson MS, Feener CA, Selig S, Hagiwara Y, Ozawa E, Kunkel LM (Jun 1994). "Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24". Proc Natl Acad Sci U S A. 91 (10): 4446–50. doi:10.1073/pnas.91.10.4446. PMC 43802. PMID 8183929.
  2. ↑ Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (Mar 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene. 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110.
  3. ↑ 3.0 3.1 "Entrez Gene: SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)".
  4. ↑ Ahn AH, Kunkel LM (Feb 1995). "Syntrophin binds to an alternatively spliced exon of dystrophin". J. Cell Biol. 128 (3): 363–71. doi:10.1083/jcb.128.3.363. PMC 2120343. PMID 7844150.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=SNTB1&oldid=1422435"